{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T22:59:55Z","timestamp":1768172395458,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T00:00:00Z","timestamp":1371686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Impot Res"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1038\/ijir.2013.28","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T07:56:01Z","timestamp":1371714961000},"page":"161-165","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Erectile dysfunction after radiotherapy for prostate cancer: a model assesing the conflicting literature on dose\u2013volume effects"],"prefix":"10.1038","volume":"25","author":[{"given":"E","family":"Rivin del Campo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"M","family":"Roach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,6,20]]},"reference":[{"key":"BFijir201328_CR1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.3322\/canjclin.56.2.106","volume":"56","author":"A Jemal","year":"2006","unstructured":"Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C et al. Cancer statistics, 2006. CA Cancer J Clin 2006; 56: 106\u2013130.","journal-title":"CA Cancer J Clin"},{"key":"BFijir201328_CR2","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/S0360-3016(02)03030-4","volume":"54","author":"JW Robinson","year":"2002","unstructured":"Robinson JW, Mortiz S, Fung T . Meta-analysis of rates of erectile function after treatment of localized prostate carcinoma. Int J Radiat Oncol Biol Phys 2002; 54: 1063\u20131068.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFijir201328_CR3","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1001\/jama.2011.1333","volume":"306","author":"M Alemozaffar","year":"2011","unstructured":"Alemozaffar M, Regan M, Cooperberg M, Wei J, Michalski J, Sandler H et al. Prediction of erectile function following treatment for prostate cancer. JAMA 2011; 306: 1205\u20131214.","journal-title":"JAMA"},{"key":"BFijir201328_CR4","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0022-5347(01)65369-2","volume":"157","author":"AL Burnett","year":"1997","unstructured":"Burnett AL . Nitric oxide in the penis: physiology and pathology. J Urol 1997; 157: 320\u2013324.","journal-title":"J Urol"},{"key":"BFijir201328_CR5","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ucl.2005.08.007","volume":"32","author":"RC Dean","year":"2005","unstructured":"Dean RC, Lue TF . Physiology of penile erection and patho-physiology of erectile dysfunction. Urol Clin North Am 2005; 32: 379\u2013395.","journal-title":"Urol Clin North Am"},{"key":"BFijir201328_CR6","doi-asserted-by":"publisher","first-page":"S130","DOI":"10.1016\/j.ijrobp.2009.04.094","volume":"76","author":"M Roach","year":"2010","unstructured":"Roach M, Nam J, Gagliardi G, El Naga I, Deasy JO, Marks LB . Radiation dose-volume effects and the penile bulb. Int J Radiat Oncol Biol Phys 2010; 76: S130\u2013S134.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFijir201328_CR7","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1148\/radiology.195.1.7534430","volume":"195","author":"S Carrier","year":"1995","unstructured":"Carrier S, Hriak H, Lee SS, Baba K, Morgan DM, Nunes L et al. Radiation-induced decrease in nitric oxide synthase-containing nerves in the rat penis. Radiology 1995; 195: 95\u201399.","journal-title":"Radiology"},{"key":"BFijir201328_CR8","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1111\/j.1743-6109.2011.02351.x","volume":"8","author":"M Kimura","year":"2011","unstructured":"Kimura M, Yan H, Rabbani Z, Satoh T, Baba S, Fang-fang Y et al. Radiation-induced erectile dysfunction using prostate-confined modern radiotherapy in a rat model. J Sex Med 2011; 8: 2215\u20132226.","journal-title":"J Sex Med"},{"key":"BFijir201328_CR9","first-page":"214","volume":"87","author":"M Roach","year":"1995","unstructured":"Roach M, Alexander M . The prognostic significance of race and survival from breast cancer: a model for assessing the reliability of reported survival differences. J Natl Med Assoc 1995; 87: 214\u2013219.","journal-title":"J Natl Med Assoc"},{"key":"BFijir201328_CR10","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1001\/jama.287.16.2106","volume":"287","author":"P Bach","year":"2002","unstructured":"Bach P, Schrag D, Brawley O, Galaznik A, Yakren S, Begg C . Survival of Blacks and Whites After a Cancer Diagnosis. JAMA 2002; 287: 2106\u20132113.","journal-title":"JAMA"},{"key":"BFijir201328_CR11","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1002\/cncr.23887","volume":"113","author":"R Schroeck","year":"2008","unstructured":"Schroeck R, Donatucci C, Smathers E, Sun L, Albala DM, Polascik TJ et al. Defining potency: a comparison of the International Index of Erectile Function Short Version and the Expanded Cancer Index Composite. Cancer 2008; 113: 2667\u20132694.","journal-title":"Cancer"},{"key":"BFijir201328_CR12","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","volume":"49","author":"R Rosen","year":"1997","unstructured":"Rosen R, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A . The international index of erectile function (IIEF): a multifunctional scale for assessment of erectile dysfunction. Urology 1997; 49: 822\u2013830.","journal-title":"Urology"},{"key":"BFijir201328_CR13","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1111\/j.1743-6109.2008.01155.x","volume":"6","author":"J Cappeleri","year":"2009","unstructured":"Cappeleri J, Bushmakin MS, Symonds T, Schnetzler G . Scoring correspondence in outcomes related to erectile dysfunction treatment on a 4-point scale (SCORE-4). J Sex Med 2009; 6: 809\u2013819.","journal-title":"J Sex Med"},{"key":"BFijir201328_CR14","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0090-4295(01)00940-2","volume":"57","author":"BM Fisch","year":"2001","unstructured":"Fisch BM, Picket B, Weinberg V, Roach M . Dose of radiation received by the bulb of the penis correlates with a risk of impotence after three-dimensional conformal radiotherapy for prostate cancer. Urology 2001; 57: 955\u2013959.","journal-title":"Urology"},{"key":"BFijir201328_CR15","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1016\/j.ijrobp.2004.05.026","volume":"60","author":"M Roach","year":"2004","unstructured":"Roach M, Winter K, Michalski JM, Cox JD, Purdy JA, Bosch W et al. Penile bulb dose and impotence after three-dimensional conformal radiotherapy for prostate cancer on RTOG 9406: findings from a prospective, multi-institutional, phase I\/II dose-escalation study. Int J Radiat Oncol Biol Phys 2004; 60: 1351\u20131356.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFijir201328_CR16","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.ijrobp.2004.05.030","volume":"60","author":"AG Wernicke","year":"2004","unstructured":"Wernicke AG, Valincenti R, Dieva K, Houser C, Pequignot E . Radiation dose delivered to the proximal penis as a predictor of the risk of erectile dysfunction after three-dimensional conformal radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 2004; 60: 1357\u20131363.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFijir201328_CR17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.radonc.2006.07.037","volume":"80","author":"SA Mangar","year":"2006","unstructured":"Mangar SA, Sydes MR, Tucker HL, Coffey J, Sohaib SA, Gianolini S et al. Evaluating the relationship between erectile dysfunction and dose received by the penile bulb: using data from a randomized controlled trial of conformal radiotherapy in prostate cancer. Radiother Oncol 2006; 80: 355\u2013362.","journal-title":"Radiother Oncol"},{"key":"BFijir201328_CR18","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.ijrobp.2003.12.028","volume":"59","author":"U Selek","year":"2004","unstructured":"Selek U, Cheung R, Lii M, Allen P, Steadham RE, Vantreese TR et al. Erectile dysfunction and radiation dose to the penile base structures: a lack of correlation. Int J Radiat Oncol Biol Phys 2004; 59: 1039\u20131046.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFijir201328_CR19","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/sj.pcan.4500938","volume":"10","author":"MW Brown","year":"2007","unstructured":"Brown MW, Brooks JP, Albert PS, Poggi MM . An analysis of erectile function after intensity modulated radiation therapy for localized prostate carcinoma. Prostate Cancer Prostatic Dis 2007; 10: 189\u2013193.","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"BFijir201328_CR20","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.ijrobp.2007.10.052","volume":"71","author":"GJ van der Wielen","year":"2008","unstructured":"van der Wielen GJ, Hoogeman MS, Dohle GR, van Putten WL, Incrocci L . Dose-volume parameters of the corpora cavernosa do not correlate with erectile dysfunction after external beam radiotherapy for prostate cancer: results from a dose-escalation trial. Int J Radiat Oncol Biol Phys 2008; 71: 795\u2013800.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFijir201328_CR21","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.ijrobp.2009.07.1748","volume":"78","author":"E Wiegner","year":"2010","unstructured":"Wiegner E, King C . Sexual function after stereotactic body radiotherapy for prostate cancer: results of a prospective clinical trial. Int J Radiat Oncol Biol Phys 2010; 78: 442\u2013448.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BFijir201328_CR22","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1097\/COC.0b013e318173a563","volume":"32","author":"WM Mendenhall","year":"2009","unstructured":"Mendenhall WM, Henderson RH, Indelicato DJ, Keole SR, Mendenhall NP . Erectile dysfunction after radiotherapy for prostate cancer. Am J Clin Onc 2009; 32: 443\u2013447.","journal-title":"Am J Clin Onc"},{"key":"BFijir201328_CR23","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.radonc.2007.07.018","volume":"84","author":"GJ van der Wielen","year":"2007","unstructured":"van der Wielen GJ, Mulhall JP, Incrocci L . Erectile dysfunction after radiotherapy for prostate cancer and radiation dose to the penile structures: a critical review. Radiother Oncol 2007; 84: 107\u2013113.","journal-title":"Radiother Oncol"},{"key":"BFijir201328_CR24","doi-asserted-by":"publisher","first-page":"4619","DOI":"10.1002\/cncr.27398","volume":"118","author":"BS Hoppe","year":"2012","unstructured":"Hoppe BS, Nichols RC, Henderson RH, Morris CG, Williams CR, Costa J et al. Erectile function, incontinence, and other quality of life outcomes following proton therapy for prostate cancer in men 60 years old and younger. Cancer 2012; 118: 4619\u20134626.","journal-title":"Cancer"},{"key":"BFijir201328_CR25","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1007\/s00066-012-0227-8","volume":"188","author":"A Magli","year":"2012","unstructured":"Magli A, Giangreco M, Crespi M, Negri A, Ceschia T, De Giorgi G et al. Erectile dysfunction after prostate three-dimensional conformal radiation therapy \u2013 correlation with the dose to the penile bulb. Strahlenther Onkol 2012; 188: 997\u20131002.","journal-title":"Strahlenther Onkol"},{"key":"BFijir201328_CR26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.radonc.2009.04.004","volume":"93","author":"L Perna","year":"2009","unstructured":"Perna L, Fiorino C, Cozzarini C, Broggi S, Cattaneo GM, De Cobelli F et al. Sparing the penile bulb in the radical irradiation of clinically localised prostate carcinoma: a comparison between MRI and CT prostatic apex definition in 3DCRT, Linac-IMRT and Helical Tomotherapy. Radiother Oncol 2009; 93: 57\u201363.","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Impotence Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijir201328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir201328","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir201328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T15:24:09Z","timestamp":1648653849000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijir201328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,20]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["BFijir201328"],"URL":"https:\/\/doi.org\/10.1038\/ijir.2013.28","relation":{},"ISSN":["0955-9930","1476-5489"],"issn-type":[{"value":"0955-9930","type":"print"},{"value":"1476-5489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,20]]},"assertion":[{"value":"3 December 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}