{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:19:11Z","timestamp":1793053151825,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1038\/ijo.2017.280","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T03:41:01Z","timestamp":1511149261000},"page":"535-541","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats"],"prefix":"10.1038","volume":"42","author":[{"given":"J M","family":"Poret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Souza-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Marcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Gaudet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T H","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H D","family":"Braymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Harrison-Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S D","family":"Primeaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"BFijo2017280_CR1","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1093\/ajcn\/68.6.1157","volume":"68","author":"GA Bray","year":"1998","unstructured":"Bray GA, Popkin BM . Dietary fat intake does affect obesity!. Am J Clin Nutr 1998; 68: 1157\u20131173.","journal-title":"Am J Clin Nutr"},{"key":"BFijo2017280_CR2","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.1210\/jc.2004-0535","volume":"89","author":"GA Bray","year":"2004","unstructured":"Bray GA . Medical consequences of obesity. J Clin Endocrinol Metab 2004; 89: 2583\u20132589.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2017280_CR3","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1001\/jama.2016.6458","volume":"315","author":"KM Flegal","year":"2016","unstructured":"Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL . Trends in obesity among adults in the United States, 2005 to 2014. JAMA 2016; 315: 2284\u20132291.","journal-title":"JAMA"},{"key":"BFijo2017280_CR4","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1093\/eurheartj\/ehn387","volume":"29","author":"GR Hajer","year":"2008","unstructured":"Hajer GR, van Haeften TW, Visseren FL . Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008; 29: 2959\u20132971.","journal-title":"Eur Heart J"},{"key":"BFijo2017280_CR5","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/j.1365-2796.2008.01922.x","volume":"263","author":"WP James","year":"2008","unstructured":"James WP . The epidemiology of obesity: the size of the problem. J Intern Med 2008; 263: 336\u2013352.","journal-title":"J Intern Med"},{"key":"BFijo2017280_CR6","first-page":"79","volume":"49","author":"L Lissner","year":"1995","unstructured":"Lissner L, Heitmann BL . Dietary fat and obesity: evidence from epidemiology. Eur J Clin Nutr 1995; 49: 79\u201390.","journal-title":"Eur J Clin Nutr"},{"key":"BFijo2017280_CR7","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1161\/01.ATV.0000216787.85457.f3","volume":"26","author":"P Poirier","year":"2006","unstructured":"Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol 2006; 26: 968\u2013976.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"BFijo2017280_CR8","doi-asserted-by":"publisher","first-page":"450","DOI":"10.2459\/JCM.0b013e3282eee9a8","volume":"9","author":"P Calabr\u00f2","year":"2008","unstructured":"Calabr\u00f2 P, Limongelli G, Pacileo G, Di Salvo G, Golino P, Calabr\u00f2 R . The role of adiposity as a determinant of an inflammatory milieu. J Cardiovasc Med 2008; 9: 450\u2013460.","journal-title":"J Cardiovasc Med"},{"key":"BFijo2017280_CR9","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1007\/s10753-014-9914-1","volume":"37","author":"G Ghigliotti","year":"2014","unstructured":"Ghigliotti G, Barisione C, Garibaldi S, Fabbi P, Brunelli C, Spallarossa P et al. Adipose tissue immune response: novel triggers and consequences for chronic inflammatory conditions. Inflammation 2014; 37: 1337\u20131353.","journal-title":"Inflammation"},{"key":"BFijo2017280_CR10","doi-asserted-by":"publisher","first-page":"539","DOI":"10.4330\/wjc.v6.i7.539","volume":"6","author":"E Golia","year":"2014","unstructured":"Golia E, Limongelli G, Natale F, Fimiani F, Maddaloni V, Russo PE et al. Adipose tissue and vascular inflammation in coronary artery disease. World J Cardiol 2014; 6: 539\u2013554.","journal-title":"World J Cardiol"},{"key":"BFijo2017280_CR11","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1038\/oby.2011.68","volume":"19","author":"YY Lam","year":"2011","unstructured":"Lam YY, Mitchell AJ, Holmes AJ, Denyer GS, Gummesson A, Caterson ID et al. Role of the gut in visceral fat inflammation and metabolic disorders. Obesity 2011; 19: 2113\u20132120.","journal-title":"Obesity"},{"key":"BFijo2017280_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1463-1326.2006.00590.x","volume":"9","author":"N Rasouli","year":"2007","unstructured":"Rasouli N, Molavi B, Elbein SC, Kern PA . Ectopic fat accumulation and metabolic syndrome. Diabetes Obes Metab 2007; 9: 1\u201310.","journal-title":"Diabetes Obes Metab"},{"key":"BFijo2017280_CR13","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1139\/cjpp-2015-0141","volume":"94","author":"TD Allerton","year":"2015","unstructured":"Allerton TD, Primeaux SD . High-fat diet differentially regulates metabolic parameters in obesity-resistant S5B\/Pl rats and obesity-prone Osborne-Mendel rats. Can J Physiol Pharmacol 2015; 94: 206\u2013215.","journal-title":"Can J Physiol Pharmacol"},{"key":"BFijo2017280_CR14","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.pcad.2013.10.016","volume":"56","author":"M Bastien","year":"2014","unstructured":"Bastien M, Poirier P, Lemieux I, Despr\u00e9s J-P . Overview of epidemiology and contribution of obesity to cardiovascular disease. Prog Cardiovasc Dis 2014; 56: 369\u2013381.","journal-title":"Prog Cardiovasc Dis"},{"key":"BFijo2017280_CR15","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.physbeh.2004.08.039","volume":"83","author":"GA Bray","year":"2004","unstructured":"Bray GA, Paeratakul S, Popkin BM . Dietary fat and obesity: a review of animal, clinical and epidemiological studies. Physiol Behav 2004; 83: 549\u2013555.","journal-title":"Physiol Behav"},{"key":"BFijo2017280_CR16","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1038\/ijo.2010.78","volume":"34","author":"SD Primeaux","year":"2010","unstructured":"Primeaux SD, Barnes MJ, Braymer HD, Bray GA . Sensitivity to the satiating effects of Exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B\/Pl rats. IntJ Obes 2010; 34: 1427\u20131433.","journal-title":"IntJ Obes"},{"key":"BFijo2017280_CR17","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1093\/jn\/100.9.1041","volume":"100","author":"R Schemmel","year":"1970","unstructured":"Schemmel R, Mickelsen O, Gill JL . Dietary obesity in rats: body weight and body fat accretion in seven strains of rats. J Nutr 1970; 100: 1041\u20131048.","journal-title":"J Nutr"},{"key":"BFijo2017280_CR18","doi-asserted-by":"publisher","first-page":"R1376","DOI":"10.1152\/ajpregu.00162.2004","volume":"288","author":"CL White","year":"2005","unstructured":"White CL, Braymer HD, York DA, Bray GA . Effect of a high or low ambient perinatal temperature on adult obesity in Osborne-Mendel and S5B\/Pl rats. Am J Physiol Regul Integr Comp Physiol 2005; 288: R1376\u2013R1384.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFijo2017280_CR19","doi-asserted-by":"publisher","first-page":"615","DOI":"10.7150\/ijbs.17051","volume":"13","author":"Q Yang","year":"2017","unstructured":"Yang Q, Xiao T, Guo J, Su Z . Complex relationship between obesity and the fat mass and obesity locus. Int J Biol Sci 2017; 13: 615\u2013629.","journal-title":"Int J Biol Sci"},{"key":"BFijo2017280_CR20","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S0925-4439(99)00091-5","volume":"1500","author":"E Dusserre","year":"2000","unstructured":"Dusserre E, Moulin P, Vidal H . Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues. Biochim Biophys Acta 2000; 1500: 88\u201396.","journal-title":"Biochim Biophys Acta"},{"key":"BFijo2017280_CR21","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/sj.ijo.0801792","volume":"25","author":"A Festa","year":"2001","unstructured":"Festa A, D'Agostino R, Williams K, Karter AJ, Mayer-Davis EJ, Tracy RP et al. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord 2001; 25: 1407\u20131415.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"BFijo2017280_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1467-789X.2009.00623.x","volume":"11","author":"MM Ibrahim","year":"2010","unstructured":"Ibrahim MM . Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev 2010; 11: 11\u201318.","journal-title":"Obes Rev"},{"key":"BFijo2017280_CR23","doi-asserted-by":"publisher","first-page":"e1002695","DOI":"10.1371\/journal.pgen.1002695","volume":"8","author":"CS Fox","year":"2012","unstructured":"Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N et al. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genet 2012; 8: e1002695.","journal-title":"PLoS Genet"},{"key":"BFijo2017280_CR24","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.metabol.2011.10.004","volume":"61","author":"A Michaud","year":"2012","unstructured":"Michaud A, Drolet R, No\u00ebl S, Paris G, Tchernof A . Visceral fat accumulation is an indicator of adipose tissue macrophage infiltration in women. Metabolism 2012; 61: 689\u2013698.","journal-title":"Metabolism"},{"key":"BFijo2017280_CR25","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1001\/2012.jama.11132","volume":"308","author":"IJ Neeland","year":"2012","unstructured":"Neeland IJ, Turer AT, Ayers CR, Powell-Wiley TM, Vega GL, Farzaneh-Far R et al. Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults. JAMA 2012; 308: 1150\u20131159.","journal-title":"JAMA"},{"key":"BFijo2017280_CR26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1161\/CIRCULATIONAHA.106.675355","volume":"116","author":"CS Fox","year":"2007","unstructured":"Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 2007; 116: 39\u201348.","journal-title":"Circulation"},{"key":"BFijo2017280_CR27","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/joim.12540","volume":"280","author":"U Smith","year":"2016","unstructured":"Smith U, Kahn BB . Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med 2016; 280: 465\u2013475.","journal-title":"J Intern Med"},{"key":"BFijo2017280_CR28","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1126\/science.1201475","volume":"332","author":"D Wu","year":"2011","unstructured":"Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 2011; 332: 243\u2013247.","journal-title":"Science"},{"key":"BFijo2017280_CR29","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.febslet.2007.11.057","volume":"582","author":"C de Luca","year":"2008","unstructured":"de Luca C, Olefsky JM . Inflammation and insulin resistance. FEBS Lett 2008; 582: 97\u2013105.","journal-title":"FEBS Lett"},{"key":"BFijo2017280_CR30","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nri2921","volume":"11","author":"N Ouchi","year":"2011","unstructured":"Ouchi N, Parker JL, Lugus JJ, Walsh K . Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011; 11: 85\u201397.","journal-title":"Nat Rev Immunol"},{"key":"BFijo2017280_CR31","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.jacc.2011.01.051","volume":"58","author":"MG Farb","year":"2011","unstructured":"Farb MG, Bigornia S, Mott M, Tanriverdi K, Morin KM, Freedman JE et al. Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol 2011; 58: 232\u2013237.","journal-title":"J Am Coll Cardiol"},{"key":"BFijo2017280_CR32","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1016\/j.peptides.2006.08.008","volume":"27","author":"MJ Barnes","year":"2006","unstructured":"Barnes MJ, Holmes G, Primeaux SD, York DA, Bray GA . Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity. Peptides 2006; 27: 3292\u20133298.","journal-title":"Peptides"},{"key":"BFijo2017280_CR33","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.physbeh.2017.03.015","volume":"174","author":"H Douglas Braymer","year":"2017","unstructured":"Douglas Braymer H, Zachary H, Schreiber AL, Primeaux SD . Lingual CD36 and nutritional status differentially regulate fat preference in obesity-prone and obesity-resistant rats. Physiol Behav 2017; 174: 120\u2013127.","journal-title":"Physiol Behav"},{"key":"BFijo2017280_CR34","doi-asserted-by":"publisher","first-page":"R1346","DOI":"10.1152\/ajpregu.00582.2012","volume":"305","author":"CSY Chen","year":"2013","unstructured":"Chen CSY, Bench EM, Allerton TD, Schreiber AL, Arceneaux KP, Primeaux SD . Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. Am J Physiol Regul Integr Comp Physiol 2013; 305: R1346\u2013R1355.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"BFijo2017280_CR35","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/S0031-9384(98)00336-9","volume":"66","author":"D Greenberg","year":"1999","unstructured":"Greenberg D, McCaffery J, Potack JZ, Bray GA, York DA . Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats. Physiol Behav 1999; 66: 621\u2013626.","journal-title":"Physiol Behav"},{"key":"BFijo2017280_CR36","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1016\/j.peptides.2004.08.020","volume":"25","author":"X Liu","year":"2004","unstructured":"Liu X, York DA, Bray GA . Regulation of ghrelin gene expression in stomach and feeding response to a ghrelin analogue in two strains of rats. Peptides 2004; 25: 2171\u20132177.","journal-title":"Peptides"},{"key":"BFijo2017280_CR37","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.bbr.2007.03.005","volume":"180","author":"SD Primeaux","year":"2007","unstructured":"Primeaux SD, Barnes MJ, Bray GA . Olfactory bulbectomy increases food intake and hypothalamic neuropeptide Y in obesity-prone but not obesity-resistant rats. Behav Brain Res 2007; 180: 190\u2013196.","journal-title":"Behav Brain Res"},{"key":"BFijo2017280_CR38","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/oby.2007.579","volume":"15","author":"CL White","year":"2007","unstructured":"White CL, Ishihara Y, York DA, Bray GA . Effect of meta-chlorophenylpiperazine and cholecystokinin on food intake of Osborne-Mendel and S5B\/P1 rats. Obesity 2007; 15: 624\u2013631.","journal-title":"Obesity"},{"issue":"6 Pt 2","key":"BFijo2017280_CR39","first-page":"R1111","volume":"262","author":"S Okada","year":"1992","unstructured":"Okada S, York DA, Bray GA, Mei J, Erlanson-Albertsson C . Differential inhibition of fat intake in two strains of rat by the peptide enterostatin. Am J Physiol 1992; 262 (6 Pt 2): R1111\u2013R1116.","journal-title":"Am J Physiol"},{"key":"BFijo2017280_CR40","first-page":"49","volume":"6","author":"DB Hausman","year":"1997","unstructured":"Hausman DB, Loh MY, Flatt WP, Martin RJ . Adipose tissue expansion and the development of obesity: influence of dietary fat type. Asia Pac J Clin Nutr 1997; 6: 49\u201355.","journal-title":"Asia Pac J Clin Nutr"},{"key":"BFijo2017280_CR41","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/sj.ijo.0803792","volume":"32","author":"O Petrescu","year":"2008","unstructured":"Petrescu O, Cheema AF, Fan X, Bradbury MW, Berk PD . Differences in adipocyte long chain fatty acid uptake in Osborne-Mendel and S5B\/Pl rats in response to high-fat diets. Int J Obes 2008; 32: 853\u2013862.","journal-title":"Int J Obes"},{"key":"BFijo2017280_CR42","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.114.009990","volume":"130","author":"A Dregan","year":"2014","unstructured":"Dregan A, Charlton J, Chowienczyk P, Gulliford MC . Chronic inflammatory disorders and risk of type 2 diabetes mellitus, coronary heart disease, and stroke: a population-based cohort study. Circulation 2014; 130: 837\u2013844.","journal-title":"Circulation"},{"key":"BFijo2017280_CR43","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1210\/jc.2011-3475","volume":"97","author":"M Hamer","year":"2012","unstructured":"Hamer M, Stamatakis E . Metabolically healthy obesity and risk of all-cause and cardiovascular disease mortality. J Clin Endocrinol Metab 2012; 97: 2482\u20132488.","journal-title":"J Clin Endocrinol Metab"},{"key":"BFijo2017280_CR44","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1758-5996-5-31","volume":"5","author":"VC Luft","year":"2013","unstructured":"Luft VC, Schmidt MI, Pankow JS, Couper D, Ballantyne CM, Young JH et al. Chronic inflammation role in the obesity-diabetes association: a case-cohort study. Diabetol Metab Syndr 2013; 5: 31.","journal-title":"Diabetol Metab Syndr"},{"key":"BFijo2017280_CR45","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/B978-0-12-411619-1.00006-9","volume":"537","author":"SD Parlee","year":"2014","unstructured":"Parlee SD, Lentz SI, Mori H, MacDougald OA . Quantifying size and number of adipocytes in adipose tissue. Methods Enzymol 2014; 537: 93\u2013122.","journal-title":"Methods Enzymol"},{"key":"BFijo2017280_CR46","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1111\/acer.12796","volume":"39","author":"FM Souza-Smith","year":"2015","unstructured":"Souza-Smith FM, Siggins RW, Molina PE . Mesenteric lymphatic-perilymphatic adipose crosstalk: role in alcohol-induced perilymphatic adipose tissue inflammation. Alcohol Clin Exp Res 2015; 39: 1380\u20131387.","journal-title":"Alcohol Clin Exp Res"},{"key":"BFijo2017280_CR47","first-page":"369","volume":"58","author":"SD Primeaux","year":"2013","unstructured":"Primeaux SD, Braymer HD, Bray GA . CD36 mRNA in the gastrointestinal tract is differentially regulated by dietary fat intake in obesity-prone and obesity-resistant rats. Dig Dis Sci 2013; 58: 369\u2013370.","journal-title":"Dig Dis Sci"},{"key":"BFijo2017280_CR48","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1172\/JCI29881","volume":"117","author":"CN Lumeng","year":"2007","unstructured":"Lumeng CN, Bodzin JL, Saltiel AR . Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007; 117: 175\u2013184.","journal-title":"J Clin Invest"},{"key":"BFijo2017280_CR49","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1172\/JCI200319451","volume":"112","author":"H Xu","year":"2003","unstructured":"Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112: 1821\u20131830.","journal-title":"J Clin Invest"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo2017280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2017280","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ijo.2017.280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/ijo2017280.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:31:40Z","timestamp":1684416700000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo2017280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,20]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["BFijo2017280"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2017.280","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,20]]},"assertion":[{"value":"20 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}