{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:56:57Z","timestamp":1761418617993,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T00:00:00Z","timestamp":1249344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012592","name":"Foundation for Research Science and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012592","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008247","name":"Otago University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008247","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Animal models indicate that exposure to environmental strains of mycobacteria can modulate immune responses and influence the effectiveness of live mycobacterial vaccines. Here, we describe that between the two recently reported <jats:italic>Mycobacterium avium<\/jats:italic> isolates, strain WAg 206 (but not strain WAg 207) interferes with human monocyte\u2010derived dendritic cell (MDDC) activation. WAg 206, unlike WAg 207, did not elicit inflammatory cytokine production (TNF\u03b1, IL\u20101\u03b2, IL\u201012) or costimulatory molecule expression (HLA\u2010DR, CD83, CD80, CD86) by human MDDCs <jats:italic>in vitro<\/jats:italic>. These data highlight the potential for environmental mycobacteria to modulate immune responses in humans, and suggest a mechanism by which earlier exposure to such microbes may compromise the efficacy of live mycobacterial vaccines, as has been observed in some human BCG vaccine trials.<\/jats:p>","DOI":"10.1038\/icb.2009.51","type":"journal-article","created":{"date-parts":[[2009,8,4]],"date-time":"2009-08-04T10:00:57Z","timestamp":1249380057000},"page":"95-98","source":"Crossref","is-referenced-by-count":4,"title":["Strains of <i>Mycobacterium avium<\/i> differentially activate human dendritic cells"],"prefix":"10.1111","volume":"88","author":[{"given":"Glenn S","family":"Buchan","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Slobbe","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryce M","family":"Buddle","sequence":"additional","affiliation":[{"name":"Hopkirk Research Institute, AgResearch, Massey University  Palmerston North New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,8,4]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0737613100"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2003.12.011"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5271.104"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2073"},{"key":"e_1_2_6_6_1","first-page":"9","article-title":"Dendritic cells (I): biological functions","volume":"46","author":"Satthaporn S","year":"2001","journal-title":"J R Coll Surg Edinb"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115611"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.1.98-106.2004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01826-06"},{"key":"e_1_2_6_10_1","first-page":"145","article-title":"TB infection: an exploratory study of BCG protective properties and the possible role of environmental mycobacteria","volume":"44","author":"Chihota VN","year":"1998","journal-title":"Cent Afr J Med"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.1994.tb00447.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.60.10.4410-4413.1992"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.6.3330-3341.2005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.4049\/jimmunol.155.5.2515","article-title":"IL\u201012 increases resistance of BALB\/c mice to Mycobacterium tuberculosis infection","volume":"155","author":"Flynn JL","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/21900"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4033-4040.1999"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0606407"}],"container-title":["Immunology &amp; 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