{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:22:41Z","timestamp":1780514561837,"version":"3.54.1"},"reference-count":99,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int J Oral Sci"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/ijos.2017.1","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T14:01:20Z","timestamp":1489154480000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities"],"prefix":"10.1038","volume":"9","author":[{"given":"Yan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M","family":"Bornstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Lambrichts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Yang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinus","family":"Politis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhilde","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"issue":"3","key":"BFijos20171_CR1","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ijom.2014.10.023","volume":"44","author":"V Moraschini","year":"2015","unstructured":"Moraschini V, Poubel LA, Ferreira VF et al. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg 2015; 44 (3): 377\u2013388.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"8","key":"BFijos20171_CR2","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1177\/00220345930720080901","volume":"72","author":"AG Mason","year":"1993","unstructured":"Mason AG, Holland GR . The reinnervation of healing extraction sockets in the ferret. J Dent Res 1993; 72 (8): 1215\u20131221.","journal-title":"J Dent Res"},{"key":"BFijos20171_CR3","unstructured":"Br\u00e5nemark PI, Rydevik B, Shalak R et al. Osseointegration in skeletal reconstruction and joint replacement. Rancho Santa Fe: Second International Workshop on Osseointegration in Skeletal Reconstruction and Joint Replacement, 1994.."},{"issue":"11","key":"BFijos20171_CR4","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1177\/00220345000790110301","volume":"79","author":"D van Steenberghe","year":"2000","unstructured":"van Steenberghe D . From osseointegration to osseoperception. J Dent Res 2000; 79 (11): 1833\u20131837.","journal-title":"J Dent Res"},{"issue":"7","key":"BFijos20171_CR5","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/clr.12344","volume":"26","author":"Y Huang","year":"2015","unstructured":"Huang Y, Jacobs R, Van Dessel J et al. A systematic review on the innervation of peri-implant tissues with special emphasis on the influence of implant placement and loading protocols. Clin Oral Implants Res 2015; 26 (7): 737\u2013746.","journal-title":"Clin Oral Implants Res"},{"issue":"4","key":"BFijos20171_CR6","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/j.1365-2842.2006.01621.x","volume":"33","author":"R Jacobs","year":"2006","unstructured":"Jacobs R, Van Steenberghe D . From osseoperception to implant-mediated sensory-motor interactions and related clinical implications. J Oral Rehabil 2006; 33 (4): 282\u2013292.","journal-title":"J Oral Rehabil"},{"issue":"1\/2","key":"BFijos20171_CR7","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1440-1681.2005.04144.x","volume":"32","author":"I Klineberg","year":"2005","unstructured":"Klineberg I, Calford MB, Dreher B et al. A consensus statement on osseoperception. Clin Exp Pharmacol Physiol 2005; 32 (1\/2): 145\u2013146.","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"1","key":"BFijos20171_CR8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/ijos.2014.53","volume":"7","author":"Y Huang","year":"2015","unstructured":"Huang Y, van Dessel J, Martens W et al. Sensory innervation around immediately vs. delayed loaded implants: a pilot study. Int J Oral Sci 2015; 7 (1): 49\u201355.","journal-title":"Int J Oral Sci"},{"issue":"4","key":"BFijos20171_CR9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1111\/j.1365-2842.2006.01632.x","volume":"33","author":"J Feine","year":"2006","unstructured":"Feine J, Jacobs R, Lobbezoo F et al. A functional perspective on oral implants\u2014state-of-the-science and future recommendations. J Oral Rehabil 2006; 33 (4): 309\u2013312.","journal-title":"J Oral Rehabil"},{"issue":"3","key":"BFijos20171_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/jopr.12310","volume":"25","author":"SK Mishra","year":"2016","unstructured":"Mishra SK, Chowdhary R, Chrcanovic BR et al. Osseoperception in dental implants: a systematic review. J Prosthodont 2016; 25 (3): 185\u2013195.","journal-title":"J Prosthodont"},{"issue":"3","key":"BFijos20171_CR11","first-page":"283","volume":"7","author":"L dos Santos Corpas","year":"2014","unstructured":"dos Santos Corpas L, Lambrichts I, Quirynen M et al. Peri-implant bone innervation: histological findings in humans. Eur J Oral Implantol 2014; 7 (3): 283\u2013292.","journal-title":"Eur J Oral Implantol"},{"issue":"6","key":"BFijos20171_CR12","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1111\/cid.12053","volume":"16","author":"M Kazemi","year":"2014","unstructured":"Kazemi M, Geramipanah F, Negahdari R et al. Active tactile sensibility of single-tooth implants versus natural dentition: a split-mouth double-blind randomized clinical trial. Clin Implant Dent Relat Res 2014; 16 (6): 947\u2013955.","journal-title":"Clin Implant Dent Relat Res"},{"issue":"8","key":"BFijos20171_CR13","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1007\/s00784-013-1174-1","volume":"18","author":"P Habre-Hallage","year":"2014","unstructured":"Habre-Hallage P, Dricot L, Hermoye L et al. Cortical activation resulting from the stimulation of periodontal mechanoreceptors measured by functional magnetic resonance imaging (fMRI). Clin Oral Investig 2014; 18 (8): 1949\u20131961.","journal-title":"Clin Oral Investig"},{"issue":"2","key":"BFijos20171_CR14","first-page":"193","volume":"15","author":"BH Choi","year":"2000","unstructured":"Choi BH . Periodontal ligament formation around titanium implants using cultured periodontal ligament cells: a pilot study. Int J Oral Maxillofac Implants 2000; 15 (2): 193\u2013196.","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"4","key":"BFijos20171_CR15","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.mehy.2007.02.013","volume":"69","author":"Q Yuan","year":"2007","unstructured":"Yuan Q, Gong P, Tan Z . Schwann cell graft: a method to promote sensory responses of osseointegrated implants. Med Hypotheses 2007; 69 (4): 800\u2013803.","journal-title":"Med Hypotheses"},{"issue":"2","key":"BFijos20171_CR16","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.mehy.2013.04.025","volume":"81","author":"L Ma","year":"2013","unstructured":"Ma L, Xiang L, Yao Y et al. CGRP-alpha application: a potential treatment to improve osseoperception of endosseous dental implants. Med Hypotheses 2013; 81 (2): 297\u2013299.","journal-title":"Med Hypotheses"},{"issue":"2","key":"BFijos20171_CR17","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0894-1130(98)80007-0","volume":"11","author":"AB Dagum","year":"1998","unstructured":"Dagum AB . Peripheral nerve regeneration, repair, and grafting. J Hand Ther 1998; 11 (2): 111\u2013117.","journal-title":"J Hand Ther"},{"issue":"2","key":"BFijos20171_CR18","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3892\/ijmm.2015.2438","volume":"37","author":"J Qin","year":"2016","unstructured":"Qin J, Wang L, Sun Y et al. Concentrated growth factor increases Schwann cell proliferation and neurotrophic factor secretion and promotes functional nerve recovery in vivo. Int J Mol Med 2016; 37 (2): 493\u2013500.","journal-title":"Int J Mol Med"},{"issue":"11","key":"BFijos20171_CR19","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/S0278-2391(97)90187-7","volume":"55","author":"DH Whitman","year":"1997","unstructured":"Whitman DH, Berry RL, Green DM . Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg 1997; 55 (11): 1294\u20131299.","journal-title":"J Oral Maxillofac Surg"},{"issue":"6","key":"BFijos20171_CR20","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/S1079-2104(98)90029-4","volume":"85","author":"RE Marx","year":"1998","unstructured":"Marx RE, Carlson ER, Eichstaedt RM et al. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998; 85 (6): 638\u2013646.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"4","key":"BFijos20171_CR21","first-page":"529","volume":"14","author":"E Anitua","year":"1999","unstructured":"Anitua E . Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants 1999; 14 (4): 529\u2013535.","journal-title":"Int J Oral Maxillofac Implants"},{"issue":"3","key":"BFijos20171_CR22","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1034\/j.1600-0501.2003.00810.x","volume":"14","author":"G Weibrich","year":"2003","unstructured":"Weibrich G, Kleis WK, Hafner G et al. Comparison of platelet, leukocyte, and growth factor levels in point-of-care platelet-enriched plasma, prepared using a modified Curasan kit, with preparations received from a local blood bank. Clin Oral Implants Res 2003; 14 (3): 357\u2013362.","journal-title":"Clin Oral Implants Res"},{"key":"BFijos20171_CR23","first-page":"55","volume":"42","author":"J Choukroun","year":"2001","unstructured":"Choukroun J, Adda F, Schoeffler C et al. [Une opportunit\u00e9 en paro-implantologie: le PRF]. Implantodontie 2001; 42: 55\u201362.French.","journal-title":"Implantodontie"},{"issue":"3","key":"BFijos20171_CR24","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/j.tripleo.2005.07.008","volume":"101","author":"DM Dohan","year":"2006","unstructured":"Dohan DM, Choukroun J, Diss A et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 101 (3): e37\u2013e44.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"4","key":"BFijos20171_CR25","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1002\/jbm.a.32894","volume":"95","author":"DM Dohan Ehrenfest","year":"2010","unstructured":"Dohan Ehrenfest DM, Bielecki T, Corso MD et al. Shedding light in the controversial terminology for platelet-rich products: platelet-rich plasma (PRP), platelet-rich fibrin (PRF), platelet-leukocyte gel (PLG), preparation rich in growth factors (PRGF), classification and commercialism. J Biomed Mater Res A 2010; 95 (4): 1280\u20131282.","journal-title":"J Biomed Mater Res A"},{"key":"BFijos20171_CR26","first-page":"69","volume":"1","author":"M Corigliano","year":"2010","unstructured":"Corigliano M, Sacco L, Baldoni E . [CGF-una proposta terapeutica per la medicina rigenerativa.] Odontoiatria 2010; 1: 69\u201381 Italian.","journal-title":"Odontoiatria"},{"issue":"3","key":"BFijos20171_CR27","doi-asserted-by":"publisher","first-page":"e0121713","DOI":"10.1371\/journal.pone.0121713","volume":"10","author":"E Anitua","year":"2015","unstructured":"Anitua E, Zalduendo M, Troya M et al. Leukocyte inclusion within a platelet rich plasma-derived fibrin scaffold stimulates a more pro-inflammatory environment and alters fibrin properties. PLoS One 2015; 10 (3): e0121713.","journal-title":"PLoS One"},{"issue":"2","key":"BFijos20171_CR28","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1423-0410.2006.00815.x","volume":"91","author":"GC Leitner","year":"2006","unstructured":"Leitner GC, Gruber R, Neum\u00fcller J et al. Platelet content and growth factor release in platelet-rich plasma: a comparison of four different systems. Vox Sang 2006; 91 (2): 135\u2013139.","journal-title":"Vox Sang"},{"issue":"1","key":"BFijos20171_CR29","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40729-016-0052-4","volume":"2","author":"H Masuki","year":"2016","unstructured":"Masuki H, Okudera T, Watanebe T et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). Int J Implant Dent 2016; 2 (1): 19.","journal-title":"Int J Implant Dent"},{"issue":"3","key":"BFijos20171_CR30","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","volume":"27","author":"DM Dohan Ehrenfest","year":"2009","unstructured":"Dohan Ehrenfest DM, Rasmusson L, Albrektsson T . Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009; 27 (3): 158\u2013167.","journal-title":"Trends Biotechnol"},{"issue":"1","key":"BFijos20171_CR31","first-page":"17","volume":"1","author":"DD Ehrenfest","year":"2013","unstructured":"Ehrenfest DD, Sammartino G, Shibli JA et al. Guidelines for the publication of articles related to platelet concentrates (platelet-rich plasma-PRP, or platelet-rich fibrin-PRF): the international classification of the POSEIDO. Poseido 2013; 1 (1): 17\u201327.","journal-title":"Poseido"},{"issue":"1","key":"BFijos20171_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.32098\/mltj.01.2014.02","volume":"4","author":"DM Dohan Ehrenfest","year":"2014","unstructured":"Dohan Ehrenfest DM . Classification of platelet concentrates (platelet-rich plasma-PRP, platelet-rich fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J 2014; 4 (1): 3\u20139.","journal-title":"Muscles Ligaments Tendons J"},{"issue":"2","key":"BFijos20171_CR33","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1007\/s12035-015-9251-x","volume":"52","author":"DP Kuffler","year":"2015","unstructured":"Kuffler DP . Platelet-rich plasma promotes axon regeneration, wound healing, and pain reduction: fact or fiction. Mol Neurobiol 2015; 52 (2): 990\u20131014.","journal-title":"Mol Neurobiol"},{"issue":"Pt 1","key":"BFijos20171_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1469-7580.1999.19410001.x","volume":"194","author":"G Terenghi","year":"1999","unstructured":"Terenghi G . Peripheral nerve regeneration and neurotrophic factors. J Anat 1999; 194 (Pt 1): 1\u201314.","journal-title":"J Anat"},{"issue":"4","key":"BFijos20171_CR35","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3109\/09537104.2015.1116686","volume":"27","author":"MD Fabbro","year":"2016","unstructured":"Fabbro MD, Bortolin M, Taschieri S et al. Antimicrobial properties of platelet-rich preparations. A systematic review of the current pre-clinical evidence. Platelets 2016; 27 (4): 276\u2013285.","journal-title":"Platelets"},{"issue":"4","key":"BFijos20171_CR36","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/micr.22104","volume":"33","author":"M Siemionow","year":"2013","unstructured":"Siemionow M, Uygur S, Ozturk C et al. Techniques and materials for enhancement of peripheral nerve regeneration: a literature review. Microsurgery 2013; 33 (4): 318\u2013328.","journal-title":"Microsurgery"},{"issue":"3","key":"BFijos20171_CR37","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1097\/SCS.0b013e3181d878e9","volume":"21","author":"P Gentile","year":"2010","unstructured":"Gentile P, Bottini DJ, Spallone D et al. Application of platelet-rich plasma in maxillofacial surgery: clinical evaluation. J Craniofac Surg 2010; 21 (3): 900\u2013904.","journal-title":"J Craniofac Surg"},{"key":"BFijos20171_CR38","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1742-4933-10-23","volume":"10","author":"A Albanese","year":"2013","unstructured":"Albanese A, Licata ME, Polizzi B et al. Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration. Immun Ageing 2013; 10: 23.","journal-title":"Immun Ageing"},{"issue":"1","key":"BFijos20171_CR39","first-page":"59","volume":"11","author":"I Georgakopoulos","year":"2014","unstructured":"Georgakopoulos I, Tsantis S, Georgakopoulos P et al. The impact of platelet rich plasma (PRP) in osseointegration of oral implants in dental panoramic radiography: texture based evaluation. Clin Cases Miner Bone Metab 2014; 11 (1): 59\u201366.","journal-title":"Clin Cases Miner Bone Metab"},{"issue":"4","key":"BFijos20171_CR40","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/00008505-200110000-00002","volume":"10","author":"RE Marx","year":"2001","unstructured":"Marx RE . Platelet-rich plasma (PRP): what is PRP and what is not PRP. Implant Dent 2001; 10 (4): 225\u2013228.","journal-title":"Implant Dent"},{"issue":"24","key":"BFijos20171_CR41","doi-asserted-by":"publisher","first-page":"6972","DOI":"10.1046\/j.1432-1327.2000.01824.x","volume":"267","author":"K Unsicker","year":"2000","unstructured":"Unsicker K, Strelau J . Functions of transforming growth factor-beta isoforms in the nervous system. Cues based on localization and experimental in vitro and in vivo evidence. Eur J Biochem 2000; 267 (24): 6972\u20136975.","journal-title":"Eur J Biochem"},{"issue":"4","key":"BFijos20171_CR42","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.1085-9489.2003.03029.x","volume":"8","author":"T Gordon","year":"2003","unstructured":"Gordon T, Sulaiman O, Boyd JG . Experimental strategies to promote functional recovery after peripheral nerve injuries. J Peripher Nerv Syst 2003; 8 (4): 236\u2013250.","journal-title":"J Peripher Nerv Syst"},{"issue":"4","key":"BFijos20171_CR43","doi-asserted-by":"publisher","first-page":"859","DOI":"10.3171\/2014.4.JNS131251","volume":"121","author":"W Sulaiman","year":"2014","unstructured":"Sulaiman W, Dreesen TD . Effect of local application of transforming growth factor-\u03b2 at the nerve repair site following chronic axotomy and denervation on the expression of regeneration-associated genes. Laboratory investigation. J Neurosurg 2014; 121 (4): 859\u2013874.","journal-title":"J Neurosurg"},{"issue":"11","key":"BFijos20171_CR44","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1517\/13543780903241607","volume":"18","author":"S Graham","year":"2009","unstructured":"Graham S, Leonidou A, Lester M et al. Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing. Expert Opin Investig Drugs 2009; 18 (11): 1633\u20131654.","journal-title":"Expert Opin Investig Drugs"},{"issue":"3","key":"BFijos20171_CR45","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1111\/j.1529-8027.2009.00228.x","volume":"14","author":"T Yamazaki","year":"2009","unstructured":"Yamazaki T, Sabit H, Oya T et al. Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves. J Peripher Nerv Syst 2009; 14 (3): 165\u2013176.","journal-title":"J Peripher Nerv Syst"},{"issue":"2","key":"BFijos20171_CR46","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.blre.2013.02.001","volume":"27","author":"T Burnouf","year":"2013","unstructured":"Burnouf T, Goubran HA, Chen TM et al. Blood-derived biomaterials and platelet growth factors in regenerative medicine. Blood Rev 2013; 27 (2): 77\u201389.","journal-title":"Blood Rev"},{"issue":"12","key":"BFijos20171_CR47","doi-asserted-by":"publisher","first-page":"e14393","DOI":"10.1371\/journal.pone.0014393","volume":"5","author":"U Hellman","year":"2010","unstructured":"Hellman U, Malm L, Ma LP et al. Growth factor PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan. PLoS One 2010; 5 (12): e14393.","journal-title":"PLoS One"},{"issue":"8","key":"BFijos20171_CR48","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1242\/dev.072348","volume":"139","author":"F Mackenzie","year":"2012","unstructured":"Mackenzie F, Ruhrberg C . Diverse roles for VEGF-A in the nervous system. Development 2012; 139 (8): 1371\u20131380.","journal-title":"Development"},{"issue":"10","key":"BFijos20171_CR49","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1038\/jcbfm.2009.100","volume":"29","author":"DM Hermann","year":"2009","unstructured":"Hermann DM, Zechariah A . Implications of vascular endothelial growth factor for postischemic neurovascular remodeling. J Cereb Blood Flow Metab 2009; 29 (10): 1620\u20131643.","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"BFijos20171_CR50","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1002\/glia.20496","volume":"55","author":"G Liang","year":"2007","unstructured":"Liang G, Cline GW, Macica CM . IGF-1 stimulates de novo fatty acid biosynthesis by Schwann cells during myelination. Glia 2007; 55 (6): 632\u2013641.","journal-title":"Glia"},{"key":"BFijos20171_CR51","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jconrel.2014.03.021","volume":"183","author":"K Nagata","year":"2014","unstructured":"Nagata K, Itaka K, Baba M et al. Muscle-targeted hydrodynamic gene introduction of insulin-like growth factor-1 using polyplex nanomicelle to treat peripheral nerve injury. J Control Release 2014; 183: 27\u201334.","journal-title":"J Control Release"},{"issue":"3","key":"BFijos20171_CR52","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s004290100205","volume":"204","author":"C Grothe","year":"2001","unstructured":"Grothe C, Nikkhah G . The role of basic fibroblast growth factor in peripheral nerve regeneration. Anat Embryol 2001; 204 (3): 171\u2013177.","journal-title":"Anat Embryol"},{"issue":"3","key":"BFijos20171_CR53","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","volume":"83","author":"S Werner","year":"2003","unstructured":"Werner S, Grose R . Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003; 83 (3): 835\u2013870.","journal-title":"Physiol Rev"},{"issue":"3","key":"BFijos20171_CR54","first-page":"605","volume":"40","author":"Y Sawamura","year":"1997","unstructured":"Sawamura Y, Ikeda J, Miyamachi K et al. Full functional recovery after surgical repair of transected abducens nerve: case report. Neurosurgery 1997; 40 (3): 605\u2013607.","journal-title":"Neurosurgery"},{"issue":"6","key":"BFijos20171_CR55","doi-asserted-by":"publisher","first-page":"E1321","DOI":"10.1227\/NEU.0b013e31822a9fd2","volume":"69","author":"DP Kuffler","year":"2011","unstructured":"Kuffler DP, Reyes O, Sosa IJ et al. Neurological recovery across a 12-cm-long ulnar nerve gap repaired 3.25 years post trauma: case report. Neurosurgery 2011; 69 (6): E1321\u2013E1326.","journal-title":"Neurosurgery"},{"issue":"5","key":"BFijos20171_CR56","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1007\/s00167-013-2479-y","volume":"22","author":"M S\u00e1nchez","year":"2014","unstructured":"S\u00e1nchez M, Yoshioka T, Ortega M et al. Ultrasound-guided platelet-rich plasma injections for the treatment of common peroneal nerve palsy associated with multiple ligament injuries of the knee. Knee Surg Sports Traumatol Arthrosc 2014; 22 (5): 1084\u20131089.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"8","key":"BFijos20171_CR57","doi-asserted-by":"publisher","first-page":"e272","DOI":"10.1016\/j.bjoms.2012.08.018","volume":"51","author":"E Anitua","year":"2013","unstructured":"Anitua E, Bego\u00f1a L, Orive G . Treatment of hemimandibular paresthesia in a patient with bisphosphonate-related osteonecrosis of the jaw (BRONJ) by combining surgical resection and PRGF-Endoret. Br J Oral Maxillofac Surg 2013; 51 (8): e272\u2013e274.","journal-title":"Br J Oral Maxillofac Surg"},{"issue":"1","key":"BFijos20171_CR58","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/ijd.12162","volume":"53","author":"S Anjayani","year":"2014","unstructured":"Anjayani S, Wirohadidjojo YW, Adam AM et al. Sensory improvement of leprosy peripheral neuropathy in patients treated with perineural injection of platelet-rich plasma. Int J Dermatol 2014; 53 (1): 109\u2013113.","journal-title":"Int J Dermatol"},{"issue":"11","key":"BFijos20171_CR59","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.4103\/1673-5374.165322","volume":"10","author":"MA Malahias","year":"2015","unstructured":"Malahias MA, Johnson EO, Babis GC et al. Single injection of platelet-rich plasma as a novel treatment of carpal tunnel syndrome. Neural Regen Res 2015; 10 (11): 1856\u20131859.","journal-title":"Neural Regen Res"},{"issue":"10","key":"BFijos20171_CR60","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.ijom.2016.06.003","volume":"45","author":"A Khojasteh","year":"2016","unstructured":"Khojasteh A, Hosseinpour S, Nazeman P et al. The effect of a platelet-rich fibrin conduit on neurosensory recovery following inferior alveolar nerve lateralization: a preliminary clinical study. Int J Oral Maxillofac Surg 2016; 45 (10): 1303\u20131308.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"11","key":"BFijos20171_CR61","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/jcpe.12612","volume":"43","author":"A Temmerman","year":"2016","unstructured":"Temmerman A, Vandessel J, Castro A et al. The use of leucocyte and platelet-rich fibrin in socket management and ridge preservation: a split-mouth, randomized, controlled clinical trial. J Clin Periodontol 2016; 43 (11): 990\u2013999.","journal-title":"J Clin Periodontol"},{"issue":"3","key":"BFijos20171_CR62","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3928\/1081597X-20130129-04","volume":"29","author":"J Javaloy","year":"2013","unstructured":"Javaloy J, Ali\u00f3 JL, Rodriguez AE et al. Effect of platelet-rich plasma in nerve regeneration after LASIK. J Refract Surg 2013; 29 (3): 213\u2013219.","journal-title":"J Refract Surg"},{"issue":"1","key":"BFijos20171_CR63","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jneumeth.2007.02.017","volume":"163","author":"AL Lu\u00eds","year":"2007","unstructured":"Lu\u00eds AL, Amado S, Geuna S et al. Long-term functional and morphological assessment of a standardized rat sciatic nerve crush injury with a non-serrated clamp. J Neurosci Methods 2007; 163 (1): 92\u2013104.","journal-title":"J Neurosci Methods"},{"issue":"1","key":"BFijos20171_CR64","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/01.mlg.0000249726.98801.77","volume":"117","author":"TY Farrag","year":"2007","unstructured":"Farrag TY, Lehar M, Verhaegen P et al. Effect of platelet rich plasma and fibrin sealant on facial nerve regeneration in a rat model. Laryngoscope 2007; 117 (1): 157\u2013165.","journal-title":"Laryngoscope"},{"issue":"8","key":"BFijos20171_CR65","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/j.ijom.2008.05.010","volume":"37","author":"RF Elgazzar","year":"2008","unstructured":"Elgazzar RF, Mutabagani MA, Abdelaal SE et al. Platelet rich plasma may enhance peripheral nerve regeneration after cyanoacrylate reanastomosis: a controlled blind study on rats. Int J Oral Maxillofac Surg 2008; 37 (8): 748\u2013755.","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"3","key":"BFijos20171_CR66","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1055\/s-2008-1076752","volume":"24","author":"Y Sariguney","year":"2008","unstructured":"Sariguney Y, Yavuzer R, Elmas C et al. Effect of platelet-rich plasma on peripheral nerve regeneration. J Reconstr Microsurg 2008; 24 (3): 159\u2013167.","journal-title":"J Reconstr Microsurg"},{"issue":"2","key":"BFijos20171_CR67","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3171\/2010.9.JNS091928","volume":"114","author":"E Emel","year":"2011","unstructured":"Emel E, Erg\u00fcn SS, Kotan D et al. Effects of insulin-like growth factor-I and platelet-rich plasma on sciatic nerve crush injury in a rat model. J Neurosurg 2011; 114 (2): 522\u2013528.","journal-title":"J Neurosurg"},{"issue":"5","key":"BFijos20171_CR68","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/micr.22105","volume":"33","author":"M Lichtenfels","year":"2013","unstructured":"Lichtenfels M, Colom\u00e9 L, Sebben AD et al. Effect of platelet rich plasma and platelet rich fibrin on sciatic nerve regeneration in a rat model. Microsurgery 2013; 33 (5): 383\u2013390.","journal-title":"Microsurgery"},{"issue":"9","key":"BFijos20171_CR69","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1055\/s-0034-1372483","volume":"30","author":"E Giannessi","year":"2014","unstructured":"Giannessi E, Coli A, Stornelli MR et al. An autologously generated platelet-rich plasma suturable membrane may enhance peripheral nerve regeneration after neurorraphy in an acute injury model of sciatic nerve neurotmesis. J Reconstr Microsurg 2014; 30 (9): 617\u2013626.","journal-title":"J Reconstr Microsurg"},{"issue":"14","key":"BFijos20171_CR70","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.4103\/1673-5374.137587","volume":"9","author":"JY Kim","year":"2014","unstructured":"Kim JY, Jeon WJ, Kim DH et al. An inside-out vein graft filled with platelet-rich plasma for repair of a short sciatic nerve defect in rats. Neural Regen Res 2014; 9 (14): 1351\u20131357.","journal-title":"Neural Regen Res"},{"issue":"4","key":"BFijos20171_CR71","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3944\/AOTT.2014.13.0029","volume":"48","author":"L K\u00fc\u00e7\u00fck","year":"2014","unstructured":"K\u00fc\u00e7\u00fck L, G\u00fcnay H, Erba\u015f O et al. Effects of platelet-rich plasma on nerve regeneration in a rat model. Acta Orthop Traumatol Turc 2014; 48 (4): 449\u2013454.","journal-title":"Acta Orthop Traumatol Turc"},{"issue":"23\/24","key":"BFijos20171_CR72","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1089\/ten.tea.2013.0729","volume":"20","author":"C Zheng","year":"2014","unstructured":"Zheng C, Zhu Q, Liu X et al. Improved peripheral nerve regeneration using acellular nerve allografts loaded with platelet-rich plasma. Tissue Eng Part A 2014; 20 (23\/24): 3228\u20133240.","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"BFijos20171_CR73","first-page":"1","volume":"3","author":"S Abbasipour-Dalivand","year":"2015","unstructured":"Abbasipour-Dalivand S, Mohammadi R, Mohammadi V . Effects of local administration of platelet rich plasma on functional recovery after bridging sciatic nerve defect using silicone rubber chamber: an experimental study. Bull Emerg Trauma 2015; 3 (1): 1\u20137.","journal-title":"Bull Emerg Trauma"},{"key":"BFijos20171_CR74","first-page":"362","volume":"87","author":"C Firat","year":"2016","unstructured":"Firat C, Aytekin AH, Durak MA et al. Comparison of the effects of PRP and hyaluronic acid in promoting peripheral nerve regeneration An experimental study with vascular conduit model in rats'. Ann Ital Chir 2016; 87: 362\u2013374.","journal-title":"Ann Ital Chir"},{"issue":"2","key":"BFijos20171_CR75","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/aja.2008.37","volume":"11","author":"XG Ding","year":"2009","unstructured":"Ding XG, Li SW, Zheng XM et al. The effect of platelet-rich plasma on cavernous nerve regeneration in a rat model. Asian J Androl 2009; 11 (2): 215\u2013221.","journal-title":"Asian J Androl"},{"issue":"11","key":"BFijos20171_CR76","doi-asserted-by":"publisher","first-page":"2838","DOI":"10.1111\/j.1743-6109.2012.02881.x","volume":"9","author":"CC Wu","year":"2012","unstructured":"Wu CC, Wu YN, Ho HO et al. The neuroprotective effect of platelet-rich plasma on erectile function in bilateral cavernous nerve injury rat model. J Sex Med 2012; 9 (11): 2838\u20132848.z.","journal-title":"J Sex Med"},{"issue":"5","key":"BFijos20171_CR77","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/lary.20860","volume":"120","author":"HH Cho","year":"2010","unstructured":"Cho HH, Jang S, Lee SC et al. Effect of neural-induced mesenchymal stem cells and platelet-rich plasma on facial nerve regeneration in an acute nerve injury model. Laryngoscope 2010; 120 (5): 907\u2013913.","journal-title":"Laryngoscope"},{"issue":"29","key":"BFijos20171_CR78","first-page":"2286","volume":"7","author":"F Ye","year":"2012","unstructured":"Ye F, Li H, Qiao G et al. Platelet-rich plasma gel in combination with Schwann cells for repair of sciatic nerve injury. Neural Regen Res 2012; 7 (29): 2286\u20132292.","journal-title":"Neural Regen Res"},{"issue":"1","key":"BFijos20171_CR79","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jss.2013.01.020","volume":"183","author":"X Xie","year":"2013","unstructured":"Xie X, Zhao S, Wu H et al. Platelet-rich plasma enhances autograft revascularization and reinnervation in a dog model of anterior cruciate ligament reconstruction. J Surg Res 2013; 183 (1): 214\u2013222.","journal-title":"J Surg Res"},{"issue":"7","key":"BFijos20171_CR80","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.jcyt.2013.04.004","volume":"15","author":"T Zhao","year":"2013","unstructured":"Zhao T, Yan W, Xu K et al. Combined treatment with platelet-rich plasma and brain-derived neurotrophic factor-overexpressing bone marrow stromal cells supports axonal remyelination in a rat spinal cord hemi-section model. Cytotherapy 2013; 15 (7): 792\u2013804.","journal-title":"Cytotherapy"},{"issue":"5","key":"BFijos20171_CR81","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.3892\/ijmm.2016.2520","volume":"37","author":"J Qin","year":"2016","unstructured":"Qin J, Wang L, Zheng L et al. Concentrated growth factor promotes Schwann cell migration partly through the integrin \u03b21-mediated activation of the focal adhesion kinase pathway. Int J Mol Med 2016; 37 (5): 1363\u20131370.","journal-title":"Int J Mol Med"},{"issue":"2","key":"BFijos20171_CR82","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/micr.20599","volume":"29","author":"A Piskin","year":"2009","unstructured":"Piskin A, Kaplan S, Akta\u015f A et al. Platelet gel does not improve peripheral nerve regeneration: an electrophysiological, stereological, and electron microscopic study. Microsurgery 2009; 29 (2): 144\u2013153.","journal-title":"Microsurgery"},{"issue":"4","key":"BFijos20171_CR83","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/micr.20876","volume":"31","author":"S Kaplan","year":"2011","unstructured":"Kaplan S, Pi\u015fkin A, Ayyildiz M et al. The effect of melatonin and platelet gel on sciatic nerve repair: an electrophysiological and stereological study. Microsurgery 2011; 31 (4): 306\u2013313.","journal-title":"Microsurgery"},{"issue":"3","key":"BFijos20171_CR84","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3109\/00207454.2012.742077","volume":"123","author":"H Li","year":"2013","unstructured":"Li H, Han Z, Liu D et al. Autologous platelet-rich plasma promotes neurogenic differentiation of human adipose-derived stem cells in vitro. Int J Neurosci 2013; 123 (3): 184\u2013190.","journal-title":"Int J Neurosci"},{"issue":"5","key":"BFijos20171_CR85","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/term.1756","volume":"10","author":"C Zheng","year":"2016","unstructured":"Zheng C, Zhu Q, Liu X et al. Effect of platelet-rich plasma (PRP) concentration on proliferation, neurotrophic function and migration of Schwann cells in vitro. J Tissue Eng Regen Med 2016; 10 (5): 428\u2013436.","journal-title":"J Tissue Eng Regen Med"},{"key":"BFijos20171_CR86","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez M, Anitua E, Delgado D et al. Ultrasound-guided plasma rich in growth factors injections and scaffolds hasten motor nerve functional recovery in an ovine model of nerve crush injury. J Tissue Eng Regen Med 2015 e-pub ahead of print doi:10.1002\/term.2079.","DOI":"10.1002\/term.2079"},{"issue":"7","key":"BFijos20171_CR87","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1097\/SCS.0000000000003066","volume":"27","author":"F \u015eenses","year":"2016","unstructured":"\u015eenses F, \u00d6nder ME, Ko\u00e7yi\u011fit ID et al. Effect of platelet-rich fibrin on peripheral nerve regeneration. J Craniofac Surg 2016; 27 (7): 1759\u20131764.","journal-title":"J Craniofac Surg"},{"key":"BFijos20171_CR88","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/j.expneurol.2014.09.006","volume":"261","author":"KM Chan","year":"2014","unstructured":"Chan KM, Gordon T, Zochodne DW et al. Improving peripheral nerve regeneration: from molecular mechanisms to potential therapeutic targets. Exp Neurol 2014; 261: 826\u2013835.","journal-title":"Exp Neurol"},{"issue":"1","key":"BFijos20171_CR89","doi-asserted-by":"publisher","first-page":"35","DOI":"10.32098\/mltj.01.2014.07","volume":"4","author":"HC Wang James","year":"2014","unstructured":"Wang James HC . Can PRP effectively treat injured tendons? Muscles Ligaments Tendons J 2014; 4 (1): 35\u201337.","journal-title":"Muscles Ligaments Tendons J"},{"issue":"1","key":"BFijos20171_CR90","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tips.2007.10.010","volume":"29","author":"E Anitua","year":"2008","unstructured":"Anitua E, S\u00e1nchez M, Orive G et al. Delivering growth factors for therapeutics. Trends Pharmacol Sci 2008; 29 (1): 37\u201341.","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"BFijos20171_CR91","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1111\/j.1600-0501.2005.01203.x","volume":"17","author":"F Graziani","year":"2006","unstructured":"Graziani F, Ivanovski S, Cei S et al. The in vitro effect of different PRP concentrations on osteoblasts and fibroblasts. Clin Oral Implants Res 2006; 17 (2): 212\u2013219.","journal-title":"Clin Oral Implants Res"},{"issue":"4","key":"BFijos20171_CR92","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.joms.2003.12.003","volume":"62","author":"RE Marx","year":"2004","unstructured":"Marx RE . Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004; 62 (4): 489\u2013496.","journal-title":"J Oral Maxillofac Surg"},{"issue":"Suppl 4","key":"BFijos20171_CR93","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1007\/s00586-008-0751-5","volume":"17","author":"K Nishida","year":"2008","unstructured":"Nishida K, Suzuki T, Kakutani K et al. Gene therapy approach for disc degeneration and associated spinal disorders. Eur Spine J 2008; 17 (Suppl 4): 459\u2013466.","journal-title":"Eur Spine J"},{"key":"BFijos20171_CR94","doi-asserted-by":"crossref","first-page":"134582","DOI":"10.1155\/2013\/134582","volume":"2013","author":"N Zhang","year":"2013","unstructured":"Zhang N, Wu YP, Qian SJ et al. Research progress in the mechanism of effect of PRP in bone deficiency healing. Scientific World Journal 2013; 2013: 134582.","journal-title":"Scientific World Journal"},{"issue":"2","key":"BFijos20171_CR95","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.joen.2010.10.011","volume":"37","author":"M Torabinejad","year":"2011","unstructured":"Torabinejad M, Corr R, Buhrley M et al. An animal model to study regenerative endodontics. J Endod 2011; 37 (2): 197\u2013202.","journal-title":"J Endod"},{"issue":"1","key":"BFijos20171_CR96","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40824-016-0061-7","volume":"20","author":"SN Kaushik","year":"2016","unstructured":"Kaushik SN, Kim B, Walma AMC et al. Biomimetic microenvironments for regenerative endodontics. Biomater Res 2016; 20 (1): 14.","journal-title":"Biomater Res"},{"key":"BFijos20171_CR97","unstructured":"Dard M Methods and interpretation of performance studies for dental implants. In: Boutrand JP (ed). Biocompatibility and Performance of Medical Devices. Oxford, UK: Woodhead Publishing Ltd., 2012; 308\u2013344."},{"issue":"5","key":"BFijos20171_CR98","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1177\/0300985815593124","volume":"52","author":"LM Wancket","year":"2015","unstructured":"Wancket LM . Animal models for evaluation of bone implants and devices: comparative bone structure and common model uses. Vet Pathol 2015; 52 (5): 842\u2013850.","journal-title":"Vet Pathol"},{"issue":"2","key":"BFijos20171_CR99","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1210\/endo.139.2.5751","volume":"139","author":"J Aerssens","year":"1998","unstructured":"Aerssens J, Boonen S, Lowet G et al. Interspecies differences in bone composition, density, and quality: potential implications for in vivo bone research. Endocrinology 1998; 139 (2): 663\u2013670.","journal-title":"Endocrinology"}],"container-title":["International Journal of Oral Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ijos20171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijos20171","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ijos20171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T16:54:28Z","timestamp":1750092868000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ijos20171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":99,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["BFijos20171"],"URL":"https:\/\/doi.org\/10.1038\/ijos.2017.1","relation":{},"ISSN":["1674-2818","2049-3169"],"issn-type":[{"value":"1674-2818","type":"print"},{"value":"2049-3169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"17 January 2017","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 March 2017","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}