{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:16:55Z","timestamp":1782775015671,"version":"3.54.5"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["595907"],"award-info":[{"award-number":["595907"]}]},{"name":"Australian National Health and Medical Research Council","award":["595989"],"award-info":[{"award-number":["595989"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Ro\/SSA and La\/SSB comprise a linked set of autoantigens that are clinically important members of the extractable nuclear antigen family and key translational biomarkers for lupus and primary Sj\u00f6gren's syndrome. Autoantibodies directed against the Ro60 and La polypeptide components of the Ro\/La ribonucleoprotein complex, and the structurally unrelated Ro52 protein, mediate tissue damage in the neonatal lupus syndrome, a model of passively acquired autoimmunity in humans in which the most serious manifestation is congenital heart block (CHB). Recent studies have concentrated on two distinct pathogenic mechanisms by which maternal anti\u2010Ro\/La autoantibodies can cause CHB: by forming immune complexes with apoptotic cells in developing fetal heart; and\/or by acting as functional autoantibodies that cross\u2010react with and inhibit calcium channels. Although the precise role of the individual autoantibodies is yet to be settled, maternal anti\u2010Ro60 and anti\u2010Ro52 remain the most likely culprits. This article will discuss the molecular pathways that culminate in the development of CHB, including the recent discovery of \u03b22 glycoprotein I as a protective factor, and present a proteomic approach based on direct mass spectrometric sequencing, which may give a more representative snapshot of the idiotype repertoire of these autoantibodies than genomic\u2010based technologies.<\/jats:p>","DOI":"10.1038\/icb.2011.108","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T11:26:08Z","timestamp":1326799568000},"page":"304-309","source":"Crossref","is-referenced-by-count":33,"title":["Pathogenicity and proteomic signatures of autoantibodies to Ro and La"],"prefix":"10.1111","volume":"90","author":[{"given":"Rhianna","family":"Lindop","sequence":"first","affiliation":[{"name":"Department of Immunology, Flinders Medical Centre and Flinders University  Bedford Park South Australia 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