{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:30:06Z","timestamp":1789702206363,"version":"4.0.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T00:00:00Z","timestamp":1263254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1038\/ijo.2009.277","type":"journal-article","created":{"date-parts":[[2010,1,12]],"date-time":"2010-01-12T10:29:47Z","timestamp":1263292187000},"page":"712-719","source":"Crossref","is-referenced-by-count":45,"title":["Bifidobacterium as an oral delivery carrier of oxyntomodulin for obesity therapy: inhibitory effects on food intake and body weight in overweight mice"],"prefix":"10.1038","volume":"34","author":[{"given":"R T","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W S","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Y","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y Z","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q S","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Q","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,1,12]]},"reference":[{"key":"BFijo2009277_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0014-5793(82)80709-6","volume":"146","author":"D Bataille","year":"1982","unstructured":"Bataille D, Tatemoto K, Gespach C, Jornvall H, Rosselin G, Mutt V . Isolation of glucagon-37 (bioactive enteroglucagon\/oxyntomodulin) from porcine jejuno-ileum. Characterization of the peptide. FEBS Lett 1982; 146: 79\u201386.","journal-title":"FEBS Lett"},{"key":"BFijo2009277_CR2","doi-asserted-by":"crossref","first-page":"11880","DOI":"10.1016\/S0021-9258(18)67324-7","volume":"261","author":"S Mojsov","year":"1986","unstructured":"Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF . Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem 1986; 261: 11880\u201311889.","journal-title":"J Biol Chem"},{"key":"BFijo2009277_CR3","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1210\/endo-126-1-110","volume":"126","author":"EY Lui","year":"1990","unstructured":"Lui EY, Asa SL, Drucker DJ, Lee YC, Brubaker PL . Glucagon and related peptides in fetal rat hypothalamus in vivo and in vitro. Endocrinology 1990; 126: 110\u2013117.","journal-title":"Endocrinology"},{"key":"BFijo2009277_CR4","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/BF01119301","volume":"2","author":"M Dubrasquet","year":"1982","unstructured":"Dubrasquet M, Bataille D, Gespach C . Oxyntomodulin (glucagon-37 or bioactive enteroglucagon): a potent inhibitor of pentagastrin-stimulated acid secretion in rats. Biosci Rep 1982; 2: 391\u2013395.","journal-title":"Biosci Rep"},{"key":"BFijo2009277_CR5","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1007\/BF01538078","volume":"34","author":"B Schjoldager","year":"1989","unstructured":"Schjoldager B, Mortensen PE, Myhre J, Christiansen J, Holst JJ . Oxyntomodulin from distal gut. Role in regulation of gastric and pancreatic functions. Dig Dis Sci 1989; 34: 1411\u20131419.","journal-title":"Dig Dis Sci"},{"key":"BFijo2009277_CR6","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1210\/jcem-57-3-488","volume":"57","author":"MA Ghatei","year":"1983","unstructured":"Ghatei MA, Uttenthal LO, Christofides ND, Bryant MG, Bloom SR . Molecular forms of human enteroglucagon in tissue and plasma: plasma responses to nutrient stimuli in health and in disorders of the upper gastrointestinal tract. J Clin Endocrinol Metab 1983; 57: 488\u2013495.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2009277_CR7","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1136\/bmj.2.6200.1252","volume":"2","author":"HS Besterman","year":"1979","unstructured":"Besterman HS, Cook GC, Sarson DL, Christofides ND, Bryant MG, Gregor M et al. Gut hormones in tropical malabsorption. Br Med J 1979; 2: 1252\u20131255.","journal-title":"Br Med J"},{"key":"BFijo2009277_CR8","first-page":"471","volume":"5","author":"DL Sarson","year":"1981","unstructured":"Sarson DL, Scopinaro N, Bloom SR . Gut hormone changes after jejunoileal (JIB) or biliopancreatic (BPB) bypass surgery for morbid obesity. Int J Obes 1981; 5: 471\u2013480.","journal-title":"Int J Obes"},{"key":"BFijo2009277_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3109\/00365527909179871","volume":"14","author":"JJ Holst","year":"1979","unstructured":"Holst JJ, Sorensen TI, Andersen AN, Stadil F, Andersen B, Lauritsen KB et al. Plasma enteroglucagon after jejunoileal bypass with 3:1 or 1:3 jejunoileal ratio. Scand J Gastroenterol 1979; 14: 205\u2013207.","journal-title":"Scand J Gastroenterol"},{"key":"BFijo2009277_CR10","doi-asserted-by":"publisher","first-page":"4244","DOI":"10.1210\/endo.142.10.8430","volume":"142","author":"CL Dakin","year":"2001","unstructured":"Dakin CL, Gunn I, Small CJ, Edwards CM, Hay DL, Smith DM et al. Oxyntomodulin inhibits food intake in the rat. Endocrinology 2001; 142: 4244\u20134250.","journal-title":"Endocrinology"},{"key":"BFijo2009277_CR11","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1210\/en.2003-1338","volume":"145","author":"CL Dakin","year":"2004","unstructured":"Dakin CL, Small CJ, Batterham RL, Neary NM, Cohen MA, Patterson M et al. Peripheral oxyntomodulin reduces food intake and body weight gain in rats. Endocrinology 2004; 145: 2687\u20132695.","journal-title":"Endocrinology"},{"key":"BFijo2009277_CR12","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.2337\/diabetes.54.8.2390","volume":"54","author":"K Wynne","year":"2005","unstructured":"Wynne K, Park AJ, Small CJ, Patterson M, Ellis SM, Murphy KG et al. Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes 2005; 54: 2390\u20132395.","journal-title":"Diabetes"},{"key":"BFijo2009277_CR13","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1053\/j.gastro.2004.04.063","volume":"127","author":"LL Baggio","year":"2004","unstructured":"Baggio LL, Huang Q, Brown TJ, Drucker DJ . Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 2004; 127: 546\u2013558.","journal-title":"Gastroenterology"},{"key":"BFijo2009277_CR14","first-page":"25","volume":"6","author":"K Wynne","year":"2007","unstructured":"Wynne K, Bloom S . Oxyntomodulin: a new therapy for obesity? Sci Sch Autumn 2007; 6: 25\u201329.","journal-title":"Sci Sch Autumn"},{"key":"BFijo2009277_CR15","first-page":"32","volume":"45","author":"C De Simone","year":"1991","unstructured":"De Simone C, Rosati E, Moretti S, Salvadori B, Vesely R, Jirillo E . Probiotics and stimulation of the immune response. Eur J Clin Nutr 1991; 45: 32\u201334.","journal-title":"Eur J Clin Nutr"},{"key":"BFijo2009277_CR16","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1001\/jama.1996.03530350052034","volume":"275","author":"GW Elmer","year":"1996","unstructured":"Elmer GW, Surawicz CM, McFarl LV . Biotherapeutic agents. A neglected modality for the treatment and prevention of selected intestinal and vaginal infections. JAMA 1996; 275: 870\u20138766.","journal-title":"JAMA"},{"key":"BFijo2009277_CR17","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0027-5107(94)90182-1","volume":"311","author":"K Orrhage","year":"1994","unstructured":"Orrhage K, Sillerstrom E, Gustafsson JA, Nord CE, Rafter J . Binding of mutagenic heterocyclic amines by intestinal and lactic acid bacteria. Mutat Res 1994; 311: 239\u2013248.","journal-title":"Mutat Res"},{"key":"BFijo2009277_CR18","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1093\/carcin\/18.4.833","volume":"18","author":"J Singh","year":"1997","unstructured":"Singh J, Rivenson A, Tomita M, Shimamura S, Ishibashi N, Reddy BS . Bifidobacterium longum, a lactic acid-producing intestinal bacterium inhibits colon cancer and modulates the intermediate biomarkers of colon carcinogenesis. Carcinogenesis 1997; 18: 833\u2013841.","journal-title":"Carcinogenesis"},{"key":"BFijo2009277_CR19","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1271\/bbb.66.2362","volume":"66","author":"T Nakamura","year":"2002","unstructured":"Nakamura T, Sasaki T, Fujimori M . Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme\/pro-drug therapy of hypoxic solid tumors. Biosci Biotechnol Biochem 2002; 66: 2362\u20132366.","journal-title":"Biosci Biotechnol Biochem"},{"key":"BFijo2009277_CR20","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/sj.cgt.7700530","volume":"10","author":"X Li","year":"2003","unstructured":"Li X, Fu GF, Fan YR, Liu WH, Liu XJ, Wang JJ et al. Bifidobacterium adolescentis as a delivery system of endostatin for cancer gene therapy: selective inhibitor of angiogenesis and hypoxic tumor growth. Cancer Gene Ther 2003; 10: 105\u2013111.","journal-title":"Cancer Gene Ther"},{"key":"BFijo2009277_CR21","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1007\/s10529-007-9376-8","volume":"29","author":"MLR Escogido","year":"2007","unstructured":"Escogido MLR, Rodr\u00edguez ADL, de la Rosa APB . A novel binary expression vector for production of human IL-10 in Escherichia coli and Bifidobacterium longum. Biotechnol Lett 2007; 29: 1249\u20131253.","journal-title":"Biotechnol Lett"},{"key":"BFijo2009277_CR22","doi-asserted-by":"publisher","first-page":"5630","DOI":"10.1128\/AEM.71.9.5630-5632.2005","volume":"72","author":"GS Moon","year":"2005","unstructured":"Moon GS, Pyun YR, Park MS, Ji GE, Kim WJ . Secretion of recombinant pediocin PA-1 by Bifidobacterium longum, Using the signal sequence for bifidobacterial \u03b1-amylase. Appl Environ Microbiol 2005; 72: 5630\u20135632.","journal-title":"Appl Environ Microbiol"},{"key":"BFijo2009277_CR23","first-page":"321","volume":"19","author":"ZS Zhu","year":"2007","unstructured":"Zhu ZS, Wang LS, Zeng WS, Zheng YJ, Luo SQ, Li YX et al. Isolation and identification of a Bifidobacterium strain with a plasmid polymerase by PCR. J Microecol (China) 2007; 19: 321\u2013323.","journal-title":"J Microecol (China)"},{"key":"BFijo2009277_CR24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1099\/13500872-142-1-109","volume":"142","author":"A Argnani","year":"1996","unstructured":"Argnani A, Leer RJ, van Luijk N, Pouwels PH . A convenient and reproducible method to genetically transform bacteria of the genus Bifidobacterium. Microbiology 1996; 142: 109\u2013114.","journal-title":"Microbiology"},{"key":"BFijo2009277_CR25","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1093\/ajcn\/71.2.405","volume":"71","author":"NM De Roos","year":"2000","unstructured":"De Roos NM, Katan MB . Effects of probiotic bacteria on diarrhea, lipid metabolism, and carcinogenesis: a review of papers published between 1988 and 1998. Am J Clin Nutr 2000; 71: 405\u2013411.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2009277_CR26","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.3168\/jds.S0022-0302(03)73839-9","volume":"86","author":"JZ Xiao","year":"2003","unstructured":"Xiao JZ, Kondo S, Takahashi N, Miyaji K, Oshida K, Hiramatsu A et al. Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci 2003; 86: 2452\u20132461.","journal-title":"J Dairy Sci"},{"key":"BFijo2009277_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000203284","volume":"54","author":"A Ataie-Jafari","year":"2009","unstructured":"Ataie-Jafari A, Larijani B, Majd HA, Tahbaz F . Cholesterol-lowering effect of probiotic yogurt in comparison with ordinary yogurt in mildly to moderately hypercholesterolemic subjects. Ann Nutr Metab 2009; 54: 22\u201327.","journal-title":"Ann Nutr Metab"},{"key":"BFijo2009277_CR28","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1152\/ajpgi.1997.273.1.G139","volume":"273","author":"JV Castell","year":"1997","unstructured":"Castell JV, Friedrich G, Kuhn CS, Poppe GE . Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake. Gastrointest Liver Physiol 1997; 273: 139\u2013146.","journal-title":"Gastrointest Liver Physiol"},{"key":"BFijo2009277_CR29","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/ajcn\/27.3.276","volume":"27","author":"BS Worthington","year":"1974","unstructured":"Worthington BS, Boatman ES, Kenny GE . Intestinal absorption of intact proteins in normal and protein-deficient rats. Am J Clin Nutr 1974; 27: 276\u2013286.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2009277_CR30","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1210\/endo.133.2.8102095","volume":"133","author":"L Gros","year":"1993","unstructured":"Gros L, Thorens B, Bataille D, Kervran A . Glucagon-like peptide-1-(7\u201336) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line. Endocrinology 1993; 133: 631\u2013638.","journal-title":"Endocrinology"},{"key":"BFijo2009277_CR31","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1159\/000201367","volume":"57","author":"W Schepp","year":"1996","unstructured":"Schepp W, Dehne K, Riedel T, Schmidtler J, Schaffer K, Classen M . Oxyntomodulin: a cAMP-dependent stimulus of rat parietal cell function via the receptor for glucagon-like peptide-1 (7\u201336) NH2. Digestion 1996; 57: 398\u2013405.","journal-title":"Digestion"},{"key":"BFijo2009277_CR32","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0014-5793(94)01430-9","volume":"358","author":"Y Wei","year":"1995","unstructured":"Wei Y, Mojsov S . Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett 1995; 358: 219\u2013224.","journal-title":"FEBS Lett"},{"key":"BFijo2009277_CR33","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1210\/endo.137.7.8770921","volume":"137","author":"B Bullock","year":"1996","unstructured":"Bullock B, Heller R, Habener J . Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology 1996; 137: 2968\u20132978.","journal-title":"Endocrinology"},{"key":"BFijo2009277_CR34","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1152\/ajpregu.1992.263.3.R591","volume":"263","author":"CW Lin","year":"1992","unstructured":"Lin CW, Miller TR . Both CCK-A and CCK-B\/gastrin receptors are present on rabbit vagus nerve. Am J Physiol Regul Integr Comp Physiol 1992; 263: 591\u2013595.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFijo2009277_CR35","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0006-8993(91)90248-T","volume":"553","author":"ES Corp","year":"1991","unstructured":"Corp ES, Smith GP . Characterization of axonally transported [125I]PYY binding sites in rat vagus nerve. Brain Res 1991; 553: 175\u2013179.","journal-title":"Brain Res"},{"key":"BFijo2009277_CR36","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/00006676-200005000-00003","volume":"20","author":"Y Anini","year":"2000","unstructured":"Anini Y, Jarrousse C, Chariot J, Nagain C, Yanaihara N, Sasaki K et al. xyntomodulin inhibits pancreatic secretion through the nervous system in rats. Pancreas 2000; 20: 348\u2013360.","journal-title":"Pancreas"},{"key":"BFijo2009277_CR37","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.2337\/diabetes.50.8.1714","volume":"50","author":"DE Cummings","year":"2001","unstructured":"Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS . A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001; 50: 1714\u20131719.","journal-title":"Diabetes"},{"key":"BFijo2009277_CR38","doi-asserted-by":"publisher","first-page":"E297","DOI":"10.1152\/ajpendo.00582.2003","volume":"287","author":"DE Cummings","year":"2004","unstructured":"Cummings DE, Frayo RS, Marmonier C, Aubert R, Chapelot D . Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues. Am J Physiol Endocrinol Metab 2004; 287: E297\u2013E304.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2009277_CR39","doi-asserted-by":"publisher","first-page":"E1173","DOI":"10.1152\/ajpendo.00233.2002","volume":"283","author":"CL Dakin","year":"2002","unstructured":"Dakin CL, Small CJ, Park AJ, Seth A, Ghatei MA, Bloom SR . Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats. Am J Physiol Endocrinol Metab 2002; 283: E1173\u2013E1177.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2009277_CR40","doi-asserted-by":"publisher","first-page":"3513","DOI":"10.1210\/en.2008-0796","volume":"150","author":"M Patterson","year":"2009","unstructured":"Patterson M, Murphy KG, Patel SR, Patel NA, Greenwood HC, Cooke JH et al. Hypothalamic injection of oxyntomodulin suppresses circulating ghrelin-like immunoreactivity. Endocrinology 2009; 150: 3513\u20133520.","journal-title":"Endocrinology"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo2009277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2009277","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2009277.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:21:33Z","timestamp":1684430493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo2009277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,12]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["BFijo2009277"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2009.277","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,12]]}}}