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To investigate the influence of prior BCG sensitization on oral vaccine efficacy, we assessed CMI responses and BCG colonization of the alimentary tract lymphatics 5 months after oral vaccination, in both previously naive mice and in mice that had been sensitized to BCG by injection 6 months previously. CMI responses did not differ significantly between mice that received subcutaneous BCG followed by oral BCG and those that received either injected or oral BCG alone. <jats:italic>In vivo<\/jats:italic> BCG colonization was predominant in the mesenteric lymph nodes after oral vaccination; this colonizing ability was not influenced by prior BCG sensitization. From this murine model study, we conclude that although prior parenteral\u2010route BCG sensitization does not detrimentally affect BCG colonization after oral vaccination, there is no significant immune\u2010boosting effect of the oral vaccine either.<\/jats:p>","DOI":"10.1038\/icb.2009.85","type":"journal-article","created":{"date-parts":[[2009,11,17]],"date-time":"2009-11-17T10:36:33Z","timestamp":1258454193000},"page":"224-227","source":"Crossref","is-referenced-by-count":0,"title":["Murine immune responses to oral BCG immunization in the presence or absence of prior BCG sensitization"],"prefix":"10.1111","volume":"88","author":[{"given":"Martin L","family":"Cross","sequence":"first","affiliation":[{"name":"Centre for Innovation, University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R","family":"Lambeth","sequence":"additional","affiliation":[{"name":"Centre for Innovation, University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank E","family":"Aldwell","sequence":"additional","affiliation":[{"name":"Centre for Innovation, University of Otago  Dunedin New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,11,17]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03306.x"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2449-2452.2006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.01.150"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2008.01.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00539-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2009.0414"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.1.101-108.2003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.3.1903-1905.2005"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.11.017"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00052-08"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2008.09.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1711.2005.01369.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2008.08.028"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4666(02)00490-8"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.4049\/jimmunol.163.8.4246","article-title":"Role of IL\u201012 in the induction and potentiation of IFN\u2010gamma in response to Bacillus Calmette\u2013Guerin","volume":"163","author":"O'Donnell MA","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.09.088"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01826-06"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.09.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0606407"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.07.033"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.3.1410-1416.2002"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2007.03.039"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.icb.7100126"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/00480169.2006.36701"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703510104"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2006.00810.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00386-2"}],"container-title":["Immunology &amp; 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