{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:19:53Z","timestamp":1790957993722,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T00:00:00Z","timestamp":1472428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T00:00:00Z","timestamp":1472428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1038\/ijo.2016.154","type":"journal-article","created":{"date-parts":[[2016,8,29]],"date-time":"2016-08-29T07:42:04Z","timestamp":1472456524000},"page":"1715-1722","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Proinflammatory environment and role of TNF-\u03b1 in endometrial function of obese women having polycystic ovarian syndrome"],"prefix":"10.1038","volume":"40","author":[{"given":"L","family":"Or\u00f3stica","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Astorga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Plaza-Parrochia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Carvajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Gabler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,29]]},"reference":[{"key":"BFijo2016154_CR1","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1017\/S1462399408000598","volume":"10","author":"E Diamanti-Kandarakis","year":"2008","unstructured":"Diamanti-Kandarakis E . Polycystic ovarian syndrome pathophysiology, molecular aspects and clinical implications. Expert Rev Mol Med 2008; 10: e3.","journal-title":"Expert Rev Mol Med"},{"key":"BFijo2016154_CR2","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1210\/jc.2006-0178","volume":"91","author":"R Azziz","year":"2006","unstructured":"Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 2006; 91: 4237\u20134245.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2016154_CR3","first-page":"19","volume":"81","author":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","unstructured":"The Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81: 19\u201325.","journal-title":"Fertil Steril"},{"key":"BFijo2016154_CR4","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1530\/REP-11-0114","volume":"142","author":"AI Frolova","year":"2011","unstructured":"Frolova AI, Moley KH . Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles. Reproduction 2011; 142: 211\u2013220.","journal-title":"Reproduction"},{"key":"BFijo2016154_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1381612822666160810111528","volume":"22","author":"L Or\u00f3stica","year":"2016","unstructured":"Or\u00f3stica L, Rosas C, Plaza-Parrochia F, Astorga I, Gabler F, Garc\u00eda V et al. Review: altered steroid metabolism and insulin signaling in PCOS endometria: impact in tissue function. Curr Pharm Des 2016; 22: 1\u201311.","journal-title":"Curr Pharm Des"},{"key":"BFijo2016154_CR6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.2119\/molmed.2009.00118","volume":"16","author":"R Fornes","year":"2010","unstructured":"Fornes R, Ormazabal P, Rosas C, Gabler F, Vantman D, Romero C et al. Changes in the expresi\u00f3n of insulin signaling pathway molecules in endometria from PCOS women with or without insulin resistance. Mol Med 2010; 16: 129\u2013136.","journal-title":"Mol Med"},{"key":"BFijo2016154_CR7","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1093\/humrep\/deq232","volume":"25","author":"C Rosas","year":"2010","unstructured":"Rosas C, Gabler F, Vantman D, Romero C, Vega M . Levels of Rabs and WAVE family proteins associated to translocation of GLUT4 to the cell surface in endometria from control and hyperinsulinemic PCOS women. Hum Reprod 2010; 25: 2870\u20132877.","journal-title":"Hum Reprod"},{"key":"BFijo2016154_CR8","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1530\/REP-10-0056","volume":"140","author":"K Kohan","year":"2010","unstructured":"Kohan K, Carvajal R, Gabler F, Vantman D, Romero C, Vega M . Role of the transcriptional factors FOXO1 and PPARG on gene expression of SLC2A4 in endometrial tissue from women with polycystic ovary syndrome. Reproduction 2010; 140: 123\u2013131.","journal-title":"Reproduction"},{"key":"BFijo2016154_CR9","first-page":"1","volume":"45","author":"P Ormazabal","year":"2013","unstructured":"Ormazabal P, Romero C, Quest AFG, Vega M . Testosterone modulates the expression of molecules linked to insulin action and glucose uptake in endometrial cells. Horm Metab Res 2013; 45: 1\u20136.","journal-title":"Horm Metab Res"},{"key":"BFijo2016154_CR10","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1093\/humrep\/det116","volume":"28","author":"R Carvajal","year":"2013","unstructured":"Carvajal R, Rosas C, Kohan K, Gabler F, Vantman D, Romero C et al. Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients. Hum Reprod 2013; 28: 2235\u20132244.","journal-title":"Hum Reprod"},{"key":"BFijo2016154_CR11","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1177\/1933719115618283","volume":"23","author":"C Rosas","year":"2015","unstructured":"Rosas C, Or\u00f3stica L, Poblete C, Carvajal R, Gabler F, Romero C et al. Hyperandrogenism decreases GRP78 protein level and glucose uptake in human endometrial stromal cells. Reprod Sci 2015; 23: 761\u2013770.","journal-title":"Reprod Sci"},{"key":"BFijo2016154_CR12","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1530\/rep.1.00521","volume":"130","author":"M Mitchell","year":"2005","unstructured":"Mitchell M, Armstrong DT, Robker RL, Norman RJ . Adipokines: implications for female fertility and obesity. Reproduction 2005; 130: 583\u2013597.","journal-title":"Reproduction"},{"key":"BFijo2016154_CR13","doi-asserted-by":"publisher","first-page":"T47","DOI":"10.1530\/JOE-13-0339","volume":"220","author":"H Cao","year":"2014","unstructured":"Cao H . Adipocytokines in obesity and metabolic disease. J Endocrinol 2014; 220: T47\u2013T59.","journal-title":"J Endocrinol"},{"key":"BFijo2016154_CR14","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1126\/science.7678183","volume":"259","author":"GS Hotamisligil","year":"1993","unstructured":"Hotamisligil GS, Shargill NS, Spiegelman BM . Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87\u201391.","journal-title":"Science"},{"key":"BFijo2016154_CR15","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1172\/JCI117495","volume":"94","author":"GS Hotamisligil","year":"1994","unstructured":"Hotamisligil GS, Budavari A, Murray D, Spiegelman BM . Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-\u03b1. J Clin Invest 1994; 94: 1543\u20131549.","journal-title":"J Clin Invest"},{"key":"BFijo2016154_CR16","doi-asserted-by":"publisher","first-page":"13018","DOI":"10.1074\/jbc.271.22.13018","volume":"271","author":"P Peraldi","year":"1996","unstructured":"Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM . Tumor necrosis factor (TNF)-\u03b1 inhibits insulin signaling through stimulation of the p55 TNF. receptor and activation of sphingomyelinase. J Biol Chem 1996; 271: 13018\u201313022.","journal-title":"J Biol Chem"},{"key":"BFijo2016154_CR17","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1055\/s-0035-1555806","volume":"47","author":"V Garc\u00eda","year":"2015","unstructured":"Garc\u00eda V, Or\u00f3stica L, Poblete C, Rosas C, Astorga I, Romero C et al. Endometria from obese PCOS women with hyperinsulinemia exhibit altered adiponectin signaling. Horm Metab Res 2015; 47: 901\u2013909.","journal-title":"Horm Metab Res"},{"key":"BFijo2016154_CR18","doi-asserted-by":"publisher","first-page":"E350","DOI":"10.1152\/ajpendo.00307.2010","volume":"300","author":"T Hajri","year":"2011","unstructured":"Hajri T, Tao H, Wattacheril J, Marks-Shulman P, Abumrad NN . Regulation of adiponectin production by insulin: interactions with tumor necrosis factor-\u03b1 and interleukin-6. Am J Physiol Endocrinol Metab 2011; 300: E350\u2013E360.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2016154_CR19","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1210\/jc.2008-1389","volume":"94","author":"SA Salama","year":"2009","unstructured":"Salama SA, Kamel MW, Diaz-Arrastia CR, Xu X, Veenstra TD, Salih S et al. Effect of tumor necrosis factor-\u00f0\u00bc on estrogen metabolism and endometrial cells: potential physiological and pathological relevance. J Clin Endocrinol Metab 2009; 94: 285\u2013293.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2016154_CR20","doi-asserted-by":"publisher","first-page":"368543","DOI":"10.1155\/2013\/368543","volume":"2013","author":"S Nair","year":"2013","unstructured":"Nair S, Nguyen H, Salama S, Al-Hendy A . Obesity and the endometrium: adipocyte-secreted proinflammatory TNF \u03b1 cytokine enhances the proliferation of human endometrial glandular cells. Obstet Gynecol Int 2013; 2013: 368543.","journal-title":"Obstet Gynecol Int"},{"key":"BFijo2016154_CR21","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.1301\/nr.2007.jun.S13-S23","volume":"65","author":"AC Rutledge","year":"2007","unstructured":"Rutledge AC, Adeli K . Fructose and the metabolic syndrome: pathophysiology and molecular mechanisms. Nutr Rev 2007; 65: S13\u2013S23.","journal-title":"Nutr Rev"},{"key":"BFijo2016154_CR22","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nm1166","volume":"11","author":"D Cai","year":"2005","unstructured":"Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-\u03b2 and NF-\u03baB. Nat Med 2005; 11: 183\u2013190.","journal-title":"Nat Med"},{"key":"BFijo2016154_CR23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.beem.2006.03.005","volume":"20","author":"LC Giudice","year":"2006","unstructured":"Giudice LC . Endometrium in PCOS: implantation and predisposition to endocrine CA. Best Pract Res Clin Endocrinol Metab 2006; 20: 235\u2013244.","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"BFijo2016154_CR24","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.fertnstert.2005.09.053","volume":"85","author":"S Quezada","year":"2006","unstructured":"Quezada S, Avellaira C, Johnson MC, Gabler F, Fuentes A, Vega M . Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome. Fertil Steril 2006; 85: 1017\u20131026.","journal-title":"Fertil Steril"},{"key":"BFijo2016154_CR25","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","volume":"22","author":"M Matsuda","year":"1999","unstructured":"Matsuda M, DeFronzo RA . Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22: 1462\u20131470.","journal-title":"Diabetes Care"},{"key":"BFijo2016154_CR26","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.2337\/dc07-1067","volume":"30","author":"K McAuley","year":"2007","unstructured":"McAuley K, Mann J, Chase J, Lotz T, Shaw G . Point: HOMA\u2014satisfactory for the time being: HOMA: the best bet for the simple determination of insulin sensitivity, until something better comes along. Diabetes Care 2007; 30: 2411\u20132413.","journal-title":"Diabetes Care"},{"key":"BFijo2016154_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0015-0282(16)30062-0","volume":"1","author":"RN Noyes","year":"1950","unstructured":"Noyes RN, Hertig AT, Rock J . Dating the endometrial biopsy. Fertil Steril 1950; 1: 3\u201325.","journal-title":"Fertil Steril"},{"key":"BFijo2016154_CR28","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nrm1368","volume":"5","author":"LF Chen","year":"2004","unstructured":"Chen LF, Green WC . Shaping the nuclear action of NF-kB. Nat Rev Mol Cell Biol 2004; 5: 392\u2013401.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"BFijo2016154_CR29","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1210\/en.2003-1606","volume":"145","author":"G Krikun","year":"2004","unstructured":"Krikun G, Mor G, Alvero A, Guller S, Schatz F, Sapi E et al. A novel immortalized human endometrial stromal cell line with normal progestational response. Endocrinology 2004; 145: 2291\u20132296.","journal-title":"Endocrinology"},{"key":"BFijo2016154_CR30","first-page":"1359","volume":"142","author":"B Falini","year":"1993","unstructured":"Falini B, Flenghi L, Pileri S, Gambacorta M, Bigerna B, Durkop H et al. PG-M1: A new monoclonal antibody directed against a fixative-resistant epitope on the macrophage-restricted form of the CD68 molecule. Am J Pathol 1993; 142: 1359\u20131372.","journal-title":"Am J Pathol"},{"key":"BFijo2016154_CR31","doi-asserted-by":"publisher","first-page":"E731","DOI":"10.1152\/ajpendo.00475.2004","volume":"288","author":"B Wang","year":"2005","unstructured":"Wang B, Jenkins JR, Trayhurn P . Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-\u03b1. Am J Physiol Endocrinol Metab 2005; 288: E731\u2013E740.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2016154_CR32","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.diabet.2007.08.002","volume":"34","author":"M Guerre-Millo","year":"2008","unstructured":"Guerre-Millo M . Adiponectin: an update. Diabetes Metab 2008; 34: 12\u201318.","journal-title":"Diabetes Metab"},{"key":"BFijo2016154_CR33","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1042\/BJ20091045","volume":"425","author":"M Liu","year":"2009","unstructured":"Liu M, Liu F . Transcriptional and post-translational regulation of adiponectin. Biochem J 2009; 425: 41\u201352.","journal-title":"Biochem J"},{"key":"BFijo2016154_CR34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1530\/REP-15-0216","volume":"150","author":"F Figueroa","year":"2015","unstructured":"Figueroa F, Motta A, Acosta M, Mohamed F, Oliveros L, Forneris M . Role of macrophage secretions on rat polycystic ovary: its effect on apoptosis. Reproduction 2015; 150: 437\u2013448.","journal-title":"Reproduction"},{"key":"BFijo2016154_CR35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.fertnstert.2011.11.023","volume":"97","author":"AJ wDuleba","year":"2012","unstructured":"wDuleba AJ, Dokras A . Is PCOS an inflammatory process? Fertil Steril 2012; 97: 7\u201312.","journal-title":"Fertil Steril"},{"key":"BFijo2016154_CR36","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1210\/jcem.86.6.7580","volume":"86","author":"CC Kelly","year":"2001","unstructured":"Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N . Low grade chronic inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metab 2001; 86: 2453\u20132455.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2016154_CR37","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1210\/jc.2002-021573","volume":"88","author":"G Faulds","year":"2003","unstructured":"Faulds G, Ryd\u00e9n M, Ek I, Wahrenberg H, Arner P . Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome. J Clin Endocrinol Metab 2003; 88: 2269\u20132273.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2016154_CR38","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.placenta.2008.10.012","volume":"30","author":"S Haider","year":"2010","unstructured":"Haider S, Kn\u00f6fler M . Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta 2010; 30: 111\u2013123.","journal-title":"Placenta"},{"key":"BFijo2016154_CR39","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1093\/molehr\/5.12.1141","volume":"5","author":"S Tabibzadeh","year":"1999","unstructured":"Tabibzadeh S, Satyaswaroop PG, von Wolff M, Strowitzki T . Regulation of TNF-\u03b1 mRNA expression in endometrial cells by TNF-\u03b1 and by oestrogen withdrawal. Mol Hum Reprod 1999; 5: 1141\u20131149.","journal-title":"Mol Hum Reprod"},{"key":"BFijo2016154_CR40","first-page":"1126","volume":"86","author":"DJ Jakubowicz","year":"2001","unstructured":"Jakubowicz DJ, Sepp\u00e4l\u00e4 M, Jakubowicz S, Rodriguez-Armas O, Rivas-Santiago A, Koistinen H et al. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab 2001; 86: 1126\u20131133.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2016154_CR41","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/1477-7827-9-131","volume":"9","author":"JH Yun","year":"2011","unstructured":"Yun JH, Choi JW, Lee KJ, Shin JS, Baek KH . The promoter -1031(T\/C) polymorphism in tumor necrosis factor-alpha associated with polycystic ovary s\u00edndrome. Reprod Biol Endocrinol 2011; 9: 131.","journal-title":"Reprod Biol Endocrinol"},{"key":"BFijo2016154_CR42","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.1210\/jcem.87.8.8715","volume":"87","author":"B Peral","year":"2002","unstructured":"Peral B, San Mill\u00e1n JL, Castello R, Moghetti P, Escobar-Morreale HF . The methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism. J Clin Endocrinol Metab 2002; 87: 3977\u20133983.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2016154_CR43","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.2337\/diabetes.47.11.1757","volume":"47","author":"JM Fernandez-Real","year":"1998","unstructured":"Fernandez-Real JM, Broch M, Ricart W, Casamitjana R, Gutierrez C, Vendrell J et al. Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance. Diabetes 1998; 47: 1757\u20131762.","journal-title":"Diabetes"},{"key":"BFijo2016154_CR44","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/sj.ijo.0802078","volume":"26","author":"A Johansson","year":"2002","unstructured":"Johansson A, Ahr\u00e9n B, Forsberg H, Olsson T . Testosterone and diurnal rhythmicity of leptin, TNF-alpha and TNF-II receptor in insulin-resistant myotonic dystrophy patients. Int J Obes Relat Metab Disord 2002; 26: 1386\u20131392.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFijo2016154_CR45","doi-asserted-by":"publisher","first-page":"G657","DOI":"10.1152\/ajpgi.00230.2007","volume":"293","author":"TA Markel","year":"2007","unstructured":"Markel TA, Crisostomo PR, Wang M, Herring CM, Meldrum DR . Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production. Am J Physiol Gastrointest Liver Physiol 2007; 293: G657\u2013G662.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"BFijo2016154_CR46","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0092-8674(03)00521-X","volume":"114","author":"O Micheau","year":"2003","unstructured":"Micheau O, Tschopp J . Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003; 114: 181\u2013190.","journal-title":"Cell"},{"key":"BFijo2016154_CR47","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","volume":"18","author":"M Karin","year":"2000","unstructured":"Karin M, Ben-Neriah Y . Phosphorylation meets ubiquitination: the control of NF-\u03baB activity. Annu Rev Immunol 2000; 18: 621\u2013663.","journal-title":"Annu Rev Immunol"},{"key":"BFijo2016154_CR48","first-page":"E849","volume":"276","author":"LF del Aguila","year":"1999","unstructured":"del Aguila LF, Claffey KP, Kirwan JP . TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells. Am J Physiol 1999; 276: E849\u2013E855.","journal-title":"Am J Physiol"},{"key":"BFijo2016154_CR49","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.phrs.2016.02.027","volume":"107","author":"M Massaro","year":"2016","unstructured":"Massaro M, Scoditti E, Pellegrino M, Carluccio MA, Calabriso N, Wabitsch M et al. Therapeutic potential of the dual peroxisome proliferator activated receptor (PPAR)\u03b1\/\u03b3 agonist aleglitazar in attenuating TNF-\u03b1-mediated inflammation and insulin resistance in human adipocytes. Pharmacol Res 2016; 107: 125\u2013136.","journal-title":"Pharmacol Res"},{"key":"BFijo2016154_CR50","doi-asserted-by":"publisher","first-page":"E350","DOI":"10.1152\/ajpendo.00307.2010","volume":"300","author":"T Hajri","year":"2011","unstructured":"Hajri T, Tao H, Wattacheril J, Marks-Shulman P, Abumrad NN . Regulation of adiponectin production by insulin: interactions with tumor necrosis factor-\u03b1 and interleukin-6. Am J Physiol Endocrinol Metab 2011; 300: E350\u2013E360.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"BFijo2016154_CR51","doi-asserted-by":"crossref","unstructured":"Fulghesu AM, Sanna F, Uda S, Magnini R, Portoghese E, Batetta B . IL-6 serum levels and production is related to an altered immune response in polycystic ovary syndrome girls with insulin resistance. Mediators Inflamm 2011. ID 389317.","DOI":"10.1155\/2011\/389317"},{"key":"BFijo2016154_CR52","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.fertnstert.2010.11.036","volume":"95","author":"HF Escobar-Morreale","year":"2011","unstructured":"Escobar-Morreale HF, Luque-Ram\u00edrez M, Gonz\u00e1lez F . Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis. Fertil Steril 2011; 95: 1048\u20131058.","journal-title":"Fertil Steril"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijo2016154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijo2016154","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijo2016154.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T19:21:46Z","timestamp":1647372106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo2016154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,29]]},"references-count":52,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["BFijo2016154"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2016.154","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,29]]},"assertion":[{"value":"6 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}