{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:54:35Z","timestamp":1781279675931,"version":"3.54.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1038\/ijo.2012.63","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T17:52:58Z","timestamp":1335289978000},"page":"410-415","source":"Crossref","is-referenced-by-count":41,"title":["Association between obesity, hypertriglyceridemia and low hepatitis B viral load"],"prefix":"10.1038","volume":"37","author":[{"name":"for the REVEAL-HBV Study Group","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-H","family":"Chiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H-I","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-L","family":"Jen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-N","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L-Y","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-L","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U H","family":"Iloeje","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-J","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"BFijo201263_CR1","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/j.1440-1746.2011.06695.x","volume":"26","author":"CJ Chen","year":"2011","unstructured":"Chen CJ, Yang HI . Natural history of chronic hepatitis B REVEALed. J Gastroenterol Hepatol 2011; 26: 628\u2013638.","journal-title":"J Gastroenterol Hepatol"},{"key":"BFijo201263_CR2","doi-asserted-by":"publisher","first-page":"S72","DOI":"10.1002\/hep.22884","volume":"49","author":"CJ Chen","year":"2009","unstructured":"Chen CJ, Yang HI, Iloeje UH . Hepatitis B virus DNA levels and outcomes in chronic hepatitis B. Hepatology 2009; 49: S72\u2013S84.","journal-title":"Hepatology"},{"key":"BFijo201263_CR3","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/jama.295.1.65","volume":"295","author":"CJ Chen","year":"2006","unstructured":"Chen CJ, Yang HI, Su J, Jen CL, You SL, Lu SN et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295: 65\u201373.","journal-title":"JAMA"},{"key":"BFijo201263_CR4","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.cgh.2007.06.015","volume":"5","author":"UH Iloeje","year":"2007","unstructured":"Iloeje UH, Yang HI, Jen CL, Su J, Wang LY, You SL et al. Risk and predictors of mortality associated with chronic hepatitis B infection. Clin Gastroenterol Hepatol 2007; 5: 921\u2013931.","journal-title":"Clin Gastroenterol Hepatol"},{"key":"BFijo201263_CR5","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1053\/j.gastro.2005.11.016","volume":"130","author":"UH Iloeje","year":"2006","unstructured":"Iloeje UH, Yang HI, Su J, Jen CL, You SL, Chen CJ . Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130: 678\u2013686.","journal-title":"Gastroenterology"},{"key":"BFijo201263_CR6","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/S0140-6736(09)60207-5","volume":"373","author":"YF Liaw","year":"2009","unstructured":"Liaw YF, Chu CM . Hepatitis B virus infection. Lancet 2009; 373: 582\u2013592.","journal-title":"Lancet"},{"key":"BFijo201263_CR7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.mehy.2007.08.032","volume":"71","author":"A Shlomai","year":"2008","unstructured":"Shlomai A, Shaul Y . The \"metabolovirus\" model of hepatitis B virus suggests nutritional therapy as an effective anti-viral weapon. Med Hypotheses 2008; 71: 53\u201357.","journal-title":"Med Hypotheses"},{"issue":"Suppl 1","key":"BFijo201263_CR8","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1467-789X.2007.00435.x","volume":"9","author":"KC Huang","year":"2008","unstructured":"Huang KC . Obesity and its related diseases in Taiwan. Obes Rev 2008; 9(Suppl 1): 32\u201334.","journal-title":"Obes Rev"},{"key":"BFijo201263_CR9","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1053\/j.gastro.2008.03.073","volume":"135","author":"CL Chen","year":"2008","unstructured":"Chen CL, Yang HI, Yang WS, Liu CJ, Chen PJ, You SL et al. Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B\/C infection: a follow-up study in Taiwan. Gastroenterology 2008; 135: 111\u2013121.","journal-title":"Gastroenterology"},{"key":"BFijo201263_CR10","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1136\/gut.2004.052167","volume":"54","author":"JA Davila","year":"2005","unstructured":"Davila JA, Morgan RO, Shaib Y, McGlynn KA, El-Serag HB . Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study. Gut 2005; 54: 533\u2013539.","journal-title":"Gut"},{"key":"BFijo201263_CR11","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s10552-008-9287-6","volume":"20","author":"M Inoue","year":"2009","unstructured":"Inoue M, Kurahashi N, Iwasaki M, Tanaka Y, Mizokami M, Noda M et al. Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II). Cancer Causes Control 2009; 20: 741\u2013750.","journal-title":"Cancer Causes Control"},{"key":"BFijo201263_CR12","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1002\/hep.21208","volume":"43","author":"MS Lai","year":"2006","unstructured":"Lai MS, Hsieh MS, Chiu YH, Chen TH . Type 2 diabetes and hepatocellular carcinoma: A cohort study in high prevalence area of hepatitis virus infection. Hepatology 2006; 43: 1295\u20131302.","journal-title":"Hepatology"},{"key":"BFijo201263_CR13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1136\/gut.2008.157735","volume":"58","author":"GL Wong","year":"2009","unstructured":"Wong GL, Wong VW, Choi PC, Chan AW, Chim AM, Yiu KK et al. Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B. Gut 2009; 58: 111\u2013117.","journal-title":"Gut"},{"key":"BFijo201263_CR14","doi-asserted-by":"publisher","first-page":"5576","DOI":"10.1200\/JCO.2008.16.1075","volume":"26","author":"MW Yu","year":"2008","unstructured":"Yu MW, Shih WL, Lin CL, Liu CJ, Jian JW, Tsai KS et al. Body-mass index and progression of hepatitis B: a population-based cohort study in men. J Clin Oncol 2008; 26: 5576\u20135582.","journal-title":"J Clin Oncol"},{"key":"BFijo201263_CR15","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1365-2036.2007.03538.x","volume":"27","author":"E Tsochatzis","year":"2008","unstructured":"Tsochatzis E, Papatheodoridis GV, Manesis EK, Kafiri G, Tiniakos DG, Archimandritis AJ . Metabolic syndrome is associated with severe fibrosis in chronic viral hepatitis and non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2008; 27: 80\u201389.","journal-title":"Aliment Pharmacol Ther"},{"key":"BFijo201263_CR16","doi-asserted-by":"publisher","first-page":"e31","DOI":"10.1016\/j.orcp.2011.04.005","volume":"6","author":"CH Chiang","year":"2012","unstructured":"Chiang CH, Lai JS, Sheu JC, Yen LL, Liu CJ, Huang KC . The risky body mass index ranges for significant hepatitis B viral load: A campus-based study. Obes Res Clin Pract 2012; 6: e31\u2013e38.","journal-title":"Obes Res Clin Pract"},{"key":"BFijo201263_CR17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0140-6736(03)15268-3","volume":"363","author":"WHO","year":"2004","unstructured":"WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004; 363: 157\u2013163.","journal-title":"Lancet"},{"key":"BFijo201263_CR18","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1056\/NEJMoa013215","volume":"347","author":"HI Yang","year":"2002","unstructured":"Yang HI, Lu SN, Liaw YF, You SL, Sun CA, Wang LY et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002; 347: 168\u2013174.","journal-title":"N Engl J Med"},{"key":"BFijo201263_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/ajg.2010.404","volume":"106","author":"Y Huang","year":"2011","unstructured":"Huang Y, Lok AS . Viral factors and outcomes of chronic HBV infection. Am J Gastroenterol 2011; 106: 93\u201395.","journal-title":"Am J Gastroenterol"},{"key":"BFijo201263_CR20","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1002\/hep.23163","volume":"50","author":"SH Wang","year":"2009","unstructured":"Wang SH, Yeh SH, Lin WH, Wang HY, Chen DS, Chen PJ . Identification of androgen response elements in the enhancer I of hepatitis B virus: a mechanism for sex disparity in chronic hepatitis B. Hepatology 2009; 50: 1392\u20131402.","journal-title":"Hepatology"},{"key":"BFijo201263_CR21","doi-asserted-by":"publisher","first-page":"3643","DOI":"10.1200\/JCO.2011.36.2335","volume":"29","author":"YT Huang","year":"2011","unstructured":"Huang YT, Jen CL, Yang HI, Lee MH, Su J, Lu SN et al. Lifetime risk and sex difference of hepatocellular carcinoma among patients with chronic hepatitis B and C. J Clin Oncol 2011; 29: 3643\u20133650.","journal-title":"J Clin Oncol"},{"key":"BFijo201263_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/hep.23348","volume":"51","author":"YC Chen","year":"2010","unstructured":"Chen YC, Chu CM, Liaw YF . Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B. Hepatology 2010; 51: 435\u2013444.","journal-title":"Hepatology"},{"key":"BFijo201263_CR23","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1530\/EJE-09-0348","volume":"161","author":"BB Yeap","year":"2009","unstructured":"Yeap BB, Chubb SA, Hyde Z, Jamrozik K, Hankey GJ, Flicker L et al. Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study. Eur J Endocrinol 2009; 161: 591\u2013598.","journal-title":"Eur J Endocrinol"},{"key":"BFijo201263_CR24","doi-asserted-by":"publisher","first-page":"5755","DOI":"10.1111\/j.1742-4658.2009.07305.x","volume":"276","author":"AM Traish","year":"2009","unstructured":"Traish AM, Feeley RJ, Guay A . Mechanisms of obesity and related pathologies: androgen deficiency and endothelial dysfunction may be the link between obesity and erectile dysfunction. FEBS J 2009; 276: 5755\u20135767.","journal-title":"FEBS J"},{"key":"BFijo201263_CR25","doi-asserted-by":"publisher","first-page":"3403","DOI":"10.1210\/jc.2008-0054","volume":"93","author":"V Kupelian","year":"2008","unstructured":"Kupelian V, Hayes FJ, Link CL, Rosen R, McKinlay JB . Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metab 2008; 93: 3403\u20133410.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo201263_CR26","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1001\/jama.295.11.1288","volume":"295","author":"EL Ding","year":"2006","unstructured":"Ding EL, Song Y, Malik VS, Liu S . Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2006; 295: 1288\u20131299.","journal-title":"JAMA"},{"key":"BFijo201263_CR27","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1056\/NEJMoa0804381","volume":"361","author":"EL Ding","year":"2009","unstructured":"Ding EL, Song Y, Manson JE, Hunter DJ, Lee CC, Rifai N et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 2009; 361: 1152\u20131163.","journal-title":"N Engl J Med"},{"key":"BFijo201263_CR28","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1002\/hep.22833","volume":"49","author":"WJ Yang","year":"2009","unstructured":"Yang WJ, Chang CJ, Yeh SH, Lin WH, Wang SH, Tsai TF et al. Hepatitis B virus X protein enhances the transcriptional activity of the androgen receptor through c-Src and glycogen synthase kinase-3beta kinase pathways. Hepatology 2009; 49: 1515\u20131524.","journal-title":"Hepatology"},{"key":"BFijo201263_CR29","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.bbrc.2009.02.078","volume":"381","author":"A Shlomai","year":"2009","unstructured":"Shlomai A, Shaul Y . The metabolic activator FOXO1 binds hepatitis B virus DNA and activates its transcription. Biochem Biophys Res Commun 2009; 381: 544\u2013548.","journal-title":"Biochem Biophys Res Commun"},{"key":"BFijo201263_CR30","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/sj.ijo.0803204","volume":"30","author":"CF Jan","year":"2006","unstructured":"Jan CF, Chen CJ, Chiu YH, Chen LS, Wu HM, Huang CC et al. A population-based study investigating the association between metabolic syndrome and hepatitis B\/C infection (Keelung Community-based Integrated Screening study No. 10). Int J Obes 2006; 30: 794\u2013799.","journal-title":"Int J Obes"},{"key":"BFijo201263_CR31","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.jhep.2011.09.013","volume":"56","author":"VW Wong","year":"2012","unstructured":"Wong VW, Wong GL, Chu WC, Chim AM, Ong A, Yeung DK et al. Hepatitis B virus infection and fatty liver in the general population. J Hepatol 2012; 56: 533\u2013540.","journal-title":"J Hepatol"},{"key":"BFijo201263_CR32","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.cca.2007.01.012","volume":"380","author":"B Luo","year":"2007","unstructured":"Luo B, Wang Y, Wang K . Association of metabolic syndrome and hepatitis B infection in a Chinese population. Clin Chim Acta 2007; 380: 238\u2013240.","journal-title":"Clin Chim Acta"},{"key":"BFijo201263_CR33","doi-asserted-by":"publisher","first-page":"28106","DOI":"10.1074\/jbc.M403176200","volume":"279","author":"SK Kang","year":"2004","unstructured":"Kang SK, Chung TW, Lee JY, Lee YC, Morton RE, Kim CH . The hepatitis B virus X protein inhibits secretion of apolipoprotein B by enhancing the expression of N-acetylglucosaminyltransferase III. J Biol Chem 2004; 279: 28106\u201328112.","journal-title":"J Biol Chem"},{"key":"BFijo201263_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cld.2007.02.011","volume":"11","author":"J Edmison","year":"2007","unstructured":"Edmison J, McCullough AJ . Pathogenesis of non-alcoholic steatohepatitis: human data. Clin Liver Dis 2007; 11: 75\u2013104 ix.","journal-title":"Clin Liver Dis"},{"key":"BFijo201263_CR35","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1016\/j.dld.2007.07.151","volume":"39","author":"E Tsochatzis","year":"2007","unstructured":"Tsochatzis E, Papatheodoridis GV, Manesis EK, Chrysanthos N, Kafiri G, Archimandritis AJ . Hepatic steatosis in chronic hepatitis B develops due to host metabolic factors: a comparative approach with genotype 1 chronic hepatitis C. Dig Liver Dis 2007; 39: 936\u2013942.","journal-title":"Dig Liver Dis"},{"key":"BFijo201263_CR36","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/hep.22603","volume":"49","author":"R Vuppalanchi","year":"2009","unstructured":"Vuppalanchi R, Chalasani N . Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology 2009; 49: 306\u2013317.","journal-title":"Hepatology"},{"key":"BFijo201263_CR37","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1007\/s10620-009-1081-0","volume":"55","author":"JR Lewis","year":"2010","unstructured":"Lewis JR, Mohanty SR . Nonalcoholic fatty liver disease: a review and update. Dig Dis Sci 2010; 55: 560\u2013578.","journal-title":"Dig Dis Sci"},{"key":"BFijo201263_CR38","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.clnu.2011.05.001","volume":"30","author":"IC Lee","year":"2011","unstructured":"Lee IC, Huang YH, Chan CC, Huo TI, Chu CJ, Lai CR et al. Impact of body mass index and viral load on liver histology in hepatitis B e antigen-negative chronic hepatitis B. Clin Nutr 2011; 30: 647\u2013652.","journal-title":"Clin Nutr"},{"key":"BFijo201263_CR39","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/ajg.2008.9","volume":"104","author":"M Kumar","year":"2009","unstructured":"Kumar M, Choudhury A, Manglik N, Hissar S, Rastogi A, Sakhuja P et al. Insulin resistance in chronic hepatitis B virus infection. Am J Gastroenterol 2009; 104: 76\u201382.","journal-title":"Am J Gastroenterol"},{"key":"BFijo201263_CR40","doi-asserted-by":"publisher","first-page":"272","DOI":"10.7150\/ijms.7.272","volume":"7","author":"RD Zheng","year":"2010","unstructured":"Zheng RD, Xu CR, Jiang L, Dou AX, Zhou K, Lu LG . Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis. Int J Med Sci 2010; 7: 272\u2013277.","journal-title":"Int J Med Sci"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo201263.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo201263","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo201263.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:28:25Z","timestamp":1684430905000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo201263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,24]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["BFijo201263"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2012.63","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,24]]}}}