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Here we examined whether AnxA6 regulates signalling and proliferation in T cells. We used a contact hypersensitivity model to immune challenge wild\u2010type (WT) and AnxA6<jats:sup>\u2212\/\u2212<\/jats:sup> mice and found that the <jats:italic>in vivo<\/jats:italic> proliferation of CD4<jats:sup>+<\/jats:sup> T cells, but not CD8<jats:sup>+<\/jats:sup> T cells, was impaired in AnxA6<jats:sup>\u2212\/\u2212<\/jats:sup> relative to WT mice. However, T\u2010cell migration and signalling through the T\u2010cell receptor <jats:italic>ex vivo<\/jats:italic> was similar between T cells isolated from AnxA6<jats:sup>\u2212\/\u2212<\/jats:sup> and WT mice. In contrast, interleukin\u20102 (IL\u20102) signalling was reduced in AnxA6<jats:sup>\u2212\/\u2212<\/jats:sup> compared with WT T cells. Further, AnxA6\u2010deficient T cells had reduced membrane order and cholesterol levels. Taken together, our data suggest that AnxA6 regulates IL\u20102 homeostasis and sensitivity in T cells by sustaining a lipid raft\u2010like membrane environment.<\/jats:p>","DOI":"10.1038\/icb.2016.15","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T09:20:56Z","timestamp":1454923256000},"page":"543-553","source":"Crossref","is-referenced-by-count":39,"title":["Annexin A6 regulates interleukin\u20102\u2010mediated T\u2010cell proliferation"],"prefix":"10.1111","volume":"94","author":[{"given":"Rhea","family":"Cornely","sequence":"first","affiliation":[{"name":"EMBL Australia Node in Single Molecule Science, School of Medical Science, University of New South Wales (UNSW)  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail H","family":"Pollock","sequence":"additional","affiliation":[{"name":"EMBL Australia Node in Single Molecule Science, School of Medical Science, University of New South Wales 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