{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:25:51Z","timestamp":1763036751593},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T00:00:00Z","timestamp":1369180800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1038\/ja.2013.46","type":"journal-article","created":{"date-parts":[[2013,5,22]],"date-time":"2013-05-22T06:17:32Z","timestamp":1369203452000},"page":"365-369","source":"Crossref","is-referenced-by-count":2,"title":["Exploring antibiotic biosynthesis: Leo Vining\u2019s insights lead to new strategies in the quest for \u2018The 10 \u00d7 '20 Initiative\u2019"],"prefix":"10.1038","volume":"66","author":[{"given":"Lei","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Madduri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,22]]},"reference":[{"key":"BFja201346_CR1","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1086\/652237","volume":"50","author":"DN Gilbert","year":"2010","unstructured":"Gilbert, D. N. et al. The 10 x \u203220 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020. Clin. Infect. Dis. 50, 1081\u20131083 (2010).","journal-title":"Clin. Infect. Dis."},{"key":"BFja201346_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0734-9750(90)90010-9","volume":"8","author":"JL Doull","year":"1990","unstructured":"Doull, J. L. & Vining, L. C. Physiology of antibiotic production in actinomycetes and some underlying control mechanisms. Biotechnol. Adv. 8, 141\u2013158 (1990).","journal-title":"Biotechnol. Adv."},{"key":"BFja201346_CR3","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0378-1119(92)90551-Y","volume":"115","author":"LC Vining","year":"1992","unstructured":"Vining, L. C. Secondary metabolism, inventive evolution and biochemical diversity - a review. Gene 115, 135\u2013140 (1992).","journal-title":"Gene"},{"key":"BFja201346_CR4","doi-asserted-by":"publisher","first-page":"R161","DOI":"10.1186\/gb-2007-8-8-r161","volume":"8","author":"A Hesketh","year":"2007","unstructured":"Hesketh, A., Chen, W., Ryding, J., Chang, S. & Bibb, M. J. The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2). Genome Biol. 8, R161 (2007).","journal-title":"Genome Biol."},{"key":"BFja201346_CR5","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.mib.2005.02.016","volume":"8","author":"MJ Bibb","year":"2005","unstructured":"Bibb, M. J. Regulation of secondary metabolism in streptomycetes. Curr. Opin. Microbiol. 8, 208\u2013215 (2005).","journal-title":"Curr. Opin. Microbiol."},{"key":"BFja201346_CR6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1186\/1471-2164-12-175","volume":"12","author":"ST Pullan","year":"2011","unstructured":"Pullan, S. T., Chandra, G., Bibb, M. J. & Merrick, M. Genome-wide analysis of the role of GlnR in Streptomyces venezuelae provides new insights into global nitrogen regulation in actinomycetes. BMC Genomics 12, 175 (2011).","journal-title":"BMC Genomics"},{"key":"BFja201346_CR7","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0378-1119(01)00723-5","volume":"279","author":"K Yang","year":"2001","unstructured":"Yang, K., Han, L., He, J., Wang, L. & Vining, L. C. A repressor-response regulator gene pair controlling jadomycin B production in Streptomyces venezuelae ISP5230. Gene 279, 165\u2013173 (2001).","journal-title":"Gene"},{"key":"BFja201346_CR8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1128\/jb.171.1.299-302.1989","volume":"171","author":"K Madduri","year":"1989","unstructured":"Madduri, K., Stuttard, C. & Vining, L. C. Lysine catabolism in Streptomyces spp. Is primarily through cadaverine: B-lactam producers also make \u03b1-aminoadipate. J. Bacteriol. 171, 299\u2013302 (1989).","journal-title":"J. Bacteriol."},{"key":"BFja201346_CR9","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1128\/jb.173.3.985-988.1991","volume":"173","author":"K Madduri","year":"1991","unstructured":"Madduri, K., Stuttard, C. & Vining, L. C. Cloning and location of a gene governing lysine \u025b-aminotransferase, an enzyme initiating \u03b2-lactam biosynthesis in Streptomyces spp. J. Bacteriol. 173, 985\u2013988 (1991).","journal-title":"J. Bacteriol."},{"key":"BFja201346_CR10","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1099\/00221287-146-4-903","volume":"146","author":"L Han","year":"2000","unstructured":"Han, L. et al. An acyl-coenzyme a carboxylase encoding gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230. Microbiology 146, 903\u2013910 (2000).","journal-title":"Microbiology"},{"key":"BFja201346_CR11","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/BF00164502","volume":"44","author":"LH Malmberg","year":"1995","unstructured":"Malmberg, L. H., Hu, W. S. & Sherman, D. H. Effects of enhanced lysine epsilon-aminotransferase activity on cephamycin biosynthesis in Streptomyces clavuligerus. Appl. Microbiol. Biotechnol. 44, 198\u2013205 (1995).","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"BFja201346_CR12","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.ymben.2010.05.001","volume":"12","author":"J Thykaer","year":"2010","unstructured":"Thykaer, J. et al. Increased glycopeptide production after overexpression of shikimate pathway genes being part of the balhimycin biosynthetic gene cluster. Metab. Eng. 12, 455\u2013461 (2010).","journal-title":"Metab. Eng."},{"key":"BFja201346_CR13","doi-asserted-by":"publisher","first-page":"7132","DOI":"10.1128\/AEM.01308-06","volume":"72","author":"Y Ryu","year":"2006","unstructured":"Ryu, Y., Butler, M. J., Chater, K. F. & Lee, K. J. Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor. Appl. Environ. Microbiol. 72, 7132\u20137139 (2006).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFja201346_CR14","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1039\/b617765b","volume":"24","author":"JS Rokem","year":"2007","unstructured":"Rokem, J. S, Lantz, A. E. & Nielsen, J. Systems biology of antibiotic production by microorganisms. Nat. Prod. Rep. 24, 1262\u20131287 (2007).","journal-title":"Nat. Prod. Rep."},{"key":"BFja201346_CR15","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/B978-0-12-385075-1.00021-4","volume":"497","author":"MH Medema","year":"2011","unstructured":"Medema, M. H., Breitling, R. & Takano, E. Synthetic biology in Streptomyces bacteria. Methods Enzymol. 497, 485\u2013501 (2011).","journal-title":"Methods Enzymol."},{"key":"BFja201346_CR16","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1002\/bit.20279","volume":"88","author":"N Gunnarsson","year":"2004","unstructured":"Gunnarsson, N., Bruheim, P. & Nielsen, J. Glucose metabolism in the antibiotic producing actinomycete Nonomuraea sp. ATCC 39727. Biotechnol. Bioeng. 88, 652\u2013663 (2004).","journal-title":"Biotechnol. Bioeng."},{"key":"BFja201346_CR17","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1038\/nbt.1498","volume":"26","author":"MA van den Berg","year":"2008","unstructured":"van den Berg, M. A. et al. Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum. Nat. Biotechnol. 26, 1161\u20131168 (2008).","journal-title":"Nat. Biotechnol."},{"key":"BFja201346_CR18","doi-asserted-by":"publisher","first-page":"6200","DOI":"10.1073\/pnas.92.13.6200","volume":"92","author":"F Fierro","year":"1995","unstructured":"Fierro, F. et al. The penicillin gene cluster is amplified in tandem repeats linked by conserved hexanucleotide sequences. Proc. Natl Acad. Sci. USA 92, 6200\u20136204 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFja201346_CR19","doi-asserted-by":"publisher","first-page":"7109","DOI":"10.1128\/AEM.01702-10","volume":"76","author":"JG Nijland","year":"2010","unstructured":"Nijland, J. G., Ebbendorf, B., Woszczynska, M., Boer, R., Bovenberg, R. A. & Driessen, A. J. Nonlinear biosynthetic gene cluster dose effect on penicillin production by Penicillium chrysogenum. Appl. Environ. Microbiol. 76, 7109\u20137115 (2010).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFja201346_CR20","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1126\/science.1904627","volume":"252","author":"G Stephanopoulos","year":"1991","unstructured":"Stephanopoulos, G. & Vallino, J. J. Network rigidity and metabolic engineering in metabolite overproduction. Science 252, 1675\u20131681 (1991).","journal-title":"Science"},{"key":"BFja201346_CR21","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.copbio.2005.04.010","volume":"16","author":"M Koffas","year":"2005","unstructured":"Koffas, M. & Stephanopoulos, G. Strain improvement by metabolic engineering: lysine production as a case study for systems biology. Curr. Opin. Biotechnol. 16, 361\u2013366 (2005).","journal-title":"Curr. Opin. Biotechnol."},{"key":"BFja201346_CR22","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1002\/anie.201106305","volume":"51","author":"NS Cortina","year":"2012","unstructured":"Cortina, N. S., Krug, D., Plaza, A., Revermann, O. & M\u00fcller, R. Myxoprincomide: a natural product from myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome. Angew. Chem. Int. Ed. Engl. 51, 811\u2013816 (2012).","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"BFja201346_CR23","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/nature04640","volume":"440","author":"DK Ro","year":"2006","unstructured":"Ro, D. K. et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440, 940\u2013943 (2006).","journal-title":"Nature"},{"key":"BFja201346_CR24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1159\/000086705","volume":"8","author":"M Inui","year":"2004","unstructured":"Inui, M., Kawaguchi, H., Murakami, S., Vert\u00e8s, A. A. & Yukawa, H. Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions. J. Mol. Microbiol. Biotechnol. 8, 243\u2013254 (2004).","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"BFja201346_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1751-7915.2010.00219.x","volume":"4","author":"JP Gomez-Escribano","year":"2011","unstructured":"Gomez-Escribano, J. P. & Bibb, M. J. Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters. Microb. Biotechnol. 4, 207\u2013215 (2011).","journal-title":"Microb. Biotechnol."},{"key":"BFja201346_CR26","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s10295-011-1083-8","volume":"39","author":"HN Lee","year":"2012","unstructured":"Lee, H. N., Kim, H. J., Kim, P., Lee, H. S. & Kim, E. S. Minimal polyketide pathway expression in an actinorhodin cluster-deleted and regulation-stimulated Streptomyces coelicolor. J. Ind. Microbiol. Biotechnol. 39, 805\u2013811 (2012).","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"BFja201346_CR27","doi-asserted-by":"publisher","first-page":"2452","DOI":"10.1128\/AEM.71.5.2452-2459.2005","volume":"71","author":"AS Eust\u00e1quio","year":"2005","unstructured":"Eust\u00e1quio, A. S., Gust, B., Galm, U., Li, S. M., Chater, K. F. & Heide, L. Heterologous expression of novobiocin and clorobiocin biosynthetic gene clusters. Appl. Environ. Microbiol. 71, 2452\u20132459 (2005).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFja201346_CR28","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1073\/pnas.0914833107","volume":"107","author":"M Komatsu","year":"2010","unstructured":"Komatsu, M., Uchiyama, T., Omura, S., Cane, D. E. & Ikeda, H. Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc. Natl Acad. Sci. USA 107, 2646\u20132651 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFja201346_CR29","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1128\/AEM.71.5.2539-2547.2005","volume":"71","author":"S Peir\u00fa","year":"2005","unstructured":"Peir\u00fa, S., Menzella, H. G., Rodr\u00edguez, E., Carney, J. & Gramajo, H. Production of the potent antibacterial polyketide erythromycin C in Escherichia coli. Appl. Environ. Microbiol. 71, 2539\u20132547 (2005).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFja201346_CR30","doi-asserted-by":"publisher","first-page":"e8317","DOI":"10.1371\/journal.pone.0008317","volume":"4","author":"L Gidijala","year":"2009","unstructured":"Gidijala, L. et al. An engineered yeast efficiently secreting penicillin. PLoS One 4, e8317 (2009).","journal-title":"PLoS One"},{"key":"BFja201346_CR31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/B978-0-12-385120-8.00014-0","volume":"498","author":"B Tsvetanova","year":"2011","unstructured":"Tsvetanova, B. et al. Genetic assembly tools for synthetic biology. Methods Enzymol. 498, 327\u2013348 (2011).","journal-title":"Methods Enzymol."},{"key":"BFja201346_CR32","doi-asserted-by":"publisher","first-page":"4301","DOI":"10.1128\/AEM.68.9.4301-4306.2002","volume":"68","author":"DE Gillespie","year":"2002","unstructured":"Gillespie, D. E. et al. Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA. Appl. Environ. Microbiol. 68, 4301\u20134306 (2002).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFja201346_CR33","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1128\/AEM.00044-12","volume":"78","author":"MD McMahon","year":"2012","unstructured":"McMahon, M. D., Guan, C., Handelsman, J. & Thomas, M. G. Metagenomic analysis of Streptomyces lividans reveals host-dependent functional expression. Appl. Environ. Microbiol. 78, 3622\u20133629 (2012).","journal-title":"Appl. Environ. Microbiol."},{"key":"BFja201346_CR34","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/ja.2011.44","volume":"64","author":"MS Butler","year":"2011","unstructured":"Butler, M. S. & Cooper, M. A. Antibiotics in the clinical pipeline in 2011. J. Antibiot. (Tokyo) 64, 413\u2013425 (2011).","journal-title":"J. Antibiot. (Tokyo)"}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ja201346.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ja201346","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ja201346.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:19:41Z","timestamp":1684430381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ja201346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,22]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["BFja201346"],"URL":"https:\/\/doi.org\/10.1038\/ja.2013.46","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,22]]}}}