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After <jats:italic>Y. pestis<\/jats:italic> overcomes the skin barrier, it encounters antigen\u2010presenting cells (APCs), such as Langerhans and dendritic cells. They transport the bacteria from the skin to the lymph nodes. However, the molecular mechanisms involved in bacterial transmission are unclear. Langerhans cells (LCs) express Langerin (CD207), a calcium\u2010dependent (C\u2010type) lectin. Furthermore, <jats:italic>Y. pestis<\/jats:italic> possesses exposed core oligosaccharides. In this study, we show that <jats:italic>Y. pestis<\/jats:italic> invades LCs and Langerin\u2010expressing transfectants. However, when the bacterial core oligosaccharides are shielded or truncated, <jats:italic>Y. pestis<\/jats:italic> propensity to invade Langerhans and Langerin\u2010expressing cells decreases. Moreover, the interaction of <jats:italic>Y. pestis<\/jats:italic> with Langerin\u2010expressing transfectants is inhibited by purified Langerin, a DC\u2010SIGN (DC\u2010specific intercellular adhesion molecule 3 grabbing nonintegrin)\u2010like molecule, an anti\u2010CD207 antibody, purified core oligosaccharides and several oligosaccharides. Furthermore, covering core oligosaccharides reduces the mortality associated with murine infection by adversely affecting the transmission of <jats:italic>Y. pestis<\/jats:italic> to lymph nodes. These results demonstrate that direct interaction of core oligosaccharides with Langerin facilitates the invasion of LCs by <jats:italic>Y. pestis<\/jats:italic>. Therefore, Langerin\u2010mediated binding of <jats:italic>Y. pestis<\/jats:italic> to APCs may promote its dissemination and infection.<\/jats:p>","DOI":"10.1038\/icb.2015.46","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T08:27:23Z","timestamp":1427876843000},"page":"815-824","source":"Crossref","is-referenced-by-count":51,"title":["Host Langerin (CD207) is a receptor for <i>Yersinia pestis<\/i> phagocytosis and promotes dissemination"],"prefix":"10.1111","volume":"93","author":[{"given":"Kun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae G","family":"Park","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei 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