{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:23:20Z","timestamp":1782980600076,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T00:00:00Z","timestamp":1406246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Oral Sci"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1038\/ijos.2014.39","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T12:17:59Z","timestamp":1406290679000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The clinical effectiveness of reflectance optical spectroscopy for the in vivo diagnosis of oral lesions"],"prefix":"10.1038","volume":"6","author":[{"given":"Diana V","family":"Messadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba S","family":"Younai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Hu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cun-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,25]]},"reference":[{"issue":"5","key":"BFijos201439_CR1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1080\/19424396.2013.12222309","volume":"41","author":"AR Kerr","year":"2013","unstructured":"Kerr AR, Shah SS . Standard examination and adjunctive techniques for detection of oral premalignant and malignant lesions. J Calif Dent Assoc 2013; 41 (5): 329\u2013331, 334\u2013342.","journal-title":"J Calif Dent Assoc"},{"issue":"2","key":"BFijos201439_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/ijos.2013.24","volume":"5","author":"DV Messadi","year":"2013","unstructured":"Messadi DV . Diagnostic aids for detection of oral precancerous conditions. Int J Oral Sci 2013; 5 (2): 59\u201365.","journal-title":"Int J Oral Sci"},{"issue":"5","key":"BFijos201439_CR3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.3322\/caac.20073","volume":"60","author":"A Jemal","year":"2010","unstructured":"Jemal A, Siegel R, Xu J et al. Cancer statistics, 2010. CA Cancer J Clin 2010; 60 (5): 277\u2013300.","journal-title":"CA Cancer J Clin"},{"key":"BFijos201439_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1758-3284-1-5","volume":"1","author":"S Fedele","year":"2009","unstructured":"Fedele S . Diagnostic aids in the screening of oral cancer. Head Neck Oncol 2009; 1: 5.","journal-title":"Head Neck Oncol"},{"issue":"6219","key":"BFijos201439_CR5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/339058a0","volume":"339","author":"J Folkman","year":"1989","unstructured":"Folkman J, Watson K, Ingber D et al. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature 1989; 339 (6219): 58\u201361.","journal-title":"Nature"},{"issue":"11","key":"BFijos201439_CR6","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/j.0022-0337.2001.65.11.tb03489.x","volume":"65","author":"R Hasina","year":"2001","unstructured":"Hasina R, Lingen MW . Angiogenesis in oral cancer. J Dent Educ 2001; 65 (11): 1282\u20131290.","journal-title":"J Dent Educ"},{"issue":"11","key":"BFijos201439_CR7","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.ejca.2009.04.007","volume":"45","author":"M Raica","year":"2009","unstructured":"Raica M, Cimpean AM, Ribatti D . Angiogenesis in pre-malignant conditions. Eur J Cancer 2009; 45 (11): 1924\u20131934.","journal-title":"Eur J Cancer"},{"issue":"1","key":"BFijos201439_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/(SICI)1096-9896(199709)183:1<39::AID-PATH1088>3.0.CO;2-L","volume":"183","author":"S Pazouki","year":"1997","unstructured":"Pazouki S, Chisholm DM, Adi MM et al. The association between tumor progression and vascularity in the oral mucosa. J Pathol 1997; 183 (1): 39\u201343.","journal-title":"J Pathol"},{"key":"BFijos201439_CR9","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2147\/VHRM.S15384","volume":"7","author":"DV Shetty","year":"2011","unstructured":"Shetty DV, Ahuja P, Taneja DK et al. Relevance of tumor angiogenesis patterns as a diagnostic value and prognostic indicator in oral precancer and cancer. Vasc Health Risk Manag 2011; 7: 41\u201347.","journal-title":"Vasc Health Risk Manag"},{"issue":"3","key":"BFijos201439_CR10","first-page":"47","volume":"2","author":"JE Bouquot","year":"2010","unstructured":"Bouquot JE, Suarez P, Vigneswaran N . Oral precancer and early cancer detection in the dental office\u2014review of new technologies. J Implant Adv Dent 2010; 2 (3): 47\u201363.","journal-title":"J Implant Adv Dent"},{"issue":"12","key":"BFijos201439_CR11","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.14219\/jada.archive.2012.0096","volume":"143","author":"JB Epstein","year":"2010","unstructured":"Epstein JB, G\u00fcneri P, Boyacioglu H et al. The limitations of the clinical oral examination in detecting dysplastic oral lesions and oral squamous cell carcinoma. J Am Dent Assoc 2010; 143 (12): 1332\u20131342.","journal-title":"J Am Dent Assoc"},{"issue":"1","key":"BFijos201439_CR12","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.oraloncology.2007.06.011","volume":"44","author":"MW Lingen","year":"2008","unstructured":"Lingen MW, Kalmar JR, Karrison T et al. Critical evaluation of diagnostic aids for the detection of oral cancer. Oral Oncol 2008; 44 (1): 10\u201322.","journal-title":"Oral Oncol"},{"key":"BFijos201439_CR13","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1196\/annals.1384.039","volume":"1098","author":"MP Rosin","year":"2007","unstructured":"Rosin MP, Poh CF, Guillard M et al. Visualization and other emerging technologies as change makers for oral cancer prevention. Ann N Y Acad Sci 2007; 1098: 167\u2013183.","journal-title":"Ann N Y Acad Sci"},{"issue":"7","key":"BFijos201439_CR14","doi-asserted-by":"publisher","first-page":"896","DOI":"10.14219\/jada.archive.2008.0276","volume":"139","author":"LL Patton","year":"2008","unstructured":"Patton LL, Epstein JB, Kerr AR . Adjunctive techniques for oral cancer examination and lesion diagnosis: a systematic review of the literature. J Am Dent Assoc 2008; 139 (7): 896\u2013905.","journal-title":"J Am Dent Assoc"},{"issue":"6","key":"BFijos201439_CR15","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1364\/AO.47.000825","volume":"47","author":"RA Schwarz","year":"2008","unstructured":"Schwarz RA, Gao W, Daye D et al. Autofluorescence and diffuse reflectance spectroscopy of oral epithelial tissue using a depth-sensitive fiber-optic probe. Appl Opt 2008; 47 (6): 825\u2013834.","journal-title":"Appl Opt"},{"key":"BFijos201439_CR16","doi-asserted-by":"publisher","DOI":"10.1364\/BIOMED.2010.BSuD105","volume-title":"Identafi, 3000 ultra a multispectral tool for improved oral lesion evaluation","author":"AF Zuluaga","year":"2010","unstructured":"Zuluaga AF, Vigneswaran N, Bradley RK et al. Identafi, 3000 ultra a multispectral tool for improved oral lesion evaluation. Washington: Optical Society of America, 2010."},{"key":"BFijos201439_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/194029","volume":"2013","author":"N Bhatia","year":"2013","unstructured":"Bhatia N, Lalla Y, Vu AN et al. Advances in optical adjunctive aids for visualisation and detection of oral malignant and potentially malignant lesions. Int J Dent 2013; 2013: 1\u201317. DOI: 10.1155\/2013\/194029.","journal-title":"Int J Dent"},{"issue":"1 Suppl","key":"BFijos201439_CR18","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1016\/j.genm.2011.09.031","volume":"9","author":"P Lane","year":"2012","unstructured":"Lane P, Follen M, MacAulay C . Has fluorescence spectroscopy come of age? A case series of oral precancers and cancers using white light, fluorescent light at 405\u2005nm, and reflected light at 545\u2005nm using the Trimira identafi 3000. Gender Med 2012; 9 (1 Suppl): S25\u2013S35.","journal-title":"Gender Med"},{"issue":"11","key":"BFijos201439_CR19","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.ejca.2009.04.007","volume":"45","author":"M Raica","year":"2009","unstructured":"Raica M, Cimpean AM, Ribatti D . Angiogenesis in pre-malignant conditions. Eur J Cancer 2009; 45 (11): 1924\u20131934.","journal-title":"Eur J Cancer"},{"key":"BFijos201439_CR20","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2147\/VHRM.S15384","volume":"7","author":"DC Shetty","year":"2011","unstructured":"Shetty DC, Ahuja P, Taneja DK et al. Relevance of tumor angiogenesis patterns as a diagnostic value and prognostic indicator in oral precancer and cancer. Vasc Health Risk Manag 2011; 7: 41\u201347.","journal-title":"Vasc Health Risk Manag"},{"issue":"3","key":"BFijos201439_CR21","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1093\/jnci\/dji023","volume":"97","author":"JC Miller","year":"2005","unstructured":"Miller JC, Pien HH, Sahani D et al. Imaging angiogenesis: applications and potential for drug development. J Natl Cancer Inst 2005; 97 (3): 172\u2013187.","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"BFijos201439_CR22","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nm0603-713","volume":"9","author":"DM McDonald","year":"2003","unstructured":"McDonald DM, Choyke PL . Imaging of angiogenesis: from microscope to clinic. Nat Med 2003; 9 (6): 713\u2013725.","journal-title":"Nat Med"},{"issue":"1","key":"BFijos201439_CR23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.oraloncology.2006.12.011","volume":"44","author":"A Amelink","year":"2008","unstructured":"Amelink A, Kaspers OP, Sterenborg HS et al. Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy. Oral Oncology 2008; 44 (1): 65\u201371.","journal-title":"Oral Oncology"},{"issue":"6","key":"BFijos201439_CR24","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1136\/mp.50.6.304","volume":"50","author":"F Gonzalez-Palacios","year":"1997","unstructured":"Gonzalez-Palacios F, Sancho M, Martinez JC et al. Microvessel density, p53 overexpression, and apoptosis in invasive breast carcinoma. Mol Pathol 1997; 50 (6): 304\u2013309.","journal-title":"Mol Pathol"},{"issue":"4","key":"BFijos201439_CR25","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1369\/jhc.4A6514.2005","volume":"54","author":"MP Pusztaszeri","year":"2006","unstructured":"Pusztaszeri MP, Seelentag W, Bosman FT . Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem 2006; 54 (4): 385\u2013395.","journal-title":"J Histochem Cytochem"},{"issue":"1","key":"BFijos201439_CR26","first-page":"9","volume":"147","author":"N Weidner","year":"1995","unstructured":"Weidner N . Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 1995; 147 (1): 9\u201319.","journal-title":"Am J Pathol"},{"issue":"6","key":"BFijos201439_CR27","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1177\/0194599811416773","volume":"145","author":"L Sweeny","year":"2011","unstructured":"Sweeny L, Dean NR, Magnuson JS et al. Assessment of tissue autofluorescence and reflectance for oral cavity cancer screening. Otolaryngol Head Neck Surg 2011; 145 (6): 956\u2013960.","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"8","key":"BFijos201439_CR28","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1002\/cncr.24177","volume":"115","author":"RA Schwarz","year":"2009","unstructured":"Schwarz RA, Gao W, Weber CR et al. Noninvasive evaluation of oral lesions using depth-sensitive optical spectroscopy: simple device for the direct visualization of oral-cavity tissue fluorescence. Cancer 2009; 115 (8): 1669\u20131679.","journal-title":"Cancer"},{"issue":"1","key":"BFijos201439_CR29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1364\/BOE.2.000089","volume":"2","author":"RA Schwarz","year":"2011","unstructured":"Schwarz RA, Gao W, Stepanek VMT et al. Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia. Biomed Opt Express 2011; 2 (1): 89\u201399.","journal-title":"Biomed Opt Express"}],"container-title":["International Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijos201439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijos201439","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijos201439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T13:49:15Z","timestamp":1689428955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijos201439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,25]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["BFijos201439"],"URL":"https:\/\/doi.org\/10.1038\/ijos.2014.39","relation":{},"ISSN":["1674-2818","2049-3169"],"issn-type":[{"value":"1674-2818","type":"print"},{"value":"2049-3169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,25]]},"assertion":[{"value":"3 June 2014","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2014","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}