{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:53:42Z","timestamp":1791071622855,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science and Technology","award":["2008ZX10002-005"],"award-info":[{"award-number":["2008ZX10002-005"]}]},{"name":"National Science and Technology","award":["2008ZX10002-007"],"award-info":[{"award-number":["2008ZX10002-007"]}]},{"name":"National Science and Technology","award":["2008ZX09312-007"],"award-info":[{"award-number":["2008ZX09312-007"]}]},{"name":"The Natural Science Foundation, Shanghai","award":["11ZR1422400"],"award-info":[{"award-number":["11ZR1422400"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Hepatitis B virus infection is still a major global health problem, despite decades of research. Interleukin (IL)\u201022 induces acute phase reactants and chemokines, favors anti\u2010microbial defence and protects tissues from damage. IL\u201022 is important in chronic skin inflammation, but its role in chronic hepatitis B (CHB) is unclear. This study explores the association between intra\u2010hepatic IL\u201022 expression, its relevant associated cytokines and the severity of liver inflammation\/fibrosis in CHB patients. IL\u201022, IL\u201017, IL\u201010, IL\u20106, non\u2010ELR\u2010CXC chemokines (CXCL\u20109, CXCL\u201010, CXCL\u201011), fibroblast growth factors and Kupffer cell (KC) numbers were measured in patients with CHB (<jats:italic>n<\/jats:italic>=65), acute hepatitis B (AHB; <jats:italic>n<\/jats:italic>=4), chronic hepatitis C (CHC; <jats:italic>n<\/jats:italic>=14) and non\u2010viral hepatitis (<jats:italic>n<\/jats:italic>=23), using immunohistochemistry. Expression of IL\u201022, IL\u201017, IL\u201010, IL\u20106, non\u2010ELR\u2010CXC chemokines and number of KCs in liver tissues were substantially higher in AHB patients than others. In CHB patients, the expression of IL\u201022, IL\u20106, CXCL\u20109 and CXCL\u201010 were significantly higher with alanine aminotransferase (ALT) levels \u2a7dtwice the upper limit of normal (ULN), compared with those with ALT levels &gt;twice the ULN, whereas IL\u201010 and IL\u201017 showed a reverse pattern. IL\u201022 was inversely (<jats:italic>P<\/jats:italic>&lt;0.01), but IL\u201017 was positively (<jats:italic>P<\/jats:italic>&lt;0.05), correlated with the histological activity index) in these patients, and a significant negative correlation between the fibrosis stage and IL\u201022 or non\u2010ELR\u2010CXC chemokines was observed. Furthermore, immunofluorescent labeling demonstrated a close spatial association of IL\u201022, CXCL\u20109, \u201010 or \u201011 in the CHB liver. We speculate that IL\u201022 and non\u2010ELR\u2010CXC chemokines synergistically may provide protection in liver inflammation\/fibrosis during CHB infection.<\/jats:p>","DOI":"10.1038\/icb.2011.79","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T09:47:08Z","timestamp":1317116828000},"page":"611-619","source":"Crossref","is-referenced-by-count":54,"title":["IL\u201022 and non\u2010ELR\u2010CXC chemokine expression in chronic hepatitis B virus\u2010infected liver"],"prefix":"10.1111","volume":"90","author":[{"given":"Xiaogang","family":"Xiang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine  Shanghai China"},{"name":"Discipline of Pathology, University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglian","family":"Gui","sequence":"additional","affiliation":[{"name":"Department of Infectious 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