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However, the characterization of the immunological phenotype of MCPIP1\u2010deficient mice has not been detailed. In this study, we performed evaluation through histological, flow cytometric, enzyme\u2010linked immunosorbent assay and real\u2010time PCR analysis and found that targeted disruption of <jats:italic>MCPIP1<\/jats:italic> gene leads to fatal, highly aggressive and widespread immune\u2010related lesions. In addition to previously observed growth retardation, splenomegaly, lymphoadenopathy, severe anemia and premature death, MCPIP1\u2010deficient mice showed disorganization of lymphoid organs, including spleen, lymph nodes and thymus, and massive infiltration of lymphocytes, macrophages and neutrophils into many other non\u2010lymphoid organs, primarily in lungs and liver. Flow cytometric analysis found significant increase in activated and differentiated T cells in peripheral blood and spleen of MCPIP1\u2010deficient mice. Moreover, heightened production of inflammatory cytokines from activated macrophages and T cells were observed in MCPIP1\u2010deficient mice. Interestingly, treatment of MCPIP1\u2010deficient mice with antibiotics resulted in significant improvement of life span and a decrease in inflammatory syndrome. Taken together, these results suggest a prominent role for MCPIP1 in the control of inflammation and immune homeostasis.<\/jats:p>","DOI":"10.1038\/icb.2013.11","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T09:40:55Z","timestamp":1365500455000},"page":"368-376","source":"Crossref","is-referenced-by-count":55,"title":["Targeted disruption of MCPIP1\/Zc3h12a results in fatal inflammatory disease"],"prefix":"10.1111","volume":"91","author":[{"given":"Ruidong","family":"Miao","sequence":"first","affiliation":[{"name":"Department of Basic Medical Science, School of Medicine, University of Missouri\u2010Kansas City Kansas City MO USA"},{"name":"School of Life Sciences, Lanzhou University Lanzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, School of Medicine, University of Missouri\u2010Kansas City Kansas City MO 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