{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:58:17Z","timestamp":1784073497297,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Uninfected female rats (Rattus novergicus) exhibit greater attraction to the males infected with protozoan parasite Toxoplasma gondii. This phenomenon is contrary to the aversion towards infected males observed in multitude of other host\u2013parasite associations. In this report, we describe a proximate mechanism for this anomaly. We demonstrate that T. gondii infection enhances hepatic production and urinary excretion of \u03b12u-globulins in rats. We further demonstrate that \u03b12u-globulins are sufficient to recapitulate male sexual attractiveness akin to effects of the infection. This manipulation possibly results in greater horizontal transmission of this parasite between the infected male and the uninfected female. It supports the notion that in some evolutionary niches parasites can alter host sexual signaling, likely leading to an increased rate of sexual transmission.<\/jats:p>","DOI":"10.1038\/ismej.2015.33","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T14:53:34Z","timestamp":1426258414000},"page":"2112-2115","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["\u03b12u-globulins mediate manipulation of host attractiveness in <i>Toxoplasma gondii<\/i>\u2013<i>Rattus novergicus<\/i> association"],"prefix":"10.1093","volume":"9","author":[{"given":"Anand","family":"Vasudevan","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Kumar","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Ning Chiang","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratories , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne Y","family":"Yew","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratories , Singapore, Singapore"},{"name":"Department of Biological Sciences, National University of Singapore , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabna","family":"Cheemadan","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajai","family":"Vyas","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Nanyang Technological University , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"2024012421183889200_CR1","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1098\/rspb.2000.1182","article-title":"Fatal attraction in rats infected with Toxoplasma gondii","volume":"267","author":"Berdoy","year":"2000","journal-title":"Proc Biol Sci"},{"key":"2024012421183889200_CR2","doi-asserted-by":"publisher","first-page":"e27229","DOI":"10.1371\/journal.pone.0027229","article-title":"Protozoan parasite Toxoplasma gondii manipulates mate choice in rats by enhancing attractiveness of males","volume":"6","author":"Dass","year":"2011","journal-title":"PLoS One"},{"key":"2024012421183889200_CR3","volume-title":"The Extended Phenotype: The Long Reach of the Gene","author":"Dawkins","year":"1999"},{"key":"2024012421183889200_CR4","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.mehy.2014.05.019","article-title":"Toxoplasmosis can be a sexually transmitted infection with serious clinical consequences. 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