{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:16:55Z","timestamp":1793823415913,"version":"4.6.1"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T00:00:00Z","timestamp":1286236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1038\/ijo.2010.171","type":"journal-article","created":{"date-parts":[[2010,10,5]],"date-time":"2010-10-05T05:48:07Z","timestamp":1286257687000},"page":"714-727","source":"Crossref","is-referenced-by-count":699,"title":["The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women"],"prefix":"10.1038","volume":"35","author":[{"given":"M N","family":"Harvie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Pegington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M P","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Frystyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Dillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Cuzick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S A","family":"Jebb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R G","family":"Cutler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T G","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Maudsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O D","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Egan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Flyvbjerg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,5]]},"reference":[{"key":"BFijo2010171_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.7326\/0003-4819-122-7-199504010-00001","volume":"122","author":"GA Colditz","year":"1995","unstructured":"Colditz GA, Willett WC, Rotnitzky A, Manson JE . Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 1995; 122: 481\u2013486.","journal-title":"Ann Intern Med"},{"key":"BFijo2010171_CR2","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1001\/jama.1995.03520300035033","volume":"273","author":"WC Willett","year":"1995","unstructured":"Willett WC, Manson JE, Stampfer MJ, Colditz GA, Rosner B, Speizer FE et al. Weight, weight change, and coronary heart disease in women. Risk within the \u2018normal\u2019 weight range. JAMA 1995; 273: 461\u2013465.","journal-title":"JAMA"},{"key":"BFijo2010171_CR3","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1467-789X.2008.00473.x","volume":"9","author":"MA Beydoun","year":"2008","unstructured":"Beydoun MA, Beydoun HA, Wang Y . Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev 2008; 9: 204\u2013218.","journal-title":"Obes Rev"},{"key":"BFijo2010171_CR4","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S0140-6736(08)60269-X","volume":"371","author":"AG Renehan","year":"2008","unstructured":"Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M . Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008; 371: 569\u2013578.","journal-title":"Lancet"},{"key":"BFijo2010171_CR5","doi-asserted-by":"publisher","first-page":"24","DOI":"10.7326\/0003-4819-138-1-200301070-00008","volume":"138","author":"A Peeters","year":"2003","unstructured":"Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al Mamun A, Bonneux L . Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med 2003; 138: 24\u201332.","journal-title":"Ann Intern Med"},{"key":"BFijo2010171_CR6","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1158\/1055-9965.EPI-04-0001","volume":"14","author":"M Harvie","year":"2005","unstructured":"Harvie M, Howell A, Vierkant RA, Kumar N, Cerhan JR, Kelemen LE et al. Association of gain and loss of weight before and after menopause with risk of postmenopausal breast cancer in the Iowa women's health study. Cancer Epidemiol Biomarkers Prev 2005; 14: 656\u2013661.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFijo2010171_CR7","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/S0140-6736(08)60740-0","volume":"371","author":"J Lindstrom","year":"2008","unstructured":"Lindstrom J, Uusitupa M . Lifestyle intervention, diabetes, and cardiovascular disease. Lancet 2008; 371: 1731\u20131733.","journal-title":"Lancet"},{"key":"BFijo2010171_CR8","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1093\/jnci\/djj494","volume":"98","author":"RT Chlebowski","year":"2006","unstructured":"Chlebowski RT, Blackburn GL, Thomson CA, Nixon DW, Shapiro A, Hoy MK et al. Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women's Intervention Nutrition Study. J Natl Cancer Inst 2006; 98: 1767\u20131776.","journal-title":"J Natl Cancer Inst"},{"key":"BFijo2010171_CR9","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1001\/jama.293.1.43","volume":"293","author":"ML Dansinger","year":"2005","unstructured":"Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ . Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 2005; 293: 43\u201353.","journal-title":"JAMA"},{"key":"BFijo2010171_CR10","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1210\/jcem-61-5-917","volume":"61","author":"RR Henry","year":"1985","unstructured":"Henry RR, Scheaffer L, Olefsky JM . Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1985; 61: 917\u2013925.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2010171_CR11","first-page":"1287","volume":"77","author":"DE Kelley","year":"1993","unstructured":"Kelley DE, Wing R, Buonocore C, Sturis J, Polonsky K, Fitzsimmons M . Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1993; 77: 1287\u20131293.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2010171_CR12","doi-asserted-by":"publisher","first-page":"6216","DOI":"10.1073\/pnas.1035720100","volume":"100","author":"RM Anson","year":"2003","unstructured":"Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A et al. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci USA 2003; 100: 6216\u20136220.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFijo2010171_CR13","first-page":"836","volume":"11","author":"MP Cleary","year":"2002","unstructured":"Cleary MP, Jacobson MK, Phillips FC, Getzin SC, Grande JP, Maihle NJ . Weight-cycling decreases incidence and increases latency of mammary tumors to a greater extent than does chronic caloric restriction in mouse mammary tumor virus-transforming growth factor-alpha female mice. Cancer Epidemiol Biomarkers Prev 2002; 11: 836\u2013843.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFijo2010171_CR14","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1093\/carcin\/23.5.817","volume":"23","author":"D Berrigan","year":"2002","unstructured":"Berrigan D, Perkins SN, Haines DC, Hursting SD . Adult-onset calorie restriction and fasting delay spontaneous tumorigenesis in p53-deficient mice. Carcinogenesis 2002; 23: 817\u2013822.","journal-title":"Carcinogenesis"},{"key":"BFijo2010171_CR15","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/pros.20878","volume":"69","author":"MJ Bonorden","year":"2009","unstructured":"Bonorden MJ, Rogozina OP, Kluczny CM, Grossmann ME, Grande JP, Lokshin A et al. Cross-sectional analysis of intermittent versus chronic caloric restriction in the TRAMP mouse. Prostate 2009; 69: 317\u2013326.","journal-title":"Prostate"},{"key":"BFijo2010171_CR16","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.nbd.2006.12.019","volume":"26","author":"VK Halagappa","year":"2007","unstructured":"Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM et al. Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease. Neurobiol Dis 2007; 26: 212\u2013220.","journal-title":"Neurobiol Dis"},{"key":"BFijo2010171_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jnutbio.2004.12.007","volume":"16","author":"MP Mattson","year":"2005","unstructured":"Mattson MP, Wan R . Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J Nutr Biochem 2005; 16: 129\u2013137.","journal-title":"J Nutr Biochem"},{"key":"BFijo2010171_CR18","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0047-6374(00)00109-3","volume":"115","author":"H Sogawa","year":"2000","unstructured":"Sogawa H, Kubo C . Influence of short-term repeated fasting on the longevity of female (NZB x NZW)F1 mice. Mech Ageing Dev 2000; 115: 61\u201371.","journal-title":"Mech Ageing Dev"},{"key":"BFijo2010171_CR19","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/ajcn\/50.2.248","volume":"50","author":"JO Hill","year":"1989","unstructured":"Hill JO, Schlundt DG, Sbrocco T, Sharp T, Pope-Cordle J, Stetson B et al. Evaluation of an alternating-calorie diet with and without exercise in the treatment of obesity. Am J Clin Nutr 1989; 50: 248\u2013254.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2010171_CR20","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1038\/sj.ijo.0802295","volume":"27","author":"S Ash","year":"2003","unstructured":"Ash S, Reeves MM, Yeo S, Morrison G, Carey D, Capra S . Effect of intensive dietetic interventions on weight and glycaemic control in overweight men with Type II diabetes: a randomised trial. Int J Obes Relat Metab Disord 2003; 27: 797\u2013802.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFijo2010171_CR21","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1002\/sim.1668","volume":"23","author":"J Tyrer","year":"2004","unstructured":"Tyrer J, Duffy SW, Cuzick J . A breast cancer prediction model incorporating familial and personal risk factors. Stat Med 2004; 23: 1111\u20131130.","journal-title":"Stat Med"},{"key":"BFijo2010171_CR22","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1210\/jc.2006-0178","volume":"91","author":"R Azziz","year":"2006","unstructured":"Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 2006; 91: 4237\u20134245.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2010171_CR23","unstructured":"Seiddell J . Waist\/hip and waist\/thigh ratios. In: Fidanza (ed). Chapman and Hall: London, 1991, pp 24\u201329."},{"key":"BFijo2010171_CR24","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1079\/PHN2005840","volume":"9","author":"U Ekelund","year":"2006","unstructured":"Ekelund U, Sepp H, Brage S, Becker W, Jakes R, Hennings M et al. Criterion-related validity of the last 7-day, short form of the International Physical Activity Questionnaire in Swedish adults. Public Health Nutr 2006; 9: 258\u2013265.","journal-title":"Public Health Nutr"},{"key":"BFijo2010171_CR25","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3109\/07853890109002089","volume":"33","author":"RD Hays","year":"2001","unstructured":"Hays RD, Morales LS . The RAND-36 measure of health-related quality of life. Ann Med 2001; 33: 350\u2013357.","journal-title":"Ann Med"},{"key":"BFijo2010171_CR26","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3109\/00016349109007163","volume":"70","author":"L Anttila","year":"1991","unstructured":"Anttila L, Koskinen P, Irjala K, Kaihola HL . Reference intervals for serum sex steroids and gonadotropins in regularly menstruating women. Acta Obstet Gynecol Scand 1991; 70: 475\u2013481.","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"6 Pt 1","key":"BFijo2010171_CR27","first-page":"E1101","volume":"269","author":"G Tonolo","year":"1995","unstructured":"Tonolo G, Ciccarese M, Brizzi P, Milia S, Dessole S, Puddu L et al. Cyclical variation of plasma lipids, apolipoproteins, and lipoprotein(a) during menstrual cycle of normal women. Am J Physiol 1995; 269 (6 Pt 1): E1101\u2013E1105.","journal-title":"Am J Physiol"},{"issue":"Suppl 1","key":"BFijo2010171_CR28","first-page":"5","volume":"39","author":"WN Schofield","year":"1985","unstructured":"Schofield WN . Predicting basal metabolic rate, new standards and review of previous work. Hum Nutr Clin Nutr 1985; 39 (Suppl 1): 5\u201341.","journal-title":"Hum Nutr Clin Nutr"},{"key":"BFijo2010171_CR29","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1056\/NEJMoa0708681","volume":"359","author":"I Shai","year":"2008","unstructured":"Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I et al. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 2008; 359: 229\u2013241.","journal-title":"N Engl J Med"},{"key":"BFijo2010171_CR30","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1136\/bmj.333.7571.740","volume":"333","author":"A Avenell","year":"2006","unstructured":"Avenell A, Sattar N, Lean M . ABC of obesity. Management: Part I\u2014behaviour change, diet, and activity. BMJ 2006; 333: 740\u2013743.","journal-title":"BMJ"},{"key":"BFijo2010171_CR31","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412\u2013419.","journal-title":"Diabetologia"},{"key":"BFijo2010171_CR32","doi-asserted-by":"publisher","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","volume":"84","author":"A Vermeulen","year":"1999","unstructured":"Vermeulen A, Verdonck L, Kaufman JM . A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666\u20133672.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2010171_CR33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","volume":"18","author":"WT Friedewald","year":"1972","unstructured":"Friedewald WT, Levy RI, Fredrickson DS . Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499\u2013502.","journal-title":"Clin Chem"},{"key":"BFijo2010171_CR34","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.canlet.2005.05.047","volume":"237","author":"DC Chen","year":"2006","unstructured":"Chen DC, Chung YF, Yeh YT, Chaung HC, Kuo FC, Fu OY et al. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 2006; 237: 109\u2013114.","journal-title":"Cancer Lett"},{"key":"BFijo2010171_CR35","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s00125-009-1508-3","volume":"52","author":"FM Finucane","year":"2009","unstructured":"Finucane FM, Luan J, Wareham NJ, Sharp SJ, O\u2019Rahilly S, Balkau B et al. Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals. Diabetologia 2009; 52: 2345\u20132349.","journal-title":"Diabetologia"},{"key":"BFijo2010171_CR36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0014-5793(94)00602-4","volume":"348","author":"J Frystyk","year":"1994","unstructured":"Frystyk J, Skjaerbaek C, Dinesen B, Orskov H . Free insulin-like growth factors (IGF-I and IGF-II) in human serum. FEBS Lett 1994; 348: 185\u2013191.","journal-title":"FEBS Lett"},{"key":"BFijo2010171_CR37","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1210\/jc.2002-021349","volume":"88","author":"GE Krassas","year":"2003","unstructured":"Krassas GE, Pontikides N, Kaltsas T, Dumas A, Frystyk J, Chen JW et al. Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye disease. J Clin Endocrinol Metab 2003; 88: 132\u2013135.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2010171_CR38","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/j.freeradbiomed.2006.12.005","volume":"42","author":"JB Johnson","year":"2007","unstructured":"Johnson JB, Summer W, Cutler RG, Martin B, Hyun DH, Dixit VD et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med 2007; 42: 665\u2013674.","journal-title":"Free Radic Biol Med"},{"key":"BFijo2010171_CR39","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1515\/CCLM.2005.050","volume":"43","author":"L Selmeci","year":"2005","unstructured":"Selmeci L, Seres L, Antal M, Lukacs J, Regoly-Merei A, Acsady G . Advanced oxidation protein products (AOPP) for monitoring oxidative stress in critically ill patients: a simple, fast and inexpensive automated technique. Clin Chem Lab Med 2005; 43: 294\u2013297.","journal-title":"Clin Chem Lab Med"},{"key":"BFijo2010171_CR40","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1158\/1055-9965.EPI-03-0026","volume":"13","author":"SS Tworoger","year":"2004","unstructured":"Tworoger SS, Yasui Y, Chang L, Stanczyk FZ, McTiernan A . Specimen allocation in longitudinal biomarker studies: controlling subject-specific effects by design. Cancer Epidemiol Biomarkers Prev 2004; 13: 1257\u20131260.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFijo2010171_CR41","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","volume":"23","author":"KG Alberti","year":"2006","unstructured":"Alberti KG, Zimmet P, Shaw J . Metabolic syndrome\u2014a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006; 23: 469\u2013480.","journal-title":"Diabet Med"},{"key":"BFijo2010171_CR42","doi-asserted-by":"publisher","first-page":"2","DOI":"10.2337\/diacare.21.1.2","volume":"21","author":"KV Williams","year":"1998","unstructured":"Williams KV, Mullen ML, Kelley DE, Wing RR . The effect of short periods of caloric restriction on weight loss and glycemic control in type 2 diabetes. Diabetes Care 1998; 21: 2\u20138.","journal-title":"Diabetes Care"},{"key":"BFijo2010171_CR43","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1172\/JCI108565","volume":"58","author":"RS Bar","year":"1976","unstructured":"Bar RS, Gorden P, Roth J, Kahn CR, De Meyts P . Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. J Clin Invest 1976; 58: 1123\u20131135.","journal-title":"J Clin Invest"},{"key":"BFijo2010171_CR44","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.1463-1326.2006.00610.x","volume":"9","author":"DK Oh","year":"2007","unstructured":"Oh DK, Ciaraldi T, Henry RR . Adiponectin in health and disease. Diabetes Obes Metab 2007; 9: 282\u2013289.","journal-title":"Diabetes Obes Metab"},{"key":"BFijo2010171_CR45","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1152\/japplphysiol.00683.2005","volume":"99","author":"N Halberg","year":"2005","unstructured":"Halberg N, Henriksen M, Soderhamn N, Stallknecht B, Ploug T, Schjerling P et al. Effect of intermittent fasting and refeeding on insulin action in healthy men. J Appl Physiol 2005; 99: 2128\u20132136.","journal-title":"J Appl Physiol"},{"key":"BFijo2010171_CR46","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1152\/japplphysiol.00209.2007","volume":"103","author":"KA Varady","year":"2007","unstructured":"Varady KA, Roohk DJ, Hellerstein MK . Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice. J Appl Physiol 2007; 103: 547\u2013551.","journal-title":"J Appl Physiol"},{"key":"BFijo2010171_CR47","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1007\/s12020-008-9090-x","volume":"33","author":"AV Araya","year":"2008","unstructured":"Araya AV, Orellana X, Espinoza J . Evaluation of the effect of caloric restriction on serum BDNF in overweight and obese subjects: preliminary evidences. Endocrine 2008; 33: 300\u2013304.","journal-title":"Endocrine"},{"key":"BFijo2010171_CR48","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1093\/jn\/137.8.1944","volume":"137","author":"MR Hayes","year":"2007","unstructured":"Hayes MR, Miller CK, Ulbrecht JS, Mauger JL, Parker-Klees L, Gutschall MD et al. A carbohydrate-restricted diet alters gut peptides and adiposity signals in men and women with metabolic syndrome. J Nutr 2007; 137: 1944\u20131950.","journal-title":"J Nutr"},{"key":"BFijo2010171_CR49","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1046\/j.1365-2796.1997.120129000.x","volume":"241","author":"E Turcato","year":"1997","unstructured":"Turcato E, Zamboni M, De Pergola G, Armellini F, Zivelonghi A, Bergamo-Andreis IA et al. Interrelationships between weight loss, body fat distribution and sex hormones in pre- and postmenopausal obese women. J Intern Med 1997; 241: 363\u2013372.","journal-title":"J Intern Med"},{"key":"BFijo2010171_CR50","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1093\/jnci\/94.8.606","volume":"94","author":"T Key","year":"2002","unstructured":"Key T, Appleby P, Barnes I, Reeves G . Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002; 94: 606\u2013616.","journal-title":"J Natl Cancer Inst"},{"key":"BFijo2010171_CR51","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1111\/j.1532-5415.2008.01692.x","volume":"56","author":"M Enomoto","year":"2008","unstructured":"Enomoto M, Adachi H, Fukami A, Furuki K, Satoh A, Otsuka M et al. Serum dehydroepiandrosterone sulfate levels predict longevity in men: 27-year follow-up study in a community-based cohort (Tanushimaru study). J Am Geriatr Soc 2008; 56: 994\u2013998.","journal-title":"J Am Geriatr Soc"},{"key":"BFijo2010171_CR52","first-page":"76","volume":"83","author":"R Alvero","year":"1998","unstructured":"Alvero R, Kimzey L, Sebring N, Reynolds J, Loughran M, Nieman L et al. Effects of fasting on neuroendocrine function and follicle development in lean women. J Clin Endocrinol Metab 1998; 83: 76\u201380.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2010171_CR53","doi-asserted-by":"publisher","first-page":"E218","DOI":"10.1152\/ajpendo.00156.2005","volume":"290","author":"P Kok","year":"2006","unstructured":"Kok P, Roelfsema F, Langendonk JG, de Wit CC, Frolich M, Burggraaf J et al. Increased circadian prolactin release is blunted after body weight loss in obese premenopausal women. Am J Physiol Endocrinol Metab 2006; 290: E218\u2013E224.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2010171_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2007.08.007","volume":"7","author":"MP Mattson","year":"2008","unstructured":"Mattson MP . Hormesis defined. Ageing Res Rev 2008; 7: 1\u20137.","journal-title":"Ageing Res Rev"},{"key":"BFijo2010171_CR55","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/oby.2005.61","volume":"13","author":"LK Heilbronn","year":"2005","unstructured":"Heilbronn LK, Civitarese AE, Bogacka I, Smith SR, Hulver M, Ravussin E . Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting. Obes Res 2005; 13: 574\u2013581.","journal-title":"Obes Res"},{"key":"BFijo2010171_CR56","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1093\/ajcn\/88.3.667","volume":"88","author":"HR Lieberman","year":"2008","unstructured":"Lieberman HR, Caruso CM, Niro PJ, Adam GE, Kellogg MD, Nindl BC et al. A double-blind, placebo-controlled test of 2 d of calorie deprivation: effects on cognition, activity, sleep, and interstitial glucose concentrations. Am J Clin Nutr 2008; 88: 667\u2013676.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2010171_CR57","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1038\/sj.ijo.0802151","volume":"26","author":"AM Johnstone","year":"2002","unstructured":"Johnstone AM, Faber P, Gibney ER, Elia M, Horgan G, Golden BE et al. Effect of an acute fast on energy compensation and feeding behaviour in lean men and women. Int J Obes Relat Metab Disord 2002; 26: 1623\u20131628.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFijo2010171_CR58","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.3945\/ajcn.2009.28380","volume":"90","author":"KA Varady","year":"2009","unstructured":"Varady KA, Bhutani S, Church EC, Klempel MC . Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. Am J Clin Nutr 2009; 90: 1138\u20131143.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2010171_CR59","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/ajcn\/81.1.69","volume":"81","author":"LK Heilbronn","year":"2005","unstructured":"Heilbronn LK, Smith SR, Martin CK, Anton SD, Ravussin E . Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr 2005; 81: 69\u201373.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2010171_CR60","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1136\/bmj.38833.411204.80","volume":"332","author":"H Truby","year":"2006","unstructured":"Truby H, Baic S, deLooy A, Fox KR, Livingstone MB, Logan CM et al. Randomised controlled trial of four commercial weight loss programmes in the UK: initial findings from the BBC \u2018diet trials\u2019. BMJ 2006; 332: 1309\u20131314.","journal-title":"BMJ"},{"key":"BFijo2010171_CR61","doi-asserted-by":"publisher","first-page":"5881","DOI":"10.1210\/jc.2003-030886","volume":"88","author":"YM Liu","year":"2003","unstructured":"Liu YM, Lacorte JM, Viguerie N, Poitou C, Pelloux V, Guy-Grand B et al. Adiponectin gene expression in subcutaneous adipose tissue of obese women in response to short-term very low calorie diet and refeeding. J Clin Endocrinol Metab 2003; 88: 5881\u20135886.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2010171_CR62","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1210\/jc.2006-1603","volume":"92","author":"DH St Pierre","year":"2007","unstructured":"St Pierre DH, Karelis AD, Coderre L, Malita F, Fontaine J, Mignault D et al. Association of acylated and nonacylated ghrelin with insulin sensitivity in overweight and obese postmenopausal women. J Clin Endocrinol Metab 2007; 92: 264\u2013269.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2010171_CR63","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1194\/jlr.M700223-JLR200","volume":"48","author":"KA Varady","year":"2007","unstructured":"Varady KA, Roohk DJ, Loe YC, McEvoy-Hein BK, Hellerstein MK . Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice. J Lipid Res 2007; 48: 2212\u20132219.","journal-title":"J Lipid Res"},{"key":"BFijo2010171_CR64","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1172\/JCI0215736","volume":"110","author":"F Kreier","year":"2002","unstructured":"Kreier F, Fliers E, Voshol PJ, Van Eden CG, Havekes LM, Kalsbeek A et al. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat\u2014functional implications. J Clin Invest 2002; 110: 1243\u20131250.","journal-title":"J Clin Invest"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo2010171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2010171","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2010171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:22:57Z","timestamp":1684416177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo2010171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,5]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["BFijo2010171"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2010.171","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.11221956.12206054","asserted-by":"object"}]},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,5]]}}}