{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:56:38Z","timestamp":1790031398103,"version":"4.0.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1038\/ijo.2016.34","type":"journal-article","created":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T09:50:00Z","timestamp":1456221000000},"page":"899-906","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Regulation of the clock gene expression in human adipose tissue by weight loss"],"prefix":"10.1038","volume":"40","author":[{"given":"O","family":"Pivovarova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6","family":"G\u00f6gebakan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sucher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Groth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Murahovschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Osterhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Rudovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kramer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A F H","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,23]]},"reference":[{"key":"BFijo201634_CR1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.cell.2015.03.015","volume":"161","author":"G Asher","year":"2015","unstructured":"Asher G, Sassone-Corsi P . Time for food: the intimate interplay between nutrition, metabolism, and the circadian clock. Cell 2015; 161: 84\u201392.","journal-title":"Cell"},{"key":"BFijo201634_CR2","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1172\/JCI46043","volume":"121","author":"W Huang","year":"2011","unstructured":"Huang W, Ramsey KM, Marcheva B, Bass J . Circadian rhythms, sleep, and metabolism. J Clin Invest 2011; 121: 2133\u20132141.","journal-title":"J Clin Invest"},{"key":"BFijo201634_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1755-8794-2-7","volume":"2","author":"A Loboda","year":"2009","unstructured":"Loboda A, Kraft WK, Fine B, Joseph J, Nebozhyn M, Zhang C et al. Diurnal variation of the human adipose transcriptome and the link to metabolic disease. BMC Med Genomics 2009; 2: 7.","journal-title":"BMC Med Genomics"},{"key":"BFijo201634_CR4","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.cell.2013.11.034","volume":"155","author":"KL Eckel-Mahan","year":"2013","unstructured":"Eckel-Mahan KL, Patel VR, de Mateo S, Orozco-Solis R, Ceglia NJ, Sahar S et al. Reprogramming of the circadian clock by nutritional challenge. Cell 2013; 155: 1464\u20131478.","journal-title":"Cell"},{"key":"BFijo201634_CR5","doi-asserted-by":"publisher","first-page":"21407","DOI":"10.1073\/pnas.0906361106","volume":"106","author":"M Keller","year":"2009","unstructured":"Keller M, Mazuch J, Abraham U, Eom GD, Herzog ED, Volk HD et al. A circadian clock in macrophages controls inflammatory immune responses. Proc Natl Acad Sci USA 2009; 106: 21407\u201321412.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BFijo201634_CR6","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1101\/gad.183500","volume":"14","author":"F Damiola","year":"2000","unstructured":"Damiola F . Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 2000; 14: 2950\u20132961.","journal-title":"Genes Dev"},{"key":"BFijo201634_CR7","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.cmet.2012.04.019","volume":"15","author":"M Hatori","year":"2012","unstructured":"Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S et al. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab 2012; 15: 848\u2013860.","journal-title":"Cell Metab"},{"key":"BFijo201634_CR8","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.cmet.2007.09.006","volume":"6","author":"A Kohsaka","year":"2007","unstructured":"Kohsaka A, Laposky AD, Ramsey KM, Estrada C, Joshu C, Kobayashi Y et al. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab 2007; 6: 414\u2013421.","journal-title":"Cell Metab"},{"key":"BFijo201634_CR9","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.1210\/jc.2014-3868","volume":"100","author":"O Pivovarova","year":"2015","unstructured":"Pivovarova O, Jurchott K, Rudovich N, Hornemann S, Lu Y, Mockel S et al. Changes of dietary fat and carbohydrate content alter central and peripheral clock in humans. J Clin Endocrinol Metab 2015; 100: 2291\u20132302.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo201634_CR10","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.mce.2015.01.024","volume":"418","author":"P Kumar Jha","year":"2015","unstructured":"Kumar Jha P, Challet E, Kalsbeek A . Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals. Mol Cell Endocrinol 2015; 418: 74\u201388.","journal-title":"Mol Cell Endocrinol"},{"key":"BFijo201634_CR11","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.cmet.2013.12.016","volume":"19","author":"Y Adamovich","year":"2014","unstructured":"Adamovich Y, Rousso-Noori L, Zwighaft Z, Neufeld-Cohen A, Golik M, Kraut-Cohen J et al. Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab 2014; 19: 319\u2013330.","journal-title":"Cell Metab"},{"key":"BFijo201634_CR12","doi-asserted-by":"publisher","first-page":"E218","DOI":"10.1210\/jc.2011-2241","volume":"97","author":"C Benedict","year":"2012","unstructured":"Benedict C, Shostak A, Lange T, Brooks SJ, Schioth HB, Schultes B et al. Diurnal rhythm of circulating nicotinamide phosphoribosyltransferase (Nampt\/visfatin\/PBEF): impact of sleep loss and relation to glucose metabolism. J Clin Endocrinol Metab 2012; 97: E218\u2013E222.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo201634_CR13","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1210\/jc.2002-021721","volume":"88","author":"A Gavrila","year":"2003","unstructured":"Gavrila A . Diurnal and ultradian dynamics of serum adiponectin in healthy men: comparison with leptin, circulating soluble leptin receptor, and cortisol patterns. J Clin Endocrinol Metab 2003; 88: 2838\u20132843.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo201634_CR14","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1126\/science.1108750","volume":"308","author":"FW Turek","year":"2005","unstructured":"Turek FW . Obesity and metabolic syndrome in circadian clock mutant mice. Science 2005; 308: 1043\u20131045.","journal-title":"Science"},{"key":"BFijo201634_CR15","doi-asserted-by":"publisher","first-page":"3321","DOI":"10.1096\/fj.12-208751","volume":"26","author":"J Delezie","year":"2012","unstructured":"Delezie J, Dumont S, Dardente H, Oudart H, Grechez-Cassiau A, Klosen P et al. The nuclear receptor REV-ERB alpha is required for the daily balance of carbohydrate and lipid metabolism. FASEB J 2012; 26: 3321\u20133335.","journal-title":"FASEB J"},{"key":"BFijo201634_CR16","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1210\/en.2008-0705","volume":"150","author":"S Yang","year":"2009","unstructured":"Yang S, Liu A, Weidenhammer A, Cooksey RC, McClain D, Kim MK et al. The role of mPer2 clock gene in glucocorticoid and feeding rhythms. Endocrinology 2009; 150: 2153\u20132160.","journal-title":"Endocrinology"},{"key":"BFijo201634_CR17","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1038\/nm.2979","volume":"18","author":"GK Paschos","year":"2012","unstructured":"Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM et al. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med 2012; 18: 1768\u20131777.","journal-title":"Nat Med"},{"key":"BFijo201634_CR18","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.jada.2010.03.017","volume":"110","author":"M Garaulet","year":"2011","unstructured":"Garaulet M . PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity. J Am Diet Assoc 2011; 110: 917\u2013921.","journal-title":"J Am Diet Assoc"},{"key":"BFijo201634_CR19","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1038\/ijo.2011.270","volume":"36","author":"M Garaulet","year":"2012","unstructured":"Garaulet M, Tardido AE, Lee YC, Smith CE, Parnell LD, Ordovas JM . SIRT1 and CLOCK 3111 T&gt;C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. Int J Obesity 2012; 36: 1436\u20131441.","journal-title":"Int J Obesity"},{"key":"BFijo201634_CR20","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1161\/CIRCRESAHA.109.208355","volume":"106","author":"E Maury","year":"2010","unstructured":"Maury E, Ramsey KM, Bass J . Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ Res 2010; 106: 447\u2013462.","journal-title":"Circ Res"},{"key":"BFijo201634_CR21","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00125-008-1194-6","volume":"52","author":"H Ando","year":"2009","unstructured":"Ando H, Takamura T, Matsuzawa-Nagata N, Shima KR, Eto T, Misu H et al. Clock gene expression in peripheral leucocytes of patients with type 2 diabetes. Diabetologia 2009; 52: 329\u2013335.","journal-title":"Diabetologia"},{"key":"BFijo201634_CR22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/sj.ijo.0803689","volume":"32","author":"P Gomez-Abellan","year":"2008","unstructured":"Gomez-Abellan P, Hernandez-Morante JJ, Lujan JA, Madrid JA, Garaulet M . Clock genes are implicated in the human metabolic syndrome. Int J Obes (Lond) 2008; 32: 121\u2013128.","journal-title":"Int J Obes (Lond)"},{"key":"BFijo201634_CR23","doi-asserted-by":"publisher","first-page":"2829","DOI":"10.1161\/CIRCULATIONAHA.111.033274","volume":"124","author":"O Gogebakan","year":"2011","unstructured":"Gogebakan O, Kohl A, Osterhoff MA, van Baak MA, Jebb SA, Papadaki A et al. Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on cardiovascular risk factors: the diet, obesity, and genes (DiOGenes) study: a randomized, controlled trial. Circulation 2011; 124: 2829\u20132838.","journal-title":"Circulation"},{"key":"BFijo201634_CR24","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/ijo.2012.80","volume":"37","author":"L Rossmeislova","year":"2013","unstructured":"Rossmeislova L, Malisova L, Kracmerova J, Stich V . Adaptation of human adipose tissue to hypocaloric diet. Int J Obes (Lond) 2013; 37: 640\u2013650.","journal-title":"Int J Obes (Lond)"},{"key":"BFijo201634_CR25","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.2337\/db09-1187","volume":"59","author":"SV de Kreutzenberg","year":"2010","unstructured":"de Kreutzenberg SV, Ceolotto G, Papparella I, Bortoluzzi A, Semplicini A, Dalla Man C et al. Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. Diabetes 2010; 59: 1006\u20131015.","journal-title":"Diabetes"},{"key":"BFijo201634_CR26","doi-asserted-by":"publisher","first-page":"E268","DOI":"10.1210\/jc.2010-1681","volume":"96","author":"J Kovsan","year":"2011","unstructured":"Kovsan J, Bluher M, Tarnovscki T, Kloting N, Kirshtein B, Madar L et al. Altered autophagy in human adipose tissues in obesity. J Clin Endocrinol Metab 2011; 96: E268\u2013E277.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo201634_CR27","doi-asserted-by":"publisher","first-page":"861","DOI":"10.2337\/dc09-1799","volume":"33","author":"MR Dasu","year":"2010","unstructured":"Dasu MR, Devaraj S, Park S, Jialal I . Increased Toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care 2010; 33: 861\u2013868.","journal-title":"Diabetes Care"},{"key":"BFijo201634_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1172\/JCI29881","volume":"117","author":"CN Lumeng","year":"2007","unstructured":"Lumeng CN, Bodzin JL, Saltiel AR . Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117: 175\u2013184.","journal-title":"J Clin Invest"},{"key":"BFijo201634_CR29","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1038\/oby.2009.164","volume":"17","author":"C Gomez-Santos","year":"2009","unstructured":"Gomez-Santos C, Gomez-Abellan P, Madrid JA, Hernandez-Morante JJ, Lujan JA, Ordovas JM et al. Circadian rhythm of clock genes in human adipose explants. Obesity 2009; 17: 1481\u20131485.","journal-title":"Obesity"},{"key":"BFijo201634_CR30","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/ijo.2012.229","volume":"37","author":"M Garaulet","year":"2013","unstructured":"Garaulet M, Gomez-Abellan P, Alburquerque-Bejar JJ, Lee YC, Ordovas JM, Scheer FA . Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond) 2013; 37: 604\u2013611.","journal-title":"Int J Obes (Lond)"},{"key":"BFijo201634_CR31","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1007\/s00125-014-3253-5","volume":"57","author":"H Kahleova","year":"2014","unstructured":"Kahleova H, Belinova L, Malinska H, Oliyarnyk O, Trnovska J, Skop V et al. Eating two larger meals a day (breakfast and lunch) is more effective than six smaller meals in a reduced-energy regimen for patients with type 2 diabetes: a randomised crossover study. Diabetologia 2014; 57: 1552\u20131560.","journal-title":"Diabetologia"},{"key":"BFijo201634_CR32","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1179\/oeh.2011.17.2.154","volume":"17","author":"Y Li","year":"2011","unstructured":"Li Y, Sato Y, Yamaguchi N . Shift work and the risk of metabolic syndrome: a nested case-control study. Int J Occup Environ Health 2011; 17: 154\u2013160.","journal-title":"Int J Occup Environ Health"},{"key":"BFijo201634_CR33","doi-asserted-by":"publisher","first-page":"e1000181","DOI":"10.1371\/journal.pbio.1000181","volume":"7","author":"G Le Martelot","year":"2009","unstructured":"Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Lo Sasso G et al. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol 2009; 7: e1000181.","journal-title":"PLoS Biol"},{"key":"BFijo201634_CR34","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.cmet.2010.10.005","volume":"12","author":"B Grimaldi","year":"2010","unstructured":"Grimaldi B, Bellet MM, Katada S, Astarita G, Hirayama J, Amin RH et al. PER2 controls lipid metabolism by direct regulation of PPARgamma. Cell Metab 2010; 12: 509\u2013520.","journal-title":"Cell Metab"},{"key":"BFijo201634_CR35","doi-asserted-by":"publisher","first-page":"3452","DOI":"10.2337\/db14-1933","volume":"64","author":"H Soussi","year":"2015","unstructured":"Soussi H, Reggio S, Alili R, Prado C, Mutel S, Pini M et al. DAPK2 down-regulation associates with attenuated adipocyte autophagic clearance in human obesity. Diabetes 2015; 64: 3452\u20133463.","journal-title":"Diabetes"},{"key":"BFijo201634_CR36","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.1038\/emboj.2011.322","volume":"30","author":"D Ma","year":"2011","unstructured":"Ma D, Panda S, Lin JD . Temporal orchestration of circadian autophagy rhythm by C\/EBPbeta. EMBO J 2011; 30: 4642\u20134651.","journal-title":"EMBO J"},{"key":"BFijo201634_CR37","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1126\/science.1170803","volume":"324","author":"Y Nakahata","year":"2009","unstructured":"Nakahata Y, Sahar S, Astarita G, Kaluzova M, Sassone-Corsi P . Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1. Science 2009; 324: 654\u2013657.","journal-title":"Science"},{"key":"BFijo201634_CR38","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1126\/science.1172156","volume":"326","author":"KA Lamia","year":"2009","unstructured":"Lamia KA, Sachdeva UM, DiTacchio L, Williams EC, Alvarez JG, Egan DF et al. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 2009; 326: 437\u2013440.","journal-title":"Science"},{"key":"BFijo201634_CR39","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1126\/science.1171641","volume":"324","author":"KM Ramsey","year":"2009","unstructured":"Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B et al. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 2009; 324: 651\u2013654.","journal-title":"Science"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijo201634.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijo201634","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijo201634.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T19:17:35Z","timestamp":1647371855000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo201634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,23]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["BFijo201634"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2016.34","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,23]]},"assertion":[{"value":"7 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2016","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2016","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}