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CD69 is expressed in all leukocytes during activation after infection with a wide range of microbial pathogens. This study explores the way in which CD69 affects cell activation after <jats:italic>Listeria monocytogenes<\/jats:italic> (Lm) infection and its effects on host protection. We show that infectivity and bacterial clearance capability are unaltered in CD69<jats:sup>\u2212\/\u2212<\/jats:sup> peritoneal macrophages, bone marrow\u2010derived macrophages and dendritic cells. We found no major altered cell populations in splenocytes of Lm\u2010infected CD69<jats:sup>\u2212\/\u2212<\/jats:sup> mice. However, an increase in the expression of Th1 cytokines was observed after infection, with increased production of type I and II interferon (IFN). In addition, CD69<jats:sup>\u2212\/\u2212<\/jats:sup> splenocytes showed increased apoptosis, consistent with IFN enhancement of lymphocyte apoptosis in response to Lm infection. CD69<jats:sup>\u2212\/\u2212<\/jats:sup> mice showed liver and spleen damage, and greatly increased susceptibility to Lm infection, compared with wild\u2010type controls. Lm\u2010specific T cells were decreased in CD69<jats:sup>\u2212\/\u2212<\/jats:sup> mice even if T\u2010cell cross\u2010presentation and T\u2010cell intrinsic priming response were not compromised. As listeriosis was increased as early as day 1 post\u2010infection but CD69<jats:sup>\u2212\/\u2212<\/jats:sup>RAG2<jats:sup>\u2212\/\u2212<\/jats:sup> mice were more efficient at controlling Listeria, we propose that CD69 controls the cross\u2010talk between innate components and lymphocytes. These results highlight a role for CD69 in preventing infection\u2010induced immunopathology.<\/jats:p>","DOI":"10.1038\/icb.2010.62","type":"journal-article","created":{"date-parts":[[2010,5,4]],"date-time":"2010-05-04T09:47:14Z","timestamp":1272966434000},"page":"707-715","source":"Crossref","is-referenced-by-count":43,"title":["CD69 limits early inflammatory diseases associated with immune response to <i>Listeria monocytogenes<\/i> infection"],"prefix":"10.1111","volume":"88","author":[{"given":"Javier","family":"Vega\u2010Ramos","sequence":"first","affiliation":[{"name":"Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona  Barcelona Spain"},{"name":"Centro Nacional de Microbiologia, Instituto de Salud Carlos III  Majadahonda Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisenda","family":"Alari\u2010Pahissa","sequence":"additional","affiliation":[{"name":"Departament de Fisiologia, Facultat de Biologia, Universitat de Barcelona 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