{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:53:42Z","timestamp":1791381222970,"version":"4.3.3"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T00:00:00Z","timestamp":1435536000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1038\/ijo.2015.121","type":"journal-article","created":{"date-parts":[[2015,6,29]],"date-time":"2015-06-29T03:41:16Z","timestamp":1435549276000},"page":"1733-1741","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Mesoderm-specific transcript (MEST) is a negative regulator of human adipocyte differentiation"],"prefix":"10.1038","volume":"39","author":[{"given":"M","family":"Karbiener","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Glantschnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D F","family":"Pisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Laurencikiene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Dahlman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Herzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E-Z","family":"Amri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Scheideler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,29]]},"reference":[{"key":"BFijo2015121_CR1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.cell.2007.10.004","volume":"131","author":"S Gesta","year":"2007","unstructured":"Gesta S, Tseng Y-H, Kahn CR . Developmental origin of fat: tracking obesity to its source. Cell 2007; 131: 242\u2013256.","journal-title":"Cell"},{"key":"BFijo2015121_CR2","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.bbalip.2009.12.006","volume":"1801","author":"S Virtue","year":"2010","unstructured":"Virtue S, Vidal-Puig A . Adipose tissue expandability, lipotoxicity and the metabolic syndrome\u2014an allostatic perspective. Biochim Biophys Acta 2010; 1801: 338\u2013349.","journal-title":"Biochim Biophys Acta"},{"key":"BFijo2015121_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mce.2009.07.031","volume":"314","author":"E Maury","year":"2010","unstructured":"Maury E, Brichard SM . Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 2010; 314: 1\u201316.","journal-title":"Mol Cell Endocrinol"},{"key":"BFijo2015121_CR4","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1194\/jlr.M500294-JLR200","volume":"46","author":"S Cinti","year":"2005","unstructured":"Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005; 46: 2347\u20132355.","journal-title":"J Lipid Res"},{"key":"BFijo2015121_CR5","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.2337\/diabetes.46.9.1393","volume":"46","author":"S Hallakou","year":"1997","unstructured":"Hallakou S, Doar\u00e9 L, Foufelle F, Kergoat M, Guerre-Millo M, Berthault MF et al. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa\/fa rat. Diabetes 1997; 46: 1393\u20131399.","journal-title":"Diabetes"},{"key":"BFijo2015121_CR6","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1172\/JCI119870","volume":"100","author":"M Adams","year":"1997","unstructured":"Adams M, Montague CT, Prins JB, Holder JC, Smith SA, Sanders L et al. Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation. J Clin Invest 1997; 100: 3149\u20133153.","journal-title":"J Clin Invest"},{"key":"BFijo2015121_CR7","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nrm3198","volume":"12","author":"AG Cristancho","year":"2011","unstructured":"Cristancho AG, Lazar MA . Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 2011; 12: 722\u2013734.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFijo2015121_CR8","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/22572","volume":"400","author":"JT Huang","year":"1999","unstructured":"Huang JT, Welch JS, Ricote M, Binder CJ, Willson TM, Kelly C et al. Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12\/15-lipoxygenase. Nature 1999; 400: 378\u2013382.","journal-title":"Nature"},{"key":"BFijo2015121_CR9","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","volume":"4","author":"ED Rosen","year":"1999","unstructured":"Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 1999; 4: 611\u2013617.","journal-title":"Mol Cell"},{"key":"BFijo2015121_CR10","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.1210\/endo.140.7.6868","volume":"140","author":"IJ Bujalska","year":"1999","unstructured":"Bujalska IJ, Kumar S, Hewison M, Stewart PM . Differentiation of adipose stromal cells: the roles of glucocorticoids and 11beta-hydroxysteroid dehydrogenase. Endocrinology 1999; 140: 3188\u20133196.","journal-title":"Endocrinology"},{"key":"BFijo2015121_CR11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1101\/sqb.2011.76.010512","volume":"76","author":"R Siersb\u00e6k","year":"2011","unstructured":"Siersb\u00e6k R, Mandrup S . Transcriptional networks controlling adipocyte differentiation. Cold Spring Harb Symp Quant Biol 2011; 76: 247\u2013255.","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"BFijo2015121_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/protein\/5.3.197","volume":"5","author":"DL Ollis","year":"1992","unstructured":"Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM et al. The alpha\/beta hydrolase fold. Protein Eng 1992; 5: 197\u2013211.","journal-title":"Protein Eng"},{"key":"BFijo2015121_CR13","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.1440-169X.1993.00551.x","volume":"35","author":"T Sado","year":"1993","unstructured":"Sado T, Nakajima N, Tada M, Takagi N . A novel mesoderm-specific cdna isolated from a mouse embryonal carcinoma cell line. Dev Growth Differ 1993; 35: 551\u2013560.","journal-title":"Dev Growth Differ"},{"key":"BFijo2015121_CR14","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/ng0995-52","volume":"11","author":"T Kaneko-Ishino","year":"1995","unstructured":"Kaneko-Ishino T, Kuroiwa Y, Miyoshi N, Kohda T, Suzuki R, Yokoyama M et al. Peg1\/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization. Nat Genet 1995; 11: 52\u201359.","journal-title":"Nat Genet"},{"key":"BFijo2015121_CR15","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1093\/hmg\/6.5.781","volume":"6","author":"S Kobayashi","year":"1997","unstructured":"Kobayashi S, Kohda T, Miyoshi N, Kuroiwa Y, Aisaka K, Tsutsumi O et al. Human PEG1\/MEST, an imprinted gene on chromosome 7. Hum Mol Genet 1997; 6: 781\u2013786.","journal-title":"Hum Mol Genet"},{"key":"BFijo2015121_CR16","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1101\/gad.14.8.963","volume":"14","author":"A Soukas","year":"2000","unstructured":"Soukas A, Cohen P, Socci ND, Friedman JM . Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev 2000; 14: 963\u2013980.","journal-title":"Genes Dev"},{"key":"BFijo2015121_CR17","doi-asserted-by":"publisher","first-page":"E117","DOI":"10.1152\/ajpendo.00244.2004","volume":"288","author":"M Takahashi","year":"2005","unstructured":"Takahashi M, Kamei Y, Ezaki O . Mest\/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am J Physiol Endocrinol Metab 2005; 288: E117\u2013E124.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2015121_CR18","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.1371\/journal.pgen.0020081","volume":"2","author":"RA Koza","year":"2006","unstructured":"Koza RA, Nikonova L, Hogan J, Rim J-S, Mendoza T, Faulk C et al. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. PLoS Genet 2006; 2: e81.","journal-title":"PLoS Genet"},{"key":"BFijo2015121_CR19","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1096\/fj.08-108266","volume":"22","author":"L Nikonova","year":"2008","unstructured":"Nikonova L, Koza RA, Mendoza T, Chao P-M, Curley JP, Kozak LP . Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J 2008; 22: 3925\u20133937.","journal-title":"FASEB J"},{"key":"BFijo2015121_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1042\/BJ20101512","volume":"436","author":"H Jung","year":"2011","unstructured":"Jung H, Lee SK, Jho E . Mest\/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation. Biochem J 2011; 436: 263\u2013269.","journal-title":"Biochem J"},{"key":"BFijo2015121_CR21","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s12576-012-0217-8","volume":"62","author":"Y Kadota","year":"2012","unstructured":"Kadota Y, Yanagawa M, Nakaya T, Kawakami T, Sato M, Suzuki S . Gene expression of mesoderm-specific transcript is upregulated as preadipocytes differentiate to adipocytes in vitro. J Physiol Sci 2012; 62: 403\u2013411.","journal-title":"J Physiol Sci"},{"key":"BFijo2015121_CR22","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1084\/jem.20042224","volume":"201","author":"A-M Rodriguez","year":"2005","unstructured":"Rodriguez A-M, Pisani D, Dechesne CA, Turc-Carel C, Kurzenne J-Y, Wdziekonski B et al. Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse. J Exp Med 2005; 201: 1397\u20131405.","journal-title":"J Exp Med"},{"key":"BFijo2015121_CR23","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1002\/stem.1603","volume":"32","author":"M Karbiener","year":"2014","unstructured":"Karbiener M, Pisani DF, Frontini A, Oberreiter LM, Lang E, Vegiopoulos A et al. MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes. Stem Cells 2014; 32: 1578\u20131590.","journal-title":"Stem Cells"},{"key":"BFijo2015121_CR24","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1007\/s00125-013-2954-5","volume":"56","author":"AML Pettersson","year":"2013","unstructured":"Pettersson AML, Stenson BM, Lorente-Cebri\u00e1n S, Andersson DP, Mejhert N, Kr\u00e4tzel J et al. LXR is a negative regulator of glucose uptake in human adipocytes. Diabetologia 2013; 56: 2044\u20132054.","journal-title":"Diabetologia"},{"key":"BFijo2015121_CR25","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cmet.2014.03.032","volume":"19","author":"H Gao","year":"2014","unstructured":"Gao H, Mejhert N, Fretz JA, Arner E, Lorente-Cebri\u00e1n S, Ehrlund A et al. Early B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue. Cell Metab 2014; 19: 981\u2013992.","journal-title":"Cell Metab"},{"key":"BFijo2015121_CR26","doi-asserted-by":"publisher","first-page":"850","DOI":"10.4161\/rna.8.5.16153","volume":"8","author":"M Karbiener","year":"2011","unstructured":"Karbiener M, Neuhold C, Opriessnig P, Prokesch A, Bogner-Strauss JG, Scheideler M . MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2. RNA Biol 2011; 8: 850\u2013860.","journal-title":"RNA Biol"},{"key":"BFijo2015121_CR27","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1186\/1471-2105-10-268","volume":"10","author":"S Pabinger","year":"2009","unstructured":"Pabinger S, Thallinger GG, Snajder R, Eichhorn H, Rader R, Trajanoski Z . QPCR: Application for real-time PCR data management and analysis. BMC Bioinformatics 2009; 10: 268.","journal-title":"BMC Bioinformatics"},{"key":"BFijo2015121_CR28","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1089\/cmb.2005.12.1047","volume":"12","author":"S Zhao","year":"2005","unstructured":"Zhao S, Fernald RD . Comprehensive algorithm for quantitative real-time polymerase chain reaction. J Comput Biol 2005; 12: 1047\u20131064.","journal-title":"J Comput Biol"},{"key":"BFijo2015121_CR29","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.2337\/db11-1508","volume":"61","author":"E Arner","year":"2012","unstructured":"Arner E, Mejhert N, Kulyt\u00e9 A, Balwierz PJ, Pachkov M, Cormont M et al. Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes 2012; 61: 1986\u20131993.","journal-title":"Diabetes"},{"key":"BFijo2015121_CR30","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1007\/s00125-005-1961-6","volume":"48","author":"P L\u00f6fgren","year":"2005","unstructured":"L\u00f6fgren P, Hoffstedt J, N\u00e4slund E, Wir\u00e9n M, Arner P . Prospective and controlled studies of the actions of insulin and catecholamine in fat cells of obese women following weight reduction. Diabetologia 2005; 48: 2334\u20132342.","journal-title":"Diabetologia"},{"key":"BFijo2015121_CR31","doi-asserted-by":"publisher","first-page":"2941","DOI":"10.1101\/gad.1709008","volume":"22","author":"MI Lefterova","year":"2008","unstructured":"Lefterova MI, Zhang Y, Steger DJ, Schupp M, Schug J, Cristancho A et al. PPARgamma and C\/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev 2008; 22: 2941\u20132952.","journal-title":"Genes Dev"},{"key":"BFijo2015121_CR32","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/1471-2164-12-152","volume":"12","author":"SF Schmidt","year":"2011","unstructured":"Schmidt SF, J\u00f8rgensen M, Chen Y, Nielsen R, Sandelin A, Mandrup S . Cross species comparison of C\/EBP\u03b1 and PPAR\u03b3 profiles in mouse and human adipocytes reveals interdependent retention of binding sites. BMC Genomics 2011; 12: 152.","journal-title":"BMC Genomics"},{"key":"BFijo2015121_CR33","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1002\/stem.200","volume":"27","author":"C Elabd","year":"2009","unstructured":"Elabd C, Chiellini C, Carmona M, Galitzky J, Cochet O, Petersen R et al. Human multipotent adipose-derived stem cells differentiate into functional brown adipocytes. Stem Cells 2009; 27: 2753\u20132760.","journal-title":"Stem Cells"},{"key":"BFijo2015121_CR34","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005; 102: 15545\u201315550.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFijo2015121_CR35","unstructured":"WHO | Obesity and overweight. http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/# (accessed 10 June 2014)."},{"key":"BFijo2015121_CR36","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/ijo.2011.192","volume":"36","author":"J Naukkarinen","year":"2012","unstructured":"Naukkarinen J, Rissanen A, Kaprio J, Pietil\u00e4inen KH . Causes and consequences of obesity: the contribution of recent twin studies. Int J Obes (Lond) 2012; 36: 1017\u20131024.","journal-title":"Int J Obes (Lond)"},{"key":"BFijo2015121_CR37","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1210\/jc.2005-2848","volume":"91","author":"KH Pietil\u00e4inen","year":"2006","unstructured":"Pietil\u00e4inen KH, Kannisto K, Korsheninnikova E, Rissanen A, Kaprio J, Ehrenborg E et al. Acquired obesity increases CD68 and tumor necrosis factor-alpha and decreases adiponectin gene expression in adipose tissue: a study in monozygotic twins. J Clin Endocrinol Metab 2006; 91: 2776\u20132781.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2015121_CR38","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1371\/journal.pmed.0050051","volume":"5","author":"KH Pietil\u00e4inen","year":"2008","unstructured":"Pietil\u00e4inen KH, Naukkarinen J, Rissanen A, Saharinen J, Ellonen P, Ker\u00e4nen H et al. Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. PLoS Med 2008; 5: e51.","journal-title":"PLoS Med"},{"key":"BFijo2015121_CR39","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1126\/science.289.5481.950","volume":"289","author":"SE Ross","year":"2000","unstructured":"Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL et al. Inhibition of adipogenesis by Wnt signaling. Science 2000; 289: 950\u2013953.","journal-title":"Science"},{"key":"BFijo2015121_CR40","doi-asserted-by":"publisher","first-page":"35503","DOI":"10.1074\/jbc.M402937200","volume":"279","author":"KA Longo","year":"2004","unstructured":"Longo KA, Wright WS, Kang S, Gerin I, Chiang S-H, Lucas PC et al. Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem 2004; 279: 35503\u201335509.","journal-title":"J Biol Chem"},{"key":"BFijo2015121_CR41","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/34848","volume":"391","author":"A Glinka","year":"1998","unstructured":"Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C . Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 1998; 391: 357\u2013362.","journal-title":"Nature"},{"key":"BFijo2015121_CR42","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/35083081","volume":"3","author":"A Bafico","year":"2001","unstructured":"Bafico A, Liu G, Yaniv A, Gazit A, Aaronson SA . Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6\/Arrow. Nat Cell Biol 2001; 3: 683\u2013686.","journal-title":"Nat Cell Biol"},{"key":"BFijo2015121_CR43","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.cmet.2013.05.020","volume":"18","author":"J Lindroos","year":"2013","unstructured":"Lindroos J, Husa J, Mitterer G, Haschemi A, Rauscher S, Haas R et al. Human but not mouse adipogenesis is critically dependent on LMO3. Cell Metab 2013; 18: 62\u201374.","journal-title":"Cell Metab"},{"key":"BFijo2015121_CR44","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1186\/1471-2164-14-656","volume":"14","author":"O Kashpur","year":"2013","unstructured":"Kashpur O, LaPointe D, Ambady S, Ryder EF, Dominko T . FGF2-induced effects on transcriptome associated with regeneration competence in adult human fibroblasts. BMC Genomics 2013; 14: 656.","journal-title":"BMC Genomics"},{"key":"BFijo2015121_CR45","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1007\/s13187-013-0486-9","volume":"28","author":"M Akram","year":"2013","unstructured":"Akram M . Mini-review on glycolysis and cancer. J Cancer Educ 2013; 28: 454\u2013457.","journal-title":"J Cancer Educ"},{"key":"BFijo2015121_CR46","doi-asserted-by":"publisher","first-page":"4567","DOI":"10.1038\/onc.2011.611","volume":"31","author":"C Zeller","year":"2012","unstructured":"Zeller C, Dai W, Steele NL, Siddiq A, Walley AJ, Wilhelm-Benartzi CSM et al. Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. Oncogene 2012; 31: 4567\u20134576.","journal-title":"Oncogene"},{"key":"BFijo2015121_CR47","doi-asserted-by":"publisher","first-page":"4516","DOI":"10.1073\/pnas.73.12.4516","volume":"73","author":"TR Russell","year":"1976","unstructured":"Russell TR, Ho R . Conversion of 3T3 fibroblasts into adipose cells: triggering of differentiation by prostaglandin F2alpha and 1-methyl-3-isobutyl xanthine. Proc Natl Acad Sci USA 1976; 73: 4516\u20134520.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFijo2015121_CR48","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1172\/JCI114345","volume":"84","author":"H Hauner","year":"1989","unstructured":"Hauner H, Entenmann G, Wabitsch M, Gaillard D, Ailhaud G, Negrel R et al. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium. J Clin Invest 1989; 84: 1663\u20131670.","journal-title":"J Clin Invest"},{"key":"BFijo2015121_CR49","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3109\/14653241003695042","volume":"12","author":"K Hemmrich","year":"2010","unstructured":"Hemmrich K, Gummersbach C, Paul NE, Goy D, Suschek CV, Kr\u00f6ncke K-D et al. Nitric oxide and downstream second messenger cGMP and cAMP enhance adipogenesis in primary human preadipocytes. Cytotherapy 2010; 12: 547\u2013553.","journal-title":"Cytotherapy"},{"key":"BFijo2015121_CR50","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1128\/MCB.20.3.1008-1020.2000","volume":"20","author":"JE Reusch","year":"2000","unstructured":"Reusch JE, Colton LA, Klemm DJ . CREB activation induces adipogenesis in 3T3-L1 cells. Mol Cell Biol 2000; 20: 1008\u20131020.","journal-title":"Mol Cell Biol"},{"key":"BFijo2015121_CR51","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/0092-8674(94)90055-8","volume":"77","author":"DD Ginty","year":"1994","unstructured":"Ginty DD, Bonni A, Greenberg ME . Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 1994; 77: 713\u2013725.","journal-title":"Cell"},{"key":"BFijo2015121_CR52","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1074\/jbc.273.2.917","volume":"273","author":"DJ Klemm","year":"1998","unstructured":"Klemm DJ, Roesler WJ, Boras T, Colton LA, Felder K, Reusch JE . Insulin stimulates cAMP-response element binding protein activity in HepG2 and 3T3-L1 cell lines. J Biol Chem 1998; 273: 917\u2013923.","journal-title":"J Biol Chem"},{"key":"BFijo2015121_CR53","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.1646483","volume":"252","author":"M Sheng","year":"1991","unstructured":"Sheng M, Thompson MA, Greenberg ME . CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases. Science 1991; 252: 1427\u20131430.","journal-title":"Science"},{"key":"BFijo2015121_CR54","doi-asserted-by":"publisher","first-page":"4938","DOI":"10.1210\/en.2012-1441","volume":"153","author":"CM Guo","year":"2012","unstructured":"Guo CM, Kasaraneni N, Sun K, Myatt L . Cross talk between PKC and CREB in the induction of COX-2 by PGF2\u03b1 in human amnion fibroblasts. Endocrinology 2012; 153: 4938\u20134945.","journal-title":"Endocrinology"},{"key":"BFijo2015121_CR55","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/2464","volume":"20","author":"L Lefebvre","year":"1998","unstructured":"Lefebvre L, Viville S, Barton SC, Ishino F, Keverne EB, Surani MA . Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nat Genet 1998; 20: 163\u2013169.","journal-title":"Nat Genet"},{"key":"BFijo2015121_CR56","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.tins.2005.06.005","volume":"28","author":"WA Carlezon","year":"2005","unstructured":"Carlezon WA, Duman RS, Nestler EJ . The many faces of CREB. Trends Neurosci 2005; 28: 436\u2013445.","journal-title":"Trends Neurosci"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo2015121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2015121","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2015121.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:29:53Z","timestamp":1684416593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo2015121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,29]]},"references-count":56,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["BFijo2015121"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2015.121","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,29]]},"assertion":[{"value":"23 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2015","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}