{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:15:12Z","timestamp":1771460112322,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T00:00:00Z","timestamp":1253577600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1038\/ijo.2009.182","type":"journal-article","created":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T08:59:52Z","timestamp":1253609992000},"page":"1348-1355","source":"Crossref","is-referenced-by-count":29,"title":["Capsiate administration results in an uncoupling protein-3 downregulation, an enhanced muscle oxidative capacity and a decreased abdominal fat content in vivo"],"prefix":"10.1038","volume":"33","author":[{"given":"B","family":"Faraut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Giannesini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Matarazzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Le Fur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Rougon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Cozzone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Bendahan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,9,22]]},"reference":[{"key":"BFijo2009182_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1006\/bbrc.1997.6740","volume":"235","author":"A Vidal-Puig","year":"1997","unstructured":"Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB . UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 1997; 235: 79\u201382.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFijo2009182_CR2","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1079\/PNS2003277","volume":"62","author":"P Schrauwen","year":"2003","unstructured":"Schrauwen P, Hesselink M . Uncoupling protein 3 and physical activity: the role of uncoupling protein 3 in energy metabolism revisited. Proc Nutr Soc 2003; 62: 635\u2013643.","journal-title":"Proc Nutr Soc"},{"key":"BFijo2009182_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cmet.2005.06.002","volume":"2","author":"MD Brand","year":"2005","unstructured":"Brand MD, Esteves TC. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab 2005; 2: 85\u201393.","journal-title":"Cell Metab"},{"key":"BFijo2009182_CR4","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1096\/fj.03-0515fje","volume":"17","author":"P Schrauwen","year":"2003","unstructured":"Schrauwen P, Hoeks J, Schaart E, Kornips B, Binas B, Van De Vusse GJ et al. Uncoupling protein 3 as a mitochondrial fatty acid anion exporter. FASEB J 2003; 17: 2272\u20132274.","journal-title":"FASEB J"},{"key":"BFijo2009182_CR5","doi-asserted-by":"publisher","first-page":"E1474","DOI":"10.1152\/ajpendo.00292.2006","volume":"292","author":"B Faraut","year":"2007","unstructured":"Faraut B, Giannesini B, Matarazzo V, Marqueste T, Dalamasso C, Rougon G et al. Downregulation of uncoupling protein-3 is linked to changes in muscle mitochondrial energy metabolism in vivo as a result of capsiate administration. Am J Physiol Endocrinol Metab 2007; 292: E1474\u2013E1482.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2009182_CR6","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1271\/bbb.65.2033","volume":"65","author":"K Ohnuki","year":"2001","unstructured":"Ohnuki K, Niwa S, Maeda S, Inoue N, Yazawa S, Fushiki T et al. CH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. Biosci Biotechnol Biochem 2001; 65: 2033\u20132036.","journal-title":"Biosci Biotechnol Biochem"},{"key":"BFijo2009182_CR7","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1002\/mrm.20637","volume":"54","author":"B Giannesini","year":"2005","unstructured":"Giannesini B, Izquierdo M, Le Fur Y, Cozzone PJ, Fingerle J, Himber J et al. New experimental setup for studying strictly noninvasively skeletal muscle function in rat using 1H-magnetic resonance (MR) imaging and 31P-MR spectroscopy. Magn Reson Med 2005; 54: 1058\u20131064.","journal-title":"Magn Reson Med"},{"key":"BFijo2009182_CR8","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1271\/bbb.66.319","volume":"66","author":"K Kobata","year":"2002","unstructured":"Kobata K, Kawaguchi M, Watanabe T . Enzymatic synthesis of a capsinoid by the acylation of vanillyl alcohol with fatty acid derivatives catalyzed by lipases. Biosci Biotechnol Biochem 2002; 66: 319\u2013327.","journal-title":"Biosci Biotechnol Biochem"},{"key":"BFijo2009182_CR9","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1271\/bbb.65.2735","volume":"65","author":"K Ohnuki","year":"2001","unstructured":"Ohnuki K, Haramizu S, Oki K, Watanabe T, Yazawa S, Fushiki T . Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice. Biosci Biotechnol Biochem 2001; 65: 2735\u20132740.","journal-title":"Biosci Biotechnol Biochem"},{"key":"BFijo2009182_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1006\/jmre.1997.1244","volume":"129","author":"L Vanhamme","year":"1997","unstructured":"Vanhamme L, van den Boogaart A, Van Huffel S . Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 1997; 129: 35\u201343.","journal-title":"J Magn Reson"},{"key":"BFijo2009182_CR11","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1002\/mrm.1910010303","volume":"1","author":"DL Arnold","year":"1984","unstructured":"Arnold DL, Matthews PM, Radda GK . Metabolic recovery after exercise and the assessment of mitochondrial function in vivo in human skeletal muscle by means of 31P NMR. Magn Reson Med 1984; 1: 307\u2013315.","journal-title":"Magn Reson Med"},{"key":"BFijo2009182_CR12","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1152\/japplphysiol.00828.2002","volume":"95","author":"Y Masuda","year":"2003","unstructured":"Masuda Y, Haramizu S, Oki K, Ohnuki K, Yazawa S, Kawada T et al. Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J Appl Physiol 2003; 95: 2408\u20132415.","journal-title":"J Appl Physiol"},{"key":"BFijo2009182_CR13","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1046\/j.1365-201X.2003.01167.x","volume":"178","author":"MD Jensen","year":"2003","unstructured":"Jensen MD . Fate of fatty acids at rest and during exercise: regulatory mechanisms. Acta Physiol Scand 2003; 178: 385\u2013390.","journal-title":"Acta Physiol Scand"},{"key":"BFijo2009182_CR14","doi-asserted-by":"publisher","first-page":"16251","DOI":"10.1074\/jbc.M910177199","volume":"275","author":"DW Gong","year":"2000","unstructured":"Gong DW, Monemdjou S, Gavrilova O, Leon LR, Marcus-Samuels B, Chou CJ et al. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem 2000; 275: 16251\u201316257.","journal-title":"J Biol Chem"},{"key":"BFijo2009182_CR15","doi-asserted-by":"publisher","first-page":"20240","DOI":"10.1074\/jbc.M102540200","volume":"276","author":"GW Cline","year":"2001","unstructured":"Cline GW, Vidal-Puig AJ, Dufour S, Cadman KS, Lowell BB, Shulman GI et al. In vivo effects of uncoupling protein-3 gene disruption on mitochondrial energy metabolism. J Biol Chem 2001; 276: 20240\u201320244.","journal-title":"J Biol Chem"},{"key":"BFijo2009182_CR16","doi-asserted-by":"publisher","first-page":"16258","DOI":"10.1074\/jbc.M910179199","volume":"275","author":"AJ Vidal-Puig","year":"2000","unstructured":"Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y et al. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem 2000; 275: 16258\u201316266.","journal-title":"J Biol Chem"},{"key":"BFijo2009182_CR17","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/35019082","volume":"406","author":"JC Clapham","year":"2000","unstructured":"Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 2000; 406: 415\u2013418.","journal-title":"Nature"},{"key":"BFijo2009182_CR18","doi-asserted-by":"publisher","first-page":"E1304","DOI":"10.1152\/ajpendo.00401.2005","volume":"290","author":"SR Costford","year":"2006","unstructured":"Costford SR, Chaudhry SN, Salkhordeh M, Harper ME . Effects of the presence, absence, and overexpression of uncoupling protein-3 on adiposity and fuel metabolism in congenic mice. Am J Physiol Endocrinol Metab 2006; 290: E1304\u2013E1312.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2009182_CR19","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/0026-0495(87)90063-1","volume":"36","author":"S Fujioka","year":"1987","unstructured":"Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S . Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 1987; 36: 54\u201359.","journal-title":"Metabolism"},{"key":"BFijo2009182_CR20","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1152\/jappl.1991.70.5.2164","volume":"70","author":"R Ross","year":"1991","unstructured":"Ross R, Leger L, Guardo R, De Guise J, Pike BG . Adipose tissue volume measured by magnetic resonance imaging and computerized tomography in rats. J Appl Physiol 1991; 70: 2164\u20132172.","journal-title":"J Appl Physiol"},{"key":"BFijo2009182_CR21","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1038\/oby.2003.91","volume":"11","author":"G Mingrone","year":"2003","unstructured":"Mingrone G, Rosa G, Greco AV, Manco M, Vega N, Hesselink MK et al. Decreased uncoupling protein expression and intramyocytic triglyceride depletion in formerly obese subjects. Obes Res 2003; 11: 632\u2013640.","journal-title":"Obes Res"},{"key":"BFijo2009182_CR22","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1007\/s001250051547","volume":"43","author":"P Schrauwen","year":"2000","unstructured":"Schrauwen P, Schaart G, Saris WH, Slieker LJ, Glatz JF, Vidal H et al. The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in type II diabetic subjects. Diabetologia 2000; 43: 1408\u20131416.","journal-title":"Diabetologia"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo2009182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2009182","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2009182.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:20:30Z","timestamp":1684430430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo2009182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9,22]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["BFijo2009182"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2009.182","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9,22]]}}}