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Further study of the specific antibody response during schistosomiasis may yield the vaccines and diagnostics needed to combat this disease. Therefore, for the purposes of antigen discovery, sera and antibody\u2010secreting cell (ASC) probes from semi\u2010permissive rats and sera from susceptible mice were used to screen a schistosome protein microarray. Following <jats:italic>Schistosoma japonicum<\/jats:italic> infection, rats had reduced pathology, increased antibody responses and broader antigen recognition profiles compared with mice. With successive infections, rat global serological reactivity and the number of recognized antigens increased. The local antibody response in rat skin and lung, measured with ASC probes, increased after parasite migration and contributed antigen\u2010specific antibodies to the multivalent serological response. In addition, the temporal variation of anti\u2010parasite serum antibodies after infection and reinfection followed patterns that appear related to the antigen driving the response. Among the 29 antigens differentially recognized by the infected hosts were numerous known vaccine candidates, drug targets and several <jats:italic>S. japonicum<\/jats:italic> homologs of human schistosomiasis resistance markers\u2014the tegument allergen\u2010like proteins. From this set, we prioritized eight proteins that may prove to be novel schistosome vaccine and diagnostic antigens.<\/jats:p>","DOI":"10.1038\/icb.2015.61","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T08:40:03Z","timestamp":1433493603000},"page":"52-65","source":"Crossref","is-referenced-by-count":12,"title":["Specific humoral response of hosts with variable schistosomiasis susceptibility"],"prefix":"10.1111","volume":"94","author":[{"given":"Patrick","family":"Driguez","sequence":"first","affiliation":[{"name":"Infectious Disease Division, QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamish EG","family":"McWilliam","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity  Melbourne Victoria 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