{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:28:56Z","timestamp":1790533736557,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>The pathogenic gram\u2010positive bacteria, <jats:italic>Listeria monocytogenes<\/jats:italic> is a facultative infectious intracellular pathogen that causes listeriosis. Effective elimination of infection is dependent upon a functioning innate immune system and activation of inflammatory responses by pathogen recognition receptors (PRRs). In this review, we trace the route of <jats:italic>L. monocytogenes<\/jats:italic> invasion as it disseminates from the intestinal epithelium, through the bloodstream of the host, to the liver and spleen. Along this route, we highlight the diverse, region specific, innate defences in place throughout the course of infection. We provide an overview of recent advances in our knowledge of key innate immune defences against <jats:italic>L. monocytogenes<\/jats:italic>, focusing on the PRRs in various cell types known to be critical in the detection of this pathogen.<\/jats:p>","DOI":"10.1038\/icb.2014.27","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T09:39:50Z","timestamp":1397554790000},"page":"563-569","source":"Crossref","is-referenced-by-count":20,"title":["Tracing innate immune defences along the path of <i>Listeria monocytogenes<\/i> infection"],"prefix":"10.1111","volume":"92","author":[{"given":"Tim","family":"Regan","sequence":"first","affiliation":[{"name":"Department of Pathology, University College Cork Cork Ireland"},{"name":"Alimentary Pharmabiotic Centre, University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"MacSharry","sequence":"additional","affiliation":[{"name":"Alimentary Pharmabiotic Centre, University College Cork Cork Ireland"},{"name":"School of Medicine, University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Brint","sequence":"additional","affiliation":[{"name":"Department of Pathology, University College Cork Cork Ireland"},{"name":"Alimentary Pharmabiotic Centre, University College Cork Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"e_1_2_13_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(97)80005-6"},{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420090077035"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1461"},{"key":"e_1_2_13_4_1","first-page":"4","article-title":"Listeria: review of epidemiology and pathogenesis","volume":"40","author":"Ramaswamy V","year":"2007","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.3.584-640.2001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81070-3"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01136-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00141-0"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1292"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00516-10"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/345175a0"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.11.4231-4237.1995"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1992.tb05252.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90188-I"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1967"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.058"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003015"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104911"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.050690"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.05.018"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001194"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045186"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07965"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07383"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203245"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.274"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062872"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.049"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001326"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200838718"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.07.017"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.06.012"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.4.2407"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002368"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.179.1.259"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300498"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.72.4.2131-2139.2004"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.4.2064"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1086\/588815"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.7.3869"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901346"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.11.7558"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04515"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201040425"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1864"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020609"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4337"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2004.00360.x"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-010-9425-2"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040976"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040769"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060045"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.5.12787"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320145110"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065007"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxt050"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033299"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010250"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1876"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031051"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.14.3797"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2010.00149"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609672104"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00077-11"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.03.012"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.03.011"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702729104"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.6802"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5594"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06479"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.2014.27","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2014.27","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1038\/icb.2014.27","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2014.27","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T16:38:42Z","timestamp":1694018322000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.2014.27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,15]]},"references-count":70,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1038\/icb.2014.27"],"URL":"https:\/\/doi.org\/10.1038\/icb.2014.27","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,15]]}}}