{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:48:44Z","timestamp":1788871724569,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T00:00:00Z","timestamp":1384214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["637306"],"award-info":[{"award-number":["637306"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["575500"],"award-info":[{"award-number":["575500"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    Mice homozygous for a point mutation in the\n                    <jats:italic>Rc3h1<\/jats:italic>\n                    gene encoding Roquin1, designated\n                    <jats:italic>sanroque<\/jats:italic>\n                    mice, develop a severe antibody\u2010mediated autoimmune condition. The disease is T\u2010cell intrinsic, exacerbated by macrophage\u2010intrinsic defects and driven by excessive T follicular helper cell generation and spontaneous germinal centre (GC) formation. This culminates in abnormally high numbers of plasma cells secreting high\u2010affinity autoreactive immunoglobulin G (IgG). Obf1 is a transcriptional co\u2010activator required for normal T\u2010cell\u2010dependent antibody responses, and it is essential for GC formation under all circumstances so far tested. We crossed\n                    <jats:italic>sanroque<\/jats:italic>\n                    mice with Obf1\u2010null mice to determine whether the hyperactivity of\n                    <jats:italic>sanroque<\/jats:italic>\n                    T cells could drive\n                    <jats:italic>Obf1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    B cells to differentiate to GC B cells, or conversely, if Obf1 loss would prevent\n                    <jats:italic>sanroque<\/jats:italic>\n                    \u2010mediated autoimmune disease. Surprisingly, while\n                    <jats:italic>sanroque\/Obf1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice did not form GC, they still developed autoimmune disease and succumbed even more rapidly than did\n                    <jats:italic>sanroque<\/jats:italic>\n                    mice. The disease was mediated by autoreactive IgM, which may have been derived from a pre\u2010existing population of autoreactive B cells in the\n                    <jats:italic>Obf1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice responding to the over\u2010exuberant activity of\n                    <jats:italic>sanroque<\/jats:italic>\n                    CD4 cells.\n                  <\/jats:p>","DOI":"10.1038\/icb.2013.71","type":"journal-article","created":{"date-parts":[[2013,11,12]],"date-time":"2013-11-12T06:56:44Z","timestamp":1384239404000},"page":"12-19","source":"Crossref","is-referenced-by-count":19,"title":["Germinal center\u2010independent, IgM\u2010mediated autoimmunity in\n                    <i>sanroque<\/i>\n                    mice lacking Obf1"],"prefix":"10.1111","volume":"92","author":[{"given":"Stephane","family":"Chevrier","sequence":"first","affiliation":[{"name":"Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research Parkville Victoria Australia"},{"name":"Department of Medical Biology, The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kratina","sequence":"additional","affiliation":[{"name":"Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research Parkville Victoria Australia"},{"name":"Department of Medical Biology, The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Emslie","sequence":"additional","affiliation":[{"name":"Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research Parkville Victoria Australia"},{"name":"Department of Medical Biology, The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Karnowski","sequence":"additional","affiliation":[{"name":"CSL Limited, Bio21 Institute Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research Parkville Victoria Australia"},{"name":"Department of Medical Biology, The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,12]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07628.x"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1902"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.01.011"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.12.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03555"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081886"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110578"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111504"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042325"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/383538a0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/383542a0"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.17.5066"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20022014"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081571"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-365130"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830261255"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(00)00098-4"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.7.4104"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601742"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.23.8320-8331.2002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00911-X"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxg109"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.4049\/jimmunol.144.11.4218","article-title":"Distribution of IL\u20105 receptor\u2010positive B cells. 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