{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T09:14:28Z","timestamp":1696065268163},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":8118,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunology &amp; Cell Biology"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This paper examines the histology of rat lungs following intestinal immunization with killed mucoid <jats:italic>Pseudomonas aerugtnosa<\/jats:italic> and subsequent pulmonary challenge with live <jats:italic>P. aeruginosa.<\/jats:italic> The lungs of non\u2010immune challenged rats developed a confluent haemorrhagic pneumonitis with degeneration and sloughing of the mucosa of the airways; perivascular infiltration with mononuclear cells was apparent 1\u20132 h post\u2010challenge; some neutrophils were present by 2 h post\u2010challenge; by 12h post\u2010challenge oedema and intra\u2010alveolar haemorrhage were prominent and Gram\u2010negative organisms were seen in large quantities. In contrast, immunized challenged animals showed a pronounced neutrophilic response 1\u20132 h post\u2010challenge; by 12 h post\u2010challenge patchy abscesses were apparent with resolving inflammation and no organisms visible. The findings suggest that intestinal immunization prevents the development of fatal <jats:italic>P. aeruginosa<\/jats:italic> infections in the lung by accelerating the recruitment of polymorphonuclear neutrophils<\/jats:p>","DOI":"10.1038\/icb.1995.68","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T09:09:07Z","timestamp":1183453747000},"page":"440-445","source":"Crossref","is-referenced-by-count":3,"title":["Histopathology of the lung following intratracheal challenge with live <i>Pseudomonas aeruginosa<\/i> in intestinally immunized rats"],"prefix":"10.1111","volume":"73","author":[{"given":"NR","family":"WILSON","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ML","family":"DUNKLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"BURET","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"YOUNG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AW","family":"CRIPPS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2001.01339.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(86)80748-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.3.793"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92103-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90498-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.59.12.1131"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1128\/iai.57.1.235-238.1989","article-title":"Effect of oral immunization with Pseudomonas aeruginosa on the development of specific antibacterial immunity in the lungs","volume":"57","author":"Freihorst J","year":"1989","journal-title":"Infect. 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