{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:56:58Z","timestamp":1789952218726,"version":"4.0.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Antibiot"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1038\/ja.2014.108","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T12:04:50Z","timestamp":1407326690000},"page":"661-665","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["From milk to rifampicin and back again: history of failures and successes in the treatment for tuberculosis"],"prefix":"10.1038","volume":"67","author":[{"given":"Michele A","family":"Riva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"key":"BFja2014108_CR1","doi-asserted-by":"publisher","first-page":"87s","DOI":"10.1183\/09031936.02.00309102","volume":"36","author":"MD Iseman","year":"2002","unstructured":"Iseman, M. D. Tuberculosis therapy: past, present and future. Eur. Respir. J. Suppl. 36, 87s\u201394s (2002).","journal-title":"Eur. Respir. J. Suppl."},{"key":"BFja2014108_CR2","first-page":"w13665","volume":"142","author":"AH Diacon","year":"2012","unstructured":"Diacon, A. H., von Groote-Bidlingmaier, F. & Donald., P. R. From magic mountain to table mountain. Swiss Med. Wkly. 142, w13665 (2012).","journal-title":"Swiss Med. Wkly."},{"key":"BFja2014108_CR3","volume-title":"Les maladies \u00e0 l\u2019aube de la civilisation occidentale","author":"MD Grmek","year":"1983","unstructured":"Grmek, M. D. Les maladies \u00e0 l\u2019aube de la civilisation occidentale, Payot: Paris, (1983)."},{"key":"BFja2014108_CR4","first-page":"23","volume-title":"Storia scientifico-letteraria della tubercolosi dall\u2019antichit\u00e0 ai giorni nostri","author":"A Bernardi","year":"2012","unstructured":"Bernardi, A., Barbuti, N. & Montagna, M. T. Il morbo oscuro. Storia scientifico-letteraria della tubercolosi dall\u2019antichit\u00e0 ai giorni nostri 23\u201331 Mario Adda Editore: Bari, (2012)."},{"key":"BFja2014108_CR5","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1016\/j.rmed.2006.08.006","volume":"100","author":"TM Daniel","year":"2006","unstructured":"Daniel, T. M. The history of tuberculosis. Respir. Med. 100, 1862\u20131870 (2006).","journal-title":"Respir. Med."},{"key":"BFja2014108_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.explore.2013.03.001","volume":"9","author":"L Dossey","year":"2013","unstructured":"Dossey, L. The royal touch: a look at healing in times past. Explore (NY) 9, 121\u2013127 (2013).","journal-title":"Explore (NY)"},{"key":"BFja2014108_CR7","first-page":"326","volume-title":"Storia della medicina dall\u2019antichit\u00e0 ad oggi","author":"G Cosmacini","year":"2008","unstructured":"Cosmacini, G. L\u2019arte lunga. Storia della medicina dall\u2019antichit\u00e0 ad oggi 326\u2013327 Laterza: Roma-Bari, (2008)."},{"key":"BFja2014108_CR8","volume-title":"La tisi nell\u2019Italia dell\u2019Ottocento","author":"E Tognotti","year":"2012","unstructured":"Tognotti, E. Il morbo lento. La tisi nell\u2019Italia dell\u2019Ottocento, Franco Angeli: Milan, (2012)."},{"key":"BFja2014108_CR9","volume-title":"The influence of climate in the prevention and cure of chronic disease, more particularly of the chest and digestive organs","author":"J Clark","year":"1829","unstructured":"Clark, J. The influence of climate in the prevention and cure of chronic disease, more particularly of the chest and digestive organs, Thomas and George Underwood: London, (1829)."},{"key":"BFja2014108_CR10","first-page":"359","volume":"104","author":"MA Riva","year":"2013","unstructured":"Riva, M. A., Ploia, P. R., Rocca, S. & Cesana, G. \u2018Phthisiophobia\u2019: the difficult recognition of transmission of tuberculosis to health care workers. Med. Lav. 104, 359\u2013367 (2013).","journal-title":"Med. Lav."},{"key":"BFja2014108_CR11","volume-title":"Dal Mal sottile alla tubercolosi resistente. Un secolo di sanatori in Valtellina","author":"MA Riva","year":"2012","unstructured":"Riva, M. A. In Dal Mal sottile alla tubercolosi resistente. Un secolo di sanatori in Valtellina ed. Del Curto D., 45\u201349 Grafiche Rusconi: Bellano, (2012)."},{"key":"BFja2014108_CR12","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1111\/1469-0691.12555","volume":"20","author":"E Cambau","year":"2014","unstructured":"Cambau, E. & Drancourt, M. Steps towards the discovery of Mycobacterium tuberculosis by Robert Koch, 1882. Clin. Microbiol. Infect. 20, 196\u2013201 (2014).","journal-title":"Clin. Microbiol. Infect."},{"key":"BFja2014108_CR13","volume-title":"Medicine 10\u2019s Greatest Discoveries","author":"M Friedman","year":"1998","unstructured":"Friedman, M. & Friedland, G. W. Medicine 10\u2019s Greatest Discoveries, Yale University Press: New Haven (CT), (1998)."},{"key":"BFja2014108_CR14","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1086\/513773","volume":"25","author":"JA Sbarbaro","year":"1997","unstructured":"Sbarbaro, J. A. & Iseman, M. D. \u2018Koch's lymph\u2019 107 years later\u2014an oldie but not a goldie. Clin. Infect. Dis. 25, 664\u2013665 (1997).","journal-title":"Clin. Infect. Dis."},{"key":"BFja2014108_CR15","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1574-695X.2012.01002.x","volume":"66","author":"H Yang","year":"2012","unstructured":"Yang, H., Kruh-Garcia, N. A. & Dobos, K. M. Purified protein derivatives of tuberculin\u2014past, present, and future. FEMS Immunol. Med. Microbiol. 66, 273\u2013280 (2012).","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"BFja2014108_CR16","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1128\/CMR.11.3.514","volume":"11","author":"A Glatman-Freedman","year":"1998","unstructured":"Glatman-Freedman, A. & Casadevall, A. Serum therapy for tuberculosis revisited: reappraisal of the role of antibody-mediated immunity against Mycobacterium tuberculosis. Clin. Microbiol. Rev. 11, 514\u2013532 (1998).","journal-title":"Clin. Microbiol. Rev."},{"key":"BFja2014108_CR17","volume-title":"Dal Mal sottile alla tubercolosi resistente. Un secolo di sanatori in Valtellina","author":"E Manzini","year":"2012","unstructured":"Manzini, E. & Di Mauro, S. In Dal Mal sottile alla tubercolosi resistente. Un secolo di sanatori in Valtellina ed. Del Curto D., 39\u201343 Grafiche Rusconi: Bellano, (2012)."},{"key":"BFja2014108_CR18","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1136\/thx.38.5.326","volume":"38","author":"A Sakula","year":"1983","unstructured":"Sakula, A. Carlo Forlanini, inventor of artificial pneumothorax for treatment of pulmonary tuberculosis. Thorax 38, 326\u2013332 (1983).","journal-title":"Thorax"},{"key":"BFja2014108_CR19","volume-title":"La peste bianca. Milano e la lotta antitubercolare (1882-1945)","author":"G Cosmacini","year":"2004","unstructured":"Cosmacini, G., De Filippis, M. & Sanseverino, P. La peste bianca. Milano e la lotta antitubercolare (1882-1945), Franco Angeli: Milan, (2004)."},{"key":"BFja2014108_CR20","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1258\/j.jmb.2007.06-15","volume":"15","author":"BJ Hawgood","year":"2007","unstructured":"Hawgood, B. J. Albert Calmette (1863-1933) and Camille Gu\u00e9rin (1872-1961): the C and G of BCG vaccine. J. Med. Biogr. 15, 139\u2013146 (2007).","journal-title":"J. Med. Biogr."},{"key":"BFja2014108_CR21","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1093\/jhmas\/jrg042","volume":"59","author":"TG Benedek","year":"2004","unstructured":"Benedek, T. G. The history of gold therapy for tuberculosis. J. Hist. Med. Allied Sci. 59, 50\u201389 (2004).","journal-title":"J. Hist. Med. Allied Sci."},{"key":"BFja2014108_CR22","first-page":"953","volume":"90","author":"J Lehmann","year":"1994","unstructured":"Lehmann, J. Twenty years afterward: historical notes on the discovery of the antituberculosis effect of paraaminosalicylic acid (PAS) and the first clinical trials. Am. Rev. Respir. Dis. 90, 953\u2013956 (1994).","journal-title":"Am. Rev. Respir. Dis."},{"key":"BFja2014108_CR23","doi-asserted-by":"publisher","first-page":"66","DOI":"10.3181\/00379727-55-14461","volume":"55","author":"A Schatz","year":"1944","unstructured":"Schatz, A., Bugie, E. & Waksman, S. A. Streptomycin, a substance exhibiting antibiotic activity against Gram-positive and Gram-negative bacteria. Proc. Soc. Exp. Biol. Med. 55, 66\u201369 (1944).","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"BFja2014108_CR24","first-page":"120","volume":"9","author":"TM Daniel","year":"2005","unstructured":"Daniel, T. M. Selman Abraham Waksman and the discovery of streptomycin. Int. J. Tuberc. Lung Dis. 9, 120\u2013122 (2005).","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"BFja2014108_CR25","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1136\/bmj.2.4582.769","volume":"2","author":"Medical Research Council","year":"1948","unstructured":"Medical Research Council. Streptomycin treatment of pulmonary tuberculosis. Br. Med. J. 2, 769\u2013782 (1948).","journal-title":"Br. Med. J."},{"key":"BFja2014108_CR26","first-page":"221","volume":"25","author":"W Fox","year":"1956","unstructured":"Fox, W. & Sutherland, I. A five-year assessment of patients in a controlled trial of streptomycin, para-aminosalicylic acid, and streptomycin plus para-aminosalicylic acid, in pulmonary tuberculosis. Q. J. Med. 25, 221\u2013243 (1956).","journal-title":"Q. J. Med."},{"key":"BFja2014108_CR27","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/infdis\/119.6.678","volume":"119","author":"W McDermott","year":"1969","unstructured":"McDermott, W. The story of INH. J. Infect. Dis. 119, 678\u2013683 (1969).","journal-title":"J. Infect. Dis."},{"key":"BFja2014108_CR28","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1136\/bmj.1.4911.435","volume":"1","author":"Medical Research Council","year":"1955","unstructured":"Medical Research Council. Various combinations of isoniazid with streptomycin or with P.A.S. in the treatment of pulmonary tuberculosis. Br. Med. J. 1, 435\u2013445 (1955).","journal-title":"Br. Med. J."},{"key":"BFja2014108_CR29","first-page":"51","volume":"21","author":"Tuberculosis Chemotherapy Centre","year":"1959","unstructured":"Tuberculosis Chemotherapy Centre. A concurrent comparison of home and sanatorium treatment of pulmonary tuberculosis in South India. Bull. World Health Organ. 21, 51\u2013144 (1959).","journal-title":"Bull. World Health Organ."},{"key":"BFja2014108_CR30","first-page":"117","volume":"107","author":"B Doster","year":"1973","unstructured":"Doster, B., Murray, F. J., Newman, R. & Woolpert, S. F. Ethambutol in the initial treatment of pulmonary tuberculosis. U.S. Public Health Service tuberculosis therapy trials. Am. Rev. Respir. Dis. 107, 117\u2013190 (1973).","journal-title":"Am. Rev. Respir. Dis."},{"issue":"Suppl 3","key":"BFja2014108_CR31","doi-asserted-by":"publisher","first-page":"S402","DOI":"10.1093\/clinids\/5.Supplement_3.S402","volume":"5","author":"P Sensi","year":"1983","unstructured":"Sensi, P. History of the development of rifampin. Rev. Infect. Dis. 5 (Suppl 3), S402\u2013S406 (1983).","journal-title":"Rev. Infect. Dis."},{"key":"BFja2014108_CR32","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1136\/bmj.319.7215.972","volume":"319","author":"J Aronson","year":"1999","unstructured":"Aronson, J. That\u2019s show business. Br. Med. J. 319, 972 (1999).","journal-title":"Br. Med. J."},{"key":"BFja2014108_CR33","first-page":"221","volume-title":"Chronicles of Drug Discovery","author":"P Sensi","year":"1982","unstructured":"Sensi, P. In Chronicles of Drug Discovery eds Bindra J, S., Lednicer D., 201\u2013221 Wiley: New York, (1982)."},{"key":"BFja2014108_CR34","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0041-3879(79)90001-1","volume":"60","author":"Hong Kong Chest Service, BMR Council","year":"1979","unstructured":"Hong Kong Chest Service, BMR Council. Controlled trial of 6-month and 8-month regimens in the treatment of pulmonary tuberculosis: the results up to 24 months. Tubercle 60, 201\u20132010 (1979).","journal-title":"Tubercle"},{"key":"BFja2014108_CR35","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/S0140-6736(95)91090-5","volume":"345","author":"R Bayer","year":"1995","unstructured":"Bayer, R. & Wilkinson, D. Directly observed therapy for tuberculosis: history of an idea. Lancet 345, 1545\u20131548 (1995).","journal-title":"Lancet"},{"key":"BFja2014108_CR36","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/S0140-6736(11)61062-3","volume":"379","author":"K Dheda","year":"2012","unstructured":"Dheda, K. & Migliori, G. B. The global rise of extensively drug-resistant tuberculosis: is the time to bring back sanatoria now overdue? Lancet 379, 773\u2013775 (2012).","journal-title":"Lancet"},{"key":"BFja2014108_CR37","first-page":"571","volume":"10","author":"IY Motus","year":"2006","unstructured":"Motus, I. Y. et al. Reviving an old idea: can artificial pneumothorax play a role in the modern management of tuberculosis? Int. J. Tuberc. Lung Dis. 10, 571\u2013577 (2006).","journal-title":"Int. J. Tuberc. Lung Dis."},{"issue":"Suppl 1","key":"BFja2014108_CR38","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/1471-2172-14-S1-S3","volume":"14","author":"N Alvarez","year":"2013","unstructured":"Alvarez, N. et al. Passive administration of purified secretory IgA from humancolostrum induces protection against Mycobacterium tuberculosis in a murine model of progressive pulmonary infection. BMC Immunol. 14 (Suppl 1), S3 (2013).","journal-title":"BMC Immunol."},{"key":"BFja2014108_CR39","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1016\/S0140-6736(12)60940-4","volume":"379","author":"J Hughes","year":"2012","unstructured":"Hughes, J., Cox, H. & Ford, N. Sanatoria for drug-resistant tuberculosis: an outdated response. Lancet 379, 2148 (2012).","journal-title":"Lancet"},{"key":"BFja2014108_CR40","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3109\/10520295.2013.822559","volume":"89","author":"MA Riva","year":"2014","unstructured":"Riva, M. A. et al. Histochemistry: historical development and current use in pathology. Biotech. Histochem. 89, 81\u201390 (2014).","journal-title":"Biotech. Histochem."}],"container-title":["The Journal of Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ja2014108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ja2014108","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ja2014108.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:20:25Z","timestamp":1684430425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ja2014108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["BFja2014108"],"URL":"https:\/\/doi.org\/10.1038\/ja.2014.108","relation":{},"ISSN":["0021-8820","1881-1469"],"issn-type":[{"value":"0021-8820","type":"print"},{"value":"1881-1469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]},"assertion":[{"value":"18 May 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}