{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:36:54Z","timestamp":1791920214889,"version":"4.3.4"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T00:00:00Z","timestamp":1246320000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1038\/ijo.2009.124","type":"journal-article","created":{"date-parts":[[2009,6,30]],"date-time":"2009-06-30T08:58:33Z","timestamp":1246352313000},"page":"857-865","source":"Crossref","is-referenced-by-count":78,"title":["A randomized double-blind placebo-controlled study of the long-term efficacy and safety of diethylpropion in the treatment of obese subjects"],"prefix":"10.1038","volume":"33","author":[{"given":"C","family":"Cercato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V A","family":"Roizenblatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C C","family":"Lean\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A P","family":"Lopes Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M C","family":"Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Halpern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,6,30]]},"reference":[{"key":"BFijo2009124_CR1","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1056\/NEJM199910073411501","volume":"341","author":"EE Calle","year":"1999","unstructured":"Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath Jr W . Body-mass index and mortality in a prospective cohort of US adults. N Engl J Med 1999; 341: 1097\u20131105.","journal-title":"N Engl J Med"},{"key":"BFijo2009124_CR2","doi-asserted-by":"publisher","first-page":"3145","DOI":"10.1161\/STROKEAHA.108.523001","volume":"39","author":"Y Winter","year":"2008","unstructured":"Winter Y, Rohrmann S, Linseisen J, Lanczik O, Ringleb PA, Hebebrand J et al. Contribution of obesity and abdominal fat mass to risk of stroke and transient ischemic attacks. Stroke 2008; 39: 3145\u20133151.","journal-title":"Stroke"},{"key":"BFijo2009124_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1590\/S0041-87812004000300004","volume":"59","author":"C Cercato","year":"2004","unstructured":"Cercato C, Mancini MC, Arguello AM, Passos VQ, Villares SM, Halpern A . Systemic hypertension, diabetes mellitus, and dyslipidemia in relation to body mass index: evaluation of a Brazilian population. Rev Hosp Clin Fac Med Sao Paulo 2004; 59: 113\u2013118.","journal-title":"Rev Hosp Clin Fac Med Sao Paulo"},{"key":"BFijo2009124_CR4","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.ecl.2008.08.004","volume":"37","author":"GA Bray","year":"2008","unstructured":"Bray GA . Medications for weight reduction. Endocrinol Metab Clin North Am 2008; 37: 923\u2013942.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"BFijo2009124_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1046\/j.1467-789X.2003.00083.x","volume":"4","author":"A Halpern","year":"2003","unstructured":"Halpern A, Mancini MC . Treatment of obesity: an update on anti-obesity medications. Obes Rev 2003; 4: 25\u201342.","journal-title":"Obes Rev"},{"key":"BFijo2009124_CR6","doi-asserted-by":"publisher","first-page":"820","DOI":"10.2165\/00003495-199243060-00003","volume":"43","author":"T Silverstone","year":"1992","unstructured":"Silverstone T . Appetite suppressants. A review. Drugs 1992; 43: 820\u2013836.","journal-title":"Drugs"},{"key":"BFijo2009124_CR7","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/S0033-3182(77)71101-6","volume":"18","author":"S Cohen","year":"1977","unstructured":"Cohen S . Diethylpropion (tenuate): an infrequently abused anorectic. Psychosomatics 1977; 18: 28\u201333.","journal-title":"Psychosomatics"},{"key":"BFijo2009124_CR8","doi-asserted-by":"publisher","first-page":"380","DOI":"10.7326\/0003-4819-143-5-200509060-00013","volume":"143","author":"E Colman","year":"2005","unstructured":"Colman E . Anorectics on trial: a half century of federal regulation of prescription appetite suppressants. Ann Intern Med 2005; 143: 380\u2013385.","journal-title":"Ann Intern Med"},{"key":"BFijo2009124_CR9","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/sj.ijo.0801889","volume":"26","author":"CK Haddock","year":"2002","unstructured":"Haddock CK, Poston WS, Dill PL, Foreyt JP, Ericsson M . Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials. Int J Obes Relat Metab Disord 2002; 26: 262\u2013273.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFijo2009124_CR10","doi-asserted-by":"publisher","first-page":"1814","DOI":"10.1001\/archinte.161.15.1814","volume":"161","author":"G Glazer","year":"2001","unstructured":"Glazer G . Long-term pharmacotherapy of obesity 2000: a review of efficacy and safety. Arch Intern Med 2001; 161: 1814\u20131824.","journal-title":"Arch Intern Med"},{"key":"BFijo2009124_CR11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1742-1241.1965.tb03144.x","volume":"19","author":"JJ Silverstone","year":"1965","unstructured":"Silverstone JJ, Solomon T . The long-term management of obesity in general practice. Br J Clin Pract 1965; 19: 395\u2013398.","journal-title":"Br J Clin Pract"},{"key":"BFijo2009124_CR12","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1185\/03007997309111712","volume":"1","author":"RHG McKay","year":"1973","unstructured":"McKay RHG . Long-term use of diethylpropion in obesity. Curr Med Res Opin 1973; 1: 489\u2013493.","journal-title":"Curr Med Res Opin"},{"key":"BFijo2009124_CR13","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412\u2013419.","journal-title":"Diabetologia"},{"key":"BFijo2009124_CR14","volume-title":"Common Statistical Methods for Clinical Research with SAS Examples","author":"GA Walker","year":"2002","unstructured":"Walker GA . Common Statistical Methods for Clinical Research with SAS Examples 2nd edn. SAS Institute: Cary, NC, 2002."},{"key":"BFijo2009124_CR15","volume-title":"Biostatistics: A Foundation for Analysis in the Health Sciences","author":"WW Daniel","year":"1995","unstructured":"Daniel WW . Biostatistics: A Foundation for Analysis in the Health Sciences 6th edn. Wiley: New York, 1995."},{"key":"BFijo2009124_CR16","volume-title":"Biostatistics\u2014A Methodology for the Health Sciences","author":"LD Fisher","year":"1993","unstructured":"Fisher LD, Van Belle G . Biostatistics\u2014A Methodology for the Health Sciences 1st edn. John Wiley & Sons: New York, 1993."},{"key":"BFijo2009124_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1177\/000992286700600607","volume":"6","author":"MC Andelman","year":"1967","unstructured":"Andelman MC, Jones C, Nathan S . Treatment of obesity in underprivileged adolescents: comparison of diethylpropion hydrochloride with placebo in a double-blind study. Clin Pediatr 1967; 6: 327\u2013330.","journal-title":"Clin Pediatr"},{"key":"BFijo2009124_CR18","first-page":"40","volume":"16","author":"OT Bolding","year":"1975","unstructured":"Bolding OT . Diethylpropion hydrochloride: an effective appetite supressant. Curr Ther Res 1975; 16: 40\u201348.","journal-title":"Curr Ther Res"},{"key":"BFijo2009124_CR19","first-page":"763","volume":"10","author":"PA Boileau","year":"1968","unstructured":"Boileau PA . Control of weight gain during pregnancy: use of dietylpropion hydrochloride. Appl Ther 1968; 10: 763\u2013765.","journal-title":"Appl Ther"},{"key":"BFijo2009124_CR20","first-page":"209","volume":"38","author":"OT Bolding","year":"1968","unstructured":"Bolding OT . A double-blind evaluation of tenuate dospan in overweight patients from a private gynecologic practice. J Med Assoc State of Alabama 1968; 38: 209\u2013212.","journal-title":"J Med Assoc State of Alabama"},{"key":"BFijo2009124_CR21","first-page":"437","volume":"17","author":"HG McQuarrie","year":"1975","unstructured":"McQuarrie HG . Clinical assessment of the use of an anorectic drug in a total weight reduction program. Curr Ther Res 1975; 17: 437\u2013443.","journal-title":"Curr Ther Res"},{"key":"BFijo2009124_CR22","first-page":"234","volume":"41","author":"R Abramson","year":"1980","unstructured":"Abramson R, Garg M, Cioffari A, Rotman PA . An evaluation of behavioral techniques reinforced with an anorectic drug in a double-blind weight loss study. J Clin Psychiatry 1980; 41: 234\u2013237.","journal-title":"J Clin Psychiatry"},{"key":"BFijo2009124_CR23","doi-asserted-by":"publisher","first-page":"532","DOI":"10.7326\/0003-4819-142-7-200504050-00012","volume":"142","author":"Z Li","year":"2005","unstructured":"Li Z, Maglione M, Tu W, Mojica W, Arterburn D, Shugarman LR et al. Meta-analysis: pharmacologic treatment of obesity. Ann Intern Med 2005; 142: 532\u2013546.","journal-title":"Ann Intern Med"},{"key":"BFijo2009124_CR24","first-page":"21","volume":"43","author":"W Coutinho","year":"1999","unstructured":"Coutinho W . Consenso Latino-Americano de obesidade Arq. bras. Endocrinol Metab 1999; 43: 21\u201367.","journal-title":"Endocrinol Metab"},{"key":"BFijo2009124_CR25","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1136\/bmj.39385.413113.25","volume":"335","author":"D Rucker","year":"2007","unstructured":"Rucker D, Padwal R, Li SK, Curioni C, Lau DC . Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ 2007; 335: 1194\u20131199.","journal-title":"BMJ"},{"key":"BFijo2009124_CR26","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1016\/S0140-6736(08)61525-1","volume":"372","author":"A Astrup","year":"2008","unstructured":"Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM . Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet 2008; 372: 1906\u20131913.","journal-title":"Lancet"},{"key":"BFijo2009124_CR27","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1093\/ajcn\/51.3.331","volume":"51","author":"A Astrup","year":"1990","unstructured":"Astrup A, Andersen T, Christensen NJ, B\u00fclow J, Madsen J, Breum L et al. Impaired glucose-induced thermogenesis and arterial norepinephrine response persist after weight reduction in obese humans. Am J Clin Nutr 1990; 51: 331\u2013337.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2009124_CR28","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1093\/ajcn\/87.6.1596","volume":"87","author":"A Flaa","year":"2008","unstructured":"Flaa A, Sandvik L, Kjeldsen SE, Eide IK, Rostrup M . Does sympathoadrenal activity predict changes in body fat? An 18-y follow-up study. Am J Clin Nutr 2008; 87: 1596\u20131601.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2009124_CR29","first-page":"398","volume":"16","author":"YK Seedat","year":"1974","unstructured":"Seedat YK, Reddy J . Diethylpropion hydrochloride (Tenuate Dospan) in combination with hypotensive agents in the treatment of obesity associated with hypertension. Curr Ther Res Clin Exp 1974; 16: 398\u2013413.","journal-title":"Curr Ther Res Clin Exp"},{"key":"BFijo2009124_CR30","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1097\/00000441-196604000-00010","volume":"251","author":"HI Russek","year":"1966","unstructured":"Russek HI . Control of obesity in patients with angina pectoris: a double-blind study with diethylpropion hydrochloride. Am J Med Sci 1966; 251: 461\u2013464.","journal-title":"Am J Med Sci"},{"key":"BFijo2009124_CR31","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1056\/NEJM199608293350901","volume":"29","author":"L Abenhaim","year":"1996","unstructured":"Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X et al. Appetite supressant drugs and the risk of primary pulmonary hypertension. International Primary Pulmonary Hypertension Study Group. N Engl J Med 1996; 29: 609\u2013616.","journal-title":"N Engl J Med"},{"key":"BFijo2009124_CR32","first-page":"160","volume":"27","author":"HP Gurtner","year":"1985","unstructured":"Gurtner HP . Aminorex and pulmonary hypertension. A review. Cor Vasa 1985; 27: 160\u2013171.","journal-title":"Cor Vasa"},{"key":"BFijo2009124_CR33","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S0895-4356(97)00289-8","volume":"51","author":"MS Kramer","year":"1998","unstructured":"Kramer MS, Lane DA . Aminorex, dexfenfluramine, and primary pulmonary hypertension. J Clin Epidemiol 1998; 51: 361\u2013364.","journal-title":"J Clin Epidemiol"},{"key":"BFijo2009124_CR34","first-page":"963","volume":"5","author":"HL Wang","year":"2004","unstructured":"Wang HL . The serotonin receptor and transporter as potential therapeutic targets for pulmonary hypertension. Curr Opin Investig Drugs 2004; 5: 963\u2013966.","journal-title":"Curr Opin Investig Drugs"},{"key":"BFijo2009124_CR35","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1183\/09031936.03.00095303","volume":"22","author":"MJ Abramowicz","year":"2003","unstructured":"Abramowicz MJ, Van Haecke P, Demedts M, Delcroix M . Primary pulmonary hypertension after amfepramone (diethylpropion) with BMPR2 mutation. Eur Respir J 2003; 22: 560\u2013562.","journal-title":"Eur Respir J"},{"key":"BFijo2009124_CR36","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1136\/hrt.74.6.660","volume":"74","author":"SH Thomas","year":"1995","unstructured":"Thomas SH, Butt AY, Corris PA, Egan JJ, Higenbottam TW, Madden BP et al. Appetite suppressants and primary pulmonary hypertension in the United Kingdom. Br Heart J 1995; 74: 660\u2013663.","journal-title":"Br Heart J"},{"key":"BFijo2009124_CR37","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1111\/j.1600-0773.1977.tb02142.x","volume":"41","author":"S Fristr\u00f6m","year":"1977","unstructured":"Fristr\u00f6m S, Airaksinen MM, Halmekoski J . Release of platelet 5-hydroxytryptamine by some anorexic and other sympathomimetics and their acetyl derivatives. Acta Pharmacol Toxicol (Copenh) 1977; 41: 218\u2013224.","journal-title":"Acta Pharmacol Toxicol (Copenh)"},{"key":"BFijo2009124_CR38","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.5858\/2008-132-1397-PACCOO","volume":"132","author":"AK Haque","year":"2008","unstructured":"Haque AK, Gadre S, Taylor J, Haque SA, Freeman D, Duarte A . Pulmonary and cardiovascular complications of obesity: an autopsy study of 76 obese subjects. Arch Pathol Lab Med 2008; 132: 1397\u20131404.","journal-title":"Arch Pathol Lab Med"},{"key":"BFijo2009124_CR39","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/j.1467-789X.2008.00478.x","volume":"9","author":"AG de Sousa","year":"2008","unstructured":"de Sousa AG, Cercato C, Mancini MC, Halpern A . Obesity and obstructive sleep apnea-hypopnea syndrome. Obes Rev 2008; 9: 340\u2013354.","journal-title":"Obes Rev"},{"key":"BFijo2009124_CR40","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1089\/ars.2007.1587","volume":"9","author":"IR Preston","year":"2007","unstructured":"Preston IR . Clinical perspective of hypoxia-mediated pulmonary hypertension. Antioxid Redox Signal 2007; 9: 711\u2013721.","journal-title":"Antioxid Redox Signal"},{"key":"BFijo2009124_CR41","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1038\/sj.ijo.0802475","volume":"27","author":"R Padwal","year":"2003","unstructured":"Padwal R, Li S, Lau D . Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes Relat Metab Disord 2003; 27: 1437\u20131446.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFijo2009124_CR42","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1046\/j.1467-789X.2003.00109.x","volume":"4","author":"GL Gadbury","year":"2003","unstructured":"Gadbury GL, Coffey CS, Allison DB . Modern statistical methods for handling missing repeated measurements in obesity trial data: beyond LOCF. Obes Rev 2003; 4: 175\u2013184.","journal-title":"Obes Rev"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo2009124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2009124","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2009124.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T20:57:26Z","timestamp":1685048246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo2009124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,30]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["BFijo2009124"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2009.124","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,30]]}}}