{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:15:43Z","timestamp":1770232543416,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 DK067255"],"award-info":[{"award-number":["RO1 DK067255"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI080581"],"award-info":[{"award-number":["R01 AI080581"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>Elevated levels of interleukin (IL)\u201018 have been reported in a number of allergic diseases. We recently reported that IL\u201018 in the blood and IL\u201018R\u03b1 mRNA in the oesophagus are induced during human eosinophilic oesophagitis (EoE). Additionally, we earlier showed that invariant natural killer T (iNKT) cells are critical to EoE pathogenesis; however, the mechanism of iNKT cell activation in EoE is not well understood. Therefore, the current study focused on the hypothesis that allergen\u2010induced IL\u201018 may have an important role in iNKT cell\u2010mediated EoE pathogenesis. We first validated the human EoE findings of IL\u201018 in experimental EoE by examining blood levels of IL\u201018 and oesophageal IL\u201018R\u03b1 mRNA levels in aeroallergen\u2010 and food allergen\u2010induced experimental mouse models of EoE. We demonstrate that blood IL\u201018 protein and oesophageal IL\u201018R\u03b1 mRNA are induced in the mouse model of EoE and that IL\u201018R\u03b1 is expressed by iNKT cells in the oesophagus. Intranasal delivery of rIL\u201018 induced both mast cells and eosinophilic inflammation in the oesophagus in a time\u2010 and dose\u2010dependent manner. To establish the significance of IL\u201018 in EoE pathogenesis, we examined DOX\u2010inducible rtTA\u2010CC10\u2010IL\u201018 bitransgenic mice that induce IL\u201018 protein expression in the oesophagus. Our analysis indicated that induction of IL\u201018 in these mice resulted in the development of many of the characteristics of EoE, including oesophageal intraepithelial eosinophilia, increased mast cells, oesophageal remodelling and fibrosis. The current study provides evidence that IL\u201018 may induce iNKT cell activation to release the eosinophil\u2010activating cytokine IL\u20105, as IL\u20105\u2010deficient mice and iNKT cell\u2010deficient (CD1d null) mice do not induce EoE in response to intranasal IL\u201018 challenge. Taken together, these findings provide evidence that allergen\u2010induced IL\u201018 has a significant role in promoting IL\u20105\u2010 and iNKT\u2010dependent EoE pathogenesis.<\/jats:p>","DOI":"10.1038\/icb.2015.30","type":"journal-article","created":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T10:36:45Z","timestamp":1427193405000},"page":"849-857","source":"Crossref","is-referenced-by-count":25,"title":["Allergen\u2010induced interleukin\u201018 promotes experimental eosinophilic oesophagitis in mice"],"prefix":"10.1111","volume":"93","author":[{"given":"Parmesh","family":"Dutt","sequence":"first","affiliation":[{"name":"Section of Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jai Shankar","family":"Shukla","sequence":"additional","affiliation":[{"name":"Section of Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sathisha Upparahalli","family":"Ventateshaiah","sequence":"additional","affiliation":[{"name":"Section of Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddesha Jalahalli","family":"Mariswamy","sequence":"additional","affiliation":[{"name":"Section of Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Mattner","sequence":"additional","affiliation":[{"name":"Division of Immunobiology, Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Mikrobiologisches Institut\u2010Klinische Mikrobiologie, Immunologie und Hygiene, Universit\u00e4tsklinikum Erlangen and Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshi","family":"Shukla","sequence":"additional","affiliation":[{"name":"Section of Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anil","family":"Mishra","sequence":"additional","affiliation":[{"name":"Section of Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine  New Orleans LA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10224"},{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.5.2464"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00223.2011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/cti.2013.13"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.12"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12201"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2217\/cpr.14.31"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26679"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.04.016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2006.08.006"},{"key":"e_1_2_8_11_1","first-page":"224","article-title":"IL\u201018 in autoimmunity: review","volume":"17","author":"Boraschi D","year":"2006","journal-title":"Europ Cyto Net"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.3.355"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181818fb9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03239.x"},{"key":"e_1_2_8_15_1","first-page":"33","article-title":"[Interleukin 13 and 18 serum concentration in children with cow milk hypersensitivity]","volume":"8","author":"Bala G","year":"2004","journal-title":"Med Wieku Rozwoj"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.2.1096"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03097.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.5.1512"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.4049\/jimmunol.161.7.3400","article-title":"IL\u201012 up\u2010regulates IL\u201018 receptor expression on T cells, Th1 cells, and B cells: synergism with IL\u201018 for IFN\u2010gamma production","volume":"161","author":"Yoshimoto T","year":"1998","journal-title":"J Immunol"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/12.2.151"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13962"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/77811"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.01.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-0203-5"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31802c0d06"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00070.2013"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03408"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2003.07.007"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.09.010"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.038"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31817f0197"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199805283382206"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.009"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.10.031"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.120095"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060617"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000471"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3321"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.105"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0954-7894.2002.01346.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082013000800004"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.05.036"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357006"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02210.x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.039"},{"key":"e_1_2_8_46_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1053\/j.gastro.2010.03.057","article-title":"Interleukin\u201015 expression is increased in human eosinophilic esophagitis and mediates pathogenesis in mice","volume":"139","author":"Zhu X","journal-title":"Gastroenterology"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00148.2009"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6273"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6560"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.2015.30","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2015.30","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1038\/icb.2015.30","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2015.30","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:47:14Z","timestamp":1694051234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.2015.30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,24]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1038\/icb.2015.30"],"URL":"https:\/\/doi.org\/10.1038\/icb.2015.30","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,24]]}}}