{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:09:33Z","timestamp":1761743373834,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Impot Res"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1038\/ijir.2010.8","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T10:03:08Z","timestamp":1278064988000},"page":"227-233","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of vascular smooth muscle and corpus cavernosum on hypercholesterolemia. Is resveratrol promising on erectile dysfunction?"],"prefix":"10.1038","volume":"22","author":[{"given":"B C","family":"Soner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Murat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Guven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Esen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Gidener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,7,1]]},"reference":[{"key":"BFijir20108_CR1","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/S0302-2838(03)00305-1","volume":"44","author":"F Montorsi","year":"2003","unstructured":"Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003; 44: 360\u2013364.","journal-title":"Eur Urol"},{"key":"BFijir20108_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1097\/01.ju.0000075055.34506.59","volume":"170","author":"RA Kloner","year":"2003","unstructured":"Kloner RA, Mullin SH, Shook T, Matthews R, Mayeda G, Burstein S et al. Erectile dysfunction in the cardiac patient: how common and should we treat? J Urol 2003; 170: 46\u201350.","journal-title":"J Urol"},{"key":"BFijir20108_CR3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/S0002-9149(02)03113-2","volume":"91","author":"H Solomon","year":"2003","unstructured":"Solomon H, Man JW, Wierzbicki AS, Jackson G . Relation of erectile dysfunction to angiographic coronary artery disease. Am J Cardiol 2003; 91: 230\u2013231.","journal-title":"Am J Cardiol"},{"key":"BFijir20108_CR4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1001\/archinte.166.2.201","volume":"166","author":"JK Min","year":"2006","unstructured":"Min JK, Williams KA, Okwuosa TM, Bell GW, Panutich MS, Ward RP . Prediction of coronary heart disease by erectile dysfunction in men referred for nuclear stress testing. Arch Intern Med 2006; 166: 201\u2013206.","journal-title":"Arch Intern Med"},{"key":"BFijir20108_CR5","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.eururo.2005.05.014","volume":"48","author":"A Ponholzer","year":"2005","unstructured":"Ponholzer A, Temml C, Obermayr R, Wehrberger C, Madersbacher S . Is erectile dysfunction an indicator for increased risk of coronary heart disease and stroke? Eur Urol 2005; 48: 512\u2013518.","journal-title":"Eur Urol"},{"key":"BFijir20108_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1161\/01.CIR.0000133278.81226.C9","volume":"110","author":"C Gazzaruso","year":"2004","unstructured":"Gazzaruso C, Giordanetti S, De Amici E, Bertone G, Falcone C, Geroldi D et al. Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients. Circulation 2004; 110: 22\u201326.","journal-title":"Circulation"},{"key":"BFijir20108_CR7","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.eururo.2005.08.002","volume":"48","author":"C Vlachopoulos","year":"2005","unstructured":"Vlachopoulos C, Rokkas K, Ioakeimidis N, Aggeli C, Michaelides A, Roussakis G et al. Prevalence of asymptomatic coronary artery disease in men with vasculogenic erectile dysfunction: a prospective angiographic study. Eur Urol 2005; 48: 996\u20131002.","journal-title":"Eur Urol"},{"key":"BFijir20108_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/01.CIR.99.8.e1","volume":"99","author":"AM Gotto","year":"1999","unstructured":"Gotto AM, Grundy SM . Lowering LDL-cholesterol: questions from recent analysis of clinical trials. Data from the Interdisciplinary Council of Reducing the Risk for Coronary Heart Disease. Circulation 1999; 99: 1\u20137.","journal-title":"Circulation"},{"key":"BFijir20108_CR9","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.2174\/138161208786898752","volume":"14","author":"AW Shindel","year":"2008","unstructured":"Shindel AW, Kishore S, Lue TF . Drugs designed to improve endothelial function: effects on erectile dysfunction. Curr Pharm Des 2008; 14: 3758\u20133767.","journal-title":"Curr Pharm Des"},{"key":"BFijir20108_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.vph.2005.07.012","volume":"44","author":"G Schmitz","year":"2006","unstructured":"Schmitz G, Langmann T . Pharmacogenomics of cholesterol-lowering therapy. Vascul Pharmacol 2006; 44: 75\u201389.","journal-title":"Vascul Pharmacol"},{"key":"BFijir20108_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/j.1743-6109.2005.20105.x","volume":"2","author":"JS Kalsi","year":"2005","unstructured":"Kalsi JS, Ralph DJ, Thomas P, Bellringer J, Minhas S, Kell PD et al. A nitric oxide-releasing PDE5 inhibitor relaxes human corpus cavernosum in the absence of endogenous nitric oxide. J Sex Med 2005; 2: 53\u201357.","journal-title":"J Sex Med"},{"key":"BFijir20108_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1476-511X-3-19","volume":"3","author":"S Ghatta","year":"2004","unstructured":"Ghatta S, Ramarao P . Increased contractile responses to 5-hydroxytryptamine and Angiotensin II in high fat diet fed rat thoracic aorta. Lipids Health Dis 2004; 3: 19.","journal-title":"Lipids Health Dis"},{"key":"BFijir20108_CR13","first-page":"17","volume":"108","author":"L Macovei","year":"2004","unstructured":"Macovei L . Pleiotropic effects of therapy in endothelial dysfunction syndrome. Rev Med Chir Soc Med Nat Iasi 2004; 108: 17\u201322.","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"BFijir20108_CR14","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1185\/030079903125002289","volume":"19","author":"KR Kensey","year":"2003","unstructured":"Kensey KR . The mechanistic relationships between hemorheological characteristics and cardiovascular disease. Curr Med Res Opin 2003; 19: 587\u2013596.","journal-title":"Curr Med Res Opin"},{"key":"BFijir20108_CR15","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1093\/ajcn\/82.4.751","volume":"82","author":"Q Shi","year":"2005","unstructured":"Shi Q, Vandeberg JF, Jett C, Rice K, Leland MM, Talley L et al. Arterial endothelial dysfunction in baboons fed a high-cholesterol, high-fat diet. Am J Clin Nutr 2005; 82: 751\u2013759.","journal-title":"Am J Clin Nutr"},{"key":"BFijir20108_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1056\/NEJM199007053230106","volume":"323","author":"JR Vane","year":"1990","unstructured":"Vane JR, Anggard EE, Botting RM . Regulatory functions of the vascular endothelium. N Engl J Med 1990; 323: 27\u201336.","journal-title":"N Engl J Med"},{"key":"BFijir20108_CR17","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/0306-3623(95)94002-X","volume":"26","author":"SY Kang","year":"1995","unstructured":"Kang SY, Kim SH, Schini VB, Kim ND . Dietary ginsenosides improve endothelium-dependent relaxation in the thoracic aorta of hypercholesterolemic rabbit. Gen Pharmacol 1995; 26: 483\u2013487.","journal-title":"Gen Pharmacol"},{"key":"BFijir20108_CR18","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.jacc.2004.02.062","volume":"44","author":"S M\u00fcller","year":"2004","unstructured":"M\u00fcller S, K\u00f6nig I, Meyer W, Kojda G . Inhibition of vascular oxidative stress in hypercholesterolemia by eccentric isosorbide mononitrate. J Am Coll Cardiol 2004; 44: 624\u2013631.","journal-title":"J Am Coll Cardiol"},{"key":"BFijir20108_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0014-2999(02)01497-8","volume":"442","author":"M Sanz","year":"2002","unstructured":"Sanz M, Ganado P, Tejerina T . Two angiotensin AT1 receptor antagonists, irbesartan and losartan, effects in cholesterol-fed rabbits. Eur J Pharmacol 2002; 442: 99\u2013106.","journal-title":"Eur J Pharmacol"},{"key":"BFijir20108_CR20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0022-2275(20)42066-8","volume":"32","author":"CM Lenich","year":"1991","unstructured":"Lenich CM, Chobanian AV, Brecher P, Zannis VI . Effect of dietary cholesterol and alloxan-diabetes on tissue cholesterol and apolipoprotein E mRNA levels in the rabbit. J Lipid Res 1991; 32: 431\u2013438.","journal-title":"J Lipid Res"},{"key":"BFijir20108_CR21","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.yjmcc.2006.10.018","volume":"42","author":"SV Penumathsa","year":"2007","unstructured":"Penumathsa SV, Thirunavukkarasu M, Koneru S, Juhasz B, Zhan L, Pant R et al. Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat. J Mol Cell Cardiol 2007; 42: 508\u2013516.","journal-title":"J Mol Cell Cardiol"},{"key":"BFijir20108_CR22","first-page":"533","volume":"16","author":"Z Wang","year":"2005","unstructured":"Wang Z, Zou J, Cao K, Hsieh TC, Huang Y, Wu JM . Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels. Int J Mol Med 2005; 16: 533\u2013540.","journal-title":"Int J Mol Med"},{"key":"BFijir20108_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0024-3205(96)00260-3","volume":"59","author":"T Wilson","year":"1996","unstructured":"Wilson T, Knight TJ, Beitz DC, Lewis DS, Engen RL . Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits. Life Sci 1996; 59: 15\u201321.","journal-title":"Life Sci"},{"key":"BFijir20108_CR24","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1056\/NEJM200102083440607","volume":"344","author":"RD Safian","year":"2001","unstructured":"Safian RD, Textor SC . Renal-artery stenosis. N Engl J Med 2001; 344: 431\u2013442.","journal-title":"N Engl J Med"},{"key":"BFijir20108_CR25","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S0022-4804(02)00043-4","volume":"110","author":"HA Piepot","year":"2003","unstructured":"Piepot HA, Groeneveld AB, van Lambalgen AA, Sipkema P . Endotoxin impairs endothelium-dependent vasodilation more in the coronary and renal arteries than in other arteries of the rat. J Surg Res 2003; 110: 413\u2013418.","journal-title":"J Surg Res"},{"key":"BFijir20108_CR26","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1096\/fasebj.9.13.7557022","volume":"9","author":"S Moncada","year":"1995","unstructured":"Moncada S, Higgs EA . Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 1995; 9: 1319\u20131330.","journal-title":"FASEB J"},{"key":"BFijir20108_CR27","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1023\/A:1020537506008","volume":"19","author":"RF Furchgott","year":"1999","unstructured":"Furchgott RF . Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide. Biosci Rep 1999; 19: 235\u2013251.","journal-title":"Biosci Rep"},{"key":"BFijir20108_CR28","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0022-3565(25)20381-0","volume":"258","author":"N Jaiswal","year":"1991","unstructured":"Jaiswal N, Lambrecht G, Mutschler E, Tacke R, Malik KU . Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta. J Pharmacol Exp Ther 1991; 258: 842\u2013850.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFijir20108_CR29","first-page":"487","volume":"164","author":"DF Fisher Jr","year":"1987","unstructured":"Fisher Jr DF, Fry WJ . Collateral mesenteric circulation. Surg Gynecol Obstet 1987; 164: 487\u2013492.","journal-title":"Surg Gynecol Obstet"},{"key":"BFijir20108_CR30","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1177\/152660280301000604","volume":"10","author":"AF AbuRahma","year":"2003","unstructured":"AbuRahma AF, Stone PA, Bates MC, Welch CA . Angioplasty\/stenting of the superior mesenteric artery and celiac trunk: early and late outcomes. J Endovasc Ther 2003; 10: 1046\u20131053.","journal-title":"J Endovasc Ther"},{"key":"BFijir20108_CR31","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0014-5793(04)00137-1","volume":"561","author":"CR White","year":"2004","unstructured":"White CR, Parks DA, Patel RP, Shelton J, Tarpey MM, Freeman BA et al. L-Arginine inhibits xanthine oxidase-dependent endothelial dysfunction in hypercholesterolemia. FEBS Lett 2004; 561: 94\u201398.","journal-title":"FEBS Lett"},{"key":"BFijir20108_CR32","first-page":"3","volume":"5","author":"AR McCullough","year":"2003","unstructured":"McCullough AR . The penis as a barometer of endothelial health. Rev Urol 2003; 5: 3\u20138.","journal-title":"Rev Urol"}],"container-title":["International Journal of Impotence Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijir20108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir20108","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir20108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T14:17:10Z","timestamp":1740233830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijir20108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["BFijir20108"],"URL":"https:\/\/doi.org\/10.1038\/ijir.2010.8","relation":{},"ISSN":["0955-9930","1476-5489"],"issn-type":[{"type":"print","value":"0955-9930"},{"type":"electronic","value":"1476-5489"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"1 October 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}