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There are however, side effects and disadvantages of these treatments, such as general immunosuppression as well as therapy resistance in a large proportion of patients. This evokes the wish for other, more specialised forms of treatments. The targeting of chemokines and their receptors to disrupt cell movement specifically has been seen as a promising avenue of therapy for a considerable time. We will discuss one particular chemokine and its receptor, the C\u2010C chemokine ligand CCL20 and the C\u2010C chemokine receptor CCR6, and summarise its genetic and biological role in rheumatoid arthritis (RA). 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