{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:58:12Z","timestamp":1761058692756},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>The preB cell receptor is expressed for a short period after \u03bc heavy chain is produced, that is, at the large preB cell stage in B cell development. The severe impairment of B cell differentiation observed in mice deficient for the preB cell receptor clearly demonstrated the importance of the preB cell receptor m B cell development. Analyses of bone marrow precursor B cells in normal and B cell\u2010deficient mutant mice indicated the preB cell receptor transduced signals to drive cell cycle and to induce allelic exclusion. The proliferation of the preB cell receptor\u2010expressing cells leads to the selective expansion of cells which have succeeded in the productive rearrangement of \u03bc heavy chain gene. This process builds up a preB cell pool large enough to generate sufficient numbers of mature B cells. The preB cell receptor appears to induce allelic exclusion by shutting off the expression of recombinase activation gene (<jats:italic>RAG<\/jats:italic>). In order to analyse the signal transduction pathway downstream of the preB cell receptor, we have developed a new system in which cross\u2010linking of Ig\u03b2 expressed on bone marrow proB cells mimics the signalling through the preB cell receptor to induce differentiation from proB to small preB cells.<\/jats:p>","DOI":"10.1038\/icb.1997.32","type":"journal-article","created":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T18:48:54Z","timestamp":1179773334000},"page":"209-216","source":"Crossref","is-referenced-by-count":14,"title":["The roles of preB cell receptor in early B cell development and its signal transduction"],"prefix":"10.1111","volume":"75","author":[{"given":"H","family":"Karasuyama","sequence":"first","affiliation":[{"name":"Department of Immunology, The Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Applied Immunology, The Institute of Medical Science, University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kuramochi","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kuida","sequence":"additional","affiliation":[{"name":"Department of Immunology, The Tokyo Metropolitan Institute of Medical Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60853-6"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/381751a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1984.tb01955.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/317353a0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830151110"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3107126"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1084\/jem.168.4.1363","article-title":"Feedback inhibition of immunoglobulin gene rearrangement by membrane \u03bc, but not by secreted \u03bc heavy chains","volume":"168","author":"Manz J","year":"1988","journal-title":"J. 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