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The immune response at this site is thus critical to provide innate protection against pathogens that are seen for the very first time as well as provide long\u2010term pathogen\u2010specific immunity, which would be required for an effective vaccine against sexually transmitted infection. A finely regulated immune response is therefore required to provide an effective barrier against pathogens without compromising the capacity of the genital tract to allow for successful conception and fetal development. 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