{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:31:12Z","timestamp":1769275872271,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1038\/ijo.2016.35","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T08:40:16Z","timestamp":1456821616000},"page":"1005-1011","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Associations between weight change and biomarkers of cardiometabolic risk in South Asians: secondary analyses of the PODOSA trial"],"prefix":"10.1038","volume":"40","author":[{"given":"P","family":"Welsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Cezard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Wallia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S H","family":"Wild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Tuomilehto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"McKnight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Bhopal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E","family":"Lean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Sattar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,1]]},"reference":[{"key":"BFijo201635_CR1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/ijo.2009.225","volume":"34","author":"R Nyamdorj","year":"2010","unstructured":"Nyamdorj R, Pitk\u00e4niemi J, Tuomilehto J, Hammar N, Stehouwer CD, Lam TH et al. Ethnic comparison of the association of undiagnosed diabetes with obesity. Int J Obes (Lond) 2010; 34: 332\u2013339.","journal-title":"Int J Obes (Lond)"},{"key":"BFijo201635_CR2","unstructured":"Scottish Intercollegiate Guidelines Network. Management of obesity [Article online], 2010. Available from http:\/\/www.sign.ac.uk\/pdf\/sign115.pdf. Accessed 11 December 2015."},{"key":"BFijo201635_CR3","unstructured":"Preventing type 2 diabetes: population and community-level interventions | Guidance and guidelines | NICE [Article online], 2011. Available from https:\/\/www.nice.org.uk\/guidance\/ph35. Accessed 11 December 2015."},{"key":"BFijo201635_CR4","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3390\/ijerph120100566","volume":"12","author":"T Brown","year":"2015","unstructured":"Brown T, Smith S, Bhopal R, Kasim A, Summerbell C . Diet and physical activity interventions to prevent or treat obesity in South Asian children and adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2015; 12: 566\u2013594.","journal-title":"Int J Environ Res Public Health"},{"key":"BFijo201635_CR5","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00125-005-0097-z","volume":"49","author":"A Ramachandran","year":"2006","unstructured":"Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD, Vijay V . The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia 2006; 49: 289\u2013297.","journal-title":"Diabetologia"},{"key":"BFijo201635_CR6","first-page":"1","volume":"29","author":"S Wallia","year":"2013","unstructured":"Wallia S, Bhopal RS, Douglas A, Bhopal R, Sharma A, Hutchison A et al. Culturally adapting the prevention of diabetes and obesity in South Asians (PODOSA) trial. Health Promot Int 2013; 29: 1\u201312.","journal-title":"Health Promot Int"},{"key":"BFijo201635_CR7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/S2213-8587(13)70204-3","volume":"2","author":"RS Bhopal","year":"2014","unstructured":"Bhopal RS, Douglas A, Wallia S, Forbes JF, Lean MEJ, Gill JMR et al. Effect of a lifestyle intervention on weight change in south Asian individuals in the UK at high risk of type 2 diabetes: a family-cluster randomised controlled trial. Lancet Diabetes Endocrinol 2014; 2: 218\u2013227.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"BFijo201635_CR8","doi-asserted-by":"publisher","first-page":"S19","DOI":"10.1038\/ijo.2013.92","volume":"37","author":"ML Vetter","year":"2013","unstructured":"Vetter ML, Wadden TA, Chittams J, Diewald LK, Panigrahi E, Volger S et al. Effect of lifestyle intervention on cardiometabolic risk factors: results of the POWER-UP trial. Int J Obes (Lond) 2013; 37: S19\u2013S24.","journal-title":"Int J Obes (Lond)"},{"key":"BFijo201635_CR9","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.metabol.2014.10.018","volume":"64","author":"L Chen","year":"2015","unstructured":"Chen L, Pei J-H, Kuang J, Chen H-M, Chen Z, Li Z-W et al. Effect of lifestyle intervention in patients with type 2 diabetes: a meta-analysis. Metabolism 2015; 64: 338\u2013347.","journal-title":"Metabolism"},{"key":"BFijo201635_CR10","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/1745-6215-12-220","volume":"12","author":"A Douglas","year":"2011","unstructured":"Douglas A, Bhopal RS, Bhopal R, Forbes JF, Gill JMR, Lawton J et al. Recruiting South Asians to a lifestyle intervention trial: experiences and lessons from PODOSA (Prevention of Diabetes & Obesity in South Asians). Trials 2011; 12: 220.","journal-title":"Trials"},{"key":"BFijo201635_CR11","unstructured":"World Health Organisation (WHO). Report of a WHO consultation. Part 1: diagnosis and classification of diabetes mellitus. Department of Noncommunicable Disease Surveillance: Geneva, [Article online], 1999. Available from http:\/\/apps.who.int\/iris\/bitstream\/10665\/66040\/1\/WHO_NCD_NCS_99.2.pdf. Accessed 11 December 2015."},{"key":"BFijo201635_CR12","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC . Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412\u2013419.","journal-title":"Diabetologia"},{"key":"BFijo201635_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00001648-199001000-00010","volume":"1","author":"KJ Rothman","year":"1990","unstructured":"Rothman KJ . No adjustments are needed for multiple comparisons. Epidemiology 1990; 1: 43\u201346.","journal-title":"Epidemiology"},{"key":"BFijo201635_CR14","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1001\/jama.289.14.1799","volume":"289","author":"K Esposito","year":"2003","unstructured":"Esposito K, Pontillo A, Di Palo C, Giugliano G, Masella M, Marfella R et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 2003; 289: 1799\u20131804.","journal-title":"JAMA"},{"key":"BFijo201635_CR15","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1001\/jama.1995.03530240025035","volume":"274","author":"LI Katzel","year":"1995","unstructured":"Katzel LI, Bleecker ER, Colman EG, Rogus EM, Sorkin JD, Goldberg AP . Effects of weight loss vs aerobic exercise training on risk factors for coronary disease in healthy, obese, middle-aged and older men. A randomized controlled trial. JAMA 1995; 274: 1915\u20131921.","journal-title":"JAMA"},{"key":"BFijo201635_CR16","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1123\/ijsnem.2015-0025","volume":"25","author":"J Khoo","year":"2015","unstructured":"Khoo J, Dhamodaran S, Chen D-D, Yap S-Y, Chen RY, Tian H-H . Exercise-induced weight loss is more effective than dieting for improving adipokine profile, insulin resistance and inflammation in obese men. Int J Sport Nutr Exerc Metab 2015; 25: 566\u2013575.","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"BFijo201635_CR17","doi-asserted-by":"publisher","first-page":"92","DOI":"10.7326\/0003-4819-133-2-200007180-00008","volume":"133","author":"R Ross","year":"2000","unstructured":"Ross R, Dagnone D, Jones PJ, Smith H, Paddags A, Hudson R et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 2000; 133: 92\u2013103.","journal-title":"Ann Intern Med"},{"key":"BFijo201635_CR18","doi-asserted-by":"publisher","first-page":"g4596","DOI":"10.1136\/bmj.g4596","volume":"349","author":"N Sattar","year":"2014","unstructured":"Sattar N, Forrest E, Preiss D . Non-alcoholic fatty liver disease. BMJ 2014; 349: g4596.","journal-title":"BMJ"},{"key":"BFijo201635_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s12916-014-0123-4","volume":"12","author":"N Sattar","year":"2014","unstructured":"Sattar N, Gill JMR. Type . 2 diabetes as a disease of ectopic fat? BMC Med 2014; 12: 123.","journal-title":"BMC Med"},{"key":"BFijo201635_CR20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.jhep.2011.06.010","volume":"56","author":"C Thoma","year":"2012","unstructured":"Thoma C, Day CP, Trenell MI . Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. J Hepatol 2012; 56: 255\u2013266.","journal-title":"J Hepatol"},{"key":"BFijo201635_CR21","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1007\/s00125-011-2204-7","volume":"54","author":"EL Lim","year":"2011","unstructured":"Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R . Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol. Diabetologia 2011; 54: 2506\u20132514.","journal-title":"Diabetologia"},{"key":"BFijo201635_CR22","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.2337\/db05-1320","volume":"55","author":"C Herder","year":"2006","unstructured":"Herder C, Peltonen M, K\u00f6nig W, Kraft I, M\u00fcller-Scholze S, Martin S et al. Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish diabetes prevention study. Diabetes 2006; 55: 2340\u20132346.","journal-title":"Diabetes"},{"key":"BFijo201635_CR23","first-page":"173","volume":"215","author":"R Ma","year":"2013","unstructured":"Ma R, Ploner A, Fischer K, Fall T, Ha S, Horikoshi M et al. The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. Br Dent J 2013; 215: 173.","journal-title":"Br Dent J"},{"key":"BFijo201635_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7326\/0003-4819-145-1-200607040-00004","volume":"145","author":"R Estruch","year":"2006","unstructured":"Estruch R, Mart\u00ednez-Gonz\u00e1lez MA, Corella D, Salas-Salvad\u00f3 J, Ruiz-Guti\u00e9rrez V, Covas MI et al. PREDIMED Study Investigators. Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 2006; 145: 1\u201311.","journal-title":"Ann Intern Med"},{"key":"BFijo201635_CR25","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.2105\/AJPH.2004.061713","volume":"96","author":"L Rosen","year":"2006","unstructured":"Rosen L, Manor O, Engelhard D, Zucker D . In defense of the randomized controlled trial for health promotion research. Am J Public Health 2006; 96: 1181\u20131186.","journal-title":"Am J Public Health"},{"key":"BFijo201635_CR26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.2337\/diabetes.54.3.603","volume":"54","author":"KF Petersen","year":"2005","unstructured":"Petersen KF, Dufour S, Befroy D, Lehrke M, Hendler RE, Shulman GI . Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 2005; 54: 603\u2013608.","journal-title":"Diabetes"},{"key":"BFijo201635_CR27","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1111\/dme.12722","volume":"32","author":"S Steven","year":"2015","unstructured":"Steven S, Taylor R . Restoring normoglycaemia by use of a very low calorie diet in long- and short-duration Type 2 diabetes. Diabet Med 2015; 32: 1149\u20131155.","journal-title":"Diabet Med"},{"key":"BFijo201635_CR28","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/dme.12567","volume":"32","author":"S Steven","year":"2015","unstructured":"Steven S, Carey PE, Small PK, Taylor R . Reversal of Type 2 diabetes after bariatric surgery is determined by the degree of achieved weight loss in both short- and long-duration diabetes. Diabet Med 2015; 32: 47\u201353.","journal-title":"Diabet Med"},{"key":"BFijo201635_CR29","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1002\/oby.20777","volume":"22","author":"JL Unick","year":"2014","unstructured":"Unick JL, Hogan PE, Neiberg RH, Cheskin LJ, Dutton GR, Evans-Hudnall G et al. Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention. Obesity (Silver Spring) 2014; 22: 1608\u20131616.","journal-title":"Obesity (Silver Spring)"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijo201635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijo201635","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijo201635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T19:17:41Z","timestamp":1647371861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo201635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,1]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["BFijo201635"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2016.35","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,1]]},"assertion":[{"value":"12 August 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2015","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2015","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2016","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JT received research grants, served as a consultant to and\/or a member of advisory boards for, and\/or gave lectures organized by AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, ImpetoMedical, Merck, MSD, Sanofi-Aventis, Novartis, Novo Nordisk and Servier. The remaining authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}