{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:32:15Z","timestamp":1790703135812,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":2974,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0\/"},{"start":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T00:00:00Z","timestamp":1448582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer cachexia is a multifactorial syndrome that includes muscle wasting and inflammation. As gut microbes influence host immunity and metabolism, we investigated the role of the gut microbiota in the therapeutic management of cancer and associated cachexia. A community-wide analysis of the caecal microbiome in two mouse models of cancer cachexia (acute leukaemia or subcutaneous transplantation of colon cancer cells) identified common microbial signatures, including decreased Lactobacillus spp. and increased Enterobacteriaceae and Parabacteroides goldsteinii\/ASF 519. Building on this information, we administered a synbiotic containing inulin-type fructans and live Lactobacillus reuteri 100-23 to leukaemic mice. This treatment restored the Lactobacillus population and reduced the Enterobacteriaceae levels. It also reduced hepatic cancer cell proliferation, muscle wasting and morbidity, and prolonged survival. Administration of the synbiotic was associated with restoration of the expression of antimicrobial proteins controlling intestinal barrier function and gut immunity markers, but did not impact the portal metabolomics imprinting of energy demand. In summary, this study provided evidence that the development of cancer outside the gut can impact intestinal homeostasis and the gut microbial ecosystem and that a synbiotic intervention, by targeting some alterations of the gut microbiota, confers benefits to the host, prolonging survival and reducing cancer proliferation and cachexia.<\/jats:p>","DOI":"10.1038\/ismej.2015.209","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T10:02:01Z","timestamp":1448618521000},"page":"1456-1470","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":206,"title":["Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia"],"prefix":"10.1093","volume":"10","author":[{"given":"Laure B","family":"Bindels","sequence":"first","affiliation":[{"name":"Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universit\u00e9 Catholique de Louvain , Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey M","family":"Neyrinck","sequence":"additional","affiliation":[{"name":"Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Universit\u00e9 Catholique de Louvain , Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine P","family":"Claus","sequence":"additional","affiliation":[{"name":"Department of Food and Nutritional Sciences, University of Reading , Reading, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline I","family":"Le Roy","sequence":"additional","affiliation":[{"name":"Department of Food and Nutritional Sciences, University of Reading , Reading, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Grangette","sequence":"additional","affiliation":[{"name":"Lactic Acid Bacteria and Mucosal Immunity, Centre for Infection and Immunity of Lille, INSERM U1019-CNRS 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