{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T13:25:39Z","timestamp":1724592339281},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:00:00Z","timestamp":1406160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T00:00:00Z","timestamp":1406160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Impot Res"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1038\/ijir.2014.27","type":"journal-article","created":{"date-parts":[[2014,7,24]],"date-time":"2014-07-24T07:59:02Z","timestamp":1406188742000},"page":"1-5","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A comparison of different oral therapies versus no treatment for erectile dysfunction in 196 radical nerve-sparing radical prostatectomy patients"],"prefix":"10.1038","volume":"27","author":[{"given":"A","family":"Natali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Masieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lanciotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Giancane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Vignolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Carini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Serni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,7,24]]},"reference":[{"key":"BFijir201427_CR1","first-page":"209","volume":"8","author":"JE Dall\u2019Era","year":"2006","unstructured":"Dall\u2019Era JE, Mills JN, Koul HK, Meacham RB . Penile rehabilitation after radical prostatectomy: important therapy or wishful thinking? Rev Urol 2006; 8: 209\u2013215.","journal-title":"Rev Urol"},{"key":"BFijir201427_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/j.1745-7262.2008.00366.x","volume":"10","author":"AR McCullough","year":"2008","unstructured":"McCullough AR . Rehabilitation of erectile function following radical prostatectomy. Asian J Androl 2008; 10: 61\u201374.","journal-title":"Asian J Androl"},{"key":"BFijir201427_CR3","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/j.1464-410X.2007.07409.x","volume":"101","author":"R Ayyathurai","year":"2008","unstructured":"Ayyathurai R, Manoharan M, Nieder AM, Kava B, Soloway MS . Factors affecting erectile function after radical retropubic prostatectomy: results from 1620 consecutive patients. BJU Int 2008; 101: 833\u2013836.","journal-title":"BJU Int"},{"key":"BFijir201427_CR4","first-page":"47","volume":"8","author":"AL Burnett","year":"2006","unstructured":"Burnett AL . Erectile function outcomes in the current era of anatomic nerve-sparing radical prostatectomy. Rev Urol 2006; 8: 47\u201353.","journal-title":"Rev Urol"},{"key":"BFijir201427_CR5","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.eururo.2006.06.009","volume":"50","author":"YD Dubbelman","year":"2006","unstructured":"Dubbelman YD, Dohle GR, Schr\u00f6der FH . Sexual function before and after radical retropubic prostatectomy: a systematic review of prognostic indicators for a successful outcome. Eur Urol 2006; 50: 711\u2013718.","journal-title":"Eur Urol"},{"key":"BFijir201427_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.ijir.3901353","volume":"18","author":"C Zippe","year":"2006","unstructured":"Zippe C, Nandipati K, Agarwal A, Raina R . Sexual dysfunction after pelvic surgery. Int J Impot Res 2006; 18: 1\u201318.","journal-title":"Int J Impot Res"},{"key":"BFijir201427_CR7","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/j.1743-6109.2007.00486.x","volume":"4","author":"JP Mulhall","year":"2007","unstructured":"Mulhall JP, Morgentaler A . Penile rehabilitation should become the norm for radical prostatectomy patients. J Sex Med 2007; 4: 538\u2013543.","journal-title":"J Sex Med"},{"key":"BFijir201427_CR8","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1016\/S0022-5347(01)64227-7","volume":"158","author":"F Montorsi","year":"1997","unstructured":"Montorsi F, Guazzoni G, Strambi LF, Da Pozzo LF, Nava L, Barbieri L et al. Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol 1997; 158: 1408\u20131410.","journal-title":"J Urol"},{"key":"BFijir201427_CR9","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1097\/01.ju.0000106970.97082.61","volume":"171","author":"EJ Schwartz","year":"2004","unstructured":"Schwartz EJ, Wong P, Graydon RJ . Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy. J Urol 2004; 171: 771\u2013774.","journal-title":"J Urol"},{"key":"BFijir201427_CR10","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1111\/j.1743-6109.2008.00794.x","volume":"5","author":"JP Mulhall","year":"2008","unstructured":"Mulhall JP, M\u00fcller A, Donohue JF, Mullerad M, Kobylarz K, Paduch DA et al. The functional and structural consequences of cavernous nerve injury are ameliorated by sildenafil citrate. J Sex Med 2008; 5: 1126\u20131136.","journal-title":"J Sex Med"},{"key":"BFijir201427_CR11","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.urology.2006.05.011","volume":"68","author":"MG Ferrini","year":"2006","unstructured":"Ferrini MG, Davila HH, Kovanecz I, Sanchez SP, Gonzales-Cadavid NF, Rajfer J . Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat. Urology 2006; 68: 429\u2013435.","journal-title":"Urology"},{"key":"BFijir201427_CR12","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1743-6109.2006.00208.x","volume":"3","author":"L Vignozzi","year":"2006","unstructured":"Vignozzi L, Filippi S, Morelli A, Ambrosini S, Luconi M, Vannelli GB et al. Effect of chronic tadalafil administration on penile hypoxia induced by cavernous neurotomy in the rat. J Sex Med 2006; 3: 419\u2013431.","journal-title":"J Sex Med"},{"key":"BFijir201427_CR13","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.2337\/diacare.25.8.1336","volume":"25","author":"C Desouza","year":"2002","unstructured":"Desouza C, Parulkar A, Lumpkin D, Akers D, Fonseca VA . Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes. Diabetes Care 2002; 25: 1336\u20131339.","journal-title":"Diabetes Care"},{"key":"BFijir201427_CR14","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1743-6109.2005.00081_1.x","volume":"2","author":"J Mulhall","year":"2005","unstructured":"Mulhall J, Land S, Parker M, Waters WB, Flanigan RC . The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2005; 2: 532\u2013542.","journal-title":"J Sex Med"},{"key":"BFijir201427_CR15","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1111\/j.1743-6109.2007.00482.x","volume":"4","author":"R Wang","year":"2007","unstructured":"Wang R . Penile rehabilitation after radical prostatectomy: where do we stand and where are we going? J Sex Med 2007; 4: 1085\u20131097.","journal-title":"J Sex Med"},{"key":"BFijir201427_CR16","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1111\/j.1743-6109.2007.00519.x","volume":"4","author":"G Lagoda","year":"2007","unstructured":"Lagoda G, Jin L, Lehrfeld TJ, Liu T, Burnet AL . FK506 and sildenafil promote erectile function recovery after cavernous nerve injury through anti-oxidative mechanisms. J Sex Med 2007; 4: 908\u2013916.","journal-title":"J Sex Med"},{"key":"BFijir201427_CR17","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1743-6109.2005.00081_1.x","volume":"3","author":"J Mulhall","year":"2005","unstructured":"Mulhall J, Land S, Parker M, Waters WB, Flanigan RC . The use of anerectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2005; 3: 532\u2013540.","journal-title":"J Sex Med"},{"key":"BFijir201427_CR18","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/j.1743-6109.2007.00670.x","volume":"5","author":"F Giuliano","year":"2008","unstructured":"Giuliano F, Amar E, Chevallier D, Montaigne O, Joubert JM, Chartier-Kastler E . How urologists manage erectile dysfunction after radical prostatectomy: a national survey (REPAIR) by the French urological association. J Sex Med 2008; 5: 448\u2013457.","journal-title":"J Sex Med"},{"key":"BFijir201427_CR19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1464-410X.2004.04602.x","volume":"93","author":"S Serni","year":"2004","unstructured":"Serni S, Masieri L, Lapini A, Nesi G, Carini M . A low incidence of positive surgical margins in prostate cancer at high risk of extracapsular extension after a modified anterograde radical prostatectomy. BJU Int 2004; 93: 279\u2013283.","journal-title":"BJU Int"},{"key":"BFijir201427_CR20","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S0022-5347(17)66044-0","volume":"81","author":"EW Campbell","year":"1959","unstructured":"Campbell EW . Total prostatectomy with preliminary ligation of the vascular pedicles. J Urol 1959; 81: 464\u2013467.","journal-title":"J Urol"},{"key":"BFijir201427_CR21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/sj.ijir.3900472","volume":"11","author":"RC Rosen","year":"1999","unstructured":"Rosen RC, Cappelleri JC, Smith MD, Lipsky J, Pe\u00f1a BM . Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11: 319\u2013326.","journal-title":"Int J Impot Res"},{"key":"BFijir201427_CR22","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/ijir.2008.33","volume":"20","author":"H Padma-Nathan","year":"2008","unstructured":"Padma-Nathan H, McCullough AR, Levine LA, Lipshultz LI, Siegel R, Montorsi F et alStudy Group. Randomized, double-blind, placebo-controlled study of postoperative nightly sildenafil citrate for the prevention of erectile dysfunction after bilateral nerve-sparing radical prostatectomy. Int J Impot Res 2008; 20: 479\u2013486.","journal-title":"Int J Impot Res"},{"key":"BFijir201427_CR23","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","volume":"49","author":"RC Rosen","year":"1997","unstructured":"Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mshra A . The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822\u2013830.","journal-title":"Urology"},{"key":"BFijir201427_CR24","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S0090-4295(99)00397-0","volume":"55","author":"PC Walsh","year":"2000","unstructured":"Walsh PC, Marschke P, Ricker D, Burnett AL . Patient-reported urinary continence and sexual function after anatomic radical prostatectomy. Urology 2000; 55: 58\u201361.","journal-title":"Urology"},{"key":"BFijir201427_CR25","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1016\/S0022-5347(06)00308-9","volume":"175","author":"A Bannowsky","year":"2006","unstructured":"Bannowsky A, Schulze H, van der Host C, Seif C, Braun PM, Junemann KP . Nocturnal tumescence: a parameter for postoperative erectile integrity after nerve sparing radical prostatectomy. J Urol 2006; 175: 2214\u20132217.","journal-title":"J Urol"},{"key":"BFijir201427_CR26","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/sj.ijir.3901448","volume":"18","author":"K Nandipati","year":"2006","unstructured":"Nandipati K, Raina R, Agarwal A, Zippe CD . Early combination therapy: intracavernosal injections and sildenafil following radical prostatectomy increases sexual activity and the return of natural erections. Int J Impot Res 2006; 18: 446\u2013451.","journal-title":"Int J Impot Res"},{"key":"BFijir201427_CR27","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1111\/j.1464-410X.2008.07515.x","volume":"101","author":"A Bannowsky","year":"2008","unstructured":"Bannowsky A, Schulze H, van der Horst C, Hautmann S, J\u00fcnemann KP . Recovery of erectile function after nerve-sparing radical prostatectomy: improvement with nightly low-dose sildenafil. BJU Int 2008; 101: 1279\u20131283.","journal-title":"BJU Int"},{"key":"BFijir201427_CR28","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/S0022-5347(05)67547-7","volume":"163","author":"PC Walsh","year":"2000","unstructured":"Walsh PC . Radical prostatectomy for localised prostate cancer provides durable cancer control with excellent quality of life: a structured debate. J Urol 2000; 163: 1802\u20131807.","journal-title":"J Urol"},{"key":"BFijir201427_CR29","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1016\/S0022-5347(05)64300-5","volume":"168","author":"R Katz","year":"2002","unstructured":"Katz R, Salomon L, Hoznek A, de la Taille A, Vordos D, Cicco A et al. Patient reported sexual function following laparoscopic radical prostatectomy. J Urol 2002; 168: 2078\u20132082.","journal-title":"J Urol"},{"key":"BFijir201427_CR30","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.eururo.2003.08.016","volume":"45","author":"F Montorsi","year":"2004","unstructured":"Montorsi F, Briganti A, Salonia A, Rigatti P, Burnett AL . Current and future strategies for preventing and managing erectile dysfunction following radical prostatectomy. Eur Urol 2004; 45: 123\u2013133.","journal-title":"Eur Urol"},{"key":"BFijir201427_CR31","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.eururo.2007.08.016","volume":"53","author":"A Salonia","year":"2008","unstructured":"Salonia A, Gallina A, Zanni G, Briganti A, Deh\u00f2 F, Sacc\u00e0 A et al. Acceptance of and discontinuation rate from erectile dysfunction oral treatment in patients following bilateral nerve-sparing radical prostatectomy. Eur Urol 2008; 53: 564\u2013570.","journal-title":"Eur Urol"},{"key":"BFijir201427_CR32","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/sj.ijir.3901379","volume":"18","author":"BP Jiann","year":"2006","unstructured":"Jiann BP, Yu CC, Su CC, Tsai JY . Compliance of sildenafil treatment for erectile dysfunction and factors affecting it. Int J Impot Res 2006; 18: 146\u2013149.","journal-title":"Int J Impot Res"},{"key":"BFijir201427_CR33","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.eururo.2008.06.083","volume":"54","author":"F Montorsi","year":"2008","unstructured":"Montorsi F, Brock G, Lee J, Shapiro J, Van Poppel H, Graefen M et al. Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve sparing radical prostatectomy. Eur Urol 2008; 54: 924\u2013931.","journal-title":"Eur Urol"}],"container-title":["International Journal of Impotence Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijir201427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir201427","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijir201427.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T15:11:12Z","timestamp":1648653072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijir201427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,24]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["BFijir201427"],"URL":"https:\/\/doi.org\/10.1038\/ijir.2014.27","relation":{},"ISSN":["0955-9930","1476-5489"],"issn-type":[{"value":"0955-9930","type":"print"},{"value":"1476-5489","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,24]]},"assertion":[{"value":"1 November 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}