{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:16:43Z","timestamp":1792088203355,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["358398"],"award-info":[{"award-number":["358398"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000971","name":"Diabetes Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000971","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Liver fibrosis is a progressive pathological process involving inflammation and extracellular matrix deposition. Dipeptidyl peptidase 4 (DPP4), also known as CD26, is a cell surface glycoprotein and serine protease. DPP4 binds to fibronectin, can inactivate specific chemokines, incretin hormone and neuropeptides, and influences cell adhesion and migration. Such properties suggest a pro\u2010fibrotic role for this peptidase but this hypothesis needs <jats:italic>in vivo<\/jats:italic> examination. Experimental liver injury was induced with carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) in DPP4 gene knockout (gko) mice. DPP4 gko had less liver fibrosis and inflammation and fewer B cell clusters than wild type mice in the fibrosis model. DPP4 inhibitor\u2010treated mice also developed less liver fibrosis. DNA microarray and PCR showed that many immunoglobulin (Ig) genes and some metabolism\u2010associated transcripts were differentially expressed in the gko strain compared with wild type. CCl<jats:sub>4<\/jats:sub>\u2010treated DPP4 gko livers had more IgM<jats:sup>+<\/jats:sup> and IgG<jats:sup>+<\/jats:sup> intrahepatic lymphocytes, and fewer CD4<jats:sup>+<\/jats:sup>, IgD<jats:sup>+<\/jats:sup> and CD21<jats:sup>+<\/jats:sup> intrahepatic lymphocytes. These data suggest that DPP4 is pro\u2010fibrotic in CCl<jats:sub>4<\/jats:sub>\u2010induced liver fibrosis and that the mechanisms of DPP4 pro\u2010fibrotic action include energy metabolism, B cells, NK cells and CD4<jats:sup>+<\/jats:sup> cells.<\/jats:p>","DOI":"10.1038\/icb.2016.116","type":"journal-article","created":{"date-parts":[[2016,11,30]],"date-time":"2016-11-30T09:21:31Z","timestamp":1480497691000},"page":"443-453","source":"Crossref","is-referenced-by-count":41,"title":["The pro\u2010fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride\u2010induced experimental liver injury"],"prefix":"10.1111","volume":"95","author":[{"given":"Xin M","family":"Wang","sequence":"first","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren E","family":"Holz","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaiya","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun P","family":"Cordoba","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A","family":"Evans","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret G","family":"Gall","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana J\u00falia","family":"Vieira de Ribeiro","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan Zhou","family":"Zheng","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam T","family":"Levy","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise MT","family":"Yu","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsun\u2010Wen","family":"Yao","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasa","family":"Polak","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Jolly","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8244-7057","authenticated-orcid":false,"given":"Patrick","family":"Bertolino","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W","family":"McCaughan","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-2604","authenticated-orcid":false,"given":"Mark D","family":"Gorrell","sequence":"additional","affiliation":[{"name":"Centenary Institute and Sydney Medical School, The University of Sydney  Sydney New South Wales Australia"},{"name":"A.W. Morrow Gastroenterology and Liver Centre, Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3823"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24798"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20920"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1009"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.42"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20040302"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12781"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120069197"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00387"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40594"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28393"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2015.11.004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23569"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2010.02488.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3201"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2151"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2620327"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i19.2883"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12237"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150613"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-0358"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13274"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1635114100"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2016.02.007"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072928"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00232-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(01)00328-9"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612033454351"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200323469"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.26376"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103801"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07526.x"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.211136"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2002.590501.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26115"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.150870"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0631828100"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04585.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2004.12.002"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi448"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.02.020"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-011-0175-2"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2003.00805.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.12.007"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.01.116"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi026846s"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.012"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20637"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03183.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.10.039"}],"container-title":["Immunology &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1038%2Ficb.2016.116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2016.116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1038\/icb.2016.116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1038\/icb.2016.116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T04:34:17Z","timestamp":1694061257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1038\/icb.2016.116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,20]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1038\/icb.2016.116"],"URL":"https:\/\/doi.org\/10.1038\/icb.2016.116","archive":["Portico"],"relation":{},"ISSN":["0818-9641","1440-1711"],"issn-type":[{"value":"0818-9641","type":"print"},{"value":"1440-1711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,20]]}}}