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IgG is the dominant antibody in both male and female reproductive tract mucosal secretions, and is bi\u2010directionally trafficked across epithelia by the neonatal Fc receptor (FcRn). Using pH\u2010polarized epididymal epithelia grown on Transwells, IgG specifically targeted at an extracellular chlamydial antigen; the major outer membrane protein (MOMP), enhanced uptake and translocation of infection at pH 6\u20136.5 but not at neutral pH. This was dependent on FcRn expression. Conversely, FcRn\u2010mediated transport of IgG targeting the intracellular chlamydial inclusion membrane protein A (IncA), induced aberrant inclusion morphology, recruited autophagic proteins independent of lysosomes and significantly reduced infection. Challenge of female mice with MOMP\u2010specific IgG\u2010opsonized <jats:italic>Chlamydia muridarum<\/jats:italic> delayed infection clearance but exacerbated oviduct occlusion. In male mice, MOMP\u2010IgG elicited by immunization afforded no protection against testicular chlamydial infection, whereas the transcytosis of IncA\u2010IgG significantly reduced testicular chlamydial burden. Together these data show that the protective and pathological effects of IgG are dependent on FcRn\u2010mediated transport as well as the specificity of IgG for intracellular or extracellular antigens.<\/jats:p>","DOI":"10.1038\/icb.2013.110","type":"journal-article","created":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T10:42:18Z","timestamp":1390300938000},"page":"417-426","source":"Crossref","is-referenced-by-count":28,"title":["Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens"],"prefix":"10.1111","volume":"92","author":[{"given":"Charles W","family":"Armitage","sequence":"first","affiliation":[{"name":"Institute of Health and Biomedical Innovation, Queensland University of Technology Kelvin Grove Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-8126","authenticated-orcid":false,"given":"Connor 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