{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:36:00Z","timestamp":1792794960489,"version":"4.5.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T00:00:00Z","timestamp":1327968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/ijo.2012.11","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T10:20:34Z","timestamp":1328005234000},"page":"197-203","source":"Crossref","is-referenced-by-count":7,"title":["Synergistic induction of interleukin-6 expression by endothelin-1 and cyclic AMP in adipocytes"],"prefix":"10.1038","volume":"37","author":[{"given":"S-P","family":"Chai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-C","family":"Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P-H","family":"Kao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D-H","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,31]]},"reference":[{"key":"BFijo201211_CR1","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.1210\/jc.2004-0395","volume":"89","author":"EE Kershaw","year":"2004","unstructured":"Kershaw EE, Flier JS . Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548\u20132556.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo201211_CR2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1079\/PNS200194","volume":"60","author":"P Trayhurn","year":"2001","unstructured":"Trayhurn P, Beattie JH . Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001; 60: 329\u2013339.","journal-title":"Proc Nutr Soc"},{"key":"BFijo201211_CR3","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/sj.ijo.0802028","volume":"26","author":"U Smith","year":"2002","unstructured":"Smith U . Impaired (\u2018diabetic\u2019) insulin signaling and action occur in fat cells long before glucose intolerance\u2013is insulin resistance initiated in the adipose tissue? Int J Obes Relat Metab Disord 2002; 26: 897\u2013904.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFijo201211_CR4","doi-asserted-by":"publisher","first-page":"333","DOI":"10.2174\/1566524053766022","volume":"5","author":"P Arner","year":"2005","unstructured":"Arner P . Insulin resistance in type 2 diabetes \u2013 role of the adipokines. Curr Mol Med 2005; 5: 333\u2013339.","journal-title":"Curr Mol Med"},{"key":"BFijo201211_CR5","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.metabol.2006.10.015","volume":"56","author":"MJ Dekker","year":"2007","unstructured":"Dekker MJ, Lee S, Hudson R, Kilpatrick K, Graham TE, Ross R et al. An exercise intervention without weight loss decreases circulating interleukin-6 in lean and obese men with and without type 2 diabetes mellitus. Metabolism 2007; 56: 332\u2013338.","journal-title":"Metabolism"},{"key":"BFijo201211_CR6","first-page":"4196","volume":"82","author":"V Mohamed-Ali","year":"1997","unstructured":"Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 1997; 82: 4196\u20134200.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo201211_CR7","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/332411a0","volume":"332","author":"M Yanagisawa","year":"1988","unstructured":"Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332: 411\u2013415.","journal-title":"Nature"},{"key":"BFijo201211_CR8","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1046\/j.1365-201X.1997.00212.x","volume":"161","author":"A Ottosson-Seeberger","year":"1997","unstructured":"Ottosson-Seeberger A, Lundberg JM, Alvestrand A, Ahlborg G . Exogenous endothelin-1 causes peripheral insulin resistance in healthy humans. Acta Physiol Scand 1997; 161: 211\u2013220.","journal-title":"Acta Physiol Scand"},{"key":"BFijo201211_CR9","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.2337\/diabetes.48.5.1120","volume":"48","author":"ZY Jiang","year":"1999","unstructured":"Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers Jr MG, White MF et al. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes 1999; 48: 1120\u20131130.","journal-title":"Diabetes"},{"key":"BFijo201211_CR10","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1006\/bbrc.1994.1985","volume":"202","author":"YC Chou","year":"1994","unstructured":"Chou YC, Perng JC, Juan CC, Jang SY, Kwok CF, Chen WL et al. Endothelin-1 inhibits insulin-stimulated glucose uptake in isolated rat adipocytes. Biochem Biophys Res Commun 1994; 202: 688\u2013693.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFijo201211_CR11","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/S0165-1838(98)00120-9","volume":"74","author":"TL Lee","year":"1998","unstructured":"Lee TL, Hsu CT, Yen ST, Lai CW, Cheng JT . Activation of beta3-adrenoceptors by exogenous dopamine to lower glucose uptake into rat adipocytes. J Auton Nerv Syst 1998; 74: 86\u201390.","journal-title":"J Auton Nerv Syst"},{"key":"BFijo201211_CR12","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1172\/JCI11753","volume":"107","author":"KI Ishibashi","year":"2001","unstructured":"Ishibashi KI, Imamura T, Sharma PM, Huang J, Ugi S, Olefsky JM . Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes. J Clin Invest 2001; 107: 1193\u20131202.","journal-title":"J Clin Invest"},{"key":"BFijo201211_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.bbagen.2008.12.002","volume":"1790","author":"SP Chai","year":"2009","unstructured":"Chai SP, Chang YN, Fong JC . Endothelin-1 stimulates interleukin-6 secretion from 3T3-L1 adipocytes. Biochim Biophys Acta 2009; 1790: 213\u2013218.","journal-title":"Biochim Biophys Acta"},{"key":"BFijo201211_CR14","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbagen.2007.11.013","volume":"1780","author":"YS Kao","year":"2008","unstructured":"Kao YS, Fong JC . Endothelin-1 induction of Glut1 transcription in 3T3-L1 adipocytes involves distinct PKCepsilon- and p42\/p44 MAPK-dependent pathways. Biochim Biophys Acta 2008; 1780: 154\u2013159.","journal-title":"Biochim Biophys Acta"},{"key":"BFijo201211_CR15","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1055\/s-2003-39075","volume":"35","author":"M Fasshauer","year":"2003","unstructured":"Fasshauer M, Klein J, Lossner U, Paschke R . Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes. Horm Metab Res 2003; 35: 147\u2013152.","journal-title":"Horm Metab Res"},{"key":"BFijo201211_CR16","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/sj.ijo.0802035","volume":"26","author":"V Vicennati","year":"2002","unstructured":"Vicennati V, Vottero A, Friedman C, Papanicolaou DA . Hormonal regulation of interleukin-6 production in human adipocytes. Int J Obes Relat Metab Disord 2002; 26: 905\u2013911.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFijo201211_CR17","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cellsig.2003.12.004","volume":"16","author":"JC Fong","year":"2004","unstructured":"Fong JC, Kao YS, Tsai HY, Chiou YY, Chiou GY . Synergistic effect of endothelin-1 and cyclic AMP on glucose transport in 3T3-L1 adipocytes. Cell Signal 2004; 16: 811\u2013821.","journal-title":"Cell Signal"},{"key":"BFijo201211_CR18","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.cellsig.2011.01.016","volume":"23","author":"YS Kao","year":"2011","unstructured":"Kao YS, Fong JC . A novel cross-talk between endothelin-1 and cyclic AMP signaling pathways in the regulation of GLUT1 transcription in 3T3-L1 adipocytes. Cell Signal 2011; 23: 901\u2013910.","journal-title":"Cell Signal"},{"key":"BFijo201211_CR19","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1210\/rp.56.1.309","volume":"56","author":"S Collins","year":"2001","unstructured":"Collins S, Surwit RS . The beta-adrenergic receptors and the control of adipose tissue metabolism and thermogenesis. Recent Prog Horm Res 2001; 56: 309\u2013328.","journal-title":"Recent Prog Horm Res"},{"key":"BFijo201211_CR20","doi-asserted-by":"publisher","first-page":"E1146","DOI":"10.1152\/ajpendo.00481.2004","volume":"288","author":"CC Juan","year":"2005","unstructured":"Juan CC, Chang CL, Lai YH, Ho LT . Endothelin-1 induces lipolysis in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 2005; 288: E1146\u2013E1152.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo201211_CR21","doi-asserted-by":"publisher","first-page":"378","DOI":"10.2337\/db07-0893","volume":"57","author":"V van Harmelen","year":"2008","unstructured":"van Harmelen V, Eriksson A, Astrom G, Wahlen K, Naslund E, Karpe F et al. Vascular peptide endothelin-1 links fat accumulation with alterations of visceral adipocyte lipolysis. Diabetes 2008; 57: 378\u2013386.","journal-title":"Diabetes"},{"key":"BFijo201211_CR22","doi-asserted-by":"publisher","first-page":"222","DOI":"10.2119\/2007-00119.Tilg","volume":"14","author":"H Tilg","year":"2008","unstructured":"Tilg H, Moschen AR . Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 2008; 14: 222\u2013231.","journal-title":"Mol Med"},{"key":"BFijo201211_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.cellsig.2006.06.007","volume":"19","author":"KS Tan","year":"2007","unstructured":"Tan KS, Nackley AG, Satterfield K, Maixner W, Diatchenko L, Flood PM . Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. Cell Signal 2007; 19: 251\u2013260.","journal-title":"Cell Signal"},{"key":"BFijo201211_CR24","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1007\/s00011-009-0060-4","volume":"58","author":"K Eder","year":"2009","unstructured":"Eder K, Baffy N, Falus A, Fulop AK . The major inflammatory mediator interleukin-6 and obesity. Inflamm Res 2009; 58: 727\u2013736.","journal-title":"Inflamm Res"},{"key":"BFijo201211_CR25","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1467-789X.2007.00410.x","volume":"9","author":"M Hoene","year":"2008","unstructured":"Hoene M, Weigert C . The role of interleukin-6 in insulin resistance, body fat distribution and energy balance. Obes Rev 2008; 9: 20\u201329.","journal-title":"Obes Rev"},{"key":"BFijo201211_CR26","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1097\/00003246-199711000-00018","volume":"25","author":"C Martin","year":"1997","unstructured":"Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL . Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 1997; 25: 1813\u20131819.","journal-title":"Crit Care Med"},{"key":"BFijo201211_CR27","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1097\/01.ta.0000187653.64300.f5","volume":"59","author":"RB Fonseca","year":"2005","unstructured":"Fonseca RB, Mohr AM, Wang L, Sifri ZC, Rameshwar P, Livingston DH . The impact of a hypercatecholamine state on erythropoiesis following severe injury and the role of IL-6. J Trauma 2005; 59: 884\u2013889; discussion 889\u2013890.","journal-title":"J Trauma"},{"key":"BFijo201211_CR28","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1177\/0885066609340519","volume":"24","author":"MW Dunser","year":"2009","unstructured":"Dunser MW, Hasibeder WR . Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress. J Intensive Care Med 2009; 24: 293\u2013316.","journal-title":"J Intensive Care Med"},{"key":"BFijo201211_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-2999(00)00675-0","volume":"407","author":"M Wanecek","year":"2000","unstructured":"Wanecek M, Weitzberg E, Rudehill A, Oldner A . The endothelin system in septic and endotoxin shock. Eur J Pharmacol 2000; 407: 1\u201315.","journal-title":"Eur J Pharmacol"},{"key":"BFijo201211_CR30","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.metabol.2006.04.008","volume":"55","author":"JN Fain","year":"2006","unstructured":"Fain JN, Tichansky DS, Madan AK . Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non-fat cells, not by the adipocytes. Metabolism 2006; 55: 1113\u20131121.","journal-title":"Metabolism"},{"key":"BFijo201211_CR31","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.mce.2009.08.031","volume":"318","author":"TJ Bartness","year":"2010","unstructured":"Bartness TJ, Shrestha YB, Vaughan CH, Schwartz GJ, Song CK . Sensory and sympathetic nervous system control of white adipose tissue lipolysis. Mol Cell Endocrinol 2010; 318: 34\u201343.","journal-title":"Mol Cell Endocrinol"},{"key":"BFijo201211_CR32","first-page":"R291","volume":"275","author":"M Bamshad","year":"1998","unstructured":"Bamshad M, Aoki VT, Adkison MG, Warren WS, Bartness TJ . Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol 1998; 275: R291\u2013R299.","journal-title":"Am J Physiol"},{"key":"BFijo201211_CR33","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1159\/000097185","volume":"1","author":"A Takaki","year":"1994","unstructured":"Takaki A, Huang QH, Somogyvari-Vigh A, Arimura A . Immobilization stress may increase plasma interleukin-6 via central and peripheral catecholamines. Neuroimmunomodulation 1994; 1: 335\u2013342.","journal-title":"Neuroimmunomodulation"},{"key":"BFijo201211_CR34","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11481-006-9036-0","volume":"1","author":"JP Godbout","year":"2006","unstructured":"Godbout JP, Glaser R . Stress-induced immune dysregulation: implications for wound healing, infectious disease and cancer. J Neuroimmune Pharmacol 2006; 1: 421\u2013427.","journal-title":"J Neuroimmune Pharmacol"},{"key":"BFijo201211_CR35","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jpsychores.2006.07.001","volume":"61","author":"U Wilbert-Lampen","year":"2006","unstructured":"Wilbert-Lampen U, Trapp A, Modrzik M, Fiedler B, Straube F, Plasse A . Effects of corticotropin-releasing hormone (CRH) on endothelin-1 and NO release, mediated by CRH receptor subtype R2: a potential link between stress and endothelial dysfunction? J Psychosom Res 2006; 61: 453\u2013460.","journal-title":"J Psychosom Res"},{"issue":"Suppl 2","key":"BFijo201211_CR36","doi-asserted-by":"publisher","first-page":"II\/26","DOI":"10.1007\/s003930070014","volume":"59","author":"HO Besedovsky","year":"2000","unstructured":"Besedovsky HO, del Rey A . The cytokine-HPA axis feed-back circuit. Z Rheumatol 2000; 59 (Suppl 2): II\/26\u2013II\/30.","journal-title":"Z Rheumatol"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo201211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo201211","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo201211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,18]],"date-time":"2024-04-18T18:09:35Z","timestamp":1713463775000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo201211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,31]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFijo201211"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2012.11","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,31]]}}}