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Tumor necrosis factor (TNF) and its receptors or innate pattern recognition receptors such as the toll\u2010like receptors have been shown to contribute to this process. DC derived from bone marrow cells in the presence of granulocyte\/macrophage colony\u2010stimulating factor can be used as a model to ascertain the contribution of different signals to DC maturation. Analysis of DC activated by addition of the mycobacterial vaccine strain Bacillus Calmette\u2010Gu\u00e9rin showed that of the effector molecules studied only interleukin\u201010 expression was significantly reduced in TNF\u2010negative (B6.TNF<jats:sup>\u2212\/\u2212<\/jats:sup>) DC. 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