{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T08:05:10Z","timestamp":1770624310092,"version":"3.49.0"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Natural Science Foundation of Hubei Province of China","award":["2013cfc096"],"award-info":[{"award-number":["2013cfc096"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>Adaptation of the maternal immune response to accommodate the semiallogeneic fetus is necessary for pregnancy success. However, the mechanisms by which the fetus avoids rejection despite expression of paternal alloantigens remain incompletely understood. Regulatory T cells (Treg cells) are pivotal for maintaining immune homeostasis, preventing autoimmune disease and fetus rejection. In this study, we found that maternal decidual vascular endothelial cells (DVECs) sustained Foxp3 expression in resting Treg cells <jats:italic>in vitro<\/jats:italic>. Moreover, under <jats:italic>in vitro<\/jats:italic> Treg cell induction condition with agonistic antibodies and transforming growth factor (TGF)\u2010\u03b2, DVECs promoted Treg cell differentiation from non\u2010Treg conventional T cells. Consistent with the promotion of Treg cell maintenance and differentiation, Treg cell\u2010associated gene expression such as TGF\u2010\u03b2, Epstein\u2013Barr\u2010induced gene\u20103, CD39 and glucocorticoid\u2010induced tumor necrosis factor receptor was also increased in the presence of DVECs. Further study revealed that DVECs expressed Notch ligands such as Jagged\u20101, Delta\u2010like protein 1 (DLL\u20101) and DLL\u20104, while Treg cells expressed Notch1 on their surface. The effects of DVECs on Treg cells was inhibited by siRNA\u2010induced knockdown of expression of Jagged\u20101 and DLL\u20101 in DVECs. Downregulation of Notch1 in Treg cells using lentiviral shRNA transduction decreased Foxp3 expression in Treg cells. Adoptive transfer of Notch1\u2010deficient Treg cells increased abortion rate in a murine semiallogeneic pregnancy model. Taken together, our study suggests that maternal DVECs are able to maintain decidual Treg cell identity and promote Treg cell differentiation through activation of Notch1 signal pathway in Treg cells and subsequently inhibit the immune response against semiallogeneic fetuses and preventing spontaneous abortion.<\/jats:p>","DOI":"10.1038\/icb.2015.119","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T09:20:10Z","timestamp":1451467210000},"page":"458-469","source":"Crossref","is-referenced-by-count":5,"title":["Decidual vascular endothelial cells promote maternal\u2013fetal immune tolerance by inducing regulatory T cells through canonical Notch1 signaling"],"prefix":"10.1111","volume":"94","author":[{"given":"Yanyi","family":"Yao","sequence":"first","affiliation":[{"name":"Genetics Laboratory, Maternal and Child Health Hospital of Hubei Province  Wuhan Hubei Province 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