{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:26:51Z","timestamp":1780464411520,"version":"3.54.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T00:00:00Z","timestamp":1404345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Impot Res"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1038\/ijir.2014.18","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T07:58:06Z","timestamp":1404374286000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Clinical factors associated with sexual dysfunction among men in methadone maintenance treatment and buprenorphine maintenance treatment: a meta-analysis study"],"prefix":"10.1038","volume":"26","author":[{"given":"A","family":"Yee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H S","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H M B","family":"Hisham Hashim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C G","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,3]]},"reference":[{"key":"BFijir201418_CR1","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1001\/jama.281.6.537","volume":"281","author":"EO Laumann","year":"1999","unstructured":"Laumann EO, Paik A, Rosen RC . Sexual dysfunction in the United States. JAMA 1999; 281: 537\u2013544.","journal-title":"JAMA"},{"key":"BFijir201418_CR2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1192\/bjp.182.1.50","volume":"182","author":"S Macdonald","year":"2003","unstructured":"Macdonald S, Halliday J, MacEwan T, Sharkey V, Farrington S, Wall S et al. Nithsdale Schizophrenia Surveys 24: sexual dysfunction case\u2013control study. Br J Psychiatry 2003; 182: 50\u201356.","journal-title":"Br J Psychiatry"},{"key":"BFijir201418_CR3","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11920-996-0006-2","volume":"2","author":"RC Rosen","year":"2000","unstructured":"Rosen RC . Prevalence and risk factors of sexual dysfunction in men and women. Curr Psychiatry Rep 2000; 2: 189\u2013195.","journal-title":"Curr Psychiatry Rep"},{"key":"BFijir201418_CR4","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1055\/s-2002-30675","volume":"29","author":"M Grube","year":"2002","unstructured":"Grube M, Weigand-Tomiuk H . Sexual dysfunctions in a group of psychiatric in-patients]. Psychiatrische Praxis 2002; 29: 194.","journal-title":"Psychiatrische Praxis"},{"key":"BFijir201418_CR5","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/sj.ijir.3901357","volume":"17","author":"E Oksuz","year":"2005","unstructured":"Oksuz E, Malhan S . The prevalence of male sexual dysfunction and potential risk factors in Turkish men: a Web-based survey. Int J Impot Res 2005; 17: 539\u2013545.","journal-title":"Int J Impot Res"},{"key":"BFijir201418_CR6","doi-asserted-by":"crossref","unstructured":"Mattick RP, Breen C, Kimber J, Davoli M . Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. Cochrane Database Syst Rev 2009; CD002209.","DOI":"10.1002\/14651858.CD002209.pub2"},{"key":"BFijir201418_CR7","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1055\/s-2007-979596","volume":"28","author":"L Teusch","year":"1995","unstructured":"Teusch L, Scherbaum N, B\u00f6hme H, Bender S . Different patterns of sexual dysfunctions associated with psychiatric disorders and psychopharmacological treatment: results of an investigation by semi-structured interview of schizophrenic and neurotic patients and methadone-substituted opiate addicts. Pharmacopsychiatry 1995; 28: 84\u201392.","journal-title":"Pharmacopsychiatry"},{"key":"BFijir201418_CR8","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1056\/NEJM197504242921703","volume":"292","author":"TJ Cicero","year":"1975","unstructured":"Cicero TJ, Bell RD, Wiest WG, Allison JH, Polakoski K, Robins E . Function of the male sex organs in heroin and methadone users. N Engl J Med 1975; 292: 882\u2013887.","journal-title":"N Engl J Med"},{"key":"BFijir201418_CR9","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1111\/j.1743-6109.2007.00702.x","volume":"5","author":"R Hallinan","year":"2008","unstructured":"Hallinan R, Byrne A, Agho K, McMahon C, Tynan P, Attia J . Erectile dysfunction in men receiving methadone and buprenorphine maintenance treatment. J Sexual Med 2008; 5: 684\u2013692.","journal-title":"J Sexual Med"},{"key":"BFijir201418_CR10","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1080\/10550887.2010.509279","volume":"29","author":"A Patricia","year":"2010","unstructured":"Patricia A, Cioe R, Peter D, Friedmann M, Stein MD . Erectile dysfunction in opioid users: lack of association with serum testosterone. J Addict Dis 2010; 29: 455\u2013460.","journal-title":"J Addict Dis"},{"key":"BFijir201418_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1300\/J069v24n02_08","volume":"24","author":"R Brown","year":"2005","unstructured":"Brown R, Balousek S, Mundt M, Michael Fleming MDM . Methadone maintenance and male sexual dysfunction. J Addict Dis 2005; 24: 91\u2013106.","journal-title":"J Addict Dis"},{"key":"BFijir201418_CR12","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1097\/ADM.0b013e318259b2c4","volume":"6","author":"W Chen","year":"2012","unstructured":"Chen W, Li X, Li X, Ling L, Xia Y, Chen J et al. Erectile dysfunction among male heroin addicts receiving methadone maintenance treatment in Guangdong, China. J Addict Med 2012; 6: 212\u2013218.","journal-title":"J Addict Med"},{"key":"BFijir201418_CR13","first-page":"739","volume":"36","author":"Y Zhang","year":"2011","unstructured":"Zhang Y, Wang P, Ma Z, Xu Z, Li Y . Sexual function of 612 male addicts treated by methadone. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2011; 36: 739.","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"BFijir201418_CR14","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1111\/jsm.12105","volume":"10","author":"NR Nik Jaafar","year":"2013","unstructured":"Nik Jaafar NR, Mislan N, Abdul Aziz S, Baharudin A, Ibrahim N, Midin M et al. Risk factors of erectile dysfunction in patients receiving methadone maintenance therapy. J Sexual Med 2013; 10: 2069\u20132076.","journal-title":"J Sexual Med"},{"key":"BFijir201418_CR15","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1210\/jc.2004-0929","volume":"90","author":"N Bliesener","year":"2005","unstructured":"Bliesener N, Albrecht S, Schwager A, Weckbecker K, Lichtermann D, Klingm\u00fcller D . Plasma testosterone and sexual function in men receiving buprenorphine maintenance for opioid dependence. J Clin Endocrinol Metab 2005; 90: 203\u2013206.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijir201418_CR16","doi-asserted-by":"publisher","first-page":"13-","DOI":"10.2174\/157018009787158580","volume":"6","author":"S Giacomuzzi","year":"2009","unstructured":"Giacomuzzi S, Khreis A, Riemer Y, Garber K, Ertl M . Buprenorphine and methadone maintenance treatment-sexual behaviour and dysfunction prevalence. Lett Drug Design Discov 2009; 6: 13-.","journal-title":"Lett Drug Design Discov"},{"key":"BFijir201418_CR17","first-page":"164","volume":"5","author":"F Tatari","year":"2010","unstructured":"Tatari F, Farnia V, Najafi F . Trazodone in methandone induced erectile dysfunction. Iran J Psychiatry 2010; 5: 164\u2013166.","journal-title":"Iran J Psychiatry"},{"key":"BFijir201418_CR18","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/S1470-2045(11)70002-X","volume":"12","author":"AJ Mitchell","year":"2011","unstructured":"Mitchell AJ, Chan M, Bhatti H, Halton M, Grassi L, Johansen C et al. Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. Lancet Oncol 2011; 12: 160\u2013174.","journal-title":"Lancet Oncol"},{"key":"BFijir201418_CR19","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.addbeh.2011.08.005","volume":"37","author":"V Chekuri","year":"2012","unstructured":"Chekuri V, Gerber D, Brodie A, Krishnadas R . Premature ejaculation and other sexual dysfunctions in opiate dependent men receiving methadone substitution treatment. Addict Behav 2012; 37: 124\u2013126.","journal-title":"Addict Behav"},{"key":"BFijir201418_CR20","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3109\/00952997709002743","volume":"4","author":"R Hanbury","year":"1977","unstructured":"Hanbury R, Cohen M, Stimmel B . Adequacy of sexual performance in men maintained on methadone. Am J Drug Alcohol Abuse 1977; 4: 13\u201320.","journal-title":"Am J Drug Alcohol Abuse"},{"key":"BFijir201418_CR21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.drugalcdep.2007.09.025","volume":"94","author":"G Quaglio","year":"2008","unstructured":"Quaglio G, Lugoboni F, Pattaro C, Melara B, Mezzelani P, Des Jarlais DC . Erectile dysfunction in male heroin users, receiving methadone and buprenorphine maintenance treatment. Drug and Alcohol Depen 2008; 94: 12\u201318.","journal-title":"Drug and Alcohol Depen"},{"key":"BFijir201418_CR22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/appy.12069","volume":"5","author":"A Baharudin","year":"2013","unstructured":"Baharudin A, Mislan N, Ibrahim N, Sidi H, Nik Jaafar NR . Depression in male patients on methadone maintenance therapy. Asia-Pacific Psychiatry 2013; 5: 67\u201373.","journal-title":"Asia-Pacific Psychiatry"},{"key":"BFijir201418_CR23","first-page":"1325","volume":"27","author":"WD Spring","year":"1992","unstructured":"Spring WD, Willenbring ML, Maddux TL . Sexual dysfunction and psychological distress in methadone maintenance. Subst Use Misuse 1992; 27: 1325\u20131334.","journal-title":"Subst Use Misuse"},{"key":"BFijir201418_CR24","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1080\/02791072.2001.10400569","volume":"33","author":"J Peugh","year":"2001","unstructured":"Peugh J, Belenko S . Alcohol, drugs and sexual function: a review. J Psychoactive Drugs 2001; 33: 223\u2013232.","journal-title":"J Psychoactive Drugs"},{"key":"BFijir201418_CR25","first-page":"195","volume":"22","author":"MA Emanuele","year":"1998","unstructured":"Emanuele MA, Emanuele NV . Alcohol\u2019s effects on male reproduction. Alcohol Health Res World 1998; 22: 195\u2013201.","journal-title":"Alcohol Health Res World"},{"key":"BFijir201418_CR26","first-page":"20","volume":"109","author":"S Colameco","year":"2009","unstructured":"Colameco S, Coren JS . Opioid-induced endocrinopathy. J Am Osteopath Assoc 2009; 109: 20\u201325.","journal-title":"J Am Osteopath Assoc"},{"key":"BFijir201418_CR27","doi-asserted-by":"publisher","first-page":"362","DOI":"10.12968\/bjon.2005.14.7.17939","volume":"14","author":"I Peate","year":"2005","unstructured":"Peate I . The effects of smoking on the reproductive health of men. Br J Nurs 2005; 14: 362\u2013367.","journal-title":"Br J Nurs"},{"key":"BFijir201418_CR28","doi-asserted-by":"publisher","first-page":"515","DOI":"10.2164\/jandrol.110.011874","volume":"33","author":"CM Fronczak","year":"2012","unstructured":"Fronczak CM, Kim ED, Barqawi AB . The insults of illicit drug use on male fertility. J Androl 2012; 33: 515\u2013528.","journal-title":"J Androl"},{"key":"BFijir201418_CR29","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009; 6: e1000097.","journal-title":"PLoS Med"},{"key":"BFijir201418_CR30","doi-asserted-by":"crossref","DOI":"10.5040\/9798216013310","volume-title":"Sex and sexuality","author":"RD McAnulty","year":"2006","unstructured":"McAnulty RD, Burnette MM . Sex and sexuality. Greenwood Publishing Group, 2006."},{"key":"BFijir201418_CR31","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/01.adt.0000145126.17405.6a","volume":"4","author":"MR Lofwall","year":"2005","unstructured":"Lofwall MR, Stitzer ML, Bigelow GE, Strain EC . Comparative safety and side effect profiles of buprenorphine and methadone in the outpatient treatment of opioid dependence. Addict Disord Treat 2005; 4: 49\u201364.","journal-title":"Addict Disord Treat"},{"key":"BFijir201418_CR32","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1080\/0092623X.2011.582431","volume":"37","author":"M Yule","year":"2011","unstructured":"Yule M, Davison J, Brotto L . The international index of erectile function: a methodological critique and suggestions for improvement. J Sex Marital Ther 2011; 37: 255\u2013269.","journal-title":"J Sex Marital Ther"},{"key":"BFijir201418_CR33","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1097\/JGP.0b013e31816ff35a","volume":"16","author":"D Rosen","year":"2008","unstructured":"Rosen D, Smith ML, Reynolds CF III . The prevalence of mental and physical health disorders among older methadone patients. Am J Geriatric Psych 2008; 16: 488\u2013497.","journal-title":"Am J Geriatric Psych"},{"key":"BFijir201418_CR34","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-3565(25)30047-9","volume":"192","author":"JH Mendelson","year":"1975","unstructured":"Mendelson JH, Mendelson JE, Patch VD . Plasma testosterone levels in heroin addiction and during methadone maintenance. J Pharmacol Exp Ther 1975; 192: 211\u2013217.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFijir201418_CR35","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0022-3565(25)30341-1","volume":"195","author":"J Mendelson","year":"1975","unstructured":"Mendelson J, Meyer R, Ellingboe J, Mirin S, McDougle M . Effects of heroin and methadone on plasma cortisol and testosterone. J Pharmacol Exp Ther 1975; 195: 296\u2013302.","journal-title":"J Pharmacol Exp Ther"},{"key":"BFijir201418_CR36","first-page":"216","volume":"81","author":"G Woody","year":"1988","unstructured":"Woody G, McLellan A, O\u2019Brien C, Persky H, Stevens G, Arndt I et al. Hormone secretion in methadone-dependent and abstinent patients. NIDA Res Monogr 1988; 81: 216\u2013223.","journal-title":"NIDA Res Monogr"},{"key":"BFijir201418_CR37","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/j.1365-2605.2007.00824.x","volume":"32","author":"R Hallinan","year":"2009","unstructured":"Hallinan R, Byrne A, Agho K, McMahon C, Tynan P, Attia J . Hypogonadism in men receiving methadone and buprenorphine maintenance treatment. Int J Androl 2009; 32: 131\u2013139.","journal-title":"Int J Androl"},{"key":"BFijir201418_CR38","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1080\/13548506.2012.729845","volume":"18","author":"Y Xia","year":"2013","unstructured":"Xia Y, Zhang D, Li X, Chen W, He Q, Jahn HJ et al. Sexual dysfunction during methadone maintenance treatment and its influence on patient's life and treatment: a qualitative study in South China. Psychol Health Med 2013; 18: 321\u2013329.","journal-title":"Psychol Health Med"},{"key":"BFijir201418_CR39","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1300\/J069v21n04_05","volume":"21","author":"HW Daniell","year":"2002","unstructured":"Daniell HW . Narcotic-induced hypogonadism during therapy for heroin addiction. J Addict dis 2002; 21: 47\u201353.","journal-title":"J Addict dis"},{"key":"BFijir201418_CR40","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/ADM.0b013e318172d612","volume":"2","author":"S Colameco","year":"2008","unstructured":"Colameco S, Coren JS, Zimmerman DJ . Buprenorphine-induced symptomatic hypogonadism in men: case reports and discussion. J Addict Med 2008; 2: 147\u2013150.","journal-title":"J Addict Med"},{"key":"BFijir201418_CR41","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.jsat.2010.01.008","volume":"38","author":"KM D\u00fcrsteler-MacFarland","year":"2010","unstructured":"D\u00fcrsteler-MacFarland KM, Fischer DA, Mueller S, Schmid O, Moldovanyi A, Wiesbeck GA . Symptom complaints of patients prescribed either oral methadone or injectable heroin. J Subs Abuse Treat 2010; 38: 328\u2013337.","journal-title":"J Subs Abuse Treat"},{"key":"BFijir201418_CR42","first-page":"5","volume":"13","author":"L Gr\u00f6nbladh","year":"2011","unstructured":"Gr\u00f6nbladh L, \u00d6hlund LS . Self-reported differences in side-effects for 110 heroin addicts during opioid addiction and during methadone treatment. Heroin Addict Relat Clin Probl 2011; 13: 5\u201312.","journal-title":"Heroin Addict Relat Clin Probl"},{"key":"BFijir201418_CR43","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0376-8716(93)90110-C","volume":"33","author":"DM Novick","year":"1993","unstructured":"Novick DM, Richman BL, Friedman JM, Friedman JE, Fried C, Wilson JP et al. The medical status of methadone maintenance patients in treatment for 11\u201318 years. Drug Alcohol Depend 1993; 33: 235\u2013245.","journal-title":"Drug Alcohol Depend"}],"container-title":["International Journal of Impotence Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijir201418.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir201418","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir201418.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T17:11:07Z","timestamp":1746292267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijir201418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,3]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["BFijir201418"],"URL":"https:\/\/doi.org\/10.1038\/ijir.2014.18","relation":{},"ISSN":["0955-9930","1476-5489"],"issn-type":[{"value":"0955-9930","type":"print"},{"value":"1476-5489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,3]]},"assertion":[{"value":"9 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}