{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:34:32Z","timestamp":1790670872561,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T00:00:00Z","timestamp":1263254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30871051"],"award-info":[{"award-number":["30871051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>Changes in plasma lipoprotein profiles, particularly low levels of high\u2010density lipoprotein (HDL) cholesterol, are associated with several inflammatory and immune diseases, including atherosclerosis and rheumatoid arthritis, implying the potential link between HDL and immunity. Accumulating evidence suggests that HDL possesses anti\u2010inflammatory effects and has an important function in host defense as part of the innate immune system. In addition, HDL inhibits the ability of antigen\u2010presenting cells (APCs) to stimulate T cells. It is subsequently discovered that HDL or HDL\u2010associated platelet\u2010activating factor\u2010acetylhydrolase can restore the emigratory process of monocyte\u2010derived dendritic cells and thus result in resolution of inflammatory reactions in atherosclerotic plaques. Lipid rafts in plasma membrane are the key structure responsible for the immunomodulation effects of HDL, the remarkable ability of HDL to regulate innate and adaptive immune responses extends our understanding of its atheroprotective role, and provides new therapeutic approaches to atherosclerosis and other inflammatory conditions.<\/jats:p>","DOI":"10.1038\/icb.2009.112","type":"journal-article","created":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T10:45:42Z","timestamp":1263293142000},"page":"285-290","source":"Crossref","is-referenced-by-count":52,"title":["HDL and immunomodulation: an emerging role of HDL against atherosclerosis"],"prefix":"10.1111","volume":"88","author":[{"given":"Bi\u2010lian","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University  Changsha Hunan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University  Changsha Hunan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao\u2010quan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University  Changsha Hunan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui\u2010ping","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Xiangya Hospital of Central South University  Changsha Hunan PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,12]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.06.080"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211394200"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)05524-M"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/S0022-2275(20)38312-7","article-title":"Binding of apoE\u2010rich high density lipoprotein particles by saturable sites on human blood platelets inhibits agonist\u2010induced platelet aggregation","volume":"30","author":"Desai K","year":"1989","journal-title":"J Lipid Res"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11264"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.050443"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.051672"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02834-6"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000029784.15893.10"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1102-1218"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012673"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000147534.69062.dc"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2000.00656.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.151274"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.4.4.599"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.08.006"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109610"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110100"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.12040"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.58.7.2375-2382.1990"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.E800011-JLR200"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700446-JLR200"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200304000-00006"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V59.6.1299.1299"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90836-P"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.02.005"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/08982100600848801"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26206"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200500191"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115756"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01195"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.160606"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.158642"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.793869"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.04.052"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.183442"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5388.480"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80149-1"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e32830d5f09"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403259101"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.065"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.09.003"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4501.098952"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.103.20.2495"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/42408"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2003.11.009"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.14.1.111"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.03.026"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00167-9"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M702959200"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601214"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.92"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4889(97)00061-X"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600857200"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M600428-JLR200"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801408200"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/77842"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.3.1876"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01700.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.9.4770"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1631"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.2.980"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006738200"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403506101"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007717200"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2004.10.003"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0486fje"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602247200"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.168690"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543770903198451"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.2009.112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2009.112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1038\/icb.2009.112","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2009.112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T03:32:20Z","timestamp":1694057540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.2009.112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,12]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["10.1038\/icb.2009.112"],"URL":"https:\/\/doi.org\/10.1038\/icb.2009.112","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,12]]}}}