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Here, we present a genomic and morphological characterization of cyanophage S-EIV1 that was isolated from freshwaters on Ellesmere Island (Nunavut, High Arctic Canada), and which infects the polar Synechococcus sp., strain PCCC-A2c. S-EIV1 represents a newly discovered evolutionary lineage of bacteriophages whose representatives are widespread in aquatic systems. Among the 130 predicted open reading frames (ORFs) there is no recognizable similarity to genes that encode structural proteins other than the large terminase subunit and a distant viral morphogenesis protein, indicating that the genes encoding the structural proteins of S-EIV1 are distinct from other viruses. As well, only 19 predicted coding sequences on the 79\u2009178\u2009bp circularly permuted genome have homology with genes encoding proteins of known function. Although S-EIV1 is divergent from other sequenced phage isolates, it shares synteny with phage genes captured on a fosmid from the deep-chlorophyll maximum in the Mediterranean Sea, as well as with an incision element in the genome of Anabaena variabilis (ATCC 29413). Sequence recruitment of metagenomic data indicates that S-EIV1-like viruses are cosmopolitan and abundant in a wide range of aquatic systems, suggesting they have an important ecological role.<\/jats:p>","DOI":"10.1038\/ismej.2015.24","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T14:54:17Z","timestamp":1427468057000},"page":"2046-2058","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Polar freshwater cyanophage S-EIV1 represents a new widespread evolutionary lineage of phages"],"prefix":"10.1093","volume":"9","author":[{"given":"C","family":"Ch\u00e9nard","sequence":"first","affiliation":[{"name":"Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia , Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia , Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W F","family":"Vincent","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Biologie and Centre d\u2019\u00e9tudes nordiques (CEN), Laval University , Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A","family":"Suttle","sequence":"additional","affiliation":[{"name":"Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia , Vancouver, British Columbia, Canada"},{"name":"Departments of Botany, and Microbiology & Immunology, University of British Columbia , Vancouver, British Columbia, Canada"},{"name":"Canadian Institute for Advanced Research , Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,27]]},"reference":[{"key":"2024012421181559200_CR1","first-page":"8","volume-title":"The bacteriophages","author":"Ackermann","year":"2006"},{"key":"2024012421181559200_CR2","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/0042-6822(71)90023-7","article-title":"Isolation and characterization of a virus infecting the blue-green alga Nostoc muscorum","volume":"208","author":"Adolph","year":"1971","journal-title":"Virology"},{"key":"2024012421181559200_CR3","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1093\/plankt\/19.11.1599","article-title":"Abundance, frequency of dividing cells and growth rates of Synechococcus sp. 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