{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:03:35Z","timestamp":1762430615690,"version":"3.38.0"},"reference-count":166,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Impot Res"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1038\/ijir.2011.56","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T08:59:56Z","timestamp":1325149196000},"page":"91-100","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Animal models of erectile dysfunction (ED): potential utility of non-human primates as a model of atherosclerosis-induced vascular ED"],"prefix":"10.1038","volume":"24","author":[{"given":"J K","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K-E","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Christ","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,12,29]]},"reference":[{"key":"BFijir201156_CR1","unstructured":"Impotence. NIH Consensus Statement 10, 1992; 1\u201333."},{"key":"BFijir201156_CR2","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/S0022-5347(17)34871-1","volume":"151","author":"HA Feldman","year":"1994","unstructured":"Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB . Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54\u201361.","journal-title":"J Urol"},{"key":"BFijir201156_CR3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7326\/0003-4819-139-3-200308050-00005","volume":"139","author":"CG Bacon","year":"2003","unstructured":"Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB . Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 2003; 139: 161\u2013168.","journal-title":"Ann Intern Med"},{"key":"BFijir201156_CR4","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1111\/j.1743-6109.2010.02062.x","volume":"7","author":"F Montorsi","year":"2010","unstructured":"Montorsi F, Adaikan G, Becher E, Giuliano F, Khoury S, Lue TF et al. Summary of the recommendations on sexual dysfunctions in men. J Sex Med 2010; 7: 3572\u20133588.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR5","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/scientificamerican0800-70","volume":"283","author":"I Goldstein","year":"2000","unstructured":"Goldstein I . Male sexual circuitry. Working Group for the Study of Central Mechanisms in Erectile Dysfunction. Sci Am 2000; 283: 70\u201375.","journal-title":"Sci Am"},{"issue":"1 Part 2","key":"BFijir201156_CR6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1743-6109.2009.01624.x","volume":"7","author":"C Gratzke","year":"2010","unstructured":"Gratzke C, Angulo J, Chitaley K, Dai YT, Kim NN, Paick JS et al. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med 2010; 7 (1 Part 2): 445\u2013475, Review.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR7","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1111\/j.1743-6109.2010.02025.x","volume":"7","author":"AL Burnett","year":"2010","unstructured":"Burnett AL, Goldstein I, Andersson KE, Argiolas A, Christ G, Park K et al. Future sexual medicine physiological treatment targets. J Sex Med 2010; 7: 3269\u20133304.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1152\/physrev.1995.75.1.191","volume":"75","author":"KE Andersson","year":"1995","unstructured":"Andersson KE, Wagner G . Physiology of penile erection. Physiol Rev 1995; 75: 191\u2013236.","journal-title":"Physiol Rev"},{"issue":"2 Part 2","key":"BFijir201156_CR9","first-page":"S6","volume":"170","author":"KE Andersson","year":"2003","unstructured":"Andersson KE . Erectile physiological and pathophysiological pathways involved in erectile dysfunction. J Urol 2003; 170 (2 Part 2): S6\u2013S13.","journal-title":"J Urol"},{"key":"BFijir201156_CR10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1385\/ENDO:23:2-3:093","volume":"23","author":"GJ Christ","year":"2004","unstructured":"Christ GJ, Lue T . Physiology and biochemistry of erections. Endocrine 2004; 23: 93\u2013100.","journal-title":"Endocrine"},{"key":"BFijir201156_CR11","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJM200006153422407","volume":"342","author":"TF Lue","year":"2000","unstructured":"Lue TF . Erectile dysfunction. N Engl J Med 2000; 342: 1802\u20131813.","journal-title":"N Engl J Med"},{"key":"BFijir201156_CR12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1743-6109.04038.x","volume":"1","author":"I S\u00e1enz de Tejada","year":"2004","unstructured":"S\u00e1enz de Tejada I, Angulo J, Cellek S, Gonz\u00e1lez-Cadavid N, Heaton J, Pickard R et al. J Physiology of erectile function. Sex Med 2004; 1: 254\u2013265.","journal-title":"Sex Med"},{"key":"BFijir201156_CR13","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.exger.2004.06.022","volume":"39","author":"NF Gonzalez-Cadavid","year":"2004","unstructured":"Gonzalez-Cadavid NF, Rajfer J . Molecular pathophysiology and gene therapy of aging-related erectile dysfunction. Exp Gerontol 2004; 39: 1705\u20131712.","journal-title":"Exp Gerontol"},{"issue":"1 Part 2","key":"BFijir201156_CR14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1743-6109.2009.01627.x","volume":"7","author":"I Eardley","year":"2010","unstructured":"Eardley I, Donatucci C, Corbin J, El-Meliegy A, Hatzimouratidis K, McVary K et al. Pharmacotherapy for erectile dysfunction. J Sex Med 2010; 7 (1 Part 2): 524\u2013540.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.2165\/00003495-200868020-00006","volume":"68","author":"K Hatzimouratidis","year":"2008","unstructured":"Hatzimouratidis K, Hatzichristou DG . Looking to the future for erectile dysfunction therapies. Drugs 2008; 68: 231\u2013250.","journal-title":"Drugs"},{"key":"BFijir201156_CR16","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2174\/138161210791164162","volume":"16","author":"S Gur","year":"2010","unstructured":"Gur S, Kadowitz PJ, Hellstrom WJ . Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction. Curr Pharm Des 2010; 16: 1619\u20131633.","journal-title":"Curr Pharm Des"},{"key":"BFijir201156_CR17","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1517\/14728214.2010.480973","volume":"15","author":"M Albersen","year":"2010","unstructured":"Albersen M, Shindel AW, Mwamukonda KB, Lue TF . The future is today: emerging drugs for the treatment of erectile dysfunction. Expert Opin Emerg Drugs 2010; 15: 467\u2013480.","journal-title":"Expert Opin Emerg Drugs"},{"key":"BFijir201156_CR18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-5347(17)34871-1","volume":"151","author":"HA Feldman","year":"1994","unstructured":"Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB . Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54\u201361.","journal-title":"J Urol"},{"key":"BFijir201156_CR19","first-page":"2472","volume":"24","author":"S Althof","year":"2007","unstructured":"Althof S . Depression and erectile dysfunction. Men's sexual health consult collection. N Engl J Med 2007; 24: 2472\u20132481.","journal-title":"N Engl J Med"},{"key":"BFijir201156_CR20","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.3949\/ccjm.74.Suppl_3.S30","volume":"74","author":"MM Miner","year":"2007","unstructured":"Miner MM, Kuritzky L . Erectile dysfunction: a sentinel marker for cardiovascular disease in primary care. Cleve Clin J Med 2007; 74: S30\u2013S37.","journal-title":"Cleve Clin J Med"},{"issue":"Suppl 2","key":"BFijir201156_CR21","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1038\/sj.bjp.0706630","volume":"147","author":"G McMurray","year":"2006","unstructured":"McMurray G, Casey JH, Naylor AM . Animal models in urological disease and sexual dysfunction. Br J Pharmacol 2006; 147 (Suppl 2): S62\u2013S79.","journal-title":"Br J Pharmacol"},{"key":"BFijir201156_CR22","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1111\/j.1743-6109.2008.00854.x","volume":"5","author":"N Mehta","year":"2008","unstructured":"Mehta N, Sikka S, Rajasekaran M . Rat as an animal model for male erectile function evaluation in sexual medicine research. J Sex Med 2008; 5: 1278\u20131283.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR23","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0022-5347(17)32566-1","volume":"152","author":"F Giuliano","year":"1994","unstructured":"Giuliano F, Bernab\u00e9 J, Rampin O, Courtois F, Benoit G, Rousseau JP . Telemetric monitoring of intracavernous pressure in freely moving rats during copulation. J Urol 1994; 152: 1271\u20131274.","journal-title":"J Urol"},{"key":"BFijir201156_CR24","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1111\/j.1743-6109.2009.01300.x","volume":"6","author":"W Zhao","year":"2009","unstructured":"Zhao W, Sato Y, Melman A, Andersson KE, Christ G . Metrics for evaluation of age-related changes in erectile capacity in a rodent model. J Sex Med 2009; 6: 1885\u20131892.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR25","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0022-5347(17)38543-9","volume":"145","author":"JP Heaton","year":"1991","unstructured":"Heaton JP, Varrin SJ, Morales A . The characterization of a bio-assay of erectile function in a rat model. J Urol 1991; 145: 1099\u20131012.","journal-title":"J Urol"},{"key":"BFijir201156_CR26","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.urology.2004.06.061","volume":"64","author":"Y Song","year":"2004","unstructured":"Song Y, Rajasekaran M . Effect of excitatory amino acid receptor agonists on penile erection after administration into the CA3 hippocampal region in the rat. Urology 2004; 64: 1250\u20131254.","journal-title":"Urology"},{"key":"BFijir201156_CR27","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1095\/biolreprod46.3.342","volume":"46","author":"TM Mills","year":"1992","unstructured":"Mills TM, Wiedmeier VT, Stopper VS . Androgen maintenance of erectile function in the rat penis. Biol Reprod 1992; 46: 342\u2013348.","journal-title":"Biol Reprod"},{"key":"BFijir201156_CR28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1046\/j.1464-410x.1999.00173.x","volume":"84","author":"JT Hsieh","year":"1999","unstructured":"Hsieh JT, Liu SP, Hsieh CH, Cheng JT . An in vivo evaluation of the therapeutic potential of sympatholytic agents on premature ejaculation. BJU Int 1999; 84: 503\u2013506.","journal-title":"BJU Int"},{"key":"BFijir201156_CR29","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1016\/S0022-5347(01)67512-8","volume":"153","author":"S Carrier","year":"1995","unstructured":"Carrier S, Zvara P, Nunes L, Kour NW, Rehman J, Lue TF . Regeneration of nitric oxide synthase containing nerves after cavernous nerve neurotomy in the rat. J Urol 1995; 153: 1722\u20131727.","journal-title":"J Urol"},{"key":"BFijir201156_CR30","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.expneurol.2007.05.011","volume":"207","author":"MR Nangle","year":"2007","unstructured":"Nangle MR, Keast JR . Reduced efficacy of nitrergic neurotransmission exacerbates erectile dysfunction after penile nerve injury despite axonal regeneration. Exp Neurol 2007; 207: 30\u201341.","journal-title":"Exp Neurol"},{"key":"BFijir201156_CR31","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1097\/01.ju.0000176808.94610.dd","volume":"174","author":"ME Allaf","year":"2005","unstructured":"Allaf ME, Hoke A, Burnett AL . Erythropoietin promotes the recovery of erectile function following cavernous nerve injury. J Urol 2005; 174: 2060\u20132064.","journal-title":"J Urol"},{"key":"BFijir201156_CR32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1743-6109.2005.00158.x","volume":"3","author":"M Mullerad","year":"2006","unstructured":"Mullerad M, Donohue JF, Li PS, Scardino PT, Mulhall JP . Functional sequelae of cavernous nerve injury in the rat: Is there model dependency. J Sex Med 2006; 3: 77\u201383.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1743-6109.2005.20229.x","volume":"2","author":"L De Young","year":"2005","unstructured":"De Young L, Bella A, Howard J, Brock G . Arteriogenic erectile dysfunction alters protein expression within the cavernosal tissue in an animal model. J Sex Med 2005; 2: 199\u2013206.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR34","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1046\/j.1464-410X.2003.04219.x","volume":"91","author":"MB Chancellor","year":"2003","unstructured":"Chancellor MB, Tirney S, Mattes CE, Tzeng E, Birder LA, Kanai AJ et al. Nitric oxide synthase gene transfer for erectile dysfunction in a rat model. BJU Int 2003; 91: 691\u2013696.","journal-title":"BJU Int"},{"key":"BFijir201156_CR35","doi-asserted-by":"crossref","first-page":"5709","DOI":"10.1210\/endo.136.12.7588327","volume":"136","author":"D Vernet","year":"1995","unstructured":"Vernet D, Cai L, Garban H, Babbitt ML, Murray FT, Rajfer J et al. Reduction of penile nitric oxide synthase in diabetic BB\/WORdp (type I) and BBZ\/WORdp (type II) rats with erectile dysfunction. Endocrinology 1995; 136: 5709\u20135717.","journal-title":"Endocrinology"},{"key":"BFijir201156_CR36","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1743-6109.2005.20228_1.x","volume":"2","author":"TJ Bivalacqua","year":"2005","unstructured":"Bivalacqua TJ, Usta MF, Kendirci M, Pradhan L, Alvarez X, Champion HC et al. Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy. J Sex Med 2005; 2: 187\u2013197.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR37","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1743-6109.2007.00439.x","volume":"4","author":"C Wingard","year":"2007","unstructured":"Wingard C, Fulton D, Husain S . Altered penile vascular reactivity and erection in the Zucker obese\/diabetic rat. J Sex Med 2007; 4: 348\u2013362.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1743-6109.2006.00207.x","volume":"3","author":"X Zhang","year":"2006","unstructured":"Zhang X, Filippi S, Morelli A, Luconi M, Donati S, Forti G et al. Testosterone restores diabetes induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes. J Sex Med 2006; 3: 253\u2013264.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR39","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1095\/biolreprod.104.030833","volume":"71","author":"HH Davila","year":"2004","unstructured":"Davila HH, Magee TR, Vernet D, Rajfer J, Gonzalez-Cadavid NF . Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's disease. Biol Reprod 2004; 71: 1568\u20131577.","journal-title":"Biol Reprod"},{"key":"BFijir201156_CR40","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1743-6109.2007.00459.x","volume":"4","author":"T Magee","year":"2007","unstructured":"Magee T, Kovanecz I, Davila H, Ferrini M, Cantini L, Vernet D et al. Antisense and short hairpin RNA (shRNA) constructs targeting PIN (protein inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat. J Sex Med 2007; 4: 633\u2013643.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/j.1939-4640.2002.tb02246.x","volume":"23","author":"M Rajasekaran","year":"2002","unstructured":"Rajasekaran M, Kasyan A, Jain A, Kim SW, Monga M . Altered growth factor expression in the aging penis: the Brown-Norway rat model. J Androl 2002; 23: 393\u2013399.","journal-title":"J Androl"},{"key":"BFijir201156_CR42","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1111\/j.1743-6109.2010.01920.x","volume":"7","author":"JL Hannan","year":"2010","unstructured":"Hannan JL, Blaser MC, Oldfield L, Pang JJ, Adams SM, Pang SC et al. Morphological and functional evidence for the contribution of the pudendal artery in aging-induced erectile dysfunction. J Sex Med 2010; 7: 3373\u20133384.","journal-title":"J Sex Med"},{"issue":"Suppl 2","key":"BFijir201156_CR43","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1038\/sj.bjp.0706627","volume":"147","author":"GJ Christ","year":"2006","unstructured":"Christ GJ, Hodges S . Molecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunction. Br J Pharmacol 2006; 147 (Suppl 2): S41\u2013S55.","journal-title":"Br J Pharmacol"},{"key":"BFijir201156_CR44","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1002\/j.1939-4640.2002.tb02291.x","volume":"23","author":"GJ Christ","year":"2002","unstructured":"Christ GJ . K channels as molecular targets for the treatment of erectile dysfunction. J Androl 2002; 23: S10\u2013S19.","journal-title":"J Androl"},{"key":"BFijir201156_CR45","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0022-3565(25)20824-2","volume":"251","author":"EM Hull","year":"1989","unstructured":"Hull EM, Warner RK, Bazzett TJ, Eaton RC, Thompson JT, Scaletta LL . D2\/D1 ratio in the medial preoptic area affects copulation of male rats. J Pharmacol Exp Ther 1989; 251: 422\u2013427.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFijir201156_CR46","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neures.2005.12.005","volume":"54","author":"I Kita","year":"2006","unstructured":"Kita I, Yoshida Y, Nishino S . An activation of parvocellular oxytocinergic neurons in the paraventricular nucleus in oxytocin-induced yawning and penile erection. Neurosci Res 2006; 54: 269\u2013275.","journal-title":"Neurosci Res"},{"key":"BFijir201156_CR47","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbr.2006.01.017","volume":"169","author":"S Succu","year":"2006","unstructured":"Succu S, Mascia MS, Sanna F, Melis T, Argiolas A, Melis MR . The cannabinoid CB 1 receptor antagonist SR 141716A induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male rats. Behav Brain Res 2006; 169: 274\u2013281.","journal-title":"Behav Brain Res"},{"key":"BFijir201156_CR48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ejphar.2008.05.022","volume":"589","author":"Y Kimura","year":"2008","unstructured":"Kimura Y, Naitou Y, Wanibuchi F, Yamaguchi T . 5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats. Eur J Pharmacol 2008; 589: 157\u2013162.","journal-title":"Eur J Pharmacol"},{"key":"BFijir201156_CR49","doi-asserted-by":"crossref","first-page":"H1923","DOI":"10.1152\/ajpheart.01221.2007","volume":"294","author":"N Villalba","year":"2008","unstructured":"Villalba N, Stankevicius E, Simonsen U, Prieto D . Rho kinase is involved in Ca2+ entry of rat penile small arteries. Am J Physiol Heart Circ Physiol 2008; 294: H1923\u2013H1932.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFijir201156_CR50","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0031-6997(24)01503-5","volume":"53","author":"KE Andersson","year":"2001","unstructured":"Andersson KE . Pharmacology of penile erection. Pharmacol Rev 2001; 53: 417\u2013450.","journal-title":"Pharmacol Rev"},{"issue":"3 Suppl","key":"BFijir201156_CR51","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1038\/sj.ijir.3900718","volume":"13","author":"KE Andersson","year":"2001","unstructured":"Andersson KE . Neurophysiology\/pharmacology of erection. Int J Impot Res 2001; 13 (3 Suppl): S8\u201317.","journal-title":"Int J Impot Res"},{"key":"BFijir201156_CR52","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/sj.bjp.0701461","volume":"122","author":"MB Hussain","year":"1997","unstructured":"Hussain MB, Marshall I . Characterization of alpha1-adrenoceptor subtypes mediating contractions to phenylephrine in rat thoracic aorta, mesenteric artery and pulmonary artery. Br J Pharmacol 1997; 122: 849\u2013858.","journal-title":"Br J Pharmacol"},{"key":"BFijir201156_CR53","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2147\/tcrm.2007.3.2.277","volume":"3","author":"M Kendirci","year":"2007","unstructured":"Kendirci M, Salem E, Hellstrom WJ . Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag 2007; 3: 277\u2013289.","journal-title":"Ther Clin Risk Manag"},{"key":"BFijir201156_CR54","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1046\/j.1464-410X.2002.02789.x","volume":"90","author":"JS Hyun","year":"2002","unstructured":"Hyun JS, Bivalacqua TJ, Baig MR, Yang DY, Leungwattanakij S, Abdel-Mageed A et al. Localization of peripheral dopamine D1 and D2 receptors in rat corpus cavernosum. BJU Int 2002; 90: 105\u2013112.","journal-title":"BJU Int"},{"key":"BFijir201156_CR55","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/sj.ijir.3901293","volume":"17","author":"R d\u2019Emmanuele di Villa Bianca","year":"2005","unstructured":"d\u2019Emmanuele di Villa Bianca R, Sorrentino R, Roviezzo F, Imbimbo C, Palmieri A, De Dominicis G et al. Peripheral relaxant activity of apomorphine and of a D1 selective receptor agonist on human corpus cavernosum strips. Int J Impot Res 2005; 17: 127\u2013133.","journal-title":"Int J Impot Res"},{"key":"BFijir201156_CR56","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1476-5381.1990.tb14143.x","volume":"101","author":"JP Finberg","year":"1990","unstructured":"Finberg JP, Vardi Y . Inhibitory effect of 5-hydroxytryptamine on penile erectile function in the rat. Br J Pharmacol 1990; 101: 698\u2013702.","journal-title":"Br J Pharmacol"},{"key":"BFijir201156_CR57","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1743-6109.2007.00676.x","volume":"5","author":"N Brugger","year":"2008","unstructured":"Brugger N, Kim NN, Araldi GL, Traish AM, Palmer SS . Pharmacological and functional characterization of novel EP and DP receptor agonists: DP1 receptor mediates penile erection in multiple species. J Sex Med 2008; 5: 344\u2013356.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR58","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.eururo.2008.12.024","volume":"57","author":"C Gratzke","year":"2010","unstructured":"Gratzke C, Christ GJ, Stief CG, Andersson KE, Hedlund P . Localization and function of cannabinoid receptors in the corpus cavernosum: basis for modulation of nitric oxide synthase nerve activity. Eur Urol 2010; 57: 342\u2013348.","journal-title":"Eur Urol"},{"key":"BFijir201156_CR59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.niox.2006.05.004","volume":"16","author":"H Sadeghipour","year":"2007","unstructured":"Sadeghipour H, Ghasemi M, Ebrahimi F, Dehpour AR . Effect of lithium on endothelium-dependent and neurogenic relaxation of rat corpus cavernosum: role of nitric oxide pathway. Nitric Oxide 2007; 16: 54\u201363.","journal-title":"Nitric Oxide"},{"key":"BFijir201156_CR60","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/j.1464-410X.2007.06794.x","volume":"99","author":"TJ Bivalacqua","year":"2007","unstructured":"Bivalacqua TJ, Kendirci M, Champion HC, Hellstrom WJ, Andersson KE, Hedlund P . Dysregulation of cGMP dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: Influence of in vivo gene therapy of PKG1 alpha. BJU Int 2007; 99: 1488\u20131494.","journal-title":"BJU Int"},{"key":"BFijir201156_CR61","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1093\/biolreprod\/67.1.20","volume":"67","author":"TR Magee","year":"2002","unstructured":"Magee TR, Ferrini M, Garban HJ, Vernet D, Mitani K, Rajfer J et al. Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase. Biol Reprod 2002; 67: 1033\u20131041.","journal-title":"Biol Reprod"},{"key":"BFijir201156_CR62","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1743-6109.2007.00440.x","volume":"4","author":"L Vignozzi","year":"2007","unstructured":"Vignozzi L, Morelli A, Filippi S, Ambrosini S, Mancina R, Luconi M et al. Testosterone regulates RhoA\/Rho-kinase signaling in two distinct animal models of chemical diabetes. J Sex Med 2007; 4: 620\u2013630.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR63","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/j.1743-6109.2008.01062.x","volume":"6","author":"SD Chung","year":"2009","unstructured":"Chung SD, Kuo YC, Liu SP, Chang HC, Yu HJ, Hsieh JT . The role of chloride channels in rat corpus cavernosum: in vivo study. J Sex Med 2009; 6: 708\u2013716.","journal-title":"J Sex Med"},{"issue":"Pt 2","key":"BFijir201156_CR64","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1113\/jphysiol.2005.093823","volume":"567","author":"ME Werner","year":"2005","unstructured":"Werner ME, Zvara P, Meredith AL, Aldrich RW, Nelson MT . Erectile dysfunction in mice lacking the large-conductance calcium-activated potassium (BK) channel. J Physiol 2005; 567 (Pt 2): 545\u2013556.","journal-title":"J Physiol"},{"key":"BFijir201156_CR65","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0022-5347(17)37825-4","volume":"146","author":"JK Burgers","year":"1991","unstructured":"Burgers JK, Nelson RJ, Quinlan DM, Walsh PC . Nerve growth factor, nerve grafts and amniotic membrane grafts restore erectile function in rats. J Urol 1991; 146: 463\u2013468.","journal-title":"J Urol"},{"key":"BFijir201156_CR66","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-5347(17)36555-2","volume":"148","author":"RA Ball","year":"1992","unstructured":"Ball RA, Lipton SA, Dreyer EB, Richie JP, Vickers MA . Entubulization repair of severed cavernous nerves in the rat resulting in return of erectile function. J Urol 1992; 148: 211\u2013215.","journal-title":"J Urol"},{"key":"BFijir201156_CR67","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1095\/biolreprod60.2.398","volume":"60","author":"M Burchardt","year":"1999","unstructured":"Burchardt M, Burchardt T, Chen MW, Shabsigh A, de la Taille A, Buttyan R et al. Expression of messenger ribonucleic acid splice variants for vascular endothelial growth factor in the penis of adult rats and humans. Biol Reprod 1999; 60: 398\u2013404.","journal-title":"Biol Reprod"},{"key":"BFijir201156_CR68","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1095\/biolreprod56.4.954","volume":"56","author":"H Garban","year":"1997","unstructured":"Garban H, Marquez D, Magee T, Moody J, Rajavashisth T, Rodriguez JA et al. Cloning of rat and human inducible penile nitric oxide synthase. Application for gene therapy of erectile dysfunction. Biol Reprod 1997; 56: 954\u2013963.","journal-title":"Biol Reprod"},{"key":"BFijir201156_CR69","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1745-7262.2008.00362.x","volume":"10","author":"TD Strong","year":"2008","unstructured":"Strong TD, Gebska MA, Burnett AL, Champion HC, Bivalacqua TJ . Endothelium-specific gene and stem cell-based therapy for erectile dysfunction. Asian J Androl 2008; 10: 14\u20131, 22.","journal-title":"Asian J Androl"},{"key":"BFijir201156_CR70","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ymthe.2005.10.016","volume":"13","author":"JK Ryu","year":"2006","unstructured":"Ryu JK, Cho CH, Shin HY, Song SU, Oh SM, Lee M et al. Combined angiopoietin-1 and vascular endothelial growth factor gene transfer restores cavernous angiogenesis and erectile function in a rat model of hypercholesterolemia. Mol Ther 2006; 13: 705\u2013715.","journal-title":"Mol Ther"},{"key":"BFijir201156_CR71","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/sj.ijir.3900943","volume":"15","author":"RS Rogers","year":"2003","unstructured":"Rogers RS, Graziottin TM, Lin CS, Kan YW, Lue TF . Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats. Int J Impot Res 2003; 15: 26\u201337.","journal-title":"Int J Impot Res"},{"key":"BFijir201156_CR72","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/sj.gt.3303093","volume":"15","author":"A Melman","year":"2008","unstructured":"Melman A, Biggs G, Davies K, ZhaoW, Tar MT, Christ GJ . Gene transfer with a vector expressing Maxi-K from a smooth muscle-specific promoter restores erectile function in the aging rat. Gene Ther 2008; 15: 364\u2013370.","journal-title":"Gene Ther"},{"key":"BFijir201156_CR73","doi-asserted-by":"crossref","first-page":"H1544","DOI":"10.1152\/ajpheart.00792.2003","volume":"287","author":"GJ Christ","year":"2004","unstructured":"Christ GJ, Day N, Santizo C, Sato Y, Zhao W, Sclafani T et al. Intracorporal injection of hSlo cDNA restores erectile capacity in STZdiabetic F-344 rats in vivo. Am J Physiol Heart Circ Physiol 2004; 287: H1544\u2013H1553.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFijir201156_CR74","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1095\/biolreprod65.5.1371","volume":"65","author":"TJ Bivalacqua","year":"2001","unstructured":"Bivalacqua TJ, Champion HC, Abdel-Mageed AB, Kadowitz PJ, Hellstrom WJ . Gene transfer of prepro-calcitonin gene related peptide restores erectile function in the aged rat. Biol Reprod 2001; 65: 1371\u20131377.","journal-title":"Biol Reprod"},{"key":"BFijir201156_CR75","first-page":"569","volume":"48","author":"TB Clarkson","year":"1998","unstructured":"Clarkson TB . Nonhuman primate models of atherosclerosis. Lab Anim Sci 1998; 48: 569\u2013572.","journal-title":"Lab Anim Sci"},{"key":"BFijir201156_CR76","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1549-8719.2010.00008.x","volume":"17","author":"MA Ziegler","year":"2010","unstructured":"Ziegler MA, Distasi MR, Bills RG, Miller SJ, Alloosh M, Murphy MP et al. Marvels, mysteries, and misconceptions of vascular compensation to peripheral artery occlusion. Microcirculation 2010; 17: 3\u201320, Review.","journal-title":"Microcirculation"},{"key":"BFijir201156_CR77","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.carpath.2006.09.001","volume":"15","author":"SD Proctor","year":"2006","unstructured":"Proctor SD, Russell JC . Small animal models of cardiovascular disease: tools for the study of the metabolic syndrome, dyslipidemias and atherosclerosis. J Cardiovasc Pathol 2006; 15: 318\u2013330.","journal-title":"J Cardiovasc Pathol"},{"key":"BFijir201156_CR78","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/j.1939-4640.2000.tb02109.x","volume":"21","author":"SF Sezen","year":"2000","unstructured":"Sezen SF, Burnett AL . Intracavernosal pressure monitoring in mice: responses to electrical stimulation of the cavernous nerve and to intracavernosal drug administration. J Androl 2000; 21: 311\u2013315.","journal-title":"J Androl"},{"key":"BFijir201156_CR79","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1365-2605.2006.00737.x","volume":"30","author":"S Piao","year":"2007","unstructured":"Piao S, Ryu JK, Shin HY, Han JY, Lee HS, Suh JK . The mouse as a model for the study of penile erection: moving towards a smaller animal. Int J Androl 2007; 30: 452\u2013457.","journal-title":"Int J Androl"},{"key":"BFijir201156_CR80","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1743-6109.2008.01029.x","volume":"6","author":"FS Carneiro","year":"2009","unstructured":"Carneiro FS, Sturgis LC, Giachini FR, Carneiro ZN, Lima VV, Wynne BM et al. TNF-alpha knockout mice have increased corpora cavernosa relaxation. J Sex Med 2009; 6: 115\u2013125.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR81","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1743-6109.2007.00752.x","volume":"5","author":"FS Carneiro","year":"2008","unstructured":"Carneiro FS, Giachini FR, Lima VV, Carneiro ZN, Leite R, Inscho EW et al. Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db\/db mouse. J Sex Med 2008; 5: 1156\u20131166.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR82","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1172\/JCI33467","volume":"118","author":"T Mi","year":"2008","unstructured":"Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW et al. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest 2008; 118: 1491\u20131501.","journal-title":"J Clin Invest"},{"key":"BFijir201156_CR83","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1073\/pnas.0511326103","volume":"103","author":"KJ Hurt","year":"2006","unstructured":"Hurt KJ, Sezen SF, Champion HC, Crone JK, Palese MA, Huang PL et al. Alternatively spliced neuronal nitric oxide synthase mediates penile erection. Proc Natl Acad Sci USA 2006; 103: 3440\u20133443.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFijir201156_CR84","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/BF03401627","volume":"2","author":"AL Burnett","year":"1996","unstructured":"Burnett AL, Nelson RJ, Calvin DC, Liu JX, Demas GE, Klein SL et al. Nitric oxide-dependent penile erection in mice lacking neuronal nitric oxide synthase. Mol Med 1996; 2: 288\u2013296.","journal-title":"Mol Med"},{"key":"BFijir201156_CR85","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0031-9384(99)00100-6","volume":"67","author":"LJ Kriegsfeld","year":"1999","unstructured":"Kriegsfeld LJ, Demas GE, Huang PL, Burnett AL, Nelson RJ . Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS). Physiol Behav 1999; 67: 561\u2013566.","journal-title":"Physiol Behav"},{"key":"BFijir201156_CR86","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/j.1939-4640.2002.tb02601.x","volume":"23","author":"AL Burnett","year":"2002","unstructured":"Burnett AL, Chang AG, Crone JK, Huang PL, Sezen SE . Noncholinergic penile erection in mice lacking the gene for endothelial nitric oxide synthase. J Androl 2002; 23: 92\u201397.","journal-title":"J Androl"},{"key":"BFijir201156_CR87","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1093\/emboj\/17.11.3045","volume":"17","author":"A Pfeifer","year":"1998","unstructured":"Pfeifer A, Klatt P, Massberg S, Ny L, Sausbier M, Hirneiss C et al. Defective smooth muscle regulation in cGMP kinase I-deficient mice. EMBO J 1998; 17: 3045\u20133051.","journal-title":"EMBO J"},{"key":"BFijir201156_CR88","doi-asserted-by":"crossref","first-page":"R181","DOI":"10.1152\/ajpregu.00173.2008","volume":"295","author":"ME Werner","year":"2008","unstructured":"Werner ME, Meredith AL, Aldrich RW, Nelson MT . Hypercontractility and impaired sildenafil relaxations in the BKCa channel deletion model of erectile dysfunction. Am J Physiol Regul Integr Comp Physiol 2008; 295: R181\u2013R188.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFijir201156_CR89","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1111\/j.1743-6109.2010.01880.x","volume":"7","author":"B Musicki","year":"2010","unstructured":"Musicki B, Liu T, Lagoda GA, Strong TD, Sezen SF, Johnson JM et al. Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase. J Sex Med 2010; 7: 3023\u20133032.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR90","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0022-5347(01)62140-2","volume":"161","author":"S Filippi","year":"1999","unstructured":"Filippi S, Amerini S, Maggi M, Natali A, Ledda F . Studies on the mechanisms involved in the ATP-induced relaxation in human and rabbit corpus cavernosum. J Urol 1999; 161: 326\u2013331.","journal-title":"J Urol"},{"key":"BFijir201156_CR91","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1111\/j.1743-6109.2008.00933.x","volume":"5","author":"D Xie","year":"2008","unstructured":"Xie D, Findley CM, Greenfield JM, Pippen AM, Kontos CD, Donatucci CF et al. A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits. J Sex Med 2008; 5: 2069\u20132078.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR92","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1743-6109.2008.01003.x","volume":"6","author":"IM Vural","year":"2009","unstructured":"Vural IM, Ozturk GS, Sarioglu Y . Functional characterization of nonadrenergic noncholinergic neurotransmitter release via endocannabinoids: an in vitro study in rabbit corpus cavernosum. J Sex Med 2009; 6: 717\u2013729.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR93","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejphar.2006.11.053","volume":"558","author":"NB Bozkurt","year":"2007","unstructured":"Bozkurt NB, Vural IM, Sarioglu Y, Pekiner C . Nicotine potentiates the nitrergic relaxation responses of rabbit corpus cavernosum tissue via nicotinic acetylcholine receptors. Eur J Pharmacol 2007; 558: 172\u2013178.","journal-title":"Eur J Pharmacol"},{"key":"BFijir201156_CR94","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/sj.bjp.0706956","volume":"150","author":"JS Morton","year":"2007","unstructured":"Morton JS, Daly CJ, Jackson VM, McGrath JC . Alpha(1A)- adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries. Br J Pharmacol 2007; 150: 112\u2013120.","journal-title":"Br J Pharmacol"},{"key":"BFijir201156_CR95","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/S0022-5347(01)66519-4","volume":"155","author":"NN Kim","year":"1996","unstructured":"Kim NN, Kim JJ, Hypolite J, Garc\u00eda-D\u00edaz JF, Broderick GA, Tornheim K et al. Altered contractility of rabbit penile corpus cavernosum smooth muscle by hypoxia. J Urol 1996; 155: 772\u2013778.","journal-title":"J Urol"},{"key":"BFijir201156_CR96","first-page":"243","volume":"20","author":"FH Mumtaz","year":"2006","unstructured":"Mumtaz FH, Lau DH, Siddiqui EJ, Thompson CS, Morgan RJ, Mikhailidis DP . Pharmacological properties of endothelin-1 in the rabbit corpus cavernosum. In Vivo 2006; 20: 243\u2013246.","journal-title":"In Vivo"},{"key":"BFijir201156_CR97","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/sj.ijir.3901004","volume":"15","author":"K Furukawa","year":"2003","unstructured":"Furukawa K, Nagao K, Ishii N, Uchiyama T . Responses to serotonin (5HT) in isolated corpus cavernosum penis of rabbit. Int J Impot Res 2003; 15: 267\u2013271.","journal-title":"Int J Impot Res"},{"key":"BFijir201156_CR98","first-page":"161","volume":"5","author":"HY Wu","year":"1993","unstructured":"Wu HY, Broderick GA, Suh JK, Hypolite JA, Levin RM . Effects of purines on rabbit corpus cavernosum contractile activity. Int J Impot Res 1993; 5: 161\u2013167.","journal-title":"Int J Impot Res"},{"key":"BFijir201156_CR99","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1743-6109.2008.01057.x","volume":"6","author":"A Morelli","year":"2009","unstructured":"Morelli A, Chavalmane AK, Filippi S, Fibbi B, Silvestrini E, Sarchielli E et al. Atorvastatin ameliorates sildenafil-induced penile erections in experimental diabetes by inhibiting diabetes-induced RhoA\/Rho-kinase signaling hyperactivation. J Sex Med 2009; 6: 91\u2013106.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR100","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2605.2010.01083.x","volume":"34","author":"Q Zhang","year":"2011","unstructured":"Zhang Q, Radisavljevic ZM, Siroky MB, Azadzoi KM . Dietary antioxidants improve arteriogenic erectile dysfunction. Int J Androl 2011; 34: 225\u2013235.","journal-title":"Int J Androl"},{"key":"BFijir201156_CR101","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1464-410X.2009.08717.x","volume":"105","author":"KM Azadzoi","year":"2010","unstructured":"Azadzoi KM, Golabek T, Radisavljevic ZM, Yalla SV, Siroky MB . Oxidative stress and neurodegeneration in penile ischaemia. BJU Int 2010; 105: 404\u2013410.","journal-title":"BJU Int"},{"key":"BFijir201156_CR102","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/01.ju.0000161209.39959.67","volume":"174","author":"KM Azadzoi","year":"2005","unstructured":"Azadzoi KM, Schulman RN, Aviram M, Siroky MB . Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. J Urol 2005; 174: 386\u2013393.","journal-title":"J Urol"},{"key":"BFijir201156_CR103","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/j.1939-4640.2004.tb02804.x","volume":"25","author":"KM Azadzoi","year":"2004","unstructured":"Azadzoi KM, Master TA, Siroky MB . Effect of chronic ischemia on constitutive and inducible nitric oxide synthase expression in erectile tissue. J Androl 2004; 25: 382\u2013388.","journal-title":"J Androl"},{"key":"BFijir201156_CR104","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/sj.ijir.3901186","volume":"16","author":"T Wang","year":"2004","unstructured":"Wang T, Soker S, Atala A, Siroky MB, Azadzoi KM . Alterations in angiogenic growth factors and neuronal nitric oxide synthase expression in chronic cavernosal ischemia. Int J Impot Res 2004; 16: 403\u2013411.","journal-title":"Int J Impot Res"},{"key":"BFijir201156_CR105","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/jand.2002.23.1.76","volume":"23","author":"NN Kim","year":"2002","unstructured":"Kim NN, Dhir V, Azadzoi KM, Traish AM, Flaherty E, Goldstein I . Pilot study of the endothelin-A receptor selective antagonist BMS-193884 for the treatment of erectile dysfunction. J Androl 2002; 23: 76\u201383.","journal-title":"J Androl"},{"key":"BFijir201156_CR106","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0022-5347(01)61678-1","volume":"161","author":"KM Azadzoi","year":"1999","unstructured":"Azadzoi KM, Krane RJ, Saenz de Tejada I, Goldstein I, Siroky MB . Relative roles of cyclooxygenase and nitric oxide synthase pathways in ischemia-induced increased contraction of cavernosal smooth muscle. J Urol 1999; 161: 1324\u20131328.","journal-title":"J Urol"},{"issue":"6 Part 1","key":"BFijir201156_CR107","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/S0022-5347(01)62299-7","volume":"160","author":"KM Azadzoi","year":"1998","unstructured":"Azadzoi KM, Goldstein I, Siroky MB, Traish AM, Krane RJ, Saenz de Tejada I . Mechanisms of ischemia-induced cavernosal smooth muscle relaxation impairment in a rabbit model of vasculogenic erectile dysfunction. J Urol 1998; 160 (6 Part 1): 2216\u20132222.","journal-title":"J Urol"},{"key":"BFijir201156_CR108","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/sj.ijir.3900621","volume":"12","author":"GD Henry","year":"2000","unstructured":"Henry GD, Byrne R, Hunyh TT, Abraham V, Annex BH, Hagen PO et al. Intracavernosal injections of vascular endothelial growth factor protects endothelial dependent corpora cavernosal smooth muscle relaxation in the hypercholesterolemic rabbit: a preliminary study. Int J Impot Res 2000; 12: 334\u2013339.","journal-title":"Int J Impot Res"},{"key":"BFijir201156_CR109","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1097\/01.ju.0000065247.55066.ad","volume":"170","author":"Q Dai","year":"2003","unstructured":"Dai Q, Silverstein AD, Davies MG, Hagen PO, Donatucci CF, Annex BH . Systemic basic fibroblast growth factor induces favorable histological changes in the corpus cavernosum of hypercholesterolemic rabbits. J Urol 2003; 170: 664\u2013668.","journal-title":"J Urol"},{"key":"BFijir201156_CR110","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1111\/j.1743-6109.2005.00111.x","volume":"2","author":"D Xie","year":"2005","unstructured":"Xie D, Kontos CD, Donatucci CF, Annex BH . Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues. J Sex Med 2005; 2: 634\u2013640.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR111","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1743-6109.2005.00174.x","volume":"3","author":"D Xie","year":"2006","unstructured":"Xie D, Pippen AM, Odronic SI, Annex BH, Donatucci CF . Intracavernosal basic fibroblast growth factor improves vasoreactivity in the hypercholesterolemic rabbit. J Sex Med 2006; 3: 223\u2013232.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR112","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3349\/ymj.1996.37.5.312","volume":"37","author":"ZC Xin","year":"1996","unstructured":"Xin ZC, Choi YD, Choi HK . The effects of SS-cream and its individual components on rabbit corpus cavernosal muscles. Yonsei Med J 1996; 37: 312\u2013318.","journal-title":"Yonsei Med J"},{"key":"BFijir201156_CR113","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s003450050011","volume":"18","author":"JJ Yoo","year":"2000","unstructured":"Yoo JJ, Park HJ, Atala A . Tissue-engineering applications for phallic reconstruction. World J Urol 2000; 18: 62\u201366.","journal-title":"World J Urol"},{"key":"BFijir201156_CR114","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1089\/107632703322495529","volume":"9","author":"G Falke","year":"2003","unstructured":"Falke G, Yoo JJ, Kwon TG, Moreland R, Atala A . Formation of corporal tissue architecture in vivo using human cavernosal muscle and endothelial cells seeded on collagen matrices. Tissue Eng 2003; 9: 871\u2013879.","journal-title":"Tissue Eng"},{"key":"BFijir201156_CR115","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1016\/S0022-5347(01)64780-3","volume":"157","author":"U Simonsen","year":"1997","unstructured":"Simonsen U, Prieto D, Hern\u00e1ndez M, S\u00e1enz de Tejada I, Garc\u00eda-Sacrist\u00e1n A . Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries. J Urol 1997; 157: 2356\u20132360.","journal-title":"J Urol"},{"key":"BFijir201156_CR116","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0022-5347(17)50344-4","volume":"131","author":"TF Lue","year":"1984","unstructured":"Lue TF, Zeineh SJ, Schmidt RA, Tanagho EA . Neuroanatomy of penile erection: its relevance to iatrogenic impotence. J Urol 1984; 131: 273\u2013280.","journal-title":"J Urol"},{"key":"BFijir201156_CR117","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/S0022-5347(17)50870-8","volume":"131","author":"A Mattiasson","year":"1984","unstructured":"Mattiasson A, Andersson KE, Sj\u00f6gren C . Adrenoceptors and cholinoceptors controlling noradrenaline release from adrenergic nerves in the urethra of rabbit and man. J Urol 1984; 131: 1190\u20131195.","journal-title":"J Urol"},{"key":"BFijir201156_CR118","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1113\/jphysiol.1984.sp015197","volume":"350","author":"PO Andersson","year":"1984","unstructured":"Andersson PO, Bloom SR, Mellander S . Haemodynamics of pelvic nerve induced penile erection in the dog: possible mediation by vasoactive intestinal polypeptide. J Physiol 1984; 350: 209\u2013224.","journal-title":"J Physiol"},{"key":"BFijir201156_CR119","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-2999(01)01167-0","volume":"425","author":"T Noto","year":"2001","unstructured":"Noto T, Inoue H, Mochida H, Kikkawa K . Role of adenosine and P2 receptors in the penile tumescence in anesthetized dogs. Eur J Pharmacol 2001; 425: 51\u201355.","journal-title":"Eur J Pharmacol"},{"key":"BFijir201156_CR120","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0022-5347(17)36901-X","volume":"148","author":"Y Takahashi","year":"1992","unstructured":"Takahashi Y, Ishii N, Lue TF, Tanagho EA . Effects of adenosine on canine penile erection. J Urol 1992; 148: 1323\u20131325.","journal-title":"J Urol"},{"key":"BFijir201156_CR121","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0022-5347(17)36625-9","volume":"148","author":"Y Takahashi","year":"1992","unstructured":"Takahashi Y, Aboseif SR, Benard F, Stief CG, Lue TF, Tanagho EA . Effect of intracavernous simultaneous injection of acetylcholine and vasoactive intestinal polypeptide on canine penile erection. J Urol 1992; 148: 446\u2013448.","journal-title":"J Urol"},{"key":"BFijir201156_CR122","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0022-5347(01)66199-8","volume":"155","author":"D Cahn","year":"1996","unstructured":"Cahn D, Melman A, Valcic M, Christ GJ . Forskolin: a promising new adjunct to intracavernous pharmacotherapy. J Urol 1996; 155: 1789\u20131794.","journal-title":"J Urol"},{"key":"BFijir201156_CR123","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/nau.1930130110","volume":"13","author":"F Trigo-Rocha","year":"1994","unstructured":"Trigo-Rocha F, Hsu GL, Donatucci CF, Martinez-Pi\u00f1eiro L, Lue TF, Tanagho EA . Intracellular mechanism of penile erection in monkeys. Neurourol Urodyn 1994; 13: 71\u201380.","journal-title":"Neurourol Urodyn"},{"key":"BFijir201156_CR124","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1600-0773.1990.tb00819.x","volume":"67","author":"A Giraldi","year":"1990","unstructured":"Giraldi A, Wagner G . Effects of pinacidil upon penile erectile tissue, in vitro and in vivo. Pharmacol Toxicol 1990; 67: 235\u2013238.","journal-title":"Pharmacol Toxicol"},{"key":"BFijir201156_CR125","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0022-5347(17)39001-8","volume":"142","author":"W Diederichs","year":"1989","unstructured":"Diederichs W, Kaula NF, Lue TF, Tanagho EA . The effect of subatmospheric pressure on the simian penis. J Urol 1989; 142: 1087\u20131089.","journal-title":"J Urol"},{"issue":"2 Part 1","key":"BFijir201156_CR126","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-5347(17)38773-6","volume":"142","author":"SR Aboseif","year":"1989","unstructured":"Aboseif SR, Breza J, Bosch RJ, Benard F, Stief CG, Stackl W et al. Local and systemic effects of chronic intracavernous injection of papaverine, prostaglandin E1, and saline in primates. J Urol 1989; 142 (2 Part 1): 403\u2013408.","journal-title":"J Urol"},{"key":"BFijir201156_CR127","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0022-5347(17)38705-0","volume":"142","author":"SC Mueller","year":"1989","unstructured":"Mueller SC, Aboseif S, Fahey MR, Lue TF, Tanagho EA . Spinal anesthesia and electroerection in dogs and monkeys. J Urol 1989; 142: 171\u2013175.","journal-title":"J Urol"},{"key":"BFijir201156_CR128","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/S0022-5347(17)43581-6","volume":"138","author":"M Abozeid","year":"1987","unstructured":"Abozeid M, Juenemann KP, Luo JA, Lue TF, Yen TS, Tanagho EA . Chronic papaverine treatment: the effect of repeated injections on the simian erectile response and penile tissue. J Urol 1987; 138: 1263\u20131266.","journal-title":"J Urol"},{"key":"BFijir201156_CR129","first-page":"217","volume":"4","author":"TF Lue","year":"1986","unstructured":"Lue TF . The mechanism of penile erection in the monkey. Semin Urol 1986; 4: 217\u2013224.","journal-title":"Semin Urol"},{"key":"BFijir201156_CR130","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0022-5347(17)50506-6","volume":"131","author":"MR Adams","year":"1984","unstructured":"Adams MR, Kaplan JR, Koritnik DR, Weaver DS, Bond MG . Erectile failure in cynomolgus monkeys with atherosclerosis of the arteries supplying the penis. J Urol 1984; 131: 571\u2013573.","journal-title":"J Urol"},{"key":"BFijir201156_CR131","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.eururo.2008.12.016","volume":"56","author":"GJ Christ","year":"2009","unstructured":"Christ GJ, Andersson KE, Williams K, Zhao W, D\u2019Agostino Jr R, Kaplan J et al. Smooth-muscle-specific gene transfer with the human maxi-K channel improves erectile function and enhances sexual behavior in atherosclerotic cynomolgus monkeys. Eur Urol 2009; 56: 1055\u20131066.","journal-title":"Eur Urol"},{"key":"BFijir201156_CR132","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1161\/01.ATV.4.4.323","volume":"4","author":"A Faggiotto","year":"1984","unstructured":"Faggiotto A, Ross R, Harker L . Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation. Arteriosclerosis 1984; 4: 323\u2013340.","journal-title":"Arteriosclerosis"},{"key":"BFijir201156_CR133","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1161\/01.ATV.4.4.341","volume":"4","author":"A Faggiotto","year":"1984","unstructured":"Faggiotto A, Ross R . Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque. Arteriosclerosis 1984; 4: 341\u2013356.","journal-title":"Arteriosclerosis"},{"key":"BFijir201156_CR134","first-page":"784","volume":"115","author":"JK Williams","year":"1991","unstructured":"Williams JK, Anthony MS, Clarkson TB . Coronary heart disease in rhesus monkeys with diet-induced coronary artery atherosclerosis. Arch Pathol Lab Med 1991; 115: 784\u2013790.","journal-title":"Arch Pathol Lab Med"},{"key":"BFijir201156_CR135","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1210\/jc.2004-0939","volume":"90","author":"TC Register","year":"2005","unstructured":"Register TC, Cann JA, Kaplan JR, Williams JK, Adams MR, Morgan TM et al. Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys. J Clin Endocrinol Metab 2005; 90: 1734\u20131740.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijir201156_CR136","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1742-1241.2010.02410.x","volume":"64","author":"G Jackson","year":"2010","unstructured":"Jackson G, Boon N, Eardley I, Kirby M, Dean J, Hackett G et al. Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus. Int J Clin Pract 2010; 64: 848\u2013857.","journal-title":"Int J Clin Pract"},{"key":"BFijir201156_CR137","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/157339911794940693","volume":"7","author":"C Gazzaruso","year":"2011","unstructured":"Gazzaruso C, Coppola A, Giustina A . Erectile dysfunction and coronary artery disease in patients with diabetes. Curr Diabetes Rev 2011; 7: 143\u2013147.","journal-title":"Curr Diabetes Rev"},{"key":"BFijir201156_CR138","first-page":"e609","volume":"123","author":"BG Schwartz","year":"2011","unstructured":"Schwartz BG, Kloner RA . Cardiovascular implications of erectile dysfunction. Circulation 2011; 123: e609\u2013e611.","journal-title":"Circulation"},{"key":"BFijir201156_CR139","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1191\/1358863x02vm429ra","volume":"7","author":"R Maas","year":"2002","unstructured":"Maas R, Schwedhelm E, Albsmeier J, B\u00f6ger RH . The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function. Vasc Med 2002; 7: 213\u2013225.","journal-title":"Vasc Med"},{"key":"BFijir201156_CR140","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1111\/j.1742-1241.2001.tb11141.x","volume":"55","author":"M Kirby","year":"2001","unstructured":"Kirby M, Jackson G, Betteridge J, Friedli K . Is erectile dysfunction amarker for cardiovascular disease? Int J Clin Pract 2001; 55: 614\u2013618.","journal-title":"Int J Clin Pract"},{"key":"BFijir201156_CR141","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1517\/14656566.3.7.889","volume":"3","author":"RW Jones","year":"2002","unstructured":"Jones RW, Rees RW, Minhas S, Ralph D, Persad RA, Jeremy JY . Oxygen free radicals and the penis. Expert Opin Pharmacother 2002; 3: 889\u2013897.","journal-title":"Expert Opin Pharmacother"},{"key":"BFijir201156_CR142","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJM200006153422407","volume":"342","author":"TF Lue","year":"2000","unstructured":"Lue TF . Erectile dysfunction. N Engl J Med 2000; 342: 1802\u20131813.","journal-title":"N Engl J Med"},{"key":"BFijir201156_CR143","first-page":"1","volume-title":"Male Sexual Function. A Guide to Clinical Management","author":"J Rehman","year":"2001","unstructured":"Rehman J, Melman A . Normal anatomy and physiology. In: Mulcahy, JJ (ed). Male Sexual Function. A Guide to Clinical Management, Vol. 201 Humana Press: Towata, NJ, 2001 pp 1\u201346."},{"key":"BFijir201156_CR144","first-page":"1","volume":"88","author":"N Dakak","year":"1993","unstructured":"Dakak N, Gilligan DM, Andrews NP, Diodati JG, Panza JA, Schenke WH et al. Peripheral vascular endothelial dysfunction in patients with multiple coronary risk factors (abstract). Circulation 1993; 88: 1\u2013618.","journal-title":"Circulation"},{"key":"BFijir201156_CR145","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1161\/01.CIR.84.5.1984","volume":"84","author":"AM Zeiher","year":"1991","unstructured":"Zeiher AM, Drexler H, Wollschlager H, Just H . Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis. Circulation 1991; 84: 1984\u20131992.","journal-title":"Circulation"},{"key":"BFijir201156_CR146","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1161\/01.CIR.82.4.1169","volume":"82","author":"JM McLenachan","year":"1990","unstructured":"McLenachan JM, Vita J, Fish DR, Treasure CB, Cox DA, Ganz P et al. Early evidence of endothelial vasodilator dysfunction at coronary branch points. Circulation 1990; 82: 1169\u20131173.","journal-title":"Circulation"},{"key":"BFijir201156_CR147","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1161\/01.CIR.79.2.287","volume":"79","author":"SW Werns","year":"1989","unstructured":"Werns SW, Walton JA, Hsia HH, Nabel EG, Sanz ML, Pitt B . Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation 1989; 79: 287\u2013291.","journal-title":"Circulation"},{"key":"BFijir201156_CR148","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/0735-1097(92)90271-N","volume":"19","author":"SD Katz","year":"1992","unstructured":"Katz SD, Biasucci L, Sabba C, Strom JA, Jondeau G, Galvao M et al. Impaired endothelium-mediated vasodilation in the peripheral vasculature of patients with congestive heart failure. J Am Coll Cardiol 1992; 19: 918\u2013925.","journal-title":"J Am Coll Cardiol"},{"key":"BFijir201156_CR149","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1161\/01.CIR.0000095273.92468.D9","volume":"108","author":"G Brevetti","year":"2003","unstructured":"Brevetti G, Silvestro A, Schiano V, Chiariello M . Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle\u2013brachial pressure index. Circulation 2003; 108: 2093\u20132098.","journal-title":"Circulation"},{"key":"BFijir201156_CR150","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/0140-6736(92)92621-L","volume":"340","author":"PJ Chowienczyk","year":"1992","unstructured":"Chowienczyk PJ, Watts GF, Cockcroft JR, Ritter JM . Impaired endothelium-dependent vasodilation of forearm resistance vessels in hypercholesterolaemia. Lancet 1992; 340: 1430\u20131432.","journal-title":"Lancet"},{"key":"BFijir201156_CR151","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1161\/01.ATV.0000057571.03012.F4","volume":"23","author":"TH Schindler","year":"2003","unstructured":"Schindler TH, Hornig B, Buser PT, Olschewski M, Magosaki N, Pfisterer M et al. Prognostic value of abnormal vasoreactivity of epicardial coronary arteries to sympathetic stimulation in patients with normal coronary angiograms. Arterioscler Thromb Vasc Biol 2003; 23: 495\u2013501.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFijir201156_CR152","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/01.CIR.0000025404.78001.D8","volume":"106","author":"JP Halcox","year":"2002","unstructured":"Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002; 106: 653\u2013658.","journal-title":"Circulation"},{"key":"BFijir201156_CR153","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","volume":"101","author":"V Schachinger","year":"2000","unstructured":"Schachinger V, Britten MB, Zeiher AM . Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 1899\u20131906.","journal-title":"Circulation"},{"key":"BFijir201156_CR154","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/sj.ijir.3901634","volume":"20","author":"KL Billups","year":"2008","unstructured":"Billups KL, Bank AJ, Padma-Nathan H, Katz SD, Williams RA . Erectile dysfunction as a harbinger for increased cardiometabolic risk. Int J Impot Res 2008; 20: 236\u2013242.","journal-title":"Int J Impot Res"},{"issue":"Suppl 3","key":"BFijir201156_CR155","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1743-6109.2008.01174.x","volume":"6","author":"TM Hale","year":"2009","unstructured":"Hale TM, Hannan JL, Carrier S, deBlois D, Adams MA . Targeting vascular structure for the treatment of sexual dysfunction. J Sex Med 2009; 6 (Suppl 3): 210\u2013220.","journal-title":"J Sex Med"},{"key":"BFijir201156_CR156","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/sj.ijir.3901581","volume":"20","author":"D Prieto","year":"2008","unstructured":"Prieto D . Physiological regulation of penile arteries and veins. Int J Impot Res 2008; 20: 17\u201329.","journal-title":"Int J Impot Res"},{"key":"BFijir201156_CR157","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1742-1241.1999.tb11747.x","volume":"53","author":"G Jackson","year":"1999","unstructured":"Jackson G . Erectile dysfunction and cardiovascular disease. Int J Clin Pract 1999; 53: 363\u2013368.","journal-title":"Int J Clin Pract"},{"key":"BFijir201156_CR158","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1742-1241.2001.tb11016.x","volume":"55","author":"PD O\u2019Kane","year":"2001","unstructured":"O\u2019Kane PD, Jackson G . Erectile dysfunction: is there silent obstructive coronary artery disease? Int J Clin Pract 2001; 55: 219\u2013220.","journal-title":"Int J Clin Pract"},{"key":"BFijir201156_CR159","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1442-2042.1998.tb00599.x","volume":"5","author":"MM Basar","year":"1998","unstructured":"Basar MM, Sargon MF, Basar H, Atan A, Ak F, Celik HH et al. Comparative study between corpus cavernosum-electromyography findings and electron microscopy of cavernosal muscle biopsies in erectile dysfunction patients. Int J Urol 1998; 5: 252\u2013255.","journal-title":"Int J Urol"},{"key":"BFijir201156_CR160","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1136\/hrt.2003.027680","volume":"90","author":"FD Hobbs","year":"2004","unstructured":"Hobbs FD . Cardiovascular disease: different strategies for primary and secondary prevention? Heart 2004; 90: 1217\u20131223.","journal-title":"Heart"},{"key":"BFijir201156_CR161","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/01.CIR.84.3.1273","volume":"84","author":"JM McLenachan","year":"1991","unstructured":"McLenachan JM, Williams JK, Fish RD, Ganz P, Selwyn AP . Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis. Circulation 1991; 84: 1273\u20131278.","journal-title":"Circulation"},{"key":"BFijir201156_CR162","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/3-540-27661-0_1","volume":"170","author":"P Cullen","year":"2005","unstructured":"Cullen P, Rauterberg J, Lorkowski S . The pathogenesis of atherosclerosis. Handb Exp Pharmacol 2005; 170: 3\u201370.","journal-title":"Handb Exp Pharmacol"},{"key":"BFijir201156_CR163","unstructured":"Ross R . The pathogenesis of atherosclerosis. In: Braunwald E (ed). Heart Disease: A Textbook of Cardiovascular Medicine. W.B. Saunders Co, Philadelphia, PA, 1988 pp 135\u2013152."},{"key":"BFijir201156_CR164","doi-asserted-by":"crossref","first-page":"H985","DOI":"10.1152\/ajpheart.00292.2006","volume":"291","author":"M F\u00e9l\u00e9tou","year":"2006","unstructured":"F\u00e9l\u00e9tou M, Vanhoutte PM . Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am J Physiol Heart Circ Physiol 2006; 291: H985\u2013H1002.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"BFijir201156_CR165","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.2174\/138945007782403874","volume":"8","author":"CM Thomas","year":"2007","unstructured":"Thomas CM, Smart EJ . Gender as a regulator of atherosclerosis in murine models. Curr Drug Targets 2007; 8: 1172\u20131180.","journal-title":"Curr Drug Targets"},{"key":"BFijir201156_CR166","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1161\/01.ATV.17.10.2150","volume":"17","author":"DC Schwenke","year":"1997","unstructured":"Schwenke DC . Gender differences in intima-media permeability to low-density lipoprotein at atherosclerosis-prone aortic sites in rabbits. Lack of effect of 17 beta-estradiol. Arterioscler Thromb Vasc Biol 1997; 17: 2150\u20132157.","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["International Journal of Impotence Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijir201156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir201156","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir201156.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T01:19:51Z","timestamp":1742174391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijir201156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,29]]},"references-count":166,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["BFijir201156"],"URL":"https:\/\/doi.org\/10.1038\/ijir.2011.56","relation":{},"ISSN":["0955-9930","1476-5489"],"issn-type":[{"type":"print","value":"0955-9930"},{"type":"electronic","value":"1476-5489"}],"subject":[],"published":{"date-parts":[[2011,12,29]]},"assertion":[{"value":"13 July 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 December 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}