{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:01:18Z","timestamp":1792206078223,"version":"4.4.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Obes"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1038\/ijo.2017.51","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T15:05:36Z","timestamp":1487689536000},"page":"866-872","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Healthy obesity and risk of accelerated functional decline and disability"],"prefix":"10.1038","volume":"41","author":[{"given":"J A","family":"Bell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Sabia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Singh-Manoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Kivim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"BFijo201751_CR1","unstructured":"Davies SC . 'Annual Report of the Chief Medical Officer, 2014, The Health of the 51%: Women' London: Department of Health. 2015."},{"key":"BFijo201751_CR2","volume-title":"Metabolic Regulation: A Human Perspective","author":"K Frayn","year":"2010","unstructured":"Frayn K . Metabolic Regulation: A Human Perspective. Wiley-Blackwell, 2010."},{"key":"BFijo201751_CR3","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/S0140-6736(09)60318-4","volume":"373","author":"Collaboration PS","year":"2009","unstructured":"Collaboration PS. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. The Lancet 2009; 373: 1083\u20131096.","journal-title":"The Lancet"},{"key":"BFijo201751_CR4","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1056\/NEJMoa1000367","volume":"363","author":"A Berrington de Gonzalez","year":"2010","unstructured":"Berrington de Gonzalez A, Hartge P, Cerhan JR, Flint AJ, Hannan L, MacInnis RJ et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med 2010; 363: 2211\u20132219.","journal-title":"N Engl J Med"},{"key":"BFijo201751_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2458-9-88","volume":"9","author":"DP Guh","year":"2009","unstructured":"Guh DP, Zhang W, Bansback N, Amarsi Z, Birmingham CL, Anis AH . The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009; 9: 1.","journal-title":"BMC Public Health"},{"key":"BFijo201751_CR6","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1001\/archinte.168.15.1617","volume":"168","author":"RP Wildman","year":"2008","unstructured":"Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, Wylie-Rosett J et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering - Prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Internal Med 2008; 168: 1617\u20131624.","journal-title":"Arch Internal Med"},{"key":"BFijo201751_CR7","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1038\/oby.2005.130","volume":"13","author":"G Iacobellis","year":"2005","unstructured":"Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F . Prevalence of uncomplicated obesity in an Italian obese population. Obes Res 2005; 13: 1116\u20131122.","journal-title":"Obes Res"},{"key":"BFijo201751_CR8","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.jacc.2015.06.014","volume":"66","author":"JA Bell","year":"2015","unstructured":"Bell JA, Hamer M, Batty GD, Singh-Manoux A, Sabia S, Kivim\u00e4ki M . Incidence of metabolic risk factors among healthy obese adults: 20-year follow-up. J Am Coll Cardiol 2015; 66: 871\u2013873.","journal-title":"J Am Coll Cardiol"},{"key":"BFijo201751_CR9","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jacc.2014.09.077","volume":"65","author":"JA Bell","year":"2015","unstructured":"Bell JA, Hamer M, Sabia S, Singh-Manoux A, Batty GD, Kivimaki M . The natural course of healthy obesity over 20 years. J Am Coll Cardiol 2015; 65: 101\u2013102.","journal-title":"J Am Coll Cardiol"},{"key":"BFijo201751_CR10","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/obr.12157","volume":"15","author":"J Bell","year":"2014","unstructured":"Bell J, Kivimaki M, Hamer M . Metabolically healthy obesity and risk of incident type 2 diabetes: a meta\u2010analysis of prospective cohort studies. Obes Rev 2014; 15: 504\u2013515.","journal-title":"Obes Rev"},{"key":"BFijo201751_CR11","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.atherosclerosis.2011.01.007","volume":"217","author":"UI Khan","year":"2011","unstructured":"Khan UI, Wang D, Thurston RC, Sowers M, Sutton-Tyrrell K, Matthews KA et al. Burden of subclinical cardiovascular disease in \u2018metabolically benign\u2019 and \u2018at-risk\u2019 overweight and obese women: The Study of Women's Health Across the Nation (SWAN). Atherosclerosis 2011; 217: 179\u2013186.","journal-title":"Atherosclerosis"},{"key":"BFijo201751_CR12","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1016\/j.jacc.2014.03.042","volume":"63","author":"Y Chang","year":"2014","unstructured":"Chang Y, Kim B-K, Yun KE, Cho J, Zhang Y, Rampal S et al. Metabolically-healthy obesity and coronary artery calcification. J Am College Cardiol 2014; 63: 2679\u20132686.","journal-title":"J Am College Cardiol"},{"key":"BFijo201751_CR13","doi-asserted-by":"publisher","first-page":"4761","DOI":"10.1016\/j.ijcard.2013.07.230","volume":"168","author":"J Fan","year":"2013","unstructured":"Fan J, Song Y, Chen Y, Hui R, Zhang W . Combined effect of obesity and cardio-metabolic abnormality on the risk of cardiovascular disease: a meta-analysis of prospective cohort studies. Int J Cardiol 2013; 168: 4761\u20134768.","journal-title":"Int J Cardiol"},{"key":"BFijo201751_CR14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/sj.ijo.0803715","volume":"32","author":"A Anandacoomarasamy","year":"2008","unstructured":"Anandacoomarasamy A, Caterson I, Sambrook P, Fransen M, March L . The impact of obesity on the musculoskeletal system. Int J Obes 2008; 32: 211\u2013222.","journal-title":"Int J Obes"},{"key":"BFijo201751_CR15","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jbspin.2011.05.015","volume":"79","author":"L Jiang","year":"2012","unstructured":"Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y et al. Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine 2012; 79: 291\u2013297.","journal-title":"Joint Bone Spine"},{"key":"BFijo201751_CR16","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.jbspin.2010.04.011","volume":"78","author":"L Jiang","year":"2011","unstructured":"Jiang L, Rong J, Wang Y, Hu F, Bao C, Li X et al. The relationship between body mass index and hip osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine 2011; 78: 150\u2013155.","journal-title":"Joint Bone Spine"},{"key":"BFijo201751_CR17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/bmb\/lds038","volume":"105","author":"A Litwic","year":"2013","unstructured":"Litwic A, Edwards MH, Dennison EM, Cooper C . Epidemiology and burden of osteoarthritis. Br Med Bull 2013; 105: 185\u2013199.","journal-title":"Br Med Bull"},{"key":"BFijo201751_CR18","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.berh.2014.10.002","volume":"28","author":"P Clark","year":"2014","unstructured":"Clark P, Ellis B . A public health approach to musculoskeletal health. Best Pract Res Clin Rheumatol 2014; 28: 517\u2013532.","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"BFijo201751_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nrrheum.2010.123","volume":"7","author":"RM Aspden","year":"2011","unstructured":"Aspden RM . Obesity punches above its weight in osteoarthritis. Nat Rev Rheumatol 2011; 7: 65\u201368.","journal-title":"Nat Rev Rheumatol"},{"key":"BFijo201751_CR20","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/BOR.0b013e32835a9414","volume":"25","author":"F Berenbaum","year":"2013","unstructured":"Berenbaum F, Eymard F, Houard X . Osteoarthritis, inflammation and obesity. Curr Opin Rheumatol 2013; 25: 114\u2013118.","journal-title":"Curr Opin Rheumatol"},{"key":"BFijo201751_CR21","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1093\/gerona\/glp150","volume":"65","author":"S Stenholm","year":"2010","unstructured":"Stenholm S, Koster A, Alley DE, Houston DK, Kanaya A, Lee JS et al. Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women\u2014results from the Health, Aging, and Body Composition Study. J Gerontol Series Biol Sci Med Sci 2010; 65: 84\u201392.","journal-title":"J Gerontol Series Biol Sci Med Sci"},{"key":"BFijo201751_CR22","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/0140-6736(91)93068-K","volume":"337","author":"MG Marmot","year":"1991","unstructured":"Marmot MG, Stansfeld S, Patel C, North F, Head J, White I et al. Health inequalities among British civil servants: the Whitehall II study. Lancet 1991; 337: 1387\u20131393.","journal-title":"Lancet"},{"key":"BFijo201751_CR23","doi-asserted-by":"publisher","first-page":"e1001765","DOI":"10.1371\/journal.pmed.1001765","volume":"11","author":"P W\u00fcrtz","year":"2014","unstructured":"W\u00fcrtz P, Wang Q, Kangas AJ, Richmond RC, Skarp J, Tiainen M et al. Metabolic signatures of adiposity in young adults: Mendelian randomization analysis and effects of weight change. PLoS Med 2014; 11: e1001765.","journal-title":"PLoS Med"},{"key":"BFijo201751_CR24","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1136\/bmj.305.6846.160","volume":"305","author":"J-H Brazier","year":"1992","unstructured":"Brazier J-H, Harper R, Jones N, O'cathain A, Thomas K, Usherwood T et al. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. BMJ 1992; 305: 160\u2013164.","journal-title":"BMJ"},{"key":"BFijo201751_CR25","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1136\/bmj.315.7118.1273","volume":"315","author":"H Hemingway","year":"1997","unstructured":"Hemingway H, Stafford M, Stansfeld S, Shipley M, Marmot M . Is the SF-36 a valid measure of change in population health? Results from the Whitehall II study. BMJ 1997; 315: 1273\u20131279.","journal-title":"BMJ"},{"key":"BFijo201751_CR26","volume-title":"SF-36 Health Survey: Manual and Interpretation Guide","author":"JE Ware","year":"2000","unstructured":"Ware JE, Kosinski M, Dewey JE, Gandek B . SF-36 Health Survey: Manual and Interpretation Guide. Quality Metric Inc, 2000."},{"key":"BFijo201751_CR27","doi-asserted-by":"publisher","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","volume":"49","author":"JM Guralnik","year":"1994","unstructured":"Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 1994; 49: M85\u2013M94.","journal-title":"J Gerontol"},{"key":"BFijo201751_CR28","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s11357-012-9387-9","volume":"35","author":"A Elbaz","year":"2013","unstructured":"Elbaz A, Sabia S, Brunner E, Shipley M, Marmot M, Kivimaki M et al. Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study. Age 2013; 35: 943\u2013952.","journal-title":"Age"},{"key":"BFijo201751_CR29","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1136\/hrt.2009.183350","volume":"96","author":"M Hamer","year":"2010","unstructured":"Hamer M, Kivimaki M, Lahiri A, Yerramasu A, Deanfield JE, Marmot MG et al. Walking speed and subclinical atherosclerosis in healthy older adults: the Whitehall II study. Heart 2010; 96: 380\u2013384.","journal-title":"Heart"},{"key":"BFijo201751_CR30","doi-asserted-by":"publisher","first-page":"238","DOI":"10.3109\/09593985.2011.601804","volume":"28","author":"E Rydwik","year":"2012","unstructured":"Rydwik E, Bergland A, Forsen L, Fr\u00e4ndin K . Investigation into the reliability and validity of the measurement of elderly people's clinical walking speed: A systematic review. Physiother Theory Pract 2012; 28: 238\u2013256.","journal-title":"Physiother Theory Pract"},{"issue":"1 Part 1","key":"BFijo201751_CR31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/geront\/10.1_Part_1.20","volume":"10","author":"S Katz","year":"1970","unstructured":"Katz S, Downs TD, Cash HR, Grotz RC . Progress in development of the index of ADL. Gerontol 1970; 10 (1 Part 1): 20\u201330.","journal-title":"Gerontol"},{"key":"BFijo201751_CR32","doi-asserted-by":"publisher","first-page":"963","DOI":"10.2307\/2529876","volume":"38","author":"NM Laird","year":"1982","unstructured":"Laird NM, Ware JH . Random-effects models for longitudinal data. Biometrics 1982; 38: 963\u2013974.","journal-title":"Biometrics"},{"key":"BFijo201751_CR33","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1089\/met.2010.0101","volume":"9","author":"DR Bouchard","year":"2011","unstructured":"Bouchard DR, Langlois M-F, Brochu M, Dionne IJ, Baillargeon J-P . Metabolically healthy obese women and functional capacity. Metab Syndrome Relat Disord 2011; 9: 225\u2013229.","journal-title":"Metab Syndrome Relat Disord"},{"key":"BFijo201751_CR34","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ajhg.2013.12.014","volume":"94","author":"MV Holmes","year":"2014","unstructured":"Holmes MV, Lange LA, Palmer T, Lanktree MB, North KE, Almoguera B et al. Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. Am J Hum Genet 2014; 94: 198\u2013208.","journal-title":"Am J Hum Genet"},{"key":"BFijo201751_CR35","doi-asserted-by":"publisher","first-page":"e1001618","DOI":"10.1371\/journal.pmed.1001618","volume":"11","author":"RC Richmond","year":"2014","unstructured":"Richmond RC, Smith GD, Ness AR, den Hoed M, McMahon G, Timpson NJ . Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis. PLoS Med 2014; 11: e1001618.","journal-title":"PLoS Med"},{"key":"BFijo201751_CR36","doi-asserted-by":"publisher","first-page":"305","DOI":"10.7326\/M15-1323","volume":"164","author":"Y Chang","year":"2016","unstructured":"Chang Y, Ryu S, Choi Y, Zhang Y, Cho J, Kwon M-J et al. Metabolically healthy obesity and development of chronic kidney disease: a cohort study. Ann Internal Med 2016; 164: 305\u2013312.","journal-title":"Ann Internal Med"}],"container-title":["International Journal of Obesity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijo201751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijo201751","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ijo.2017.51","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/ijo201751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:32:08Z","timestamp":1684431128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijo201751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["BFijo201751"],"URL":"https:\/\/doi.org\/10.1038\/ijo.2017.51","relation":{},"ISSN":["0307-0565","1476-5497"],"issn-type":[{"value":"0307-0565","type":"print"},{"value":"1476-5497","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]},"assertion":[{"value":"5 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}