{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:17:41Z","timestamp":1792221461333,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81302588"],"award-info":[{"award-number":["81302588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>G\u03b1q, the \u03b1\u2010subunit of Gq protein, is ubiquitously expressed in mammalian cells. It initially attracted attention for its physiological significance in cardiovascular system. In recent years, studies have also indicated the important roles of G\u03b1q in regulating immunity, supplying us a new insight into the mechanism of immune regulation. T helper type 17 (Th17) cells are potent inducers of tissue inflammation. Many studies have shown that Th17 cells are major effector cells in the pathogenesis of many experimental autoimmune diseases and human inflammatory conditions such as rheumatoid arthritis (RA). One of our previous studies has shown that G\u03b1q negatively controls the disease activity of RA. However, how G\u03b1q controls the pathogenesis of autoimmune disease is not clear. Whether this effect is via the regulation of Th17 differentiation is still not known. We aimed to find out the role of G\u03b1q in control of Th17 differentiation. We investigated the relationship between G\u03b1q and Th17 in RA patients. We then investigated the mechanism of how G\u03b1q regulated Th17 differentiation by using Gnaq<jats:sup>\u2212\/\u2212<\/jats:sup> mice. We observed that the expression of G\u03b1q was negatively associated with interleukin\u201017A expression in RA patients, indicating that G\u03b1q negatively controlled the differentiation of Th17 cells. By using Gnaq<jats:sup>\u2212\/\u2212<\/jats:sup> mice, we demonstrated that G\u03b1q inhibited the differentiation of Th17 cell via regulating the activity of extracellular signal\u2010regulated kinase\u20101\/2 to control the expression of STAT3 (signal transducer and activator of transcription 3) and ROR\u03b1 (RAR\u2010related orphan receptor\u2010\u03b1). These data suggest the possibility of targeting G\u03b1q to develop a novel therapeutic regimen for autoimmune disease.<\/jats:p>","DOI":"10.1038\/icb.2015.13","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T10:58:12Z","timestamp":1425380292000},"page":"616-624","source":"Crossref","is-referenced-by-count":17,"title":["G\u03b1q controls rheumatoid arthritis via regulation of Th17 differentiation"],"prefix":"10.1111","volume":"93","author":[{"given":"Yuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashan","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Biology Research Center, Shandong Medical College  Linyi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, The Third People's Hospital of Chengdu and The Second Affiliated Clinical College of Chengdu of Chongqing Medical University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixiu","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2299"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000186689"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00003.2005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.10049"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.15.8121"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.17.10140"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm618"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm229"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071267"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092735"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004965"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02635.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132710"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707449"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2010.02.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.11.6173"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10173"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2832"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808144106"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.091301.131133"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0122"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0014-2956.2001.02486.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901509"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.012674"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.085431"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27334"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3794"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.19.11107"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes279"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.14089"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.6.1693"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.2015.13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2015.13","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1038\/icb.2015.13","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2015.13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T07:47:37Z","timestamp":1694072857000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.2015.13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,3]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1038\/icb.2015.13"],"URL":"https:\/\/doi.org\/10.1038\/icb.2015.13","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,3]]}}}