{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:38:11Z","timestamp":1791117491139,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T00:00:00Z","timestamp":1317254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Coral reefs are deteriorating at an alarming rate mainly as a consequence of the emergence of coral diseases. The white plague disease (WPD) is the most prevalent coral disease in the southwestern Caribbean, affecting dozens of coral species. However, the identification of a single causal agent has proved problematic. This suggests more complex etiological scenarios involving alterations in the dynamic interaction between environmental factors, the coral immune system and the symbiotic microbial communities. Here we compare the microbiome of healthy and WPD-affected corals from the two reef-building species Diploria strigosa and Siderastrea siderea collected at the Tayrona National Park in the Caribbean of Colombia. Microbiomes were analyzed by combining culture-dependent methods and pyrosequencing of 16S ribosomal DNA (rDNA) V5-V6 hypervariable regions. A total of 20 410 classifiable 16S rDNA sequences reads were obtained including all samples. No significant differences in operational taxonomic unit diversity were found between healthy and affected tissues; however, a significant increase of Alphaproteobacteria and a concomitant decrease in the Beta- and Gammaproteobacteria was observed in WPD-affected corals of both species. Significant shifts were also observed in the orders Rhizobiales, Caulobacteriales, Burkholderiales, Rhodobacterales, Aleteromonadales and Xanthomonadales, although they were not consistent between the two coral species. These shifts in the microbiome structure of WPD-affected corals suggest a loss of community-mediated growth control mechanisms on bacterial populations specific for each holobiont system.<\/jats:p>","DOI":"10.1038\/ismej.2011.123","type":"journal-article","created":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T10:48:03Z","timestamp":1317293283000},"page":"502-512","source":"Crossref","is-referenced-by-count":135,"title":["Shifts in bacterial communities of two caribbean reef-building coral species affected by white plague disease"],"prefix":"10.1093","volume":"6","author":[{"given":"Anny","family":"C\u00e1rdenas","sequence":"first","affiliation":[{"name":"Department of Biology, Universidad Nacional de Colombia , Bogot\u00e1 , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis M","family":"Rodriguez-R","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology and Plant Pathology, Universidad de Los Andes , Bogot\u00e1 , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Pizarro","sequence":"additional","affiliation":[{"name":"School of Marine Biology, Universidad Jorge Tadeo Lozano , Santa Marta , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis F","family":"Cadavid","sequence":"additional","affiliation":[{"name":"Department of Biology, Universidad Nacional de Colombia , Bogot\u00e1 , Colombia"},{"name":"Institute of Genetics, Universidad Nacional de Colombia , Bogot\u00e1 , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Ar\u00e9valo-Ferro","sequence":"additional","affiliation":[{"name":"Department of Biology, Universidad Nacional de Colombia , Bogot\u00e1 , Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,9,29]]},"reference":[{"key":"2024020118231126600_CR1","doi-asserted-by":"publisher","first-page":"3031","DOI":"10.1128\/AEM.66.7.3031-3036.2000","article-title":"Penetration of the coral-bleaching bacterium Vibrio shiloi into Oculina patagonica","volume":"66","author":"Banin","year":"2000","journal-title":"Appl Environ Microbiol"},{"key":"2024020118231126600_CR2","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1111\/j.1462-2920.2007.01315.x","article-title":"Characterization of black band disease in Red Sea stony corals","volume":"9","author":"Barneah","year":"2007","journal-title":"Environ Microbiol"},{"key":"2024020118231126600_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1099\/ijs.0.02402-0","article-title":"Vibrio coralliilyticus sp. nov., a temperature-dependent pathogen of the coral Pocillopora damicornis","volume":"53","author":"Ben-Haim","year":"2003","journal-title":"Int J Syst Evol Microbiol"},{"key":"2024020118231126600_CR4","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.tim.2009.09.004","article-title":"Microbial disease and the coral holobiont","volume":"17","author":"Bourne","year":"2009","journal-title":"Trends Microbiol"},{"key":"2024020118231126600_CR5","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1080\/01621459.1992.10475194","article-title":"Estimating the number of classes via sample coverage","volume":"87","author":"Chao","year":"1992","journal-title":"J Am Stat Assoc"},{"key":"2024020118231126600_CR6","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1099\/ijs.0.02359-0","article-title":"Aurantimonas coralicida gen. nov. sp. nov., the causative agent of white plague type II on Caribbean scleractinian corals","volume":"53","author":"Denner","year":"2003","journal-title":"Int J Syst Evol Microbiol"},{"key":"2024020118231126600_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/BF02430665","article-title":"Vitality of reef coral populations off Key Largo, Florida: recruitment and mortality","volume":"2","author":"Dustan","year":"1977","journal-title":"Environ Geol"},{"key":"2024020118231126600_CR8","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1111\/j.1462-2920.2010.02392.x","article-title":"Ribosomal tag pyrosequencing of DNA and RNA from benthic coral reef microbiota: community spatial structure, rare members and nitrogen-cycling guilds","volume":"13","author":"Gaidos","year":"2011","journal-title":"Environ Microbiol"},{"key":"2024020118231126600_CR9","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1126\/science.1086050","article-title":"Long-term region-wide declines in Caribbean corals","volume":"301","author":"Gardner","year":"2003","journal-title":"Science"},{"key":"2024020118231126600_CR10","first-page":"65","article-title":"Stony coral diseases observed in southwestern Caribbean reefs","volume":"460","author":"Garz\u00f3n-Ferreira","year":"2001","journal-title":"Bull Mar Sci"},{"key":"2024020118231126600_CR11","first-page":"189","article-title":"Coral diseases and their research in colombian reefs","volume":"38","author":"Gil-Agudelo","year":"2009","journal-title":"Bol Invemar"},{"key":"2024020118231126600_CR12","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1099\/ijs.0.02430-0","article-title":"Vibrio rotiferianus sp. nov., isolated from cultures of the rotifer Brachionus plicatilis","volume":"53","author":"Gomez-Gil","year":"2003","journal-title":"Int J Syst Evol Microbiol"},{"key":"2024020118231126600_CR13","first-page":"157","article-title":"Rapid spread of diseases in Caribbean coral reefs","volume":"46","author":"Goreau","year":"1998","journal-title":"Rev Biol Trop"},{"key":"2024020118231126600_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/S0006-3207(00)00073-2","article-title":"The significance of coral disease epizootiology for coral reef conservation","volume":"96","author":"Green","year":"2000","journal-title":"Biol Conserv"},{"key":"2024020118231126600_CR15","doi-asserted-by":"publisher","first-page":"172","DOI":"10.5670\/oceanog.2007.91","article-title":"Coral disease, environmental drivers, and the balance between coral and microbial associates","volume":"20","author":"Harvell","year":"2007","journal-title":"Oceanography"},{"key":"2024020118231126600_CR16","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1126\/science.285.5433.1505","article-title":"Emerging marine diseases-climate links and anthropogenic factors","volume":"285","author":"Harvell","year":"1999","journal-title":"Science"},{"key":"2024020118231126600_CR17","volume-title":"Bergey's Manual Of Determinative Bacteriology","author":"Holt","year":"1994"},{"key":"2024020118231126600_CR18","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1126\/science.1085046","article-title":"Climate change, human impacts, and the resilience of coral reefs","volume":"301","author":"Hughes","year":"2003","journal-title":"Science"},{"key":"2024020118231126600_CR19","doi-asserted-by":"publisher","first-page":"11458","DOI":"10.1073\/pnas.0802812105","article-title":"Ecological extintion and evolution in the brave new ocean","volume":"105","author":"Jackson","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024020118231126600_CR20","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/BF01731581","article-title":"A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences","volume":"16","author":"Kimura","year":"1980","journal-title":"J Mol Evol"},{"key":"2024020118231126600_CR21","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1099\/00207713-51-4-1383","article-title":"Vibrio shiloi sp. nov., the causative agent of bleaching of the coral Oculina patagonica","volume":"51","author":"Kushmaro","year":"2001","journal-title":"Int J Syst Evol Microbiol"},{"key":"2024020118231126600_CR22","doi-asserted-by":"publisher","first-page":"e10401","DOI":"10.1371\/journal.pone.0010401","article-title":"Bacterial communities of two ubiquitous Great Barrier Reef corals reveals both site- and species-specificity of common bacterial associates","volume":"5","author":"Kvennefors","year":"2010","journal-title":"PloS one"},{"key":"2024020118231126600_CR23","first-page":"115","volume-title":"Nucleic acid techniques in bacterial systematics","author":"Lane","year":"1991"},{"key":"2024020118231126600_CR24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jembe.2007.02.015","article-title":"Are infectious diseases really killing corals? Alternative interpretation of the experimental and ecological data","volume":"346","author":"Lesser","year":"2007","journal-title":"J Exp Mar Biol Ecol"},{"key":"2024020118231126600_CR25","first-page":"321","article-title":"Saving the rainforests of the sea: an analysis of international efforts to conserve coral reefs","volume":"19","author":"Mulhall","year":"2009","journal-title":"Duke Environ Law Policy Forum"},{"key":"2024020118231126600_CR26","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1126\/science.1085706","article-title":"Global trajectories of the long-term decline of coral reef ecosystems","volume":"301","author":"Pandolfi","year":"2003","journal-title":"Science"},{"key":"2024020118231126600_CR27","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1111\/j.1461-0248.2006.00933.x","article-title":"Ecological persistence interrupted in Caribbean coral reefs","volume":"9","author":"Pandolfi","year":"2006","journal-title":"Ecol Letters"},{"key":"2024020118231126600_CR28","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3354\/dao069079","article-title":"Bacterial community structure associated with white band disease in the elkhorn coral Acropora palmata determined using culture-independent 16S rRNA techniques","volume":"69","author":"Pantos","year":"2006","journal-title":"Dis Aquat Organ"},{"key":"2024020118231126600_CR29","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1046\/j.1462-2920.2003.00427.x","article-title":"The bacterial ecology of a plague-like disease affecting the Caribbean coral Montastrea annularis","volume":"5","author":"Pantos","year":"2003","journal-title":"Environ Microbiol"},{"key":"2024020118231126600_CR30","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1574-6968.2010.02104.x","article-title":"Isolation and characterization of a Nocardiopsis sp. from honeybee guts","volume":"312","author":"Patil","year":"2010","journal-title":"FEMS Microbiol Lett"},{"key":"2024020118231126600_CR31","doi-asserted-by":"publisher","first-page":"8725","DOI":"10.1073\/pnas.092260099","article-title":"The etiology of white pox, a lethal disease of the Caribbean elkhorn coral, Acropora palmata","volume":"99","author":"Patterson","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"2024020118231126600_CR32","doi-asserted-by":"publisher","first-page":"597","DOI":"10.4269\/ajtmh.2004.70.597","article-title":"Studies on cultured and uncultured microbiota of wild culex quinquefasciatus mosquito midgut based on 16s ribosomal RNA gene analysis","volume":"70","author":"Pidiyar","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"2024020118231126600_CR33","first-page":"247","article-title":"PCR-based Assay for Detection of Four Coral Pathogens","volume":"8","author":"Polson","year":"2008","journal-title":"Proc 11th Proc 9th Int Coral Reef Symp Ft Lauderdale"},{"key":"2024020118231126600_CR34","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1111\/j.1462-2920.2006.01148.x","article-title":"The coral probiotic hypothesis","volume":"8","author":"Reshef","year":"2006","journal-title":"Environ Microbiol"},{"key":"2024020118231126600_CR35","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/S0169-5347(98)01460-8","article-title":"Coral diseases: what is really known?","volume":"13","author":"Richardson","year":"1998","journal-title":"Trends Ecol Evol"},{"key":"2024020118231126600_CR36","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s003380100138","article-title":"Diversity of bacterial associated with the caribbean coral Montastrea franksi","volume":"20","author":"Rohwer","year":"2001","journal-title":"Coral Reef"},{"key":"2024020118231126600_CR37","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1046\/j.1462-2920.2002.00302.x","article-title":"Microbial diseases of corals and global warming","volume":"4","author":"Rosenberg","year":"2002","journal-title":"Environ Microbiol"},{"key":"2024020118231126600_CR38","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nrmicro1635","article-title":"The role of microorganisms in coral health, disease and evolution","volume":"5","author":"Rosenberg","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"2024020118231126600_CR39","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/ismej.2008.104","article-title":"The role of microorganisms in coral bleaching","volume":"3","author":"Rosenberg","year":"2009","journal-title":"ISME J"},{"key":"2024020118231126600_CR40","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/j.1574-6976.2001.tb00571.x","article-title":"The species concept for prokaryotes","volume":"25","author":"Rossell\u00f3-Mora","year":"2001","journal-title":"FEMS Microbiol Rev"},{"key":"2024020118231126600_CR41","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s12223-009-0059-9","article-title":"16S rRNA gene-based identification of cultured bacterial flora from host-seeking Ixodes ricinus, Dermacentor reticulatus and Haemaphysalis concinna ticks, vectors of vertebrate pathogens","volume":"54","author":"Rudolf","year":"2009","journal-title":"Folia microbiol"},{"key":"2024020118231126600_CR42","first-page":"406","article-title":"The neighbor joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol Biol Evol"},{"key":"2024020118231126600_CR43","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ismej.2007.77","article-title":"The diversity of the bacterial communities associated with the azooxanthellate hexacoral Cirrhipathes lutkeni","volume":"1","author":"Santiago-Vazquez","year":"2007","journal-title":"ISME J"},{"key":"2024020118231126600_CR44","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/ismej.2009.103","article-title":"Successional changes in bacterial communities during the development of black band disease on the reef coral, Montipora hispida","volume":"4","author":"Sato","year":"2010","journal-title":"ISME J"},{"key":"2024020118231126600_CR45","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1128\/AEM.71.3.1501-1506.2005","article-title":"Introducing DOTUR, a computer program for defining operational taxonomic units and estimating species richness","volume":"71","author":"Schloss","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"2024020118231126600_CR46","doi-asserted-by":"publisher","first-page":"5963","DOI":"10.1128\/AEM.00843-06","article-title":"Microbial communities in the surface mucopolysaccharide layer and the black band microbial mat of black band-diseased Siderastrea siderea","volume":"72","author":"Sekar","year":"2006","journal-title":"Appl Environ Microbiol"},{"key":"2024020118231126600_CR47","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/j.1538-7305.1948.tb01338.x","article-title":"A mathematical theory of communication","volume":"27","author":"Shannon","year":"1948","journal-title":"Bell Syst Tech J"},{"key":"2024020118231126600_CR48","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/nrmicro2540","article-title":"Unravelling the effects of the environment and host genotype on the gut microbiome","volume":"9","author":"Spor","year":"2011","journal-title":"Nat Rev Microbiol"},{"key":"2024020118231126600_CR49","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1099\/00207713-44-4-846","article-title":"A place for DNA\u2013DNA reassociation and 16S rRNA sequence analysis in the present species definition in bacteriology","volume":"44","author":"Stackebrandt","year":"1994","journal-title":"Int J Syst Bacteriol"},{"key":"2024020118231126600_CR50","doi-asserted-by":"publisher","first-page":"e1000711","DOI":"10.1371\/journal.ppat.1000711","article-title":"Like will to like: abundances of closely related species can predict susceptibility to intestinal colonization by pathogenic and commensal bacteria","volume":"6","author":"Stecher","year":"2010","journal-title":"PLoS Pathog"},{"key":"2024020118231126600_CR51","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/ismej.2008.131","article-title":"Bacterial diversity and white plague disease-associated community changes in the Caribbean coral Montastraea faveolata","volume":"3","author":"Sunagawa","year":"2009","journal-title":"ISME J"},{"key":"2024020118231126600_CR52","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3354\/meps266273","article-title":"Disease and immunity in Caribbean and Indo-Pacific zooxanthellate corals","volume":"266","author":"Sutherland","year":"2004","journal-title":"Mar Ecol Prog Ser"},{"key":"2024020118231126600_CR53","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0","volume":"24","author":"Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"2024020118231126600_CR54","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1099\/ijs.0.63800-0","article-title":"Thalassomonas loyana sp. Nov., a causative agent of the white plague-like disease of corals on the Eilat coral reef","volume":"56","author":"Thompson","year":"2006","journal-title":"Int J Syst Evol Microbiol"},{"key":"2024020118231126600_CR55","doi-asserted-by":"publisher","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"2024020118231126600_CR56","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Na\u00efve bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"2024020118231126600_CR57","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1128\/IAI.01469-06","article-title":"Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia","volume":"75","author":"Waters","year":"2007","journal-title":"Infect Immun"},{"key":"2024020118231126600_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3354\/dao069001","article-title":"Status and progress in coral reef disease research","volume":"69","author":"Weil","year":"2006","journal-title":"Dis Aquat Org"},{"key":"2024020118231126600_CR59","first-page":"1231","article-title":"Geographic variability in the incidence of coral and octocoral diseases in the wider Caribbean","volume":"2","author":"Weil","year":"2002","journal-title":"Proc 9th Int Coral Reef Symp Bali"},{"key":"2024020118231126600_CR60","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1071\/MF99121","article-title":"Global and local threats to coral reef functioning and existence: review and predictions","volume":"50","author":"Wilkinson","year":"1999","journal-title":"Mar Freshwater Res"},{"key":"2024020118231126600_CR61","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1099\/00207713-52-6-1937","article-title":"Stenotrophomonas rhizophila sp. nov., a novel plant-associated bacterium with antifungal properties","volume":"52","author":"Wolf","year":"2002","journal-title":"Int J Syst Evol Microbiol"},{"key":"2024020118231126600_CR62","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.1128\/AEM.00592-09","article-title":"Comparison of species richness estimates obtained using nearly complete fragments and simulated pyrosequencing-generated fragments in 16S rRNA gene-based environmental surveys","volume":"75","author":"Youssef","year":"2009","journal-title":"Appl Environ Microbiol"}],"container-title":["The ISME Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ismej2011123.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ismej2011123","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/ismej\/article-pdf\/6\/3\/502\/56424157\/41396_2012_article_bfismej2011123.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/www.nature.com\/articles\/ismej2011123.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/academic.oup.com\/ismej\/article-pdf\/6\/3\/502\/56424157\/41396_2012_article_bfismej2011123.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:07:26Z","timestamp":1741759646000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ismej\/article\/6\/3\/502\/7590009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,29]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3,1]]}},"URL":"https:\/\/doi.org\/10.1038\/ismej.2011.123","relation":{},"ISSN":["1751-7362","1751-7370"],"issn-type":[{"value":"1751-7362","type":"print"},{"value":"1751-7370","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2012,3]]},"published":{"date-parts":[[2011,9,29]]}}}