{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:53:14Z","timestamp":1761238394473},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T00:00:00Z","timestamp":1493769600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1038\/ijo.2017.109","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T07:41:11Z","timestamp":1493797271000},"page":"1447-1453","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Joint effect of maternal plasma homocysteine and prepregnancy obesity on child blood pressure: a prospective birth cohort study"],"prefix":"10.1038","volume":"41","author":[{"given":"H","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B P","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R B","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S O","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,5,3]]},"reference":[{"key":"BFijo2017109_CR1","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1056\/NEJM199905133401901","volume":"340","author":"PF Jacques","year":"1999","unstructured":"Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH . The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999; 340: 1449\u20131454.","journal-title":"N Engl J Med"},{"key":"BFijo2017109_CR2","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1172\/JCI116187","volume":"91","author":"JS Stamler","year":"1993","unstructured":"Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D et al. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest 1993; 91: 308\u2013318.","journal-title":"J Clin Invest"},{"key":"BFijo2017109_CR3","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/oxfordjournals.aje.a008828","volume":"143","author":"P Verhoef","year":"1996","unstructured":"Verhoef P, Stampfer MJ, Buring JE, Gaziano JM, Allen RH, Stabler SP et al. Homocysteine metabolism and risk of myocardial infarction: Relation with vitamins b6, b12, and folate. Am J Epidemiol 1996; 143: 845\u2013859.","journal-title":"Am J Epidemiol"},{"key":"BFijo2017109_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10545-006-0106-5","volume":"29","author":"R Castro","year":"2006","unstructured":"Castro R, Rivera I, Blom HJ, Jakobs C, Tavares de Almeida I . Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inherit Metab Dis 2006; 29: 3\u201320.","journal-title":"J Inherit Metab Dis"},{"key":"BFijo2017109_CR5","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1586\/17512433.2015.1010516","volume":"8","author":"KS McCully","year":"2015","unstructured":"McCully KS . Homocysteine and the pathogenesis of atherosclerosis. Expert Rev Clin Pharmacol 2015; 8: 211\u2013219.","journal-title":"Expert Rev Clin Pharmacol"},{"key":"BFijo2017109_CR6","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1212\/WNL.0000000000003115","volume":"87","author":"A Shoamanesh","year":"2016","unstructured":"Shoamanesh A, Preis SR, Beiser AS, Kase CS, Wolf PA, Vasan RS et al. Circulating biomarkers and incident ischemic stroke in the framingham offspring study.Neurology 2016; 87: 1206\u20131211.","journal-title":"Neurology"},{"key":"BFijo2017109_CR7","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0895-7061(02)02984-9","volume":"15","author":"R Kahleova","year":"2002","unstructured":"Kahleova R, Palyzova D, Zvara K, Zvarova J, Hrach K, Novakova I et al. Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins. Am J Hypertens 2002; 15: 857\u2013864.","journal-title":"Am J Hypertens"},{"key":"BFijo2017109_CR8","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s11906-003-0007-z","volume":"5","author":"C van Guldener","year":"2003","unstructured":"van Guldener C, Nanayakkara PW, Stehouwer CD . Homocysteine and blood pressure. Curr Hypertens Rep 2003; 5: 26\u201331.","journal-title":"Curr Hypertens Rep"},{"key":"BFijo2017109_CR9","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/aje\/kwf157","volume":"156","author":"U Lim","year":"2002","unstructured":"Lim U, Cassano PA . Homocysteine and blood pressure in the third national health and nutrition examination survey, 1988\u20131994. Am J Epidemiol 2002; 156: 1105\u20131113.","journal-title":"Am J Epidemiol"},{"key":"BFijo2017109_CR10","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1093\/ajcn\/71.4.962","volume":"71","author":"SE Vollset","year":"2000","unstructured":"Vollset SE, Refsum H, Irgens LM, Emblem BM, Tverdal A, Gjessing HK et al. Plasma total homocysteine, pregnancy complications, and adverse pregnancy outcomes: The hordaland homocysteine study. Am J Clin Nutr 2000; 71: 962\u2013968.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2017109_CR11","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.0001-6349.2004.00291.x","volume":"83","author":"R D'Anna","year":"2004","unstructured":"D'Anna R, Baviera G, Corrado F, Ientile R, Granese D, Stella NC . Plasma homocysteine in early and late pregnancies complicated with preeclampsia and isolated intrauterine growth restriction. Acta Obstet Gynecol Scand 2004; 83: 155\u2013158.","journal-title":"Acta Obstet Gynecol Scand"},{"key":"BFijo2017109_CR12","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/01.AOG.0000129955.47943.2a","volume":"104","author":"RP Steegers-Theunissen","year":"2004","unstructured":"Steegers-Theunissen RP, Van Iersel CA, Peer PG, Nelen WL, Steegers EA . Hyperhomocysteinemia, pregnancy complications, and the timing of investigation. Obstet Gynecol 2004; 104: 336\u2013343.","journal-title":"Obstet Gynecol"},{"key":"BFijo2017109_CR13","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.1007\/s11033-010-0413-7","volume":"38","author":"SA Bukhari","year":"2011","unstructured":"Bukhari SA, Rajoka MI, Ibrahim Z, Jalal F, Rana SM, Nagra SA . Oxidative stress elevated DNA damage and homocysteine level in normal pregnant women in a segment of pakistani population. Mol Biol Rep 2011; 38: 2703\u20132710.","journal-title":"Mol Biol Rep"},{"key":"BFijo2017109_CR14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3945\/ajcn.112.057489","volume":"98","author":"B McNulty","year":"2013","unstructured":"McNulty B, McNulty H, Marshall B, Ward M, Molloy AM, Scott JM et al. Impact of continuing folic acid after the first trimester of pregnancy: findings of a randomized trial of folic acid supplementation in the second and third trimesters. Am J Clin Nutr 2013; 98: 92\u201398.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2017109_CR15","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1001\/jama.2012.39","volume":"307","author":"KM Flegal","year":"2012","unstructured":"Flegal KM, Carroll MD, Kit BK, Ogden CL . Prevalence of obesity and trends in the distribution of body mass index among us adults, 1999\u20132010. JAMA 2012; 307: 491\u2013497.","journal-title":"JAMA"},{"key":"BFijo2017109_CR16","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1161\/HYPERTENSIONAHA.113.02671","volume":"63","author":"R Gaillard","year":"2014","unstructured":"Gaillard R, Steegers EA, Duijts L, Felix JF, Hofman A, Franco OH et al. Childhood cardiometabolic outcomes of maternal obesity during pregnancy: The generation r study. Hypertension 2014; 63: 683\u2013691.","journal-title":"Hypertension"},{"key":"BFijo2017109_CR17","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.annepidem.2014.08.002","volume":"24","author":"W Perng","year":"2014","unstructured":"Perng W, Gillman MW, Mantzoros CS, Oken E . A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood. Ann Epidemiol 2014; 24: 793\u2013800 e791.","journal-title":"Ann Epidemiol"},{"key":"BFijo2017109_CR18","doi-asserted-by":"publisher","first-page":"e12564","DOI":"10.14814\/phy2.12564","volume":"3","author":"PW Nathanielsz","year":"2015","unstructured":"Nathanielsz PW, Yan J, Green R, Nijland M, Miller JW, Wu G et al. Maternal obesity disrupts the methionine cycle in baboon pregnancy. Physiol Rep 2015; 3: e12564.","journal-title":"Physiol Rep"},{"key":"BFijo2017109_CR19","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1093\/ajcn\/73.3.613","volume":"73","author":"PF Jacques","year":"2001","unstructured":"Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J . Determinants of plasma total homocysteine concentration in the framingham offspring cohort. Am J Clin Nutr 2001; 73: 613\u2013621.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2017109_CR20","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1001\/jama.2014.1","volume":"311","author":"G Wang","year":"2014","unstructured":"Wang G, Divall S, Radovick S, Paige D, Ning Y, Chen Z et al. Preterm birth and random plasma insulin levels at birth and in early childhood. JAMA 2014; 311: 587\u2013596.","journal-title":"JAMA"},{"key":"BFijo2017109_CR21","unstructured":"Defining adult overweight and obesity. Centers for disease control and prevention. Available at: https:\/\/www.cdc.gov\/obesity\/adult\/defining.Html."},{"key":"BFijo2017109_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1001\/jama.287.2.195","volume":"287","author":"X Wang","year":"2002","unstructured":"Wang X, Zuckerman B, Pearson C, Kaufman G, Chen C, Wang G et al. Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. JAMA 2002; 287: 195\u2013202.","journal-title":"JAMA"},{"key":"BFijo2017109_CR23","doi-asserted-by":"publisher","first-page":"438 e431","DOI":"10.1016\/j.ajog.2013.07.003","volume":"209","author":"Y Yu","year":"2013","unstructured":"Yu Y, Zhang S, Wang G, Hong X, Mallow EB, Walker SO et al. The combined association of psychosocial stress and chronic hypertension with preeclampsia. Am J Obstet Gynecol 2013; 209: 438 e431\u2013438 e412.","journal-title":"Am J Obstet Gynecol"},{"key":"BFijo2017109_CR24","doi-asserted-by":"crossref","unstructured":"National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Report of the national high blood pressure education program working group on high blood pressure in pregnancy. Am J Obstet Gynecol 2000; 183: S1\u2013S22.","DOI":"10.1067\/mob.2000.107928"},{"key":"BFijo2017109_CR25","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1086\/503712","volume":"78","author":"L Wang","year":"2006","unstructured":"Wang L, Wang X, Laird N, Zuckerman B, Stubblefield P, Xu X . Polymorphism in maternal lrp8 gene is associated with fetal growth. Am J Hum Genet 2006; 78: 770\u2013777.","journal-title":"Am J Hum Genet"},{"key":"BFijo2017109_CR26","unstructured":"National center for health statistics. Cdc Growth Charts, United States. Available at: http:\/\/www.cdc.gov\/growthcharts\/ 2000."},{"key":"BFijo2017109_CR27","doi-asserted-by":"publisher","first-page":"d643","DOI":"10.1136\/bmj.d643","volume":"342","author":"J Sundstrom","year":"2011","unstructured":"Sundstrom J, Neovius M, Tynelius P, Rasmussen F . Association of blood pressure in late adolescence with subsequent mortality: Cohort study of swedish male conscripts. Br Med J 2011; 342: d643.","journal-title":"Br Med J"},{"key":"BFijo2017109_CR28","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/hr.2009.32","volume":"32","author":"Z Li","year":"2009","unstructured":"Li Z, Snieder H, Harshfield GA, Treiber FA, Wang X . A 15-year longitudinal study on ambulatory blood pressure tracking from childhood to early adulthood. Hypertens Res 2009; 32: 404\u2013410.","journal-title":"Hypertens Res"},{"key":"BFijo2017109_CR29","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1542\/peds.114.2.S2.555","volume":"114","author":"National High Blood Pressure Education Program Working Group on High Blood Pressure in C, Adolescents","year":"2004","unstructured":"National High Blood Pressure Education Program Working Group on High Blood Pressure in C, Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114: 555\u2013576.","journal-title":"Pediatrics"},{"key":"BFijo2017109_CR30","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1161\/CIRCULATIONAHA.108.191394","volume":"119","author":"J Steinberger","year":"2009","unstructured":"Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B et al. Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the american heart association atherosclerosis, hypertension, and obesity in the young committee of the council on cardiovascular disease in the young; council on cardiovascular nursing; and council on nutrition, physical activity, and metabolism. Circulation 2009; 119: 628\u2013647.","journal-title":"Circulation"},{"key":"BFijo2017109_CR31","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1001\/jama.2015.2274","volume":"313","author":"Y Huo","year":"2015","unstructured":"Huo Y, Li J, Qin X, Huang Y, Wang X, Gottesman RF et al. Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in china: The csppt randomized clinical trial. JAMA 2015; 313: 1325\u20131335.","journal-title":"JAMA"},{"key":"BFijo2017109_CR32","doi-asserted-by":"publisher","first-page":"e160845","DOI":"10.1001\/jamapediatrics.2016.0845","volume":"170","author":"G Wang","year":"2016","unstructured":"Wang G, Hu FB, Mistry KB, Zhang C, Ren F, Huo Y et al. Association between maternal prepregnancy body mass index and plasma folate concentrations with child metabolic health. JAMA Pediatr 2016; 170: e160845.","journal-title":"JAMA Pediatr"},{"key":"BFijo2017109_CR33","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s11239-011-0550-4","volume":"32","author":"F Cacciapuoti","year":"2011","unstructured":"Cacciapuoti F . Hyper-homocysteinemia: A novel risk factor or a powerful marker for cardiovascular diseases? Pathogenetic and therapeutical uncertainties. J Thromb Thrombolysis 2011; 32: 82\u201388.","journal-title":"J Thromb Thrombolysis"},{"key":"BFijo2017109_CR34","unstructured":"Richard S, Lord KF Significance of low plasma homocysteine. Meametrix Clinical Laboratory, Department of Science and Education, 2006. Available at: http:\/\/www.drkendalstewart.com\/wp-content\/uploads\/2011\/09\/Significance-of-Low-Plasma-Homocysteine.pdf."},{"key":"BFijo2017109_CR35","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0009-2797(98)00015-5","volume":"110","author":"J Huang","year":"1998","unstructured":"Huang J, Khan S, O'Brien PJ . The glutathione dependence of inorganic sulfate formation from l- or d-cysteine in isolated rat hepatocytes. Chem Biol Interact 1998; 110: 189\u2013202.","journal-title":"Chem Biol Interact"},{"key":"BFijo2017109_CR36","doi-asserted-by":"publisher","first-page":"1726S","DOI":"10.1093\/jn\/136.6.1726S","volume":"136","author":"J Selhub","year":"2006","unstructured":"Selhub J . The many facets of hyperhomocysteinemia: Studies from the framingham cohorts. J Nutr 2006; 136: 1726S\u20131730S.","journal-title":"J Nutr"},{"key":"BFijo2017109_CR37","doi-asserted-by":"publisher","first-page":"e011247","DOI":"10.1136\/bmjopen-2016-011247","volume":"6","author":"N Sukumar","year":"2016","unstructured":"Sukumar N, Adaikalakoteswari A, Venkataraman H, Maheswaran H, Saravanan P . Vitamin b12 status in women of childbearing age in the uk and its relationship with national nutrient intake guidelines: Results from two national diet and nutrition surveys. BMJ Open 2016; 6: e011247.","journal-title":"BMJ Open"},{"key":"BFijo2017109_CR38","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1055\/s-2005-918889","volume":"23","author":"A Baksu","year":"2006","unstructured":"Baksu A, Taskin M, Goker N, Baksu B, Uluocak A . Plasma homocysteine in late pregnancies complicated with preeclampsia and in newborns. Am J Perinatol 2006; 23: 31\u201335.","journal-title":"Am J Perinatol"},{"key":"BFijo2017109_CR39","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1093\/aje\/153.5.474","volume":"153","author":"SE Sanchez","year":"2001","unstructured":"Sanchez SE, Zhang C, Rene Malinow M, Ware-Jauregui S, Larrabure G, Williams MA . Plasma folate, vitamin b(12), and homocyst(e)ine concentrations in preeclamptic and normotensive peruvian women. Am J Epidemiol 2001; 153: 474\u2013480.","journal-title":"Am J Epidemiol"},{"key":"BFijo2017109_CR40","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1017\/S0007114513000676","volume":"110","author":"LC van den Hil","year":"2013","unstructured":"van den Hil LC, Rob Taal H, de Jonge LL, Heppe DH, Steegers EA, Hofman A et al. Maternal first-trimester dietary intake and childhood blood pressure: The generation r study. Br J Nutr 2013; 110: 1454\u20131464.","journal-title":"Br J Nutr"},{"key":"BFijo2017109_CR41","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.placenta.2014.05.006","volume":"35","author":"L Huang","year":"2014","unstructured":"Huang L, Liu J, Feng L, Chen Y, Zhang J, Wang W . Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions. Placenta 2014; 35: 563\u2013569.","journal-title":"Placenta"},{"key":"BFijo2017109_CR42","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.placenta.2014.03.010","volume":"35","author":"N Malti","year":"2014","unstructured":"Malti N, Merzouk H, Merzouk SA, Loukidi B, Karaouzene N, Malti A et al. Oxidative stress and maternal obesity: Feto-placental unit interaction. Placenta 2014; 35: 411\u2013416.","journal-title":"Placenta"},{"key":"BFijo2017109_CR43","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0021-9150(97)00208-6","volume":"136","author":"L Tang","year":"1998","unstructured":"Tang L, Mamotte CD, Van Bockxmeer FM, Taylor RR . The effect of homocysteine on DNA synthesis in cultured human vascular smooth muscle. Atherosclerosis 1998; 136: 169\u2013173.","journal-title":"Atherosclerosis"},{"key":"BFijo2017109_CR44","doi-asserted-by":"publisher","first-page":"e89419","DOI":"10.1371\/journal.pone.0089419","volume":"9","author":"AM Roescher","year":"2014","unstructured":"Roescher AM, Timmer A, Erwich JJ, Bos AF . Placental pathology, perinatal death, neonatal outcome, and neurological development: a systematic review. PLoS ONE 2014; 9: e89419.","journal-title":"PLoS ONE"},{"key":"BFijo2017109_CR45","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1177\/153537020122600402","volume":"226","author":"NM van der Put","year":"2001","unstructured":"van der Put NM, van Straaten HW, Trijbels FJ, Blom HJ . Folate, homocysteine and neural tube defects: An overview. Exp Biol Med 2001; 226: 243\u2013270.","journal-title":"Exp Biol Med"},{"key":"BFijo2017109_CR46","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1067\/mob.2002.121105","volume":"186","author":"AM Molloy","year":"2002","unstructured":"Molloy AM, Mills JL, McPartlin J, Kirke PN, Scott JM, Daly S . Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin b12, and the 5,10-methylenetetrahydrofolate reductase 677c\u2014&gt;t variant. Am J Obstet Gynecol 2002; 186: 499\u2013503.","journal-title":"Am J Obstet Gynecol"},{"key":"BFijo2017109_CR47","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1038\/sj.ijo.0801375","volume":"24","author":"I Niedhammer","year":"2000","unstructured":"Niedhammer I, Bugel I, Bonenfant S, Goldberg M, Leclerc A . Validity of self-reported weight and height in the french gazel cohort. Int J Obes Relat Metab Disord 2000; 24: 1111\u20131118.","journal-title":"Int J Obes Relat Metab Disord"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/ijo2017109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/ijo2017109","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ijo.2017.109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/ijo2017109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T20:23:00Z","timestamp":1647375780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo2017109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,3]]},"references-count":47,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["BFijo2017109"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2017.109","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,3]]},"assertion":[{"value":"23 November 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}