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However, protection against the oviduct pathology associated with infertility is highly variable and often has no defining immunological correlate. When comparing two adjuvants (CTA1\u2010DD and a combination of Cholera toxin plus CpG\u2010oligodeoxynucleotide\u2013CT\/CpG) combined with the chlamydial major outer membrane protein (MOMP) antigen and delivered via the intranasal (IN), sublingual (SL) or transcutaneous (TC) routes, we identified two vaccine groups with contrasting outcomes following infection. SL immunization with MOMP\/CTA1\u2010DD induced a 70% reduction in the incidence of oviduct pathology, without significantly altering the course of infection. Conversely, IN immunization with MOMP\/CT\/CpG prevented an ascending infection, but not the oviduct pathology. This anomaly presented a unique opportunity to study the mechanisms by which vaccines can prevent oviduct pathology, other than by controlling the infection. The IL\u201017 signaling in the oviducts was found to associate with both the enhancement of immunity to infection and the development of oviduct pathology. This conflicting role of IL\u201017 may provide some explanation for the discordance in protection between infection and disease and suggests that controlling immunopathology, as opposed to the rapid eradication of the infection, may be essential for an effective human chlamydial vaccine that prevents infertility.<\/jats:p>","DOI":"10.1038\/icb.2013.92","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T10:42:00Z","timestamp":1387881720000},"page":"287-297","source":"Crossref","is-referenced-by-count":42,"title":["Immunity against a <i>Chlamydia<\/i> infection and disease may be determined by a balance of IL\u201017 signaling"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-8126","authenticated-orcid":false,"given":"Connor P","family":"O'Meara","sequence":"first","affiliation":[{"name":"Institute of Health and Biomedical Innovation, Queensland University of Technology Brisbane Queensland 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