{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:00:42Z","timestamp":1789437642754,"version":"build-2803163510"},"reference-count":53,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T00:00:00Z","timestamp":1495497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["490900"],"award-info":[{"award-number":["490900"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1006592"],"award-info":[{"award-number":["1006592"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1045549"],"award-info":[{"award-number":["1045549"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["1065626"],"award-info":[{"award-number":["1065626"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunol Cell Biol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>\n                    The biological role of granzyme K, a serine protease of cytotoxic T lymphocytes (CTL), is controversial. It has been reported to induce perforin\u2010mediated cell death\n                    <jats:italic>in vitro<\/jats:italic>\n                    , but is also reported to be non\u2010cytotoxic and to operate in inflammatory processes. To elucidate the biological role of this protease, we have deleted the granzyme K gene in mice (mutant allele:\n                    <jats:italic>Gzmk<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>tm1.1Pib<\/jats:italic>\n                    <\/jats:sup>\n                    ; MGI:5636646).\n                    <jats:italic>Gzmk<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice are healthy, anatomically normal, fecund and show normal hematopoietic development.\n                    <jats:italic>Gzmk<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice readily recover from lymphocytic choriomeningitis virus and mouse pox Ectromelia virus infection.\n                    <jats:italic>Ex vivo<\/jats:italic>\n                    , virus\u2010specific granzyme K\u2010deficient CTL are indistinguishable from those of wild\u2010type mice in apoptosis induction of target cells. These data suggest that granzyme K does not play an essential role in viral immunity or cytotoxicity. Our granzyme K knockout line completes the collection of mouse models for the human granzymes, and will further our understanding of their biological roles and relationships.\n                  <\/jats:p>","DOI":"10.1038\/icb.2017.35","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T04:21:01Z","timestamp":1492748461000},"page":"676-683","source":"Crossref","is-referenced-by-count":26,"title":["Granzyme K\u2010deficient mice show no evidence of impaired antiviral immunity"],"prefix":"10.1111","volume":"95","author":[{"given":"Lars T","family":"Joeckel","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody C","family":"Allison","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute of Medical Research  Parkville Victoria 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